Influence of n-3 polyunsaturated fatty acids enriched lipid emulsions on nosocomial infections and clinical outcomes in critically Ill patients: ICU lipids study

Critical Care Medicine

Volumn 43, Issue 1, 2015, Pages 31-39

  Grau Carmona, Teodoro ^a   Bonet Saris, Alfonso ^b   García De Lorenzo, Abelardo ^c   Sánchez Alvarez, Carmen ^d   Rodríguez Pozo, Angel ^e   Acosta Escribano, José ^f   Miñambres, Eduardo ^g   Herrero Meseguer, Jose Ignacio ^h   Mesejo, Alfonso ⁱ  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b HOSPITAL JOSEP TRUETA   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d HOSPITAL GENERAL UNIVERSITARIO REINA SOFÍA   (Spain)

^e HOSPITAL UNIVERSITARI ARNAU DE VILANOVA   (Spain)

^f HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^g HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^h HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

ⁱ HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

Critically ill patients; Fish oil; Nosocomial infections; Total parenteral nutrition

Indexed keywords

FISH OIL; LIPID EMULSION; OMEGA 3 FATTY ACID;

ADULT; APACHE; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DOUBLE BLIND PROCEDURE; FEMALE; HOSPITAL DISCHARGE; HOSPITAL INFECTION; HOSPITALIZATION; HUMAN; IMMUNOMODULATION; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOTAL PARENTERAL NUTRITION; CLINICAL TRIAL; COMPARATIVE STUDY; CRITICAL ILLNESS; CROSS INFECTION; INTENSIVE CARE UNIT; LENGTH OF STAY; MIDDLE AGED; PROCEDURES; STATISTICS AND NUMERICAL DATA;

CRITICAL ILLNESS; CROSS INFECTION; DOUBLE-BLIND METHOD; FAT EMULSIONS, INTRAVENOUS; FATTY ACIDS, OMEGA-3; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; PARENTERAL NUTRITION, TOTAL; PREVALENCE; RESPIRATION, ARTIFICIAL;

EID: 84925673389     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000612     Document Type: Article

References (43)

