-
1
-
-
64549104642
-
High-fat diet induces apoptosis of hypothalamic neurons
-
Moraes JC, et al: High-fat diet induces apoptosis of hypothalamic neurons. PLoS ONE 2009;4:e5045.
-
(2009)
PLoS ONE
, vol.4
-
-
Moraes, J.C.1
-
2
-
-
55849141253
-
Central control of body weight and appetite
-
Woods SC, DAlessio DA: Central control of body weight and appetite. J Clin Endocrinol Metab 2008; 93(11 suppl 1):S37-S50.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, Issue.11 SUPPL. 1
-
-
Woods, S.C.1
Dalessio, D.A.2
-
3
-
-
0016836094
-
Manifestations of hypothalamic obesity in man: A comprehensive investigation of eight patients and a reveiw of the literature
-
Bray GA, Gallagher TF Jr: Manifestations of hypothalamic obesity in man: a comprehensive investigation of eight patients and a reveiw of the literature. Medicine (Baltimore) 1975;54:301-330.
-
(1975)
Medicine (Baltimore)
, vol.54
, pp. 301-330
-
-
Bray, G.A.1
Gallagher Jr., T.F.2
-
4
-
-
0037400763
-
Epidemiology, implications and mechanisms underlying drug-induced weight gain in psychiatric patients
-
Zimmermann U, et al: Epidemiology, implications and mechanisms underlying drug-induced weight gain in psychiatric patients. J Psychiatr Res 2003;37: 193-220.
-
(2003)
J Psychiatr Res
, vol.37
, pp. 193-220
-
-
Zimmermann, U.1
-
5
-
-
50249120768
-
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
-
Tong Q, et al: Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 2008;11:998-1000.
-
(2008)
Nat Neurosci
, vol.11
, pp. 998-1000
-
-
Tong, Q.1
-
6
-
-
33748560432
-
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
-
Abizaid A, et al: Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest 2006;116:3229-3239.
-
(2006)
J Clin Invest
, vol.116
, pp. 3229-3239
-
-
Abizaid, A.1
-
7
-
-
33745978779
-
Serotonin reciprocally regulates melanocortin neurons to modulate food intake
-
Heisler LK, et al: Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006;51:239-249.
-
(2006)
Neuron
, vol.51
, pp. 239-249
-
-
Heisler, L.K.1
-
8
-
-
4344658781
-
Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity
-
Masaki T, et al: Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity. Diabetes 2004;53:2250-2260.
-
(2004)
Diabetes
, vol.53
, pp. 2250-2260
-
-
Masaki, T.1
-
9
-
-
33847635179
-
From the Cover: Antipsychotic druginduced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMPkinase
-
Kim SF, et al: From the Cover: Antipsychotic druginduced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMPkinase. Proc Natl Acad Sci USA 2007;104:3456-3459.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 3456-3459
-
-
Kim, S.F.1
-
10
-
-
0024449707
-
Abnormal food-seeking behavior after surgery for craniopharyngioma
-
Skorzewska A, et al: Abnormal food-seeking behavior after surgery for craniopharyngioma. Neuropsychobiology 1989;21:17-20.
-
(1989)
Neuropsychobiology
, vol.21
, pp. 17-20
-
-
Skorzewska, A.1
-
11
-
-
34147141924
-
Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma
-
Roth CL, et al: Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma. Pediatr Res 2007;61:496-501.
-
(2007)
Pediatr Res
, vol.61
, pp. 496-501
-
-
Roth, C.L.1
-
12
-
-
58149343864
-
Hyperleptinaemia rather than fasting hyperinsulinaemia is associated with obesity following hypothalamic damage in children
-
Shaikh MG, Grundy RG, Kirk JM: Hyperleptinaemia rather than fasting hyperinsulinaemia is associated with obesity following hypothalamic damage in children. Eur J Endocrinol 2008;159:791-797.
-
(2008)
Eur J Endocrinol
, vol.159
, pp. 791-797
-
-
Shaikh, M.G.1
Grundy, R.G.2
Kirk, J.M.3
-
13
-
-
61449105725
-
Leptin: A pivotal regulator of human energy homeostasis
-
Farooqi IS, ORahilly S: Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009;89:980S-984S.
