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Volumn 119, Issue 10, 2013, Pages 1768-1775

Modulation of c-Met signaling and cellular sensitivity to radiation: Potential implications for therapy

Author keywords

c Met; clinical targeting; DNA damage; epithelial mesenchymal transition; radiotherapy

Indexed keywords

5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; AMUVATINIB; BEVACIZUMAB; CABOZANTINIB; CETUXIMAB; CRIZOTINIB; DN 30; ERLOTINIB; FIBRONECTIN; FICLATUZUMAB; FOCAL ADHESION KINASE; FORETINIB; HEPATOCYTE NUCLEAR FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; OA 5D5; ONARTUZUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAD51 PROTEIN; RILOTUMUMAB; SCATTER FACTOR RECEPTOR; TAK 701; TIVANTINIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VIMENTIN;

EID: 84877578990     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27965     Document Type: Review
Times cited : (46)

References (86)
  • 2
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell. 1994; 77: 261-271.
    • (1994) Cell. , vol.77 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3
  • 3
    • 0032796288 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering
    • Sipeki S, Bander E, Buday L, et al. Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering. Cell Signal. 1999; 11: 885-890.
    • (1999) Cell Signal. , vol.11 , pp. 885-890
    • Sipeki, S.1    Bander, E.2    Buday, L.3
  • 4
    • 0033761488 scopus 로고    scopus 로고
    • The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase
    • Maroun CR, Naujokas MA, Holgado-Madruga M, Wong AJ, Park M,. The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol. 2000; 20: 8513-8525.
    • (2000) Mol Cell Biol. , vol.20 , pp. 8513-8525
    • Maroun, C.R.1    Naujokas, M.A.2    Holgado-Madruga, M.3    Wong, A.J.4    Park, M.5
  • 5
    • 0035977147 scopus 로고    scopus 로고
    • A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
    • Trusolino L, Bertotti A, Comoglio PM,. A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell. 2001; 107: 643-654.
    • (2001) Cell. , vol.107 , pp. 643-654
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 6
    • 33845697707 scopus 로고    scopus 로고
    • Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth
    • Bertotti A, Comoglio PM, Trusolino L,. Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. J Cell Biol. 2006; 175: 993-1003.
    • (2006) J Cell Biol. , vol.175 , pp. 993-1003
    • Bertotti, A.1    Comoglio, P.M.2    Trusolino, L.3
  • 7
    • 8044219670 scopus 로고    scopus 로고
    • Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas
    • Olivero M, Rizzo M, Madeddu R, et al. Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer. 1996; 74: 1862-1868.
    • (1996) Br J Cancer. , vol.74 , pp. 1862-1868
    • Olivero, M.1    Rizzo, M.2    Madeddu, R.3
  • 8
    • 0035067626 scopus 로고    scopus 로고
    • C-MET expression in myofibroblasts: Role in autocrine activation and prognostic significance in lung adenocarcinoma
    • Tokunou M, Niki T, Eguchi K, et al. c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma. Am J Pathol. 2001; 158: 1451-1463.
    • (2001) Am J Pathol. , vol.158 , pp. 1451-1463
    • Tokunou, M.1    Niki, T.2    Eguchi, K.3
  • 9
    • 0029444057 scopus 로고
    • Regulation of HGF and HGFR gene expression
    • Zarnegar R,. Regulation of HGF and HGFR gene expression. EXS. 1995; 74: 33-49.
    • (1995) EXS. , vol.74 , pp. 33-49
    • Zarnegar, R.1
  • 10
    • 0038115223 scopus 로고    scopus 로고
    • HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro
    • Ding S, Merkulova-Rainon T, Han ZC, Tobelem G,. HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro. Blood. 2003; 101: 4816-4822.
    • (2003) Blood. , vol.101 , pp. 4816-4822
    • Ding, S.1    Merkulova-Rainon, T.2    Han, Z.C.3    Tobelem, G.4
  • 11
    • 0033065805 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: An immunohistochemical study
    • Okano J, Shiota G, Kawasaki H,. Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study. Liver. 1999; 19: 151-159.
    • (1999) Liver. , vol.19 , pp. 151-159
    • Okano, J.1    Shiota, G.2    Kawasaki, H.3
  • 12
    • 0026485121 scopus 로고
    • Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells
    • Kmiecik TE, Keller JR, Rosen E, Vande Woude GF,. Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells. Blood. 1992; 80: 2454-2457.
