The monosodium glutamate (MSG) obese rat as a model for the study of exercise in obesity

Research Communications in Molecular Pathology and Pharmacology

Volumn 111, Issue 1-4, 2002, Pages 89-101

  Gobatto, C A ^a   Mello, M A R ^a   Souza, C T ^a   Ribeiro, I A ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Blood lactate; Body weight; Carcass fat; Exercise; Lipid profile; Monosodium glutamate (MSG); Obesity; Serum triacylglycerol

Indexed keywords

FAT; FATTY ACID; GLUCOSE; GLUTAMATE SODIUM; GLYCOGEN; INSULIN; LACTIC ACID; TRIACYLGLYCEROL;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE MODEL; EVALUATION; EXERCISE; FEMALE; FOOD INTAKE; LIPID BLOOD LEVEL; MALE; MONOSODIUM GLUTAMATE OBESE RAT MODEL; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; TRAINING; WEIGHT REDUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; MALE; OBESITY; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; SODIUM GLUTAMATE;

EID: 0141732101     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Abraham R, Swart J, Goldberg L and Coulston F. (1975). Electron microscope observations of hipotalami in neonatal Rhesus monkey (Macaca Mulatta) after administration of monosodium-L-glutamate. Experimental and molecular pathology; 23: 203-213.
2. Albanes D, Salbe AD, Levander OA, Taylor PR, Nixon DW and Winick M. (1990). The effect of early caloric restriction on colonic cellular growth in rats. Nutr. Cancer; 13: 73-80.
3. Araujo PE and Meyer J. (1973). Activity increase associated with obesity induced by monosodium glutamate in mice. Am. J. Physiol.; 225: 764-765.
4. Bourgeois, CS, Wiggins D, Hems R and Gibbons GF. (1995). VLDL output by hepatocytes from obese Zucker rats is resistant to the inhibitory effect of insulin. Am. J. Physiol.; 269: E208-E215.
5. Cretaz M, Prentki M, Zaninetti D and Jeanrenaud B. (1980). Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites. Biochem. J.; 186: 525-534.
6. De Hirsch J and Han PW. (1969). Cellularity of rat adipose tissue: effects of growth, starvation and obesity. J. Lipid Res.; 10: 77.
7. Donovan CM and Pagliassotti MJ. (1990). Enhanced efficiency of lactate removal after endurance training. J. Appl. Physiol.; 68:1053-1058.
8. Dowson Jr R and Lorden JF. (1981). Behavioral and neurochemical effects of neonatal administration of monosodium L-glutamate in mice. J. Comp. Physiol. ; 95: 71-84.
9. Engel PC and Jones JB (1978). Causes and elimination of erratic blanks in enzymatic metabolic assays involving the use of NAD in alkaline hydrazine buffers: improved conditions for the assay of L-glutamate, L-lactate, and other metabolites. Anal. Biochem.; 88: 475-485.
10. Giles KW and Mayers A. (1965). An improved diphenylamine method for the estimation of deoxyribonucleic acid. Nature; 206: 49-75.
11. Gobatto, CA, Mello, MAR, Sibuya, CY, Azevedo, JRM, Santos, LA, Kokubun, E. (2001). Maximal lactate steady state in rats submitted to swimming exercise. Comparative Biochemistry and Physiology, 130: 21-27.
12. Hassid WZ and Abraham S. (1957). Chemical procedures for analysis of polysaccharides. Methods Enzymol.; 3: 34-36.
13. Hirata AE, Andrade IS, Vaskevicius P and Dolnikoff MS. (1997).Monosodium glutamate (MSG)-obese rats develop glucose intolerance and insulin resistance to peripheral glucose uptake. Braz. J. Med. Biol. Res.; 30: 671-674.
14. Ivy JL, Zderic TW and Fogt DL. (1999). Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc. Sport Sci. Rev. 1999; 27: 1-35.
