메뉴 건너뛰기




Volumn 10, Issue 1, 2015, Pages

Lazarillo-related Lipocalins confer long-term protection against type i Spinocerebellar Ataxia degeneration contributing to optimize selective autophagy

Author keywords

ApoD; Atg1 ULK1; Atg4a; Atg8a LC3; Autophagy; Drosophila; GLaz; GstS1; Neurodegeneration; Neuroprotection; NLaz; p62; Polyubiquitinated protein clearance

Indexed keywords

APOLIPOPROTEIN D; ATAXIN 1; GLIAL LAZARILLO; LIPOCALIN; MESSENGER RNA; NEURAL LAZARILLO; PROTEIN; PROTEIN ATG8A; PROTEIN P62; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN;

EID: 84925600455     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/s13024-015-0009-8     Document Type: Article
Times cited : (22)

References (61)
  • 1
    • 84859622560 scopus 로고    scopus 로고
    • Quality control compartments coming of age
    • 1:CAS:528:DC%2BC38XmsVeisLk%3D 22280095
    • Ben-Gedalya T, Cohen E. Quality control compartments coming of age. Traffic. 2012;13:635-42.
    • (2012) Traffic , vol.13 , pp. 635-642
    • Ben-Gedalya, T.1    Cohen, E.2
  • 4
    • 77956757594 scopus 로고    scopus 로고
    • Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy
    • 1:CAS:528:DC%2BC3cXhtFChsLnF 20339376
    • Nisoli I, Chauvin JP, Napoletano F, Calamita P, Zanin V, Fanto M, et al. Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy. Cell Death Differ. 2010;17:1577-87.
    • (2010) Cell Death Differ , vol.17 , pp. 1577-1587
    • Nisoli, I.1    Chauvin, J.P.2    Napoletano, F.3    Calamita, P.4    Zanin, V.5    Fanto, M.6
  • 6
    • 44149124887 scopus 로고    scopus 로고
    • Autophagy in neuroprotection and neurodegeneration: A question of balance
    • 2544613 18806889
    • Cherra 3rd SJ, Chu CT. Autophagy in neuroprotection and neurodegeneration: a question of balance. Future Neurol. 2008;3:309-23.
    • (2008) Future Neurol , vol.3 , pp. 309-323
    • Cherra, S.J.1    Chu, C.T.2
  • 7
    • 67650261911 scopus 로고    scopus 로고
    • Cell death: A dynamic response concept
    • 1:CAS:528:DC%2BD1MXpvFCjurw%3D 19363298
    • Loos B, Engelbrecht AM. Cell death: a dynamic response concept. Autophagy. 2009;5:590-603.
    • (2009) Autophagy , vol.5 , pp. 590-603
    • Loos, B.1    Engelbrecht, A.M.2
  • 9
    • 84885923457 scopus 로고    scopus 로고
    • Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: Functional implications for cell differentiation
    • 1:CAS:528:DC%2BC3sXhtFKgurfN 23777559
    • Ruiz M, Sanchez D, Correnti C, Strong RK, Ganfornina MD. Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: functional implications for cell differentiation. FEBS J. 2013;280:3928-43.
    • (2013) FEBS J , vol.280 , pp. 3928-3943
    • Ruiz, M.1    Sanchez, D.2    Correnti, C.3    Strong, R.K.4    Ganfornina, M.D.5
  • 11
    • 0035093398 scopus 로고    scopus 로고
    • Bacterially produced apolipoprotein D binds progesterone and arachidonic acid, but not bilirubin or E-3M2H
    • 1:CAS:528:DC%2BD3MXitVKkurs%3D 11180564
    • Vogt M, Skerra A. Bacterially produced apolipoprotein D binds progesterone and arachidonic acid, but not bilirubin or E-3M2H. J Mol Recognit. 2001;14:79-86.
    • (2001) J Mol Recognit , vol.14 , pp. 79-86
    • Vogt, M.1    Skerra, A.2
  • 12
    • 33645864333 scopus 로고    scopus 로고
    • Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila
    • 1:CAS:528:DC%2BD28XjtFGiur8%3D 16581513
    • Sanchez D, Lopez-Arias B, Torroja L, Canal I, Wang X, Bastiani MJ, et al. Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Curr Biol. 2006;16:680-6.
    • (2006) Curr Biol , vol.16 , pp. 680-686
    • Sanchez, D.1    Lopez-Arias, B.2    Torroja, L.3    Canal, I.4    Wang, X.5    Bastiani, M.J.6
  • 14
    • 79956306310 scopus 로고    scopus 로고
    • Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz
    • 1:CAS:528:DC%2BC3MXmvFGjs7w%3D 21376794
    • Ruiz M, Sanchez D, Canal I, Acebes A, Ganfornina MD. Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. Exp Gerontol. 2011;46:579-89.
    • (2011) Exp Gerontol , vol.46 , pp. 579-589
    • Ruiz, M.1    Sanchez, D.2    Canal, I.3    Acebes, A.4    Ganfornina, M.D.5
  • 15
    • 84865861259 scopus 로고    scopus 로고
    • Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz
    • 1:CAS:528:DC%2BC38XhtFKit7vE 22846641
    • Ruiz M, Wicker-Thomas C, Sanchez D, Ganfornina MD. Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. Insect Biochem Mol Biol. 2012;42:776-89.
    • (2012) Insect Biochem Mol Biol , vol.42 , pp. 776-789
    • Ruiz, M.1    Wicker-Thomas, C.2    Sanchez, D.3    Ganfornina, M.D.4
  • 16
    • 33645882217 scopus 로고    scopus 로고
    • Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan
    • 1:CAS:528:DC%2BD28XjtFGiur4%3D 16581512
    • Walker DW, Muffat J, Rundel C, Benzer S. Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol. 2006;16:674-9.
    • (2006) Curr Biol , vol.16 , pp. 674-679
    • Walker, D.W.1    Muffat, J.2    Rundel, C.3    Benzer, S.4
  • 17
    • 44349118767 scopus 로고    scopus 로고
    • Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila
    • 1:CAS:528:DC%2BD1cXmt1Gmur0%3D 18458334
    • Muffat J, Walker DW, Benzer S. Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. Proc Natl Acad Sci U S A. 2008;105:7088-93.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 7088-7093
    • Muffat, J.1    Walker, D.W.2    Benzer, S.3
  • 18
    • 79960734140 scopus 로고    scopus 로고
    • Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems
    • Bajo-Graneras R, Ganfornina MD, Martin-Tejedor E, Sanchez D. Apolipoprotein D mediates autocrine protection of astrocytes and controls their reactivity level, contributing to the functional maintenance of paraquat-challenged dopaminergic systems. Glia. 2011;59:1551-66.
    • (2011) Glia , vol.59 , pp. 1551-1566
    • Bajo-Graneras, R.1    Ganfornina, M.D.2    Martin-Tejedor, E.3    Sanchez, D.4
  • 19
    • 79957970613 scopus 로고    scopus 로고
    • Apolipoprotein D alters the early transcriptional response to oxidative stress in the adult cerebellum
    • 1:CAS:528:DC%2BC3MXnvFCns7g%3D 21463325
    • Bajo-Graneras R, Sanchez D, Gutierrez G, Gonzalez C, Do Carmo S, Rassart E, et al. Apolipoprotein D alters the early transcriptional response to oxidative stress in the adult cerebellum. J Neurochem. 2011;117:949-60.
    • (2011) J Neurochem , vol.117 , pp. 949-960
    • Bajo-Graneras, R.1    Sanchez, D.2    Gutierrez, G.3    Gonzalez, C.4    Do Carmo, S.5    Rassart, E.6
  • 20
    • 77956556474 scopus 로고    scopus 로고
    • ApoD, a glia-derived apolipoprotein, is required for peripheral nerve functional integrity and a timely response to injury
    • 20607718
    • Ganfornina MD, Do Carmo S, Martinez E, Tolivia J, Navarro A, Rassart E, et al. ApoD, a glia-derived apolipoprotein, is required for peripheral nerve functional integrity and a timely response to injury. Glia. 2010;58:1320-34.
    • (2010) Glia , vol.58 , pp. 1320-1334
    • Ganfornina, M.D.1    Do Carmo, S.2    Martinez, E.3    Tolivia, J.4    Navarro, A.5    Rassart, E.6
  • 21
    • 47349099698 scopus 로고    scopus 로고
    • Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress
    • 1:CAS:528:DC%2BD1cXpvVOhtL4%3D 18419796
    • Ganfornina MD, Do Carmo S, Lora JM, Torres-Schumann S, Vogel M, Allhorn M, et al. Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell. 2008;7:506-15.
    • (2008) Aging Cell , vol.7 , pp. 506-515
    • Ganfornina, M.D.1    Do Carmo, S.2    Lora, J.M.3    Torres-Schumann, S.4    Vogel, M.5    Allhorn, M.6
  • 23
    • 63549135460 scopus 로고    scopus 로고
    • Meta-analysis of age-related gene expression profiles identifies common signatures of aging
    • de Magalhaes JP, Curado J, Church GM. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics. 2009;25:875-81.
    • (2009) Bioinformatics , vol.25 , pp. 875-881
    • De Magalhaes, J.P.1    Curado, J.2    Church, G.M.3
  • 24
    • 54149092555 scopus 로고    scopus 로고
    • Evolution of the aging brain transcriptome and synaptic regulation
    • Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, et al. Evolution of the aging brain transcriptome and synaptic regulation. PLoS One. 2008;3:e3329.
    • (2008) PLoS One , vol.3 , pp. 3329
    • Loerch, P.M.1    Lu, T.2    Dakin, K.A.3    Vann, J.M.4    Isaacs, A.5    Geula, C.6
  • 26
    • 74949122722 scopus 로고    scopus 로고
    • Apolipoprotein D: An overview of its role in aging and age-related diseases
    • 1:CAS:528:DC%2BC3cXot1ChtLo%3D 20023409
    • Muffat J, Walker DW. Apolipoprotein D: an overview of its role in aging and age-related diseases. Cell Cycle. 2010;9:269-73.
    • (2010) Cell Cycle , vol.9 , pp. 269-273
    • Muffat, J.1    Walker, D.W.2
  • 27
    • 84903367778 scopus 로고    scopus 로고
    • Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain
    • 1:CAS:528:DC%2BC2cXjs1KqtLs%3D 24612673
    • Dassati S, Waldner A, Schweigreiter R. Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain. Neurobiol Aging. 2014;35:1632-42.
    • (2014) Neurobiol Aging , vol.35 , pp. 1632-1642
    • Dassati, S.1    Waldner, A.2    Schweigreiter, R.3
  • 28
    • 84867435039 scopus 로고    scopus 로고
    • On the cause of aging and control of lifespan: Heterogeneity leads to inevitable damage accumulation, causing aging; Control of damage composition and rate of accumulation define lifespan
    • Gladyshev VN. On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan. Bioessays. 2012;34:925-9.
    • (2012) Bioessays , vol.34 , pp. 925-929
    • Gladyshev, V.N.1
  • 29
    • 77954464940 scopus 로고    scopus 로고
    • Altered lipid metabolism in a Drosophila model of Friedreich's ataxia
    • 1:CAS:528:DC%2BC3cXotlSmu7Y%3D 20460268
    • Navarro JA, Ohmann E, Sanchez D, Botella JA, Liebisch G, Molto MD, et al. Altered lipid metabolism in a Drosophila model of Friedreich's ataxia. Hum Mol Genet. 2010;19:2828-40.
    • (2010) Hum Mol Genet , vol.19 , pp. 2828-2840
    • Navarro, J.A.1    Ohmann, E.2    Sanchez, D.3    Botella, J.A.4    Liebisch, G.5    Molto, M.D.6
  • 31
    • 84961557112 scopus 로고    scopus 로고
    • An automated image analysis method to measure regularity in biological patterns: A case study in a Drosophila neurodegenerative model
    • DOI:10.1186/s13024-015-0005-z
    • Diez-Hermano S, Valero J, Rueda C, Ganfornina MD, Sanchez D. An automated image analysis method to measure regularity in biological patterns: a case study in a Drosophila neurodegenerative model. Mol Neurodegeneration. 2015;10:9, DOI:10.1186/s13024-015-0005-z.
    • (2015) Mol Neurodegeneration , vol.10 , pp. 9
    • Diez-Hermano, S.1    Valero, J.2    Rueda, C.3    Ganfornina, M.D.4    Sanchez, D.5
  • 32
    • 0033884803 scopus 로고    scopus 로고
    • Characterization of two novel lipocalins expressed in the Drosophila embryonic nervous system
    • 1:CAS:528:DC%2BD3cXmtlSnur4%3D 10949044
    • Sanchez D, Ganfornina MD, Torres-Schumann S, Speese SD, Lora JM, Bastiani MJ. Characterization of two novel lipocalins expressed in the Drosophila embryonic nervous system. Int J Dev Biol. 2000;44:349-59.
    • (2000) Int J Dev Biol , vol.44 , pp. 349-359
    • Sanchez, D.1    Ganfornina, M.D.2    Torres-Schumann, S.3    Speese, S.D.4    Lora, J.M.5    Bastiani, M.J.6
  • 33
    • 38349171781 scopus 로고    scopus 로고
    • Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases
    • 1:CAS:528:DC%2BD1cXoslWktw%3D%3D 17984172
    • Branco J, Al-Ramahi I, Ukani L, Perez AM, Fernandez-Funez P, Rincon-Limas D, et al. Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases. Hum Mol Genet. 2008;17:376-90.
    • (2008) Hum Mol Genet , vol.17 , pp. 376-390
    • Branco, J.1    Al-Ramahi, I.2    Ukani, L.3    Perez, A.M.4    Fernandez-Funez, P.5    Rincon-Limas, D.6
  • 34
    • 83455211820 scopus 로고    scopus 로고
    • Oxidative stress in synapse development and function
    • 1:CAS:528:DC%2BC3MXhs1SgtLnP 21793225
    • Milton VJ, Sweeney ST. Oxidative stress in synapse development and function. Dev Neurobiol. 2012;72:100-10.
    • (2012) Dev Neurobiol , vol.72 , pp. 100-110
    • Milton, V.J.1    Sweeney, S.T.2
  • 35
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • 1:CAS:528:DC%2BD28XlvVGlsbc%3D 16625204
    • Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006;441:885-9.
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3    Yamamoto, A.4    Nakahara, Y.5    Suzuki-Migishima, R.6
  • 36
    • 36849021043 scopus 로고    scopus 로고
    • Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    • 1:CAS:528:DC%2BD2sXhsVaht7vM 18056421
    • Juhasz G, Erdi B, Sass M, Neufeld TP. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 2007;21:3061-6.
    • (2007) Genes Dev , vol.21 , pp. 3061-3066
    • Juhasz, G.1    Erdi, B.2    Sass, M.3    Neufeld, T.P.4
  • 37
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • 1:CAS:528:DC%2BD28XlvVGlsbY%3D 16625205
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006;441:880-4.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5    Tanida, I.6
  • 38
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • 1:CAS:528:DC%2BD1cXksFGrtbg%3D 18059160
    • Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy. 2008;4:176-84.
    • (2008) Autophagy , vol.4 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5    Finley, K.D.6
  • 39
    • 84866102456 scopus 로고    scopus 로고
    • Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila
    • 1:CAS:528:DC%2BC38XhsFSjt7nK 22562043
    • Erdi B, Nagy P, Zvara A, Varga A, Pircs K, Menesi D, et al. Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. Autophagy. 2012;8:1124-35.
    • (2012) Autophagy , vol.8 , pp. 1124-1135
    • Erdi, B.1    Nagy, P.2    Zvara, A.3    Varga, A.4    Pircs, K.5    Menesi, D.6
  • 40
    • 84886826594 scopus 로고    scopus 로고
    • MTOR complexes in neurodevelopmental and neuropsychiatric disorders
    • 1:CAS:528:DC%2BC3sXhs1yitbfO 24165680
    • Costa-Mattioli M, Monteggia LM. mTOR complexes in neurodevelopmental and neuropsychiatric disorders. Nat Neurosci. 2013;16:1537-43.
    • (2013) Nat Neurosci , vol.16 , pp. 1537-1543
    • Costa-Mattioli, M.1    Monteggia, L.M.2
  • 41
    • 77950495123 scopus 로고    scopus 로고
    • Physiological significance of selective degradation of p62 by autophagy
    • 1:CAS:528:DC%2BC3cXjs12msr8%3D 20153326
    • Komatsu M, Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett. 2010;584:1374-8.
    • (2010) FEBS Lett , vol.584 , pp. 1374-1378
    • Komatsu, M.1    Ichimura, Y.2
  • 42
    • 41549151641 scopus 로고    scopus 로고
    • Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain
    • 1:CAS:528:DC%2BD1cXktFGju7Y%3D 18347073
    • Nezis IP, Simonsen A, Sagona AP, Finley K, Gaumer S, Contamine D, et al. Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol. 2008;180:1065-71.
    • (2008) J Cell Biol , vol.180 , pp. 1065-1071
    • Nezis, I.P.1    Simonsen, A.2    Sagona, A.P.3    Finley, K.4    Gaumer, S.5    Contamine, D.6
  • 43
    • 34548259958 scopus 로고    scopus 로고
    • P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    • 1:CAS:528:DC%2BD2sXoslOntb0%3D 17580304
    • Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem. 2007;282:24131-45.
    • (2007) J Biol Chem , vol.282 , pp. 24131-24145
    • Pankiv, S.1    Clausen, T.H.2    Lamark, T.3    Brech, A.4    Bruun, J.A.5    Outzen, H.6
  • 44
    • 79957916551 scopus 로고    scopus 로고
    • P62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects
    • 1:CAS:528:DC%2BC38Xks1ygtQ%3D%3D 21325881
    • Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, et al. p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy. 2011;7:572-83.
    • (2011) Autophagy , vol.7 , pp. 572-583
    • Bartlett, B.J.1    Isakson, P.2    Lewerenz, J.3    Sanchez, H.4    Kotzebue, R.W.5    Cumming, R.C.6
  • 46
    • 33845874899 scopus 로고    scopus 로고
    • Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death
    • 1:CAS:528:DC%2BD2sXis1agtA%3D%3D 17208179
    • Scott RC, Juhasz G, Neufeld TP. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol. 2007;17:1-11.
    • (2007) Curr Biol , vol.17 , pp. 1-11
    • Scott, R.C.1    Juhasz, G.2    Neufeld, T.P.3
  • 47
    • 84865623676 scopus 로고    scopus 로고
    • Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila
    • 1:CAS:528:DC%2BC38XhtlSjs73K 22952930
    • Pircs K, Nagy P, Varga A, Venkei Z, Erdi B, Hegedus K, et al. Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PLoS One. 2012;7:e44214.
    • (2012) PLoS One , vol.7 , pp. 44214
    • Pircs, K.1    Nagy, P.2    Varga, A.3    Venkei, Z.4    Erdi, B.5    Hegedus, K.6
  • 48
    • 4744349602 scopus 로고    scopus 로고
    • Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions
    • 1:CAS:528:DC%2BD2cXosVKqur8%3D 15379887
    • Nagaoka U, Kim K, Jana NR, Doi H, Maruyama M, Mitsui K, et al. Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions. J Neurochem. 2004;91:57-68.
    • (2004) J Neurochem , vol.91 , pp. 57-68
    • Nagaoka, U.1    Kim, K.2    Jana, N.R.3    Doi, H.4    Maruyama, M.5    Mitsui, K.6
  • 49
    • 84892848771 scopus 로고    scopus 로고
    • The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability
    • 1:CAS:528:DC%2BC2cXivF2mur0%3D 24412309
    • Meske V, Erz J, Priesnitz T, Ohm TG. The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability. Neurobiol Dis. 2014;64:88-97.
    • (2014) Neurobiol Dis , vol.64 , pp. 88-97
    • Meske, V.1    Erz, J.2    Priesnitz, T.3    Ohm, T.G.4
  • 50
    • 84901020692 scopus 로고    scopus 로고
    • Severe neurodegeneration with impaired autophagy mechanism triggered by ostm1 deficiency
    • 1:CAS:528:DC%2BC2cXotFGmsrg%3D 24719316
    • Heraud C, Griffiths A, Pandruvada SN, Kilimann MW, Pata M, Vacher J. Severe neurodegeneration with impaired autophagy mechanism triggered by ostm1 deficiency. J Biol Chem. 2014;289:13912-25.
    • (2014) J Biol Chem , vol.289 , pp. 13912-13925
    • Heraud, C.1    Griffiths, A.2    Pandruvada, S.N.3    Kilimann, M.W.4    Pata, M.5    Vacher, J.6
  • 51
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • 1:CAS:528:DC%2BD2sXjslOmtLs%3D 17347651
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007;26:1749-60.
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 52
    • 34250825929 scopus 로고    scopus 로고
    • Oxidation as a post-translational modification that regulates autophagy
    • 1:CAS:528:DC%2BD2sXhtVGrtLfI 17438362
    • Scherz-Shouval R, Shvets E, Elazar Z. Oxidation as a post-translational modification that regulates autophagy. Autophagy. 2007;3:371-3.
    • (2007) Autophagy , vol.3 , pp. 371-373
    • Scherz-Shouval, R.1    Shvets, E.2    Elazar, Z.3
  • 53
    • 0031555892 scopus 로고    scopus 로고
    • Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages
    • 1:CAS:528:DyaK2sXhvVylsbk%3D 9125146
    • Ishii T, Yanagawa T, Yuki K, Kawane T, Yoshida H, Bannai S. Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages. Biochem Biophys Res Commun. 1997;232:33-7.
    • (1997) Biochem Biophys Res Commun , vol.232 , pp. 33-37
    • Ishii, T.1    Yanagawa, T.2    Yuki, K.3    Kawane, T.4    Yoshida, H.5    Bannai, S.6
  • 54
    • 77954599053 scopus 로고    scopus 로고
    • P62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    • 1:CAS:528:DC%2BC3cXos1WntLg%3D 20452972
    • Jain A, Lamark T, Sjottem E, Larsen KB, Awuh JA, Overvatn A, et al. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem. 2010;285:22576-91.
    • (2010) J Biol Chem , vol.285 , pp. 22576-22591
    • Jain, A.1    Lamark, T.2    Sjottem, E.3    Larsen, K.B.4    Awuh, J.A.5    Overvatn, A.6
  • 55
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • 1:CAS:528:DC%2BD1cXhsVOjtrjJ 19029340
    • Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol. 2008;183:795-803.
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 56
    • 75749156257 scopus 로고    scopus 로고
    • PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
    • Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, et al. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol. 2010;8:e1000298.
    • (2010) PLoS Biol , vol.8 , pp. 1000298
    • Narendra, D.P.1    Jin, S.M.2    Tanaka, A.3    Suen, D.F.4    Gautier, C.A.5    Shen, J.6
  • 58
    • 79953717725 scopus 로고    scopus 로고
    • Lipocalin 2 deficiency inhibits cell proliferation, autophagy, and mitochondrial biogenesis in mouse embryonic cells
    • 1:CAS:528:DC%2BC3MXjvFejtbs%3D 21234651
    • Jin D, Zhang Y, Chen X. Lipocalin 2 deficiency inhibits cell proliferation, autophagy, and mitochondrial biogenesis in mouse embryonic cells. Mol Cell Biochem. 2011;351:165-72.
    • (2011) Mol Cell Biochem , vol.351 , pp. 165-172
    • Jin, D.1    Zhang, Y.2    Chen, X.3
  • 59
    • 84884636654 scopus 로고    scopus 로고
    • Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster
    • 1:CAS:528:DC%2BC3sXhsVCku7vL 23950728
    • Nagy P, Varga A, Pircs K, Hegedus K, Juhasz G. Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster. PLoS Genet. 2013;9:e1003664.
    • (2013) PLoS Genet , vol.9 , pp. 1003664
    • Nagy, P.1    Varga, A.2    Pircs, K.3    Hegedus, K.4    Juhasz, G.5
  • 60
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • 1:CAS:528:DC%2BD38XhtFelt7s%3D 11846609
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.