    • (1992) Blood. , vol.80 , pp. 2454-2457
    • Kmiecik, T.E.1    Keller, J.R.2    Rosen, E.3    Vande Woude, G.F.4
  • 13
    • 0028276786 scopus 로고
    • Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation
    • Rong S, Segal S, Anver M, Resau JH, Vande Woude GF,. Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. Proc Natl Acad Sci U S A. 1994; 91: 4731-4735.
    • (1994) Proc Natl Acad Sci U S A. , vol.91 , pp. 4731-4735
    • Rong, S.1    Segal, S.2    Anver, M.3    Resau, J.H.4    Vande Woude, G.F.5
  • 14
    • 0036365052 scopus 로고    scopus 로고
    • In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
    • Abounader R, Lal B, Luddy C, et al. In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis. FASEB J. 2002; 16: 108-110.
    • (2002) FASEB J. , vol.16 , pp. 108-110
    • Abounader, R.1    Lal, B.2    Luddy, C.3
  • 15
    • 0030030065 scopus 로고    scopus 로고
    • Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma
    • Rahimi N, Tremblay E, McAdam L, Park M, Schwall R, Elliott B,. Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma. Cell Growth Differ. 1996; 7: 263-270.
    • (1996) Cell Growth Differ. , vol.7 , pp. 263-270
    • Rahimi, N.1    Tremblay, E.2    McAdam, L.3    Park, M.4    Schwall, R.5    Elliott, B.6
  • 16
    • 0034129655 scopus 로고    scopus 로고
    • Activation of hepatocyte growth factor-met autocrine loop enhances tumorigenicity in a human lung adenocarcinoma cell line
    • Yi S, Tsao MS,. Activation of hepatocyte growth factor-met autocrine loop enhances tumorigenicity in a human lung adenocarcinoma cell line. Neoplasia. 2000; 2: 226-234.
    • (2000) Neoplasia. , vol.2 , pp. 226-234
    • Yi, S.1    Tsao, M.S.2
  • 17
    • 57149092131 scopus 로고    scopus 로고
    • Expression and mutational analysis of MET in human solid cancers
    • Ma PC, Tretiakova MS, MacKinnon AC, et al. Expression and mutational analysis of MET in human solid cancers. Genes Chromosomes Cancer. 2008; 47: 1025-1037.
    • (2008) Genes Chromosomes Cancer. , vol.47 , pp. 1025-1037
    • Ma, P.C.1    Tretiakova, M.S.2    Mackinnon, A.C.3
  • 18
    • 34247465448 scopus 로고    scopus 로고
    • C-Met is a potentially new therapeutic target for treatment of human melanoma
    • Puri N, Ahmed S, Janamanchi V, et al. c-Met is a potentially new therapeutic target for treatment of human melanoma. Clin Cancer Res. 2007; 13: 2246-2253.
    • (2007) Clin Cancer Res. , vol.13 , pp. 2246-2253
    • Puri, N.1    Ahmed, S.2    Janamanchi, V.3
  • 19
    • 0035992387 scopus 로고    scopus 로고
    • Overexpression of epidermal growth factor and hepatocyte growth factor receptors in a proportion of gastrinomas correlates with aggressive growth and lower curability
    • Peghini PL, Iwamoto M, Raffeld M, et al. Overexpression of epidermal growth factor and hepatocyte growth factor receptors in a proportion of gastrinomas correlates with aggressive growth and lower curability. Clin Cancer Res. 2002; 8: 2273-2285.
    • (2002) Clin Cancer Res. , vol.8 , pp. 2273-2285
    • Peghini, P.L.1    Iwamoto, M.2    Raffeld, M.3
  • 20
    • 27644543354 scopus 로고    scopus 로고
    • Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
    • Abounader R, Laterra J,. Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol. 2005; 7: 436-451.
    • (2005) Neuro Oncol. , vol.7 , pp. 436-451
    • Abounader, R.1    Laterra, J.2
  • 21
    • 84863204524 scopus 로고    scopus 로고
    • Expression of the hepatocyte growth factor and c-Met in colon cancer: Correlation with clinicopathological features and overall survival
    • Liu Y, Li Q, Zhu L,. Expression of the hepatocyte growth factor and c-Met in colon cancer: correlation with clinicopathological features and overall survival. Tumori. 2012; 98: 105-112.
    • (2012) Tumori. , vol.98 , pp. 105-112
    • Liu, Y.1    Li, Q.2    Zhu, L.3
  • 22
    • 84859873169 scopus 로고    scopus 로고
    • CMET and phospho-cMET protein levels in breast cancers and survival outcomes
    • Raghav KP, Wang W, Liu S, et al. cMET and phospho-cMET protein levels in breast cancers and survival outcomes. Clin Cancer Res. 2012; 18: 2269-2277.
    • (2012) Clin Cancer Res. , vol.18 , pp. 2269-2277
    • Raghav, K.P.1    Wang, W.2    Liu, S.3
  • 23
    • 0033124857 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: Evidence for a role in progression of astrocytic tumors. (Review)
    • Moriyama T, Kataoka H, Koono M, Wakisaka S,. Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors. (Review). Int J Mol Med. 1999; 3: 531-536.
    • (1999) Int J Mol Med. , vol.3 , pp. 531-536
    • Moriyama, T.1    Kataoka, H.2    Koono, M.3    Wakisaka, S.4
  • 24
    • 0030690583 scopus 로고    scopus 로고
    • Met and hepatocyte growth factor/scatter factor expression in human gliomas
    • Koochekpour S, Jeffers M, Rulong S, et al. Met and hepatocyte growth factor/scatter factor expression in human gliomas. Cancer Res. 1997; 57: 5391-5398.
    • (1997) Cancer Res. , vol.57 , pp. 5391-5398
    • Koochekpour, S.1    Jeffers, M.2    Rulong, S.3
  • 25
    • 0037096867 scopus 로고    scopus 로고
    • Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma
    • Arrieta O, Garcia E, Guevara P, et al. Hepatocyte growth factor is associated with poor prognosis of malignant gliomas and is a predictor for recurrence of meningioma. Cancer. 2002; 94: 3210-3218.
    • (2002) Cancer. , vol.94 , pp. 3210-3218
    • Arrieta, O.1    Garcia, E.2    Guevara, P.3
  • 26
    • 80755123221 scopus 로고    scopus 로고
    • Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?
    • Inno A, Di Salvatore M, Cenci T, et al. Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer? Clin Colorectal Cancer. 2011; 10: 325-332.
    • (2011) Clin Colorectal Cancer. , vol.10 , pp. 325-332
    • Inno, A.1    Di Salvatore, M.2    Cenci, T.3
  • 28
    • 24944468127 scopus 로고    scopus 로고
    • Overexpression of circulating c-met messenger RNA is significantly correlated with nodal stage and early recurrence in non-small cell lung cancer
    • Cheng TL, Chang MY, Huang SY, et al. Overexpression of circulating c-met messenger RNA is significantly correlated with nodal stage and early recurrence in non-small cell lung cancer. Chest. 2005; 128: 1453-1460.
    • (2005) Chest. , vol.128 , pp. 1453-1460
    • Cheng, T.L.1    Chang, M.Y.2    Huang, S.Y.3
  • 29
    • 0036188465 scopus 로고    scopus 로고
    • Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer
    • Maulik G, Kijima T, Ma PC, et al. Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clin Cancer Res. 2002; 8: 620-627.
    • (2002) Clin Cancer Res. , vol.8 , pp. 620-627
    • Maulik, G.1    Kijima, T.2    Ma, P.C.3
  • 30
    • 34249912683 scopus 로고    scopus 로고
    • C-Met activation in lung adenocarcinoma tissues: An immunohistochemical analysis
    • Nakamura Y, Niki T, Goto A, et al. c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. Cancer Sci. 2007; 98: 1006-1013.
    • (2007) Cancer Sci. , vol.98 , pp. 1006-1013
    • Nakamura, Y.1    Niki, T.2    Goto, A.3
  • 31
    • 2442513981 scopus 로고    scopus 로고
    • The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients
    • Masuya D, Huang C, Liu D, et al. The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients. Br J Cancer. 2004; 90: 1555-1562.
    • (2004) Br J Cancer. , vol.90 , pp. 1555-1562
    • Masuya, D.1    Huang, C.2    Liu, D.3
  • 32
    • 63849163410 scopus 로고    scopus 로고
    • Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
    • Cappuzzo F, Marchetti A, Skokan M, et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol. 2009; 27: 1667-1674.