15. Jen KLC, Almario R, Llagan J, Zhong S, Archer P and Lin PKH. (1992). Long-term exercise training and retirement in genetically obese rats: effects on food intake, feeding efficiency and carcass composition. Int. J. Obesity; 16: 519-527.
16. Lowe CU.(1970). Monosodium glutamate: specific brain lesion questioned. Science, 167: 1016-1017.
17. Lowry OH, Rosebrough NJ, Farr AL and Randal RJ. (1951). Protein measurement with the folin phenol reagent. Journal of Biological Chemistry; 193: 265-275.
18. Marmo MR, Nunes MT, Volpato CB, Kettelhut IC, Hell NS, Lima FB and Dolnikoff M. (1994). Reduced growth hormone mRNA levels in 28d-old MSG rat impair protein and lipid metabolism. European J. Physiol.; 427: R29.
19. McArdle, WD, Katch, FI and Katch, VL. (1994). Training the aerobic and anaerobic systems. In: McArdle, WD, Katch, FI and Katch, VL. Essentials of Exercise Physiology, Lea & Febiger, Philadelphia, USA, 1994. Pp342-369.
20. th Annual Congress of the European College of Sport Science: Jyväskylä, Fin; pp 489.
21. Nascimento Curi CMO, Marmo MR, Egami M, Ribeiro EB, Andrade IS and Dolnikoff MS. (1991). Effect of monossodium glutamate treatment during neonatal development on lipogenesis rate and lipoprotein lipase activity in adult rats. Biochem. Int.; 24: 927-935.
22. Nikoletseas MM. (1977). Obesity in exercising, hypophagic rats treated with monosodium glutamate. Physiology and Behavior; 19: 767-773.
23. Nogueira DM, Strufaldi B, Hirata MA, Abdala DSP and Hirata RDC. (1990) Métodos de Bioquímica Clínica. Pancast: São Paulo.
24. Ochi M, Fukuhara K, Sawada T, Hattori T and Kusunoki T. (1988). Development of the epididymal adipose tissue in monosodium glutamate-induced obese mice. J. Nutr. Sci. Vitaminol.; 34: 317-326.
25. Oida K, Nakai T, Hayashi T, Miyabo S and Takeda R. (1984). Plasma lipoproteins of monosodium glutamate-induced obese rats. Int. J. Obesity; 8: 385-391.
26. Oscai LB, Babviac SP, Dubach FB, McGarr JA and Spyrakis CN. (1974). Exercise or food restriction: effect on adipose tissue cellularity. Am. J. Physiol; 227: 901-904.
27. Pilis W, Zarzeczny R, Langfort J, Kaciuba-Uscilkos H, Nazar K and Wojtyna J. (1993). Anaerobic threshold in rats. Comp. Biochem. Physiol.; 106A: 285-289.
28. Poon TKY and Cameron DP. (1978). Measurement of oxygen consumption and locomotor activity in monosodium glutamate-induced obesity. Am. J. Physiol.; 234: E532-E534.
29. Ribeiro EB, Nascimento Curi CMO, Andrade IS, Hirata AE and Dolnikoff MS. (1997) Hormonal and metabolic adaptations to fasting in monosodium glutamate-obese rats. J. Comp. Physiol.; 167:430-437.
30. Scalfani A.(1984). Animal models of obesity: classification and characterization. Int. J. Obesity; 8: 491-508.
31. Silva MP, Latorraca MQ, Marcondes MCG and Mello MAR. (1999). Composição corporal de ratos alimentados com dieta hiperlipidica submetidos a treinamento fisico anaeróbio e aeróbio. Motriz; 5: 108.
32. Sjorgreen B, Nordenskjold T, Holmgren H and Wollerstrom J. (1938). Beitrag zur kenttnis des lebemrhythmik. Pflügers Arch. Gesamet Physiol. Menschen Tiere; 240:247.
33. Tokuyama K and Himms-Haggen J.(1986) Brown adipose tissue thermogenesis, torpor and obesity of glutamate treated mice. Am. J. Physiol. (Endocrinol. Metab.); 14: E407-E425.
34. Winick M, Basel JÁ and Rosso P. (1972). A Nutrition and cell growth. In: Winick M. Nutrition and development. John Wiley & Sons: New York; pp.49-97.
35. Yamamoto T, Matsuo S, Ueshima Y, Inoue F, Kinugasa A and Sawada T (1993). Plasma levels of insulin growth factor-1 are reduced at one week of age in monosodium L-glutamate-treated mice. Endocrine Journal; 40: 461-465.