메뉴 건너뛰기




Volumn 47, Issue 4, 2015, Pages 416-422

The genome and transcriptome of the zoonotic hookworm Ancylostoma ceylanicum identify infection-specific gene families

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ASSOCIATED SECRETED PROTEIN; G PROTEIN COUPLED RECEPTOR; ION CHANNEL; LECTIN; PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG;

EID: 84925862867     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3237     Document Type: Article
Times cited : (80)

References (103)
  • 1
    • 10444241029 scopus 로고    scopus 로고
    • Human hookworm infection in the 21st century
    • Brooker, S., Bethony, J. & Hotez, P.J. Human hookworm infection in the 21st century. Adv. Parasitol. 58, 197-288 (2004)
    • (2004) Adv. Parasitol. , vol.58 , pp. 197-288
    • Brooker, S.1    Bethony, J.2    Hotez, P.J.3
  • 2
    • 84871051576 scopus 로고    scopus 로고
    • Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Vos, T. et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2163-2196 (2012)
    • (2012) Lancet , vol.380 , pp. 2163-2196
    • Vos, T.1
  • 3
    • 84892614394 scopus 로고    scopus 로고
    • Global numbers of infection and disease burden of soil transmitted helminth infections in 2010
    • Pullan, R.L., Smith, J.L., Jasrasaria, R. & Brooker, S.J. Global numbers of infection and disease burden of soil transmitted helminth infections in 2010. Parasit. Vectors 7, 37 (2014)
    • (2014) Parasit. Vectors , vol.7 , pp. 37
    • Pullan, R.L.1    Smith, J.L.2    Jasrasaria, R.3    Brooker, S.J.4
  • 4
    • 77954582391 scopus 로고    scopus 로고
    • The drugs we have and the drugs we need against major helminth infections
    • Keiser, J. & Utzinger, J. The drugs we have and the drugs we need against major helminth infections. Adv. Parasitol. 73, 197-230 (2010)
    • (2010) Adv. Parasitol. , vol.73 , pp. 197-230
    • Keiser, J.1    Utzinger, J.2
  • 5
    • 81855174780 scopus 로고    scopus 로고
    • A history of hookworm vaccine development
    • Schneider, B. et al. A history of hookworm vaccine development. Hum. Vaccin. 7, 1234-1244 (2011)
    • (2011) Hum. Vaccin. , vol.7 , pp. 1234-1244
    • Schneider, B.1
  • 6
    • 0024475293 scopus 로고
    • Ancylostoma ceylanicum in the hamster: Observations on the host-parasite relationship during primary infection
    • Garside, P. & Behnke, J.M. Ancylostoma ceylanicum in the hamster: observations on the host-parasite relationship during primary infection. Parasitology 98, 283-289 (1989)
    • (1989) Parasitology , vol.98 , pp. 283-289
    • Garside, P.1    Behnke, J.M.2
  • 7
    • 84884702758 scopus 로고    scopus 로고
    • Ancylostoma ceylanicum, a re-emerging but neglected parasitic zoonosis
    • Traub, R.J. Ancylostoma ceylanicum, a re-emerging but neglected parasitic zoonosis. Int. J. Parasitol. 43, 1009-1015 (2013)
    • (2013) Int. J. Parasitol. , vol.43 , pp. 1009-1015
    • Traub, R.J.1
  • 8
    • 67349199731 scopus 로고    scopus 로고
    • A portrait of the "SCP/TAPS" proteins of eukaryotes-developing a framework for fundamental research and biotechnological outcomes
    • Cantacessi, C. et al. A portrait of the "SCP/TAPS" proteins of eukaryotes-developing a framework for fundamental research and biotechnological outcomes. Biotechnol. Adv. 27, 376-388 (2009)
    • (2009) Biotechnol. Adv. , vol.27 , pp. 376-388
    • Cantacessi, C.1
  • 9
    • 1342265431 scopus 로고    scopus 로고
    • Necator americanus: Maintenance through one hundred generations in golden hamsters (Mesocricetus auratus). II. Morphological development of the adult and its comparison with humans
    • Jian, X. et al. Necator americanus: maintenance through one hundred generations in golden hamsters (Mesocricetus auratus). II. Morphological development of the adult and its comparison with humans. Exp. Parasitol. 105, 192-200 (2003)
    • (2003) Exp. Parasitol. , vol.105 , pp. 192-200
    • Jian, X.1
  • 10
    • 0015440327 scopus 로고
    • Migration and growth of Ancylostoma ceylanicum in golden hamsters Mesocricetus auratus
    • Ray, D.K., Bhopale, K.K. & Shrivastava, V.B. Migration and growth of Ancylostoma ceylanicum in golden hamsters Mesocricetus auratus. J. Helminthol. 46, 357-362 (1972)
    • (1972) J. Helminthol. , vol.46 , pp. 357-362
    • Ray, D.K.1    Bhopale, K.K.2    Shrivastava, V.B.3
  • 11
    • 0021881376 scopus 로고
    • Ancylostoma ceylanicum (Looss, 1911) in golden hamsters (Mesocricetus auratus): Pathogenicity and humoral immune response to a primary infection