    • (2009) J Clin Oncol. , vol.27 , pp. 1667-1674
    • Cappuzzo, F.1    Marchetti, A.2    Skokan, M.3
  • 33
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker M, Gherardi E, Perryman M, Gray J,. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature. 1987; 327: 239-242.
    • (1987) Nature. , vol.327 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 34
    • 0028270761 scopus 로고
    • Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor
    • Rosen EM, Knesel J, Goldberg ID, et al. Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor. Int J Cancer. 1994; 57: 706-714.
    • (1994) Int J Cancer. , vol.57 , pp. 706-714
    • Rosen, E.M.1    Knesel, J.2    Goldberg, I.D.3
  • 35
    • 0027437547 scopus 로고
    • Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development
    • Sonnenberg E, Meyer D, Weidner KM, Birchmeier C,. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol. 1993; 123: 223-235.
    • (1993) J Cell Biol. , vol.123 , pp. 223-235
    • Sonnenberg, E.1    Meyer, D.2    Weidner, K.M.3    Birchmeier, C.4
  • 36
    • 0028221326 scopus 로고
    • Involvement of hepatocyte growth factor in kidney development
    • Santos OF, Barros EJ, Yang XM, et al. Involvement of hepatocyte growth factor in kidney development. Dev Biol. 1994; 163: 525-529.
    • (1994) Dev Biol. , vol.163 , pp. 525-529
    • Santos, O.F.1    Barros, E.J.2    Yang, X.M.3
  • 37
    • 0031037754 scopus 로고    scopus 로고
    • Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor
    • Takayama H, LaRochelle WJ, Sharp R, et al. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc Natl Acad Sci U S A. 1997; 94: 701-706.
    • (1997) Proc Natl Acad Sci U S A. , vol.94 , pp. 701-706
    • Takayama, H.1    Larochelle, W.J.2    Sharp, R.3
  • 38
    • 0032533495 scopus 로고    scopus 로고
    • C-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype
    • Otsuka T, Takayama H, Sharp R, et al. c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Cancer Res. 1998; 58: 5157-5167.
    • (1998) Cancer Res. , vol.58 , pp. 5157-5167
    • Otsuka, T.1    Takayama, H.2    Sharp, R.3
  • 39
    • 0037105707 scopus 로고    scopus 로고
    • Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer
    • Boon EM, van der Neut R, van de Wetering M, Clevers H, Pals ST,. Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. Cancer Res. 2002; 62: 5126-5128.
    • (2002) Cancer Res. , vol.62 , pp. 5126-5128
    • Boon, E.M.1    Van Der Neut, R.2    Van De Wetering, M.3    Clevers, H.4    Pals, S.T.5
  • 40
    • 28844506821 scopus 로고    scopus 로고
    • Lasting longer without oxygen: The influence of hypoxia on Notch signaling
    • Pear WS, Simon MC,. Lasting longer without oxygen: the influence of hypoxia on Notch signaling. Cancer Cell. 2005; 8: 435-437.
    • (2005) Cancer Cell. , vol.8 , pp. 435-437
    • Pear, W.S.1    Simon, M.C.2
  • 42
    • 84866875494 scopus 로고    scopus 로고
    • An in vivo model of epithelial to mesenchymal transition reveals a mitogenic switch
    • Jahn SC, Law ME, Corsino PE, et al. An in vivo model of epithelial to mesenchymal transition reveals a mitogenic switch. Cancer Lett. 2012; 326: 183-190.
    • (2012) Cancer Lett. , vol.326 , pp. 183-190
    • Jahn, S.C.1    Law, M.E.2    Corsino, P.E.3
  • 43
    • 34247170308 scopus 로고    scopus 로고
    • Ionising radiation induces changes associated with epithelial-mesenchymal transdifferentiation and increased cell motility of A549 lung epithelial cells
    • Jung JW, Hwang SY, Hwang JS, Oh ES, Park S, Han IO,. Ionising radiation induces changes associated with epithelial-mesenchymal transdifferentiation and increased cell motility of A549 lung epithelial cells. Eur J Cancer. 2007; 43: 1214-1224.