-
(2009)
Am J Clin Nutr
, vol.89
-
-
Farooqi, I.S.1
O'Rahilly, S.2
-
14
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement K, et al: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
-
15
-
-
0031937707
-
Hyperphagia in children with craniopharyngioma is associated with hyperleptinaemia and a failure in the downregulation of appetite
-
Roth C, et al: Hyperphagia in children with craniopharyngioma is associated with hyperleptinaemia and a failure in the downregulation of appetite. Eur J Endocrinol 1998;138:89-91.
-
(1998)
Eur J Endocrinol
, vol.138
, pp. 89-91
-
-
Roth, C.1
-
16
-
-
84897570258
-
The role of leptin, soluble leptin receptor, resistin, and insulin secretory dynamics in the pathogenesis of hypothalamic obesity in children
-
Guran T, et al: The role of leptin, soluble leptin receptor, resistin, and insulin secretory dynamics in the pathogenesis of hypothalamic obesity in children. Eur J Pediatr 2008.
-
(2008)
Eur J Pediatr
-
-
Guran, T.1
-
17
-
-
0030481437
-
Serum leptin levels following hypothalamic surgery
-
Brabant G, et al: Serum leptin levels following hypothalamic surgery. Horm Metab Res 1996;28:728-731.
-
(1996)
Horm Metab Res
, vol.28
, pp. 728-731
-
-
Brabant, G.1
-
18
-
-
0033497369
-
Hypothalamic obesity caused by cranial insult in children: Altered glucose and insulin dynamics and reversal by a somatostatin agonist
-
Lustig RH, et al: Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr 1999;135:162-168.
-
(1999)
J Pediatr
, vol.135
, pp. 162-168
-
-
Lustig, R.H.1
-
19
-
-
0021027470
-
Insulin-like growth factors i and II, prolactin, and insulin in 19 growth hormone-deficient children with excessive, normal, or decreased longitudinal growth after operation for craniopharyngioma
-
Bucher H, et al: Insulin-like growth factors I and II, prolactin, and insulin in 19 growth hormone-deficient children with excessive, normal, or decreased longitudinal growth after operation for craniopharyngioma. N Engl J Med 1983;309:1142-1146.
-
(1983)
N Engl J Med
, vol.309
, pp. 1142-1146
-
-
Bucher, H.1
-
20
-
-
0014298018
-
Growth hormone and insulin levels in weanling rats with ventromedial hypothalamic lesions
-
Frohman LA, Bernardis LL: Growth hormone and insulin levels in weanling rats with ventromedial hypothalamic lesions. Endocrinology 1968;82:1125-1132.
-
(1968)
Endocrinology
, vol.82
, pp. 1125-1132
-
-
Frohman, L.A.1
Bernardis, L.L.2
-
21
-
-
0017664740
-
Immediate effect of lesion of the ventromedial hypothalamic area upon glucoseinduced insulin secretion in anaesthetized rats
-
Rohner F, et al: Immediate effect of lesion of the ventromedial hypothalamic area upon glucoseinduced insulin secretion in anaesthetized rats. Diabetologia 1977;13:239-242.
-
(1972)
Diabetologia
, vol.13
, pp. 239-242
-
-
Rohner, F.1
-
22
-
-
0015366123
-
Sequential changes in glucose metabolism by adipose tissue and liver of rats after destruction of the ventromedial hypothalamic nuclei: Effect of three dietary regimens
-
Slaunwhite WR 3rd, Goldman JK, Bernardis LL: Sequential changes in glucose metabolism by adipose tissue and liver of rats after destruction of the ventromedial hypothalamic nuclei: effect of three dietary regimens. Metabolism 1972;21:619-631.
-
(1972)
Metabolism
, vol.21
, pp. 619-631
-
-
Slaunwhite III, W.R.1
Goldman, J.K.2
Bernardis, L.L.3
-
23
-
-
0019497652
-
Hypothalamic obesity. The autonomic hypothesis and the lateral hypothalamus
-
Bray GA, Inoue S, Nishizawa Y: Hypothalamic obesity. The autonomic hypothesis and the lateral hypothalamus. Diabetologia 1981(20 suppl):366-377.