1. Waitzberg DL, Torrinhas RS, Jacintho TM: New parenteral lipid emulsions for clinical use. JPEN J Parenter Enteral Nutr 2006; 30:351-367
2. Wanten GJ, Calder PC: Immune modulation by parenteral lipid emulsions. Am J Clin Nutr 2007; 85:1171-1184
3. Stapleton RD, Martin JM, Mayer K: Fish oil in critical illness: Mechanisms and clinical applications. Crit Care Clin 2010; 26:501-514, ix
4. Kinsella JE: Lipids, membrane receptors, and enzymes: Effects of dietary fatty acids. JPEN J Parenter Enteral Nutr 1990; 14:200S-217S
5. Calder PC, Yaqoob P, Harvey DJ, et al: Incorporation of fatty acids by concanavalin A-stimulated lymphocytes and the effect on fatty acid composition and membrane fluidity. Biochem J 1994; 300(Pt 2):509-518
6. Stulnig TM, Huber J, Leitinger N, et al: Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition. J Biol Chem 2001; 276:37335-37340
7. Lo CJ, Chiu KC, Fu M, et al: Fish oil decreases macrophage tumor necrosis factor gene transcription by altering the NF kappa B activity. J Surg Res 1999; 82:216-221
8. Novak TE, Babcock TA, Jho DH, et al: NF-kappa B inhibition by omega-3 fatty acids modulates LPS-stimulated macrophage TNFalpha transcription. Am J Physiol Lung Cell Mol Physiol 2003; 284:L84-L89
9. Zhao Y, Joshi-Barve S, Barve S, et al: Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation. J Am Coll Nutr 2004; 23:71-78
10. Serhan CN, Chiang N, Van Dyke TE: Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 2008; 8:349-361
11. Suchner U, Senftleben U: Immune modulation by polyunsaturated fatty acids during nutritional therapy: Interactions with synthesis and effects of eicosanoids. Infusionsther Transfusionsmed 1994; 21:167-182
12. Grimminger F, Seeger W, Mayer K: Use of n-3 fatty acid-containing lipid emulsions in the intensive care unit environment: The clinician's view. Clin Nutr 2002; 21(Suppl 2):23-29
13. Wachtler P, König W, Senkal M, et al: Influence of a total parenteral nutrition enriched with omega-3 fatty acids on leukotriene synthesis of peripheral leukocytes and systemic cytokine levels in patients with major surgery. J Trauma 1997; 42:191-198
14. Grimm H, Mertes N, Goeters C, et al: Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients. Eur J Nutr 2006; 45:55-60
15. Morlion BJ, Torwesten E, Lessire H, et al: The effect of parenteral fish oil on leukocyte membrane fatty acid composition and leukotriene-synthesizing capacity in patients with postoperative trauma. Metabolism 1996; 45:1208-1213
16. Köller M, Senkal M, Kemen M, et al: Impact of omega-3 fatty acid enriched TPN on leukotriene synthesis by leukocytes after major surgery. Clin Nutr 2003; 22:59-64
17. Wichmann MW, Thul P, Czarnetzki HD, et al: Evaluation of clinical safety and beneficial effects of a fish oil containing lipid emulsion (Lipoplus, MLF541): Data from a prospective, randomized, multicenter trial. Crit Care Med 2007; 35:700-706
18. Liang B, Wang S, Ye YJ, et al: Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients. World J Gastroenterol 2008; 14:2434-2439
19. Weiss G, Meyer F, Matthies B, et al: Immunomodulation by perioperative administration of n-3 fatty acids. Br J Nutr 2002; 87(Suppl 1):S89-S94
20. Jiang ZM, Wilmore DW, Wang XR, et al: Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg 2010; 97:804-809
21. Calder PC: Rationale and use of n-3 fatty acids in artificial nutrition. Proc Nutr Soc 2010; 69:565-573
22. Pradelli L, Mayer K, Muscaritoli M, et al: n-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: A metaanalysis. Crit Care 2012; 16:R184
23. ASPEN Board of Directors and the Clinical Guidelines Task Force: Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. JPEN J Parenter Enteral Nutr 2002; 26(1 Suppl):1SA-138SA
24. Spanish Society of Critical Care Consensus Conference: Sepsis por cateter. Medicina Intensiva 1996; 20:202-206
25. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and multiple organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
26. Calandra T, Cohen J; International Sepsis Forum Definition of Infection in the ICU Consensus Conference: The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 2005; 33:1538-1548
27. Hubmayr RD, Burchardi H, Elliot M, et al; American Thoracic Society Assembly on Critical Care; European Respiratory Society; European Society of Intensive Care Medicine; Société de Réanimation de Langue Française: Statement of the 4th International Consensus Conference in Critical Care on ICU-Acquired Pneumonia-Chicago, Illinois, May 2002. Intensive Care Med 2002; 28:1521-1536
28. Grau T, Bonet A, Rubio M, et al; Working Group on Nutrition and Metabolism of the Spanish Society of Critical Care: Liver dysfunction associated with artificial nutrition in critically ill patients. Crit Care 2007; 11:R10
29. Bonet A, Grau T; Grupo de Trabajo de Metabolismo y Nutrición de la Sociedad Española de; Medicina Intensiva Critica y Unidades Coronarias: [Multicenter study on incidence of total parenteral nutrition complications in the critically-ill patient. ICOMEP study. Part I]. Nutr Hosp 2005; 20:268-277
30. The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group: Perioperative total parenteral nutrition in surgical patients. N Engl J Med 1991; 325:525-532
31. Han YY, Lai SL, Ko WJ, et al: Effects of fish oil on inflammatory modulation in surgical intensive care unit patients. Nutr Clin Pract 2012; 27:91-98
32. Wang X, Li W, Li N, et al: Omega-3 fatty acids-supplemented parenteral nutrition decreases hyperinflammatory response and attenuates systemic disease sequelae in severe acute pancreatitis: A randomized and controlled study. JPEN J Parenter Enteral Nutr 2008; 32:236-241
33. Barbosa VM, Miles EA, Calhau C, et al: Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: A randomized, controlled clinical trial. Crit Care 2010; 14:R5
34. Chen B, Zhou Y, Yang P, et al: Safety and efficacy of fish oil-enriched parenteral nutrition regimen on postoperative patients undergoing major abdominal surgery: A meta-analysis of randomized controlled trials. JPEN J Parenter Enteral Nutr 2010; 34:387-394
35. Wei C, Hua J, Bin C, et al: Impact of lipid emulsion containing fish oil on outcomes of surgical patients: Systematic review of randomized controlled trials from Europe and Asia. Nutrition 2010; 26:474-481
36. Mayer K, Gokorsch S, Fegbeutel C, et al: Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. Am J Respir Crit Care Med 2003; 167:1321-1328
37. Sungurtekin H, Deirmenci S, Sungurtekin U, et al: Comparison of the effects of different intravenous fat emulsions in patients with systemic inflammatory response syndrome and sepsis. Nutr Clin Pract 2011; 26:665-671
38. Wang J, Yu JC, Kang WM, et al: Superiority of a fish oil-enriched emulsion to medium-chain triacylglycerols/long-chain triacylglycerols in gastrointestinal surgery patients: A randomized clinical trial. Nutrition 2012; 28:623-629
39. Heller AR, Rössler S, Litz RJ, et al: Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med 2006; 34:972-979
40. Palmer AJ, Ho CK, Ajibola O, et al: The role of -3 fatty acid supplemented parenteral nutrition in critical illness in adults: A systematic review and meta-analysis. Crit Care Med 2013; 41:307-316
41. Manzanares W, Dhaliwal R, Jurewitsch B, et al: Parenteral fish oil lipid emulsions in the critically ill: A systematic review and meta-analysis. JPEN J Parenter Enteral Nutr 2014; 38:120-128
42. Mayer K, Fegbeutel C, Hattar K, et al: Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: Impact on plasma fatty acids and lipid mediator generation. Intensive Care Med 2003; 29:1472-1481
43. Friesecke S, Lotze C, Köhler J, et al: Fish oil supplementation in the parenteral nutrition of critically ill medical patients: A randomised controlled trial. Intensive Care Med 2008; 34:1411-1420