    • (2007) Eur J Cancer. , vol.43 , pp. 1214-1224
    • Jung, J.W.1    Hwang, S.Y.2    Hwang, J.S.3    Oh, E.S.4    Park, S.5    Han, I.O.6
  • 44
    • 34548863660 scopus 로고    scopus 로고
    • Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition
    • Andarawewa KL, Erickson AC, Chou WS, et al. Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res. 2007; 67: 8662-8670.
    • (2007) Cancer Res. , vol.67 , pp. 8662-8670
    • Andarawewa, K.L.1    Erickson, A.C.2    Chou, W.S.3
  • 45
    • 81855225309 scopus 로고    scopus 로고
    • Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta-mediated epithelial-mesenchymal transition
    • Zhou YC, Liu JY, Li J, et al. Ionizing radiation promotes migration and invasion of cancer cells through transforming growth factor-beta-mediated epithelial-mesenchymal transition. Int J Radiat Oncol Biol Phys. 2011; 81: 1530-1537.
    • (2011) Int J Radiat Oncol Biol Phys. , vol.81 , pp. 1530-1537
    • Zhou, Y.C.1    Liu, J.Y.2    Li, J.3
  • 46
    • 80051798242 scopus 로고    scopus 로고
    • Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition
    • Zhang X, Li X, Zhang N, Yang Q, Moran MS,. Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition. Biochem Biophys Res Commun. 2011; 412: 188-192.
    • (2011) Biochem Biophys Res Commun. , vol.412 , pp. 188-192
    • Zhang, X.1    Li, X.2    Zhang, N.3    Yang, Q.4    Moran, M.S.5
  • 47
    • 84855277585 scopus 로고    scopus 로고
    • Radiation induces epithelial-mesenchymal transition in colorectal cancer cells
    • Kawamoto A, Yokoe T, Tanaka K, et al. Radiation induces epithelial-mesenchymal transition in colorectal cancer cells. Oncol Rep. 2012; 27: 51-57.
    • (2012) Oncol Rep. , vol.27 , pp. 51-57
    • Kawamoto, A.1    Yokoe, T.2    Tanaka, K.3
  • 48
    • 84860918386 scopus 로고    scopus 로고
    • Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years
    • Sauer R, Liersch T, Merkel S, et al. Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years. J Clin Oncol. 2012; 30: 1926-1933.
    • (2012) J Clin Oncol. , vol.30 , pp. 1926-1933
    • Sauer, R.1    Liersch, T.2    Merkel, S.3
  • 49
    • 0037193834 scopus 로고    scopus 로고
    • Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: A randomised trial
    • O'Sullivan B, Davis AM, Turcotte R, et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet. 2002; 359: 2235-2241.
    • (2002) Lancet. , vol.359 , pp. 2235-2241
    • O'Sullivan, B.1    Davis, A.M.2    Turcotte, R.3
  • 51
    • 0035102323 scopus 로고    scopus 로고
    • Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo
    • Xin X, Yang S, Ingle G, et al. Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol. 2001; 158: 1111-1120.
    • (2001) Am J Pathol. , vol.158 , pp. 1111-1120
    • Xin, X.1    Yang, S.2    Ingle, G.3
  • 52
    • 0035957990 scopus 로고    scopus 로고
    • Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions
    • Atabey N, Gao Y, Yao ZJ, et al. Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions. J Biol Chem. 2001; 276: 14308-14314.
    • (2001) J Biol Chem. , vol.276 , pp. 14308-14314
    • Atabey, N.1    Gao, Y.2    Yao, Z.J.3
  • 53
    • 0034650543 scopus 로고    scopus 로고
    • The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network
    • Webb CP, Hose CD, Koochekpour S, et al. The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network. Cancer Res. 2000; 60: 342-349.
    • (2000) Cancer Res. , vol.60 , pp. 342-349
    • Webb, C.P.1    Hose, C.D.2    Koochekpour, S.3
  • 54
    • 0032537813 scopus 로고    scopus 로고
    • Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents
    • Fan S, Wang JA, Yuan RQ, et al. Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Oncogene. 1998; 17: 131-141.
    • (1998) Oncogene. , vol.17 , pp. 131-141
    • Fan, S.1    Wang, J.A.2    Yuan, R.Q.3
  • 55
    • 0034720310 scopus 로고    scopus 로고
    • The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3′ kinase
    • Fan S, Ma YX, Wang JA, et al. The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3′ kinase. Oncogene. 2000; 19: 2212-2223.
    • (2000) Oncogene. , vol.19 , pp. 2212-2223
    • Fan, S.1    Ma, Y.X.2    Wang, J.A.3
  • 56
    • 0035503605 scopus 로고    scopus 로고
    • Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor//scatter factor in the setting of DNA damage
    • Yuan R, Fan S, Achary M, Stewart DM, Goldberg ID, Rosen EM,. Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor//scatter factor in the setting of DNA damage. Cancer Res. 2001; 61: 8022-8031.
    • (2001) Cancer Res. , vol.61 , pp. 8022-8031
    • Yuan, R.1    Fan, S.2    Achary, M.3    Stewart, D.M.4    Goldberg, I.D.5    Rosen, E.M.6
  • 57
    • 82255163062 scopus 로고    scopus 로고
    • MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks
    • Medova M, Aebersold DM, Zimmer Y,. MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks. Int J Cancer. 2012; 130: 728-734.
    • (2012) Int J Cancer. , vol.130 , pp. 728-734
    • Medova, M.1    Aebersold, D.M.2    Zimmer, Y.3
  • 58
    • 70350641537 scopus 로고    scopus 로고
    • Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage
    • Hu SY, Duan HF, Li QF, et al. Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage. Acta Pharmacol Sin. 2009; 30: 1415-1420.
    • (2009) Acta Pharmacol Sin. , vol.30 , pp. 1415-1420
    • Hu, S.Y.1    Duan, H.F.2    Li, Q.F.3
  • 59
    • 0035916363 scopus 로고    scopus 로고
    • Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation
    • Aebersold DM, Kollar A, Beer KT, Laissue J, Greiner RH, Djonov V,. Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation. Int J Cancer. 2001; 96: 41-54.
    • (2001) Int J Cancer. , vol.96 , pp. 41-54
    • Aebersold, D.M.1    Kollar, A.2    Beer, K.T.3    Laissue, J.4    Greiner, R.H.5    Djonov, V.6
  • 60
    • 80052999263 scopus 로고    scopus 로고
    • Immunohistochemical study identifying prognostic biomolecular markers in nasopharyngeal carcinoma treated by radiotherapy
    • Kim YJ, Go H, Wu HG, Jeon YK, Park SW, Lee SH,. Immunohistochemical study identifying prognostic biomolecular markers in nasopharyngeal carcinoma treated by radiotherapy. Head Neck. 2011; 33: 1458-1466.
    • (2011) Head Neck. , vol.33 , pp. 1458-1466
    • Kim, Y.J.1    Go, H.2    Wu, H.G.3    Jeon, Y.K.4    Park, S.W.5    Lee, S.H.6
  • 61
    • 84863838764 scopus 로고    scopus 로고
    • C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression
    • Bhardwaj V, Zhan Y, Cortez MA, et al. C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression. J Thorac Oncol. 2012; 7: 1211-1217.
    • (2012) J Thorac Oncol. , vol.7 , pp. 1211-1217
    • Bhardwaj, V.1    Zhan, Y.2    Cortez, M.A.3
  • 62
    • 79955420135 scopus 로고    scopus 로고
    • Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer
    • De Bacco F, Luraghi P, Medico E, et al. Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer. J Natl Cancer Inst. 2011; 103: 645-661.
    • (2011) J Natl Cancer Inst. , vol.103 , pp. 645-661
    • De Bacco, F.1    Luraghi, P.2    Medico, E.3
  • 63
    • 0037401065 scopus 로고    scopus 로고
    • Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells
    • Qian LW, Mizumoto K, Inadome N, et al. Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells. Int J Cancer. 2003; 104: 542-549.
    • (2003) Int J Cancer. , vol.104 , pp. 542-549
    • Qian, L.W.1    Mizumoto, K.2    Inadome, N.3
  • 64
    • 36448945111 scopus 로고    scopus 로고
    • Radiation-enhanced hepatocyte growth factor secretion in malignant glioma cell lines
    • discussion 613-614
    • Chu SH, Ma YB, Zhu ZA, et al. Radiation-enhanced hepatocyte growth factor secretion in malignant glioma cell lines. Surg Neurol. 2007; 68: 610-613; discussion 613-614.