-
(1981)
Diabetologia
, vol.20
, Issue.SUPPL.
, pp. 366-377
-
-
Bray, G.A.1
Inoue, S.2
Nishizawa, Y.3
-
24
-
-
0034456475
-
The central melanocortin system can directly regulate serum insulin levels
-
Fan W, et al: The central melanocortin system can directly regulate serum insulin levels. Endocrinology 2000;141:3072-3079.
-
(2000)
Endocrinology
, vol.141
, pp. 3072-3079
-
-
Fan, W.1
-
25
-
-
0034789909
-
Central melanocortin receptors regulate insulin action
-
Obici S, et al: Central melanocortin receptors regulate insulin action. J Clin Invest 2001;108:1079-1085.
-
(2001)
J Clin Invest
, vol.108
, pp. 1079-1085
-
-
Obici, S.1
-
26
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning JC, et al: Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125.
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
-
27
-
-
0017353291
-
The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity
-
Inoue S, Bray GA: The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity. Endocrinology 1977;100:108-114.
-
(1977)
Endocrinology
, vol.100
, pp. 108-114
-
-
Inoue, S.1
Bray, G.A.2
-
28
-
-
0018770622
-
Acute hyperinsulinemia and its reversal by vagotomy after lesions of the ventromedial hypothalamus in anesthetized rats
-
Berthoud HR, Jeanrenaud B: Acute hyperinsulinemia and its reversal by vagotomy after lesions of the ventromedial hypothalamus in anesthetized rats. Endocrinology 1979;105:146-151.
-
(1979)
Endocrinology
, vol.105
, pp. 146-151
-
-
Berthoud, H.R.1
Jeanrenaud, B.2
-
29
-
-
0019570590
-
Prior vagotomy blocks VMH obesity in pair-fed rats
-
Cox JE, Powley TL: Prior vagotomy blocks VMH obesity in pair-fed rats. Am J Physiol 1981;240: E573-E583.
-
(1981)
Am J Physiol
, vol.240
-
-
Cox, J.E.1
Powley, T.L.2
-
30
-
-
0030051196
-
Ventromedial hypothalamic lesioninduced vagal hyperactivity stimulates rat pancreatic cell proliferation
-
Kiba T, et al: Ventromedial hypothalamic lesioninduced vagal hyperactivity stimulates rat pancreatic cell proliferation. Gastroenterology 1996;110: 885-893.
-
(1996)
Gastroenterology
, vol.110
, pp. 885-893
-
-
Kiba, T.1
-
31
-
-
0033782038
-
The autonomic nervous system, adipose tissue plasticity, and energy balance
-
Penicaud L, et al: The autonomic nervous system, adipose tissue plasticity, and energy balance. Nutrition 2000;16:903-908.
-
(2000)
Nutrition
, vol.16
, pp. 903-908
-
-
Penicaud, L.1
-
32
-
-
0020083243
-
Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions
-
Vander Tuig JG, Knehans AW, Romsos DR: Reduced sympathetic nervous system activity in rats with ventromedial hypothalamic lesions. Life Sci 1982; 30:913-920.
-
(1982)
Life Sci
, vol.30
, pp. 913-920
-
-
Vander Tuig, J.G.1
Knehans, A.W.2
Romsos, D.R.3
-
33
-
-
0026099439
-
Altered sympathetic control of nutrient mobilization during physical exercise after lesions in the VMH
-
Balkan B, et al: Altered sympathetic control of nutrient mobilization during physical exercise after lesions in the VMH. Am J Physiol 1991;260: R368-R372.
-
(1991)
Am J Physiol
, vol.260
-
-
Balkan, B.1
-
34
-
-
0022068020
-
Hypothalamic obesity, brown adipose tissue, and sympathoadrenal activity in rats
-
Vander Tuig JG, Kerner J, Romsos DR: Hypothalamic obesity, brown adipose tissue, and sympathoadrenal activity in rats. Am J Physiol 1985;248:E607-E617.
-
(1985)
Am J Physiol
, vol.248
-
-
Vander Tuig, J.G.1
Kerner, J.2
Romsos, D.R.3
-
35
-
-
0030978821
-
Lesions of the ventromedial hypothalamus reduce postingestional thermogenesis
-
Monda M, Sullo A, De Luca B: Lesions of the ventromedial hypothalamus reduce postingestional thermogenesis. Physiol Behav 1997;61:687-691.
-
(1997)
Physiol Behav
, vol.61
, pp. 687-691
-
-
Monda, M.1
Sullo, A.2
De Luca, B.3
-
36
-
-
13144286078
-
Adrenal medullary function and expression of catecholamine-synthesizing enzymes in mice with hypothalamic obesity
-
Martins AC, et al: Adrenal medullary function and expression of catecholamine-synthesizing enzymes in mice with hypothalamic obesity. Life Sci 2004; 74:3211-3222.
-
(2004)
Life Sci
, vol.74
, pp. 3211-3222
-
-
Martins, A.C.1
-
37
-
-
33746011620
-
Cocaine- and amphetamine-regulated transcript peptide and sympatho-adrenal axis
-
Dun SL, et al: Cocaine- and amphetamine-regulated transcript peptide and sympatho-adrenal axis. Peptides 2006;27:1949-1955.
-
(2006)
Peptides
, vol.27
, pp. 1949-1955
-
-
Dun, S.L.1
-
38
-
-
0034727445
-
Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression
-
Wang C, et al: Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression. Neuroreport 2000;11:3251-3255.
-
(2000)
Neuroreport
, vol.11
, pp. 3251-3255
-
-
Wang, C.1
-
39
-
-
0036535303
-
Energy metabolism and expression of uncoupling proteins 1, 2, and 3 after 21 days of recovery from intracerebroventricular mouse leptin in rats
-
Gullicksen PS, et al: Energy metabolism and expression of uncoupling proteins 1, 2, and 3 after 21 days of recovery from intracerebroventricular mouse leptin in rats. Physiol Behav 2002;75:473-482.
-
(2002)
Physiol Behav
, vol.75
, pp. 473-482
-
-
Gullicksen, P.S.1
-
40
-
-
0032899719
-
Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
-
Haynes WG, et al: Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 1999;33(1 Pt 2):542-547.
-
(1999)
Hypertension
, vol.33
, Issue.1 PART 2
, pp. 542-547
-
-
Haynes, W.G.1
-
41
-
-
0035824440
-
A transgenic model of visceral obesity and the metabolic syndrome
-
Masuzaki H, et al: A transgenic model of visceral obesity and the metabolic syndrome. Science 2001; 294:2166-2170.
-
(2001)
Science
, vol.294
, pp. 2166-2170
-
-
Masuzaki, H.1
-
42
-
-
0032990860
-
Cortisol metabolism in human obesity: Impaired cortisone-cortisol conversion in subjects with central adiposity
-
Stewart PM, et al: Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 1999;84:1022-1027.
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1022-1027
-
-
Stewart, P.M.1
-
43
-
-
0035051205
-
Tissue-specific dysregulation of cortisol metabolism in human obesity
-
Rask E, et al: Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 2001;86:1418-1421.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 1418-1421
-
-
Rask, E.1
-
44
-
-
18744413888
-
Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism
-
Draper N, et al: Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism. J Clin Endocrinol Metab 2002;87: 4984-4990.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 4984-4990
-
-
Draper, N.1
-
45
-
-
0042165967
-
Associations between a polymorphism in the 11 beta hydroxysteroid dehydrogenase type i gene and body composition
-
Gelernter-Yaniv L, et al: Associations between a polymorphism in the 11 beta hydroxysteroid dehydrogenase type I gene and body composition. Int J Obes Relat Metab Disord 2003;27:983-986.
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, pp. 983-986
-
-
Gelernter-Yaniv, L.1
-
46
-
-
0037238703
-
Modulation of 11 beta-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers
-
Friedberg M, et al: Modulation of 11 beta-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers. J Clin Endocrinol Metab 2003;88:385-393.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 385-393
-
-
Friedberg, M.1
-
47
-
-
36549045494
-
The leptin hypothesis of depression: A potential link between mood disorders and obesity?