    • Menon, S. & Bhopale, M.K. Ancylostoma ceylanicum (Looss, 1911) in golden hamsters (Mesocricetus auratus): pathogenicity and humoral immune response to a primary infection. J. Helminthol. 59, 143-146 (1985)
    • (1985) J. Helminthol. , vol.59 , pp. 143-146
    • Menon, S.1    Bhopale, M.K.2
  • 12
    • 79955520645 scopus 로고    scopus 로고
    • Nematodes: The worm and its relatives
    • Blaxter, M. Nematodes: the worm and its relatives. PLoS Biol. 9, e1001050 (2011)
    • (2011) PLoS Biol. , vol.9 , pp. e1001050
    • Blaxter, M.1
  • 13
    • 71049181729 scopus 로고    scopus 로고
    • A phylogenetic tree of nematodes based on about 1200 full-length small subunit ribosomal DNA sequences
    • van Megen, H. et al. A phylogenetic tree of nematodes based on about 1200 full-length small subunit ribosomal DNA sequences. Nematology 11, 927-950 (2009)
    • (2009) Nematology , vol.11 , pp. 927-950
    • Van Megen, H.1
  • 14
    • 81355149268 scopus 로고    scopus 로고
    • A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits
    • Kiontke, K.C. et al. A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits. BMC Evol. Biol. 11, 339 (2011)
    • (2011) BMC Evol. Biol. , vol.11 , pp. 339
    • Kiontke, K.C.1
  • 15
    • 33745146522 scopus 로고    scopus 로고
    • The evolutionary origins of nematodes within the order Strongylida are related to predilection sites within hosts
    • Chilton, N.B., Huby-Chilton, F., Gasser, R.B. & Beveridge, I. The evolutionary origins of nematodes within the order Strongylida are related to predilection sites within hosts. Mol. Phylogenet. Evol. 40, 118-128 (2006)
    • (2006) Mol. Phylogenet. Evol. , vol.40 , pp. 118-128
    • Chilton, N.B.1    Huby-Chilton, F.2    Gasser, R.B.3    Beveridge, I.4
  • 16
    • 4444375921 scopus 로고    scopus 로고
    • Drug resistance in nematodes of veterinary importance: A status report
    • Kaplan, R.M. Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol. 20, 477-481 (2004)
    • (2004) Trends Parasitol. , vol.20 , pp. 477-481
    • Kaplan, R.M.1
  • 17
    • 78650050018 scopus 로고    scopus 로고
    • Scaffolding a Caenorhabditis nematode genome with RNA-seq
    • Mortazavi, A. et al. Scaffolding a Caenorhabditis nematode genome with RNA-seq. Genome Res. 20, 1740-1747 (2010)
    • (2010) Genome Res. , vol.20 , pp. 1740-1747
    • Mortazavi, A.1
  • 18
    • 43149115851 scopus 로고    scopus 로고
    • Velvet: Algorithms for de novo short read assembly using de Bruijn graphs
    • Zerbino, D.R. & Birney, E. Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Genome Res. 18, 821-829 (2008)
    • (2008) Genome Res. , vol.18 , pp. 821-829
    • Zerbino, D.R.1    Birney, E.2
  • 19
    • 38049107974 scopus 로고    scopus 로고
    • The canine hookworm genome: Analysis and classification of Ancylostoma caninum survey sequences
    • Abubucker, S. et al. The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences. Mol. Biochem. Parasitol. 157, 187-192 (2008)
    • (2008) Mol. Biochem. Parasitol. , vol.157 , pp. 187-192
    • Abubucker, S.1
  • 20
    • 84883086002 scopus 로고    scopus 로고
    • The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery
    • Laing, R. et al. The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery. Genome Biol. 14, R88 (2013)
    • (2013) Genome Biol. , vol.14 , pp. R88
    • Laing, R.1
  • 21
    • 84883129090 scopus 로고    scopus 로고
    • The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus
    • Schwarz, E.M. et al. The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus. Genome Biol. 14, R89 (2013)
    • (2013) Genome Biol. , vol.14 , pp. R89
    • Schwarz, E.M.1
  • 22
    • 4243088097 scopus 로고    scopus 로고
    • The genome sequence of Caenorhabditis briggsae: A platform for comparative genomics
    • Stein, L.D. et al. The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol. 1, E45 (2003)
    • (2003) PLoS Biol. , vol.1 , pp. E45
    • Stein, L.D.1
  • 23
    • 52949136971 scopus 로고    scopus 로고
    • The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism
    • Dieterich, C. et al. The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism. Nat. Genet. 40, 1193-1198 (2008)
    • (2008) Nat. Genet. , vol.40 , pp. 1193-1198
    • Dieterich, C.1
  • 24
    • 84895883455 scopus 로고    scopus 로고
    • Genome of the human hookworm Necator americanus
    • Tang, Y.T. et al. Genome of the human hookworm Necator americanus. Nat. Genet. 46, 261-269 (2014)
    • (2014) Nat. Genet. , vol.46 , pp. 261-269
    • Tang, Y.T.1
  • 25
    • 40049091292 scopus 로고    scopus 로고
    • Using native and syntenically mapped cDNA alignments to improve de novo gene finding
    • Stanke, M., Diekhans, M., Baertsch, R. & Haussler, D. Using native and syntenically mapped cDNA alignments to improve de novo gene finding. Bioinformatics 24, 637-644 (2008)
    • (2008) Bioinformatics , vol.24 , pp. 637-644
    • Stanke, M.1    Diekhans, M.2    Baertsch, R.3    Haussler, D.4
  • 26
    • 84861182813 scopus 로고    scopus 로고
    • Genome evolution in filamentous plant pathogens: Why bigger can be better
    • Raffaele, S. & Kamoun, S. Genome evolution in filamentous plant pathogens: why bigger can be better. Nat. Rev. Microbiol. 10, 417-430 (2012)
    • (2012) Nat. Rev. Microbiol. , vol.10 , pp. 417-430
    • Raffaele, S.1    Kamoun, S.2
  • 27
    • 84870607366 scopus 로고    scopus 로고
    • Lateral gene transfers have polished animal genomes: Lessons from nematodes
    • Danchin, E.G. & Rosso, M.N. Lateral gene transfers have polished animal genomes: lessons from nematodes. Front. Cell. Infect. Microbiol. 2, 27 (2012)
    • (2012) Front. Cell. Infect. Microbiol. , vol.2 , pp. 27
    • Danchin, E.G.1    Rosso, M.N.2
  • 28
    • 84877345730 scopus 로고    scopus 로고
    • Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes
    • Wu, B. et al. Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes. Proc. Natl. Acad. Sci. USA 110, 7748-7753 (2013)
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 7748-7753
    • Wu, B.1
  • 29
    • 34547613915 scopus 로고    scopus 로고
    • An anhydro-N-acetylmuramyl-l-alanine amidase with broad specificity tethered to the outer membrane of Escherichia coli
    • Uehara, T. & Park, J.T. An anhydro-N-acetylmuramyl-l-alanine amidase with broad specificity tethered to the outer membrane of Escherichia coli. J. Bacteriol. 189, 5634-5641 (2007)
    • (2007) J. Bacteriol. , vol.189 , pp. 5634-5641
    • Uehara, T.1    Park, J.T.2
  • 30
    • 77649225628 scopus 로고    scopus 로고
    • Bacterial genes in the aphid genome: Absence of functional gene transfer from Buchnera to its host
    • Nikoh, N. et al. Bacterial genes in the aphid genome: absence of functional gene transfer from Buchnera to its host. PLoS Genet. 6, e1000827 (2010)
    • (2010) PLoS Genet. , vol.6 , pp. e1000827
    • Nikoh, N.1
  • 31
    • 84879348435 scopus 로고    scopus 로고
    • Horizontal gene transfer from diverse bacteria to an insect genome enables a tripartite nested mealybug symbiosis
    • Husnik, F. et al. Horizontal gene transfer from diverse bacteria to an insect genome enables a tripartite nested mealybug symbiosis. Cell 153, 1567-1578 (2013)
    • (2013) Cell , vol.153 , pp. 1567-1578
    • Husnik, F.1
  • 32
    • 77952058969 scopus 로고    scopus 로고
    • Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation
    • Wang, Z. et al. Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation. BMC Genomics 11, 307 (2010)
    • (2010) BMC Genomics , vol.11 , pp. 307
    • Wang, Z.1
  • 33
    • 45549089420 scopus 로고    scopus 로고
    • High-throughput functional annotation and data mining with the Blast2GO suite
    • Götz, S. et al. High-throughput functional annotation and data mining with the Blast2GO suite. Nucleic Acids Res. 36, 3420-3435 (2008)
    • (2008) Nucleic Acids Res. , vol.36 , pp. 3420-3435
    • Götz, S.1
  • 34
    • 33847173733 scopus 로고    scopus 로고
    • FUNC: A package for detecting significant associations between gene sets and ontological annotations
    • Prüfer, K. et al. FUNC: a package for detecting significant associations between gene sets and ontological annotations. BMC Bioinformatics 8, 41 (2007)
    • (2007) BMC Bioinformatics , vol.8 , pp. 41
    • Prüfer, K.1
  • 35
    • 0028063868 scopus 로고
    • The food resource of adult Heligmosomoides polygyrus in the small intestine
    • Bansemir, A.D. & Sukhdeo, M.V. The food resource of adult Heligmosomoides polygyrus in the small intestine. J. Parasitol. 80, 24-28 (1994)
    • (1994) J. Parasitol. , vol.80 , pp. 24-28
    • Bansemir, A.D.1    Sukhdeo, M.V.2
  • 36
    • 65649122615 scopus 로고    scopus 로고
    • Proteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus
    • Ranjit, N. et al. Proteolytic degradation of hemoglobin in the intestine of the human hookworm Necator americanus. J. Infect. Dis. 199, 904-912 (2009)
    • (2009) J. Infect. Dis. , vol.199 , pp. 904-912
    • Ranjit, N.1
  • 37
    • 84886138923 scopus 로고    scopus 로고
    • Parasitic Helminths: Targets, Screens, Drugs, and Vaccines (ed. Caffrey, C.R.), Wiley-VCH Verlag & Co.
    • Knox, D. in Parasitic Helminths: Targets, Screens, Drugs, and Vaccines (ed. Caffrey, C.R.) 399-420 (Wiley-VCH Verlag & Co., 2012)
    • (2012) , pp. 399-420
    • Knox, D.1
  • 38
    • 84862866530 scopus 로고    scopus 로고
    • Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines
    • Pearson, M.S. et al. Molecular mechanisms of hookworm disease: stealth, virulence, and vaccines. J. Allergy Clin. Immunol. 130, 13-21 (2012)
    • (2012) J. Allergy Clin. Immunol. , vol.130 , pp. 13-21
    • Pearson, M.S.1
  • 39
    • 79551568071 scopus 로고    scopus 로고
    • A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages
    • Klotz, C. et al. A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. PLoS Pathog. 7, e1001248 (2011)
    • (2011) PLoS Pathog , vol.7 , pp. e1001248
    • Klotz, C.1
  • 40
    • 0042825912 scopus 로고    scopus 로고
    • Modulation of host immune responses by nematode cystatins
    • Hartmann, S. & Lucius, R. Modulation of host immune responses by nematode cystatins. Int. J. Parasitol. 33, 1291-1302 (2003)
    • (2003) Int. J. Parasitol. , vol.33 , pp. 1291-1302
    • Hartmann, S.1    Lucius, R.2
  • 41
    • 0035916803 scopus 로고    scopus 로고
    • Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing
    • Manoury, B., Gregory, W.F., Maizels, R.M. & Watts, C. Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. Curr. Biol. 11, 447-451 (2001)
    • (2001) Curr. Biol. , vol.11 , pp. 447-451
    • Manoury, B.1    Gregory, W.F.2    Maizels, R.M.3    Watts, C.4
  • 42
    • 78650410139 scopus 로고    scopus 로고
    • Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project
    • Gerstein, M.B. et al. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330, 1775-1787 (2010)
    • (2010) Science , vol.330 , pp. 1775-1787
    • Gerstein, M.B.1
  • 43
    • 84887120736 scopus 로고    scopus 로고
    • Dampening of expression oscillations by synchronous regulation of a microRNA and its target
    • Kim, D., Grun, D. & van Oudenaarden, A. Dampening of expression oscillations by synchronous regulation of a microRNA and its target. Nat. Genet. 45, 1337-1344 (2013)
    • (2013) Nat. Genet. , vol.45 , pp. 1337-1344
    • Kim, D.1    Grun, D.2    Van Oudenaarden, A.3
  • 44
    • 84855272287 scopus 로고    scopus 로고
    • A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi
    • Choi, Y.J. et al. A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi. PLoS Negl. Trop. Dis. 5, e1409 (2011)
    • (2011) PLoS Negl. Trop. Dis. , vol.5 , pp. e1409
    • Choi, Y.J.1
  • 45
    • 84857505845 scopus 로고    scopus 로고
    • Hookworm SCP/TAPS protein structure-a key to understanding host-parasite interactions and developing new interventions
    • Osman, A. et al. Hookworm SCP/TAPS protein structure-a key to understanding host-parasite interactions and developing new interventions. Biotechnol. Adv. 30, 652-657 (2012)
    • (2012) Biotechnol. Adv. , vol.30 , pp. 652-657
    • Osman, A.1
  • 46
    • 80051671154 scopus 로고    scopus 로고
    • Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins
    • Hewitson, J.P. et al. Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins. J. Proteomics 74, 1573-1594 (2011)
    • (2011) J. Proteomics , vol.74 , pp. 1573-1594
    • Hewitson, J.P.1
  • 47
    • 55349096514 scopus 로고    scopus 로고
    • The Caenorhabditis chemoreceptor gene families
    • Thomas, J.H. & Robertson, H.M. The Caenorhabditis chemoreceptor gene families. BMC Biol. 6, 42 (2008)
    • (2008) BMC Biol. , vol.6 , pp. 42
    • Thomas, J.H.1    Robertson, H.M.2
  • 48
    • 70549097048 scopus 로고    scopus 로고
    • Preliminary molecular characterization of the human pathogen Angiostrongylus cantonensis
    • He, H. et al. Preliminary molecular characterization of the human pathogen Angiostrongylus cantonensis. BMC Mol. Biol. 10, 97 (2009)
    • (2009) BMC Mol. Biol. , vol.10 , pp. 97
    • He, H.1
  • 50
    • 84883758487 scopus 로고    scopus 로고
    • In-depth proteomic and glycomic analysis of the adult-stage Cooperia oncophora excretome/secretome
    • Borloo, J. et al. In-depth proteomic and glycomic analysis of the adult-stage Cooperia oncophora excretome/secretome. J. Proteome Res. 12, 3900-3911 (2013)
    • (2013) J. Proteome Res. , vol.12 , pp. 3900-3911
    • Borloo, J.1
  • 51
    • 29144452851 scopus 로고    scopus 로고
    • The C-type lectin-like domain superfamily
    • Zelensky, A.N. & Gready, J.E. The C-type lectin-like domain superfamily. FEBS J. 272, 6179-6217 (2005)
    • (2005) FEBS J. , vol.272 , pp. 6179-6217
    • Zelensky, A.N.1    Gready, J.E.2
  • 52
    • 84863439648 scopus 로고    scopus 로고
    • A novel C-type lectin identified by EST analysis in tissue migratory larvae of Ascaris suum
    • Yoshida, A., Nagayasu, E., Horii, Y. & Maruyama, H. A novel C-type lectin identified by EST analysis in tissue migratory larvae of Ascaris suum. Parasitol. Res. 110, 1583-1586 (2012)
    • (2012) Parasitol. Res. , vol.110 , pp. 1583-1586
    • Yoshida, A.1    Nagayasu, E.2    Horii, Y.3    Maruyama, H.4
  • 53
    • 0033657472 scopus 로고    scopus 로고
    • Identification of a new C-type lectin, TES-70, secreted by infective larvae of Toxocara canis, which binds to host ligands
    • Loukas, A., Doedens, A., Hintz, M. & Maizels, R.M. Identification of a new C-type lectin, TES-70, secreted by infective larvae of Toxocara canis, which binds to host ligands. Parasitology 121, 545-554 (2000)
    • (2000) Parasitology , vol.121 , pp. 545-554
    • Loukas, A.1    Doedens, A.2    Hintz, M.3    Maizels, R.M.4
  • 55
    • 84883312193 scopus 로고    scopus 로고
    • Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways
    • Taylor, C.M. et al. Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways. PLoS Pathog. 9, e1003505 (2013)
    • (2013) PLoS Pathog. , vol.9 , pp. e1003505
    • Taylor, C.M.1
  • 56
    • 77955445609 scopus 로고    scopus 로고
    • Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery
    • Fyfe, P.K., Dawson, A., Hutchison, M.T., Cameron, S. & Hunter, W.N. Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery. Acta Crystallogr. D Biol. Crystallogr. 66, 881-888 (2010)
    • (2010) Acta Crystallogr. D Biol. Crystallogr. , vol.66 , pp. 881-888
    • Fyfe, P.K.1    Dawson, A.2    Hutchison, M.T.3    Cameron, S.4    Hunter, W.N.5
  • 58
    • 76649098896 scopus 로고    scopus 로고
    • Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC)
    • Sivendran, S. et al. Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorg. Med. Chem. 18, 896-908 (2010)
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 896-908
    • Sivendran, S.1
  • 59
    • 84905366562 scopus 로고    scopus 로고
    • Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs
    • Farelli, J.D. et al. Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs. PLoS Pathog. 10, e1004245 (2014)
    • (2014) PLoS Pathog. , vol.10 , pp. e1004245
    • Farelli, J.D.1
  • 60
    • 84922635506 scopus 로고    scopus 로고
    • What helminth genomes have taught us about parasite evolution
    • Zarowiecki, M. & Berriman, M. What helminth genomes have taught us about parasite evolution. Parasitology 42 (suppl. 1), S85-S97 (2015)
    • (2015) Parasitology , vol.42 , pp. S85-S97
    • Zarowiecki, M.1    Berriman, M.2
  • 61
    • 84883678210 scopus 로고    scopus 로고
    • Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance
    • Gilleard, J.S. Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance. Parasitology 140, 1506-1522 (2013)
    • (2013) Parasitology , vol.140 , pp. 1506-1522
    • Gilleard, J.S.1
  • 62
    • 0028574795 scopus 로고
    • The origins and evolutionary expansion of the strongylida (Nematoda)
    • Durette-Desset, M.C., Beveridge, I. & Spratt, D.M. The origins and evolutionary expansion of the strongylida (Nematoda). Int. J. Parasitol. 24, 1139-1165 (1994)
    • (1994) Int. J. Parasitol. , vol.24 , pp. 1139-1165
    • Durette-Desset, M.C.1    Beveridge, I.2    Spratt, D.M.3
  • 63
    • 84867176113 scopus 로고    scopus 로고
    • Helminth infections and host immune regulation
    • McSorley, H.J. & Maizels, R.M. Helminth infections and host immune regulation. Clin. Microbiol. Rev. 25, 585-608 (2012)
    • (2012) Clin. Microbiol. Rev. , vol.25 , pp. 585-608
    • McSorley, H.J.1    Maizels, R.M.2
  • 64
    • 34547695452 scopus 로고    scopus 로고
    • Female size shows similar trends in all clades of the phylum Nematoda
    • Yeates, G.W. & Boag, B. Female size shows similar trends in all clades of the phylum Nematoda. Nematology 8, 111-127 (2006)
    • (2006) Nematology , vol.8 , pp. 111-127
    • Yeates, G.W.1    Boag, B.2
  • 65
    • 0034570990 scopus 로고    scopus 로고
    • Longevity and ageing in parasitic and free-living nematodes
    • Gems, D. Longevity and ageing in parasitic and free-living nematodes. Biogerontology 1, 289-307 (2000)
    • (2000) Biogerontology , vol.1 , pp. 289-307
    • Gems, D.1
  • 66
    • 84878534378 scopus 로고    scopus 로고
    • Genomics of Loa loa, a Wolbachia-free filarial parasite of humans
    • Desjardins, C.A. et al. Genomics of Loa loa, a Wolbachia-free filarial parasite of humans. Nat. Genet. 45, 495-500 (2013)
    • (2013) Nat. Genet. , vol.45 , pp. 495-500
    • Desjardins, C.A.1
  • 67
    • 84893178251 scopus 로고    scopus 로고
    • Nitazoxanide: Nematicidal mode of action and drug combination studies
    • Somvanshi, V.S., Ellis, B.L., Hu, Y. & Aroian, R.V. Nitazoxanide: nematicidal mode of action and drug combination studies. Mol. Biochem. Parasitol. 193, 1-8 (2014)
    • (2014) Mol. Biochem. Parasitol. , vol.193 , pp. 1-8
    • Somvanshi, V.S.1    Ellis, B.L.2    Hu, Y.3    Aroian, R.V.4
  • 68
    • 84893807769 scopus 로고    scopus 로고
    • Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens
    • Crowther, G.J. et al. Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens. PLoS Negl. Trop. Dis. 8, e2628 (2014)
    • (2014) PLoS Negl. Trop. Dis. , vol.8 , pp. e2628
    • Crowther, G.J.1
  • 69
    • 84870740185 scopus 로고    scopus 로고
    • Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms
    • Hu, Y. et al. Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms. PLoS Negl. Trop. Dis. 6, e1900 (2012)
    • (2012) PLoS Negl. Trop. Dis. , vol.6 , pp. e1900
    • Hu, Y.1
  • 70
    • 84876364932 scopus 로고    scopus 로고
    • The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle
    • Srinivasan, J. et al. The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle. Genetics 193, 1279-1295 (2013)
    • (2013) Genetics , vol.193 , pp. 1279-1295
    • Srinivasan, J.1
  • 71
    • 75649124547 scopus 로고    scopus 로고
    • De novo assembly of human genomes with massively parallel short read sequencing
    • Li, R. et al. De novo assembly of human genomes with massively parallel short read sequencing. Genome Res. 20, 265-272 (2010)
    • (2010) Genome Res. , vol.20 , pp. 265-272
    • Li, R.1
  • 72
    • 61849109937 scopus 로고    scopus 로고
    • Detecting heterozygosity in shotgun genome assemblies: Lessons from obligately outcrossing nematodes
    • Barrière, A. et al. Detecting heterozygosity in shotgun genome assemblies: lessons from obligately outcrossing nematodes. Genome Res. 19, 470-480 (2009)
    • (2009) Genome Res. , vol.19 , pp. 470-480
    • Barrière, A.1
  • 73
    • 84864600753 scopus 로고    scopus 로고
    • HaploMerger: Reconstructing allelic relationships for polymorphic diploid genome assemblies
    • Huang, S. et al. HaploMerger: reconstructing allelic relationships for polymorphic diploid genome assemblies. Genome Res. 22, 1581-1588 (2012)
    • (2012) Genome Res. , vol.22 , pp. 1581-1588
    • Huang, S.1
  • 75
    • 84859768479 scopus 로고    scopus 로고
    • Oases: Robust de novo RNA-seq assembly across the dynamic range of expression levels
    • Schulz, M.H., Zerbino, D.R., Vingron, M. & Birney, E. Oases: robust de novo RNA-seq assembly across the dynamic range of expression levels. Bioinformatics 28, 1086-1092 (2012)
    • (2012) Bioinformatics , vol.28 , pp. 1086-1092
    • Schulz, M.H.1    Zerbino, D.R.2    Vingron, M.3    Birney, E.4
  • 77
    • 0036226603 scopus 로고    scopus 로고
    • BLAT-the BLAST-like alignment tool
    • Kent, W.J. BLAT-the BLAST-like alignment tool. Genome Res. 12, 656-664 (2002)
    • (2002) Genome Res. , vol.12 , pp. 656-664
    • Kent, W.J.1
  • 78
    • 29144455282 scopus 로고    scopus 로고
    • De novo identification of repeat families in large genomes
    • Price, A.L., Jones, N.C. & Pevzner, P.A. De novo identification of repeat families in large genomes. Bioinformatics 21 (suppl. 1), i351-i358 (2005)
    • (2005) Bioinformatics , vol.21 , pp. i351-i358
    • Price, A.L.1    Jones, N.C.2    Pevzner, P.A.3
  • 79
    • 84055178433 scopus 로고    scopus 로고
    • MAKER2: An annotation pipeline and genome-database management tool for second-generation genome projects
    • Holt, C. & Yandell, M. MAKER2: an annotation pipeline and genome-database management tool for second-generation genome projects. BMC Bioinformatics 12, 491 (2011)
    • (2011) BMC Bioinformatics , vol.12 , pp. 491
    • Holt, C.1    Yandell, M.2
  • 80
    • 2142657817 scopus 로고    scopus 로고
    • A combined transmembrane topology and signal peptide prediction method
    • Käll, L., Krogh, A. & Sonnhammer, E.L. A combined transmembrane topology and signal peptide prediction method. J. Mol. Biol. 338, 1027-1036 (2004)
    • (2004) J. Mol. Biol. , vol.338 , pp. 1027-1036
    • Käll, L.1    Krogh, A.2    Sonnhammer, E.L.3
  • 81
    • 0028501914 scopus 로고
    • Non-globular domains in protein sequences: Automated segmentation using complexity measures
    • Wootton, J.C. Non-globular domains in protein sequences: automated segmentation using complexity measures. Comput. Chem. 18, 269-285 (1994)
    • (1994) Comput. Chem. , vol.18 , pp. 269-285
    • Wootton, J.C.1
  • 82
    • 0030004228 scopus 로고    scopus 로고
    • Prediction and analysis of coiled-coil structures
    • Lupas, A. Prediction and analysis of coiled-coil structures. Methods Enzymol. 266, 513-525 (1996)
    • (1996) Methods Enzymol. , vol.266 , pp. 513-525
    • Lupas, A.1
  • 83
    • 84858077472 scopus 로고    scopus 로고
    • The Pfam protein families database
    • Punta, M. et al. The Pfam protein families database. Nucleic Acids Res. 40, D290-D301 (2012)
    • (2012) Nucleic Acids Res. , vol.40 , pp. D290-D301
    • Punta, M.1
  • 84
    • 77952988108 scopus 로고    scopus 로고
    • A new generation of homology search tools based on probabilistic inference
    • Eddy, S.R. A new generation of homology search tools based on probabilistic inference. Genome Inform. 23, 205-211 (2009)
    • (2009) Genome Inform , vol.23 , pp. 205-211
    • Eddy, S.R.1
  • 85
    • 79952116426 scopus 로고    scopus 로고
    • InterPro protein classification
    • McDowall, J. & Hunter, S. InterPro protein classification. Methods Mol. Biol. 694, 37-47 (2011)
    • (2011) Methods Mol. Biol. , vol.694 , pp. 37-47
    • McDowall, J.1    Hunter, S.2
  • 86
    • 0141519279 scopus 로고    scopus 로고
    • OrthoMCL: Identification of ortholog groups for eukaryotic genomes
    • Li, L., Stoeckert, C.J. Jr. & Roos, D.S. OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome Res. 13, 2178-2189 (2003)
    • (2003) Genome Res. , vol.13 , pp. 2178-2189
    • Li, L.1    Stoeckert, C.J.2    Roos, D.S.3
  • 87
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • Langmead, B. & Salzberg, S.L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357-359 (2012)
    • (2012) Nat. Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 88
    • 79961123152 scopus 로고    scopus 로고
    • RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome
    • Li, B. & Dewey, C.N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 12, 323 (2011)
    • (2011) BMC Bioinformatics , vol.12 , pp. 323
    • Li, B.1    Dewey, C.N.2
  • 90
    • 74049108922 scopus 로고    scopus 로고
    • BLAST+: Architecture and applications
    • Camacho, C. et al. BLAST+: architecture and applications. BMC Bioinformatics 10, 421 (2009)
    • (2009) BMC Bioinformatics , vol.10 , pp. 421
    • Camacho, C.1
  • 91
    • 3042666256 scopus 로고    scopus 로고
    • MUSCLE: Multiple sequence alignment with high accuracy and high throughput
    • Edgar, R.C. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32, 1792-1797 (2004)
    • (2004) Nucleic Acids Res. , vol.32 , pp. 1792-1797
    • Edgar, R.C.1
  • 92
    • 84875619226 scopus 로고    scopus 로고
    • MAFFT multiple sequence alignment software version 7: Improvements in performance and usability
    • Katoh, K. & Standley, D.M. MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol. Biol. Evol. 30, 772-780 (2013)
    • (2013) Mol. Biol. Evol. , vol.30 , pp. 772-780
    • Katoh, K.1    Standley, D.M.2
  • 93
    • 67650757433 scopus 로고    scopus 로고
    • TrimAl: A tool for automated alignment trimming in large-scale phylogenetic analyses
    • Capella-Gutiérrez, S., Silla-Martinez, J.M. & Gabaldon, T. trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Bioinformatics 25, 1972-1973 (2009)
    • (2009) Bioinformatics , vol.25 , pp. 1972-1973
    • Capella-Gutiérrez, S.1    Silla-Martinez, J.M.2    Gabaldon, T.3
  • 94
    • 65449188232 scopus 로고    scopus 로고
    • Jalview Version 2-a multiple sequence alignment editor and analysis workbench
    • Waterhouse, A.M., Procter, J.B., Martin, D.M., Clamp, M. & Barton, G.J. Jalview Version 2-a multiple sequence alignment editor and analysis workbench. Bioinformatics 25, 1189-1191 (2009)
    • (2009) Bioinformatics , vol.25 , pp. 1189-1191
    • Waterhouse, A.M.1    Procter, J.B.2    Martin, D.M.3    Clamp, M.4    Barton, G.J.5
  • 95
    • 77949718257 scopus 로고    scopus 로고
    • FastTree 2-approximately maximum-likelihood trees for large alignments
    • Price, M.N., Dehal, P.S. & Arkin, A.P. FastTree 2-approximately maximum-likelihood trees for large alignments. PLoS ONE 5, e9490 (2010)
    • (2010) PLoS ONE , vol.5 , pp. e9490
    • Price, M.N.1    Dehal, P.S.2    Arkin, A.P.3
  • 96
    • 0030854739 scopus 로고    scopus 로고
    • TRNAscan-SE: A program for improved detection of transfer RNA genes in genomic sequence
    • Lowe, T.M. & Eddy, S.R. tRNAscan-SE: a program for improved detection of transfer RNA genes in genomic sequence. Nucleic Acids Res. 25, 955-964 (1997)
    • (1997) Nucleic Acids Res. , vol.25 , pp. 955-964
    • Lowe, T.M.1    Eddy, S.R.2
  • 97
    • 38049170862 scopus 로고    scopus 로고
    • The bandit, a new DNA transposon from a hookworm-possible horizontal genetic transfer between host and parasite
    • Laha, T. et al. The bandit, a new DNA transposon from a hookworm-possible horizontal genetic transfer between host and parasite. PLoS Negl. Trop. Dis. 1, e35 (2007)
    • (2007) PLoS Negl. Trop. Dis. , vol.1 , pp. e35
    • Laha, T.1
  • 98
    • 84876581034 scopus 로고    scopus 로고
    • Dfam: A database of repetitive DNA based on profile hidden Markov models
    • Wheeler, T.J. et al. Dfam: a database of repetitive DNA based on profile hidden Markov models. Nucleic Acids Res. 41, D70-D82 (2013)
    • (2013) Nucleic Acids Res. , vol.41 , pp. D70-D82
    • Wheeler, T.J.1
  • 99
    • 23844525077 scopus 로고    scopus 로고
    • Repbase Update, a database of eukaryotic repetitive elements
    • Jurka, J. et al. Repbase Update, a database of eukaryotic repetitive elements. Cytogenet. Genome Res. 110, 462-467 (2005)
    • (2005) Cytogenet. Genome Res. , vol.110 , pp. 462-467
    • Jurka, J.1
  • 100
    • 84857745267 scopus 로고    scopus 로고
    • Database resources of the National Center for Biotechnology Information
    • Sayers, E.W. et al. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 40, D13-D25 (2012)
    • (2012) Nucleic Acids Res. , vol.40 , pp. D13-D25
    • Sayers, E.W.1
  • 101
    • 0035878724 scopus 로고    scopus 로고
    • Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements
    • Schäffer, A.A. et al. Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements. Nucleic Acids Res. 29, 2994-3005 (2001)
    • (2001) Nucleic Acids Res. , vol.29 , pp. 2994-3005
    • Schäffer, A.A.1
  • 102
    • 35448970693 scopus 로고    scopus 로고
    • Folds and activities of peptidoglycan amidases
    • Firczuk, M. & Bochtler, M. Folds and activities of peptidoglycan amidases. FEMS Microbiol. Rev. 31, 676-691 (2007)
    • (2007) FEMS Microbiol. Rev. , vol.31 , pp. 676-691
    • Firczuk, M.1    Bochtler, M.2
  • 103
    • 84891783174 scopus 로고    scopus 로고
    • Activities at the Universal Protein Resource (UniProt)
    • UniProt Consortium. Activities at the Universal Protein Resource (UniProt). Nucleic Acids Res. 42, D191-D198 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. D191-D198
    • Consortium, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.