    • (2007) Surg Neurol. , vol.68 , pp. 610-613
    • Chu, S.H.1    Ma, Y.B.2    Zhu, Z.A.3
  • 66
    • 38049097938 scopus 로고    scopus 로고
    • Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
    • McDermott U, Sharma SV, Dowell L, et al. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A. 2007; 104: 19936-19941.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , pp. 19936-19941
    • McDermott, U.1    Sharma, S.V.2    Dowell, L.3
  • 67
    • 33750352906 scopus 로고    scopus 로고
    • In vitro and in vivo potentiating the cytotoxic effect of radiation on human U251 gliomas by the c-Met antisense oligodeoxynucleotides
    • Chu SH, Zhu ZA, Yuan XH, Li ZQ, Jiang PC,. In vitro and in vivo potentiating the cytotoxic effect of radiation on human U251 gliomas by the c-Met antisense oligodeoxynucleotides. J Neurooncol. 2006; 80: 143-149.
    • (2006) J Neurooncol. , vol.80 , pp. 143-149
    • Chu, S.H.1    Zhu, Z.A.2    Yuan, X.H.3    Li, Z.Q.4    Jiang, P.C.5
  • 68
    • 84869748840 scopus 로고    scopus 로고
    • Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621
    • Michaud NR, Jani JP, Hillerman S, et al. Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621. MAbs. 2012; 4 (6).
    • (2012) MAbs. , vol.4 , Issue.6
    • Michaud, N.R.1    Jani, J.P.2    Hillerman, S.3
  • 69
  • 70
    • 79952819549 scopus 로고    scopus 로고
    • MET inhibition results in DNA breaks and synergistically sensitizes tumor cells to DNA-damaging agents potentially by breaching a damage-induced checkpoint arrest
    • Medova M, Aebersold DM, Blank-Liss W, et al. MET inhibition results in DNA breaks and synergistically sensitizes tumor cells to DNA-damaging agents potentially by breaching a damage-induced checkpoint arrest. Genes Cancer. 2010; 1: 1053-1062.
    • (2010) Genes Cancer. , vol.1 , pp. 1053-1062
    • Medova, M.1    Aebersold, D.M.2    Blank-Liss, W.3
  • 71
    • 84867885479 scopus 로고    scopus 로고
    • C-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation
    • Yu H, Li X, Sun S, Gao X, Zhou D,. c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation. Biochem Biophys Res Commun. 2012; 427: 659-665.
    • (2012) Biochem Biophys Res Commun. , vol.427 , pp. 659-665
    • Yu, H.1    Li, X.2    Sun, S.3    Gao, X.4    Zhou, D.5
  • 72
    • 84872045438 scopus 로고    scopus 로고
    • Higher levels of c-Met expression and phosphorylation identify cell lines with increased sensitivity to AMG-458, a novel selective c-Met inhibitor with radiosensitizing effects
    • Li B, Torossian A, Sun Y, Du R, Dicker AP, Lu B,. Higher levels of c-Met expression and phosphorylation identify cell lines with increased sensitivity to AMG-458, a novel selective c-Met inhibitor with radiosensitizing effects. Int J Radiat Oncol Biol Phys. 2012; 84: e525-e531.
    • (2012) Int J Radiat Oncol Biol Phys. , vol.84
    • Li, B.1    Torossian, A.2    Sun, Y.3    Du, R.4    Dicker, A.P.5    Lu, B.6
  • 73
    • 77957130831 scopus 로고    scopus 로고
    • Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer
    • Lin CI, Whang EE, Donner DB, et al. Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer. Mol Cancer Res. 2010; 8: 1217-1226.
    • (2010) Mol Cancer Res. , vol.8 , pp. 1217-1226
    • Lin, C.I.1    Whang, E.E.2    Donner, D.B.3
  • 74
    • 77958603109 scopus 로고    scopus 로고
    • Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
    • Buchanan IM, Scott T, Tandle AT, et al. Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102. J Cell Mol Med. 2011; 15: 1999-2006.
    • (2011) J Cell Mol Med. , vol.15 , pp. 1999-2006
    • Buchanan, I.M.1    Scott, T.2    Tandle, A.T.3
  • 75
    • 20444467263 scopus 로고    scopus 로고
    • Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation
    • Lal B, Xia S, Abounader R, Laterra J,. Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation. Clin Cancer Res. 2005; 11: 4479-4486.
