Structure of Staphylococcus aureus adenylo-succinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery

Acta Crystallographica Section D: Biological Crystallography

Volumn 66, Issue 8, 2010, Pages 881-888

  Fyfe, Paul K ^a   Dawson, Alice ^a   Hutchison, Marie Theres ^a   Cameron, Scott ^a   Hunter, William N ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

adenylosuccinate lyase; AMP; oxalate; purine biosynthesis; purine cycle

Indexed keywords

ADENYLOSUCCINATE LYASE; ENZYME INHIBITOR;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; MOLECULAR GENETICS; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS AUREUS; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS;

ADENYLOSUCCINATE LYASE; AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS; STRUCTURAL HOMOLOGY, PROTEIN;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS;

EID: 77955445609     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444910020081     Document Type: Article

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