-
Lu XY: The leptin hypothesis of depression: a potential link between mood disorders and obesity? Curr Opin Pharmacol 2007;7:648-652.
-
(2007)
Curr Opin Pharmacol
, vol.7
, pp. 648-652
-
-
Lu, X.Y.1
-
48
-
-
8944220719
-
Effects of both a melatonin agonist and antagonist on seasonal changes in body mass and energy intake in the garden dormouse
-
Le Gouic S, et al: Effects of both a melatonin agonist and antagonist on seasonal changes in body mass and energy intake in the garden dormouse. Int J Obes Relat Metab Disord 1996;20:661-667.
-
(1996)
Int J Obes Relat Metab Disord
, vol.20
, pp. 661-667
-
-
Le Gouic, S.1
-
49
-
-
58049198441
-
Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine betacell function
-
Staiger H, et al: Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine betacell function. PLoS ONE 2008;3:e3962.
-
(2008)
PLoS ONE
, vol.3
-
-
Staiger, H.1
-
50
-
-
0036342557
-
Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients
-
Muller HL, et al: Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J Clin Endocrinol Metab 2002;87: 3993-3996.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3993-3996
-
-
Muller, H.L.1
-
51
-
-
0141732101
-
The monosodium glutamate (MSG) obese rat as a model for the study of exercise in obesity
-
Gobatto CA, et al: The monosodium glutamate (MSG) obese rat as a model for the study of exercise in obesity. Res Commun Mol Pathol Pharmacol 2002;111:89-101.
-
(2002)
Res Commun Mol Pathol Pharmacol
, vol.111
, pp. 89-101
-
-
Gobatto, C.A.1
-
52
-
-
0035232534
-
Glucose tolerance and insulin action in monosodium glutamate (MSG) obese exercise-trained rats
-
de Mello MA, et al: Glucose tolerance and insulin action in monosodium glutamate (MSG) obese exercise-trained rats. Physiol Chem Phys Med NMR 2001;33:63-71.
-
(2001)
Physiol Chem Phys Med NMR
, vol.33
, pp. 63-71
-
-
De Mello Ma1
-
53
-
-
0020078561
-
Effects of physical training on hypothalamic obesity in rats
-
Jenkins RR, Lamb DR: Effects of physical training on hypothalamic obesity in rats. Eur J Appl Physiol Occup Physiol 1982;48:355-359.
-
(1982)
Eur J Appl Physiol Occup Physiol
, vol.48
, pp. 355-359
-
-
Jenkins, R.R.1
Lamb, D.R.2
-
54
-
-
59649113290
-
Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse
-
Haskell-Luevano C, et al: Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse. Faseb J 2009;23:642-655.
-
(2009)
Faseb J
, vol.23
, pp. 642-655
-
-
Haskell-Luevano, C.1
-
55
-
-
0032436307
-
Leptin activates hypothalamic CART neurons projecting to the spinal cord
-
Elias CF, et al: Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 1998;21:1375-1385.
-
(1998)
Neuron
, vol.21
, pp. 1375-1385
-
-
Elias, C.F.1
-
56
-
-
0035462630
-
Mutational screening of the CART gene in obese children: Identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family
-
del Giudice EM, et al: Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. Diabetes 2001;50:2157-2160.
-
(2001)
Diabetes
, vol.50
, pp. 2157-2160
-
-
Del Giudice, E.M.1
-
57
-
-
2942631413
-
Proopiomelanocortin and energy balance: Insights from human and murine genetics
-
Coll AP, et al: Proopiomelanocortin and energy balance: insights from human and murine genetics. J Clin Endocrinol Metab 2004;89:2557-2562.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 2557-2562
-
-
Coll, A.P.1
-
58
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
Krude H, et al: Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998;19: 155-157.
-
(1998)
Nat Genet
, vol.19
, pp. 155-157
-
-
Krude, H.1
-
59
-
-
0242320429
-
Obesity due to proopiomelanocortin deficiency: Three new cases and treatment trials with thyroid hormone and ACTH4-10
-
Krude H, et al: Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10. J Clin Endocrinol Metab 2003;88:4633-4640.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4633-4640
-
-
Krude, H.1
-
60
-
-
6344247722
-
An insertional polymorphism of the proopiomelanocortin gene is associated with fasting insulin levels in childhood obesity
-
Santoro N, et al: An insertional polymorphism of the proopiomelanocortin gene is associated with fasting insulin levels in childhood obesity. J Clin Endocrinol Metab 2004;89:4846-4849.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4846-4849
-
-
Santoro, N.1
-
61
-
-
0031017322
-
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
-
Comuzzie AG, et al: A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 1997; 15:273-276.
-
(1997)
Nat Genet
, vol.15
, pp. 273-276
-
-
Comuzzie, A.G.1
-
62
-
-
0030949271
-
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
-
Jackson RS, et al: Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 1997;16: 303-306.
-
(1997)
Nat Genet
, vol.16
, pp. 303-306
-
-
Jackson, R.S.1
-
63
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
Farooqi IS, et al: Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003;348:1085-1095.
-
(2003)
N Engl J Med
, vol.348
, pp. 1085-1095
-
-
Farooqi, I.S.1
-
64
-
-
33646404622
-
Melanocortin 4 receptor mutations in a large cohort of severely obese adults: Prevalence, functional classification, genotype- phenotype relationship, and lack of association with binge eating
-
Lubrano-Berthelier C, et al: Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype- phenotype relationship, and lack of association with binge eating. J Clin Endocrinol Metab 2006; 91:1811-1818.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 1811-1818
-
-
Lubrano-Berthelier, C.1
-
65
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos RJ, et al: Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008;40:768-775.
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
-
66
-
-
0038392755
-
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
-
Xu B, et al: Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 2003;6:736-742.
-
(2003)
Nat Neurosci
, vol.6
, pp. 736-742
-
-
Xu, B.1
-
67
-
-
7044262828
-
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
-
Yeo GS, et al: A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat Neurosci 2004;7:1187-1189.
-
(2004)
Nat Neurosci
, vol.7
, pp. 1187-1189
-
-
Yeo, G.S.1
-
68
-
-
64049109087
-
Energy-restricted pairfeeding normalizes low levels of brain-derived neurotrophic factor/tyrosine kinase B mRNA expression in the hippocampus, but not ventromedial hypothalamic nucleus, in diet-induced obese mice
-
Yu Y, Wang Q, Huang XF: Energy-restricted pairfeeding normalizes low levels of brain-derived neurotrophic factor/tyrosine kinase B mRNA expression in the hippocampus, but not ventromedial hypothalamic nucleus, in diet-induced obese mice. Neuroscience 2009.
-
(2009)
Neuroscience
-
-
Yu, Y.1
Wang, Q.2
Huang, X.F.3
-
69
-
-
57349156874
-
Recommendations for the diagnosis and management of Prader-Willi syndrome
-
Goldstone AP, et al: Recommendations for the diagnosis and management of Prader-Willi syndrome. J Clin Endocrinol Metab 2008;93:4183-4197.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 4183-4197
-
-
Goldstone, A.P.1
-
70
-
-
0036061558
-
Elevated plasma ghrelin levels in Prader Willi syndrome
-
Cummings DE, et al: Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med 2002;8:643-644.
-
(2002)
Nat Med
, vol.8
, pp. 643-644
-
-
Cummings, D.E.1
-
71
-
-
0036928761
-
High circulating ghrelin: A potential cause for hyperphagia and obesity in praderwilli syndrome
-
DelParigi A, et al: High circulating ghrelin: a potential cause for hyperphagia and obesity in praderwilli syndrome. J Clin Endocrinol Metab 2002;87: 5461-5464.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 5461-5464
-
-
Delparigi, A.1
-
72
-
-
0037240916
-
Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome
-
Haqq AM, et al: Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. J Clin Endocrinol Metab 2003;88:174-178.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 174-178
-
-
Haqq, A.M.1
-
73
-
-
0033050867
-
Body fat determined by skinfold measurements is elevated despite underweight in infants with Prader-Labhart-Willi syndrome
-
Eiholzer U, Blum WF, Molinari L: Body fat determined by skinfold measurements is elevated despite underweight in infants with Prader-Labhart-Willi syndrome. J Pediatr 1999;134:222-225.
-
(1999)
J Pediatr
, vol.134
, pp. 222-225
-
-
Eiholzer, U.1
Blum, W.F.2
Molinari, L.3
-
74
-
-
0345602037
-
Peptides associated with hyperphagia in adults with Prader-Willi syndrome before and during GH treatment
-
Hoybye C, et al: Peptides associated with hyperphagia in adults with Prader-Willi syndrome before and during GH treatment. Growth Horm IGF Res 2003;13:322-327.
-
(2003)
Growth Horm IGF Res
, vol.13
, pp. 322-327
-
-
Hoybye, C.1
-
75
-
-
0030447214
-
Characterization of alterations in glucose and insulin metabolism in Prader-Willi subjects
-
Schuster DP, Osei K, Zipf WB: Characterization of alterations in glucose and insulin metabolism in Prader-Willi subjects. Metabolism 1996;45:1514-1520.
-
(1996)
Metabolism
, vol.45
, pp. 1514-1520
-
-
Schuster, D.P.1
Osei, K.2
Zipf, W.B.3
-
76
-
-
18844416580
-
Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma
-
Goldstone AP, et al: Fasting and postprandial hyperghrelinemia in Prader-Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma. J Clin Endocrinol Metab 2005;90:2681-2690.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 2681-2690
-
-
Goldstone, A.P.1
-
77
-
-
0028852641
-
Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: A study of five cases
-
Swaab DF, Purba JS, Hofman MA: Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases. J Clin Endocrinol Metab 1995;80:573-579.
-
(1995)
J Clin Endocrinol Metab
, vol.80
, pp. 573-579
-
-
Swaab, D.F.1
Purba, J.S.2
Hofman, M.A.3
-
78
-
-
19944431708
-
Clinical and genetic epidemiology of Bardet-Biedl syndrome in Newfoundland: A 22-year prospective, population-based, cohort study
-
Moore SJ, et al: Clinical and genetic epidemiology of Bardet-Biedl syndrome in Newfoundland: a 22-year prospective, population-based, cohort study. Am J Med Genet A 2005;132:352-360.
-
(2005)
Am J Med Genet A
, vol.132
, pp. 352-360
-
-
Moore, S.J.1
-
79
-
-
41849134729
-
Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
-
Rahmouni K, et al: Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. J Clin Invest 2008;118:1458-1467.
-
(2008)
J Clin Invest
, vol.118
, pp. 1458-1467
-
-
Rahmouni, K.1
-
80
-
-
63149175815
-
Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling
-
Seo S, et al: Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet 2009;18:1323-1331.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1323-1331
-
-
Seo, S.1
-
81
-
-
0033062278
-
New criteria for improved diagnosis of Bardet-Biedl syndrome: Results of a population survey
-
Beales PL, et al: New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey. J Med Genet 1999;36:437-446.
-
(1999)
J Med Genet
, vol.36
, pp. 437-446
-
-
Beales, P.L.1
-
82
-
-
0242408534
-
Energy metabolism in Bardet-Biedl syndrome
-
Grace C, et al: Energy metabolism in Bardet-Biedl syndrome. Int J Obes Relat Metab Disord 2003; 27:1319-1324.
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, pp. 1319-1324
-
-
Grace, C.1
-
83
-
-
33748994054
-
Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians
-
Benzinou M, et al: Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians. Diabetes 2006;55:2876-2882.
-
(2006)
Diabetes
, vol.55
, pp. 2876-2882
-
-
Benzinou, M.1
-
84
-
-
0034016043
-
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
-
Holder JL Jr, Butte NF, Zinn AR: Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Hum Mol Genet 2000;9:101-108.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 101-108
-
-
Holder Jr., J.L.1
Butte, N.F.2
Zinn, A.R.3
-
85
-
-
18444412266
-
Deletion of the SIM1 gene (6q16.2) in a patient with a Prader-Willi-like phenotype
-
Faivre L, et al: Deletion of the SIM1 gene (6q16.2) in a patient with a Prader-Willi-like phenotype. J Med Genet 2002;39:594-596.
-
(2002)
J Med Genet
, vol.39
, pp. 594-596
-
-
Faivre, L.1
-
86
-
-
56049124612
-
A 5-Mb microdeletion at 6q16.- -q16.3 with SIM gene deletion and obesity
-
Wang JC, et al: A 5-Mb microdeletion at 6q16.- -q16.3 with SIM gene deletion and obesity. Am J Med Genet [A] 2008;146A:2975-2978.
-
(2008)
Am J Med Genet [A]
, vol.146 A
, pp. 2975-2978
-
-
Wang, J.C.1
-
87
-
-
56749159050
-
Detailed phenotype-genotype study in five patients with chromosome 6q16 deletion: Narrowing the critical region for Prader-Willilike phenotype
-
Bonaglia MC, et al: Detailed phenotype-genotype study in five patients with chromosome 6q16 deletion: narrowing the critical region for Prader-Willilike phenotype. Eur J Hum Genet 2008;16: 1443-1449.
-
(2008)
Eur J Hum Genet
, vol.16
, pp. 1443-1449
-
-
Bonaglia, M.C.1
-
88
-
-
0035393437
-
Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus
-
Michaud JL, et al: Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus. Hum Mol Genet 2001;10:1465-1473.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1465-1473
-
-
Michaud, J.L.1
-
89
-
-
33847257845
-
Studies of the SIM1 gene in relation to human obesity and obesity-related traits
-
Hung CC, et al: Studies of the SIM1 gene in relation to human obesity and obesity-related traits. Int J Obes (Lond) 2007;31:429-434.
-
(2007)
Int J Obes (Lond)
, vol.31
, pp. 429-434
-
-
Hung, C.C.1
-
90
-
-
0036766420
-
The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma
-
Mason PW, Krawiecki N, Meacham LR: The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Arch Pediatr Adolesc Med 2002;156:887-892.
-
(2002)
Arch Pediatr Adolesc Med
, vol.156
, pp. 887-892
-
-
Mason, P.W.1
Krawiecki, N.2
Meacham, L.R.3
-
91
-
-
33644762827
-
Dexamphetamine use for management of obesity and hypersomnolence following hypothalamic injury
-
Ismail D, OConnell MA, Zacharin MR: Dexamphetamine use for management of obesity and hypersomnolence following hypothalamic injury. J Pediatr Endocrinol Metab 2006;19:129-134.
-
(2006)
J Pediatr Endocrinol Metab
, vol.19
, pp. 129-134
-
-
Ismail, D.1
OConnell, M.A.2
Zacharin, M.R.3
-
92
-
-
64749097994
-
Treatment of hypothalamic obesity with caffeine and ephedrine
-
Greenway FL, Bray GA: Treatment of hypothalamic obesity with caffeine and ephedrine. Endocr Pract 2008;14:697-703.
-
(2008)
Endocr Pract
, vol.14
, pp. 697-703
-
-
Greenway, F.L.1
Bray, G.A.2
-
93
-
-
10744228321
-
Octreotide therapy of pediatric hypothalamic obesity: A double-blind, placebo-controlled trial
-
Lustig RH, et al: Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab 2003;88:2586-2592.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 2586-2592
-
-
Lustig, R.H.1
-
94
-
-
0036833479
-
Triiodothyronine supplementation for hypothalamic obesity
-
Fernandes JK, et al: Triiodothyronine supplementation for hypothalamic obesity. Metabolism 2002;51: 1381-1383.
-
(2002)
Metabolism
, vol.51
, pp. 1381-1383
-
-
Fernandes, J.K.1
-
95
-
-
35948962283
-
Impact sibutramine therapy in children with hypothalamic obesity or obesity with aggravating syndromes
-
Danielsson P, et al: Impact sibutramine therapy in children with hypothalamic obesity or obesity with aggravating syndromes. J Clin Endocrinol Metab 2007;92:4101-4106.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 4101-4106
-
-
Danielsson, P.1
|