    • (2005) Clin Cancer Res. , vol.11 , pp. 4479-4486
    • Lal, B.1    Xia, S.2    Abounader, R.3    Laterra, J.4
  • 76
    • 84861733799 scopus 로고    scopus 로고
    • MET: A promising anticancer therapeutic target
    • Peters S, Adjei AA,. MET: a promising anticancer therapeutic target. Nat Rev Clin Oncol. 2012; 9: 314-326.
    • (2012) Nat Rev Clin Oncol. , vol.9 , pp. 314-326
    • Peters, S.1    Adjei, A.A.2
  • 77
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • Sequist LV, von Pawel J, Garmey EG, et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol. 2011; 29: 3307-3315.
    • (2011) J Clin Oncol. , vol.29 , pp. 3307-3315
    • Sequist, L.V.1    Von Pawel, J.2    Garmey, E.G.3
  • 78
    • 76749121298 scopus 로고    scopus 로고
    • Preliminary results from phase II study of ARQ 197 in patients with microphthalmia transcription factor family-associated tumors [abstract]
    • Abstract
    • Goldberg J, Demetri GD, Choy E, et al. Preliminary results from phase II study of ARQ 197 in patients with microphthalmia transcription factor family-associated tumors [abstract]. J Clin Oncol. 2009; 27 (suppl 15):Abstract 10502.
    • (2009) J Clin Oncol. , vol.27 , Issue.SUPPL. 15 , pp. 10502
    • Goldberg, J.1    Demetri, G.D.2    Choy, E.3
  • 79
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther. 2011; 10: 2298-2308.
    • (2011) Mol Cancer Ther. , vol.10 , pp. 2298-2308
    • Yakes, F.M.1    Chen, J.2    Tan, J.3
  • 80
    • 81255195494 scopus 로고    scopus 로고
    • MET and VEGF: Synergistic targets in castration-resistant prostate cancer
    • Aftab DT, McDonald DM,. MET and VEGF: synergistic targets in castration-resistant prostate cancer. Clin Transl Oncol. 2011; 13: 703-709.
    • (2011) Clin Transl Oncol. , vol.13 , pp. 703-709
    • Aftab, D.T.1    McDonald, D.M.2
  • 82
    • 32944467848 scopus 로고    scopus 로고
    • Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors
    • Burgess T, Coxon A, Meyer S, et al. Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors. Cancer Res. 2006; 66: 1721-1729.
    • (2006) Cancer Res. , vol.66 , pp. 1721-1729
    • Burgess, T.1    Coxon, A.2    Meyer, S.3
  • 83
    • 79955766450 scopus 로고    scopus 로고
    • A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma
    • Wen PY, Schiff D, Cloughesy TF, et al. A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro Oncol. 2011; 13: 437-446.
    • (2011) Neuro Oncol. , vol.13 , pp. 437-446
    • Wen, P.Y.1    Schiff, D.2    Cloughesy, T.F.3
  • 84
    • 0031906957 scopus 로고    scopus 로고
    • Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF
    • Prat M, Crepaldi T, Pennacchietti S, Bussolino F, Comoglio PM,. Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF. J Cell Sci. 1998; 111 (pt 2): 237-247.
    • (1998) J Cell Sci. , vol.111 , Issue.PART 2 , pp. 237-247
    • Prat, M.1    Crepaldi, T.2    Pennacchietti, S.3    Bussolino, F.4    Comoglio, P.M.5
  • 85
    • 33645518840 scopus 로고    scopus 로고
    • Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
    • Petrelli A, Circosta P, Granziero L, et al. Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity. Proc Natl Acad Sci U S A. 2006; 103: 5090-5095.
    • (2006) Proc Natl Acad Sci U S A. , vol.103 , pp. 5090-5095
    • Petrelli, A.1    Circosta, P.2    Granziero, L.3
  • 86
    • 78650509347 scopus 로고    scopus 로고
    • Randomized multicenter double-blind placebo-controlled phase ii study evaluating metmab, an antibody to met receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer [abstract]
    • Abstract
    • Spigel DR, Ervin T, Ramlau R, et al. Randomized multicenter double-blind placebo-controlled phase ii study evaluating metmab, an antibody to met receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer [abstract]. Ann Oncol. 2010; 21 (Suppl 8):Abstract LBA15.
    • (2010) Ann Oncol. , vol.21 , Issue.SUPPL. 8
    • Spigel, D.R.1    Ervin, T.2    Ramlau, R.3


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