On the cause of aging and control of lifespan: Heterogeneity leads to inevitable damage accumulation, causing aging; Control of damage composition and rate of accumulation define lifespan

BioEssays

Volumn 34, Issue 11, 2012, Pages 925-929

  Gladyshev, Vadim N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

AGING; ARTICLE; CALORIC RESTRICTION; CANCER CELL; CELL CYCLE REGULATION; CELL DAMAGE; CELL DIVISION; CELL HETEROGENEITY; CELL METABOLISM; CELL SURVIVAL; DNA DAMAGE; ENZYME SPECIFICITY; GENETIC MANIPULATION; GENETIC TRