Serum leptin levels following hypothalamic surgery

Hormone and Metabolic Research

Volumn 28, Issue 12, 1996, Pages 728-731

  Brabant, G ^a   Horn, R ^a   Mayr, B ^a   Von Zur Muhlen A ^a   Honegger, J ^b   Buchfelder, M ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

craniopharyngioma; ob gene; obesity; pituitary adenoma; rhGH

Indexed keywords

LEPTIN; RECOMBINANT GROWTH HORMONE;

ADOLESCENT; ADULT; ARTICLE; BLOOD ANALYSIS; BODY MASS; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HORMONE SUBSTITUTION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; HYPOTHALAMUS TUMOR; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030481437     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-979888     Document Type: Article

References (34)

1. Broebeck JR, Tepperman J, Long CNH: Experimental hyperphagia in the albino rat. Yale Journal of Biological Medicine 15: 831-853 (1943).
2. Hetherington AW, Ranson SW: Experimental hypothalamo-hypophyseal obesity in the rat. Proc Exp Biol Med 4: 465-466 (1939).
3. Parkinson WL, Weingarten HP: Dissociative analysis of ventromedial hypothalamic obesity syndrome. Am J Physiol 259: R829-R835 (1990).
4. Rabin BM: Independence of food intake and obesity following ventromedial hypothalamic lesions. Physiol Behav 13: 769-775 (1974).
5. Cianfarani S, Nicholl RM, Medbach S, Charlesworth MC, Savage MO: Reduced growth hormone secretion in Turner syndrome: is body weight a key factor? Horm Res 39: 47-50 (1993).
6. Fröhlich A: Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie. Wiener Klinische Runschau 15: 883-906 (1901).
7. Jeanrenaud B: Central nervous system and peripheral abnormalities: clues to the understanding of obesity and NIDDM. Diabetologia 37 (Supl 2): 170-178 (1994).
8. Reeves AG, Plum F: Hyperphagia, rage and dementia accompanying a ventromedial hypothalamic neoplasm. Arch Neurolog 20: 616-624 (1969).
9. Sklar CA, Grumbach MM, Kaplan SL, Conte FA: Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: Report of 10 patients. J Clin Endocrinol Metab 52: 9-16 (1981).
10. Wilber JF: Neuropeptides, appetite regulation, and human obesity. JAMA 266: 257-259 (1991).
11. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432 (1994).
12. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse of protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549 (1995).
13. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546 (1995).
14. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boon T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543 (1990).
15. Weigle DS, Bukowski TR, Foster DC, Holdermann S, Kramer JM, Lasser G, Lofton CE, Prunkhard DE, Raymond C, Kijper JL: Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96: 2065-2070 (1995).
16. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell, 84: 491-495 (1996).
17. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI: Identification and expression cloning of a leptin receptor. OB-R Cell 83: 1263-1271 (1995).
18. Fredrich RC, Löllmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS: Expression of ob mRNA and its encoded protein in rodents. J Clin Invest 96: 1658 (1995).
19. Funahashi T, Shimomura I, Hiraoka H, Arai T, Takahashi M, Nakamura T, Nozaki S, Yamashita S, Takemura K, Tokunaga K, Matsuzawa Y: Enhanced expression of rat obese (ob) gene in adipose tissue of ventromedial hypothalamus (VMH)-lesioned rats. Biochemical Biophysic Research Comm 211; 469-475 (1995).
20. Maffei M, Fei H, Lee G, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G, Friedman JM: Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci 92: 6957-6960 (1995).
21. Geldszus R, Mayr B, Horn R, Geisthövel F, von zur Mühlen A, Brabant G: Serum leptin and weight reduction in female obesity. Eur J Endocrinol 135: 659-662 (1996).
22. Horn R, Geldszus R, Pötter E, von zur Mühlen A, Brabant G: Radioimmunoassay for the detection of leptin in human serum. Experiment Clin Endocrinol & Diabet 104: in press (1996).
23. NIH Technology Assesment Conference Panel. Methods for voluntary weight loss and contorl. Annual Internal Medicine 116: 942-946 (1992).
24. Blum WF: Insulin-like growth factors and their binding proteins. In: Ranke MB (ed). Functional endocrinologic diagnostics in children and adolescence. J+J Verlag Mannheim (1992), 102-107.
25. Brabant G, Geldszus R, Horn R, Pötter E, Benecke H, von zur Mühlen A: Kinetic alterations of leptin plasma levels in obese subjects during fasting. Diabetes 45 (Suppl 2): 1170A (1996).
26. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF: serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England of Journal Medicine 334: 292-295 (1996).
27. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M: Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 45: 695-698 (1996).
28. Hamilton BS, Paglia D, Kwan AYM, Deitel M: Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med 1: 953-698 (1995).
29. Lönnquist F, Arner P, Norfors L, Schaling M: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Medicine 1: 950-953 (1995).
30. McGregor GP, Desage JF, Ehlenz K, Fischer A, Heese F, Hegele A, Lämmer C, Peiser C, Lang RE: Radioimmunological measurement of leptin in plasma of obese and diabetic human subjects. Endocrinology 137: 1501-1504 (1996).
31. Chua SC, White DW, Wu-Peng S, Liu SM, Okada N, Kershaw EE, Chung WK, Power-Kehoe L, Chua M, Tartaglia LA, Leibel RL: Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45: 1141-1143 (1996).
32. Lee G, Pronca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM: Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635 (1996).
33. Phillips MS, Liu QY, Hammond HA, Dugan V, Hey PJ, Caskey CT, Hess JF: Leptin receptor missense mutation in the fatty Zucker rat. Nature Gen 13: 18-19 (1996).
34. Schwartz MW, Peskind E, Raskin E, Boyko EJ, Porte D: Cerebrospinal fluid leptin levels: relationship to plasma levels and adiposity in humans. Nature Med 2: 589-592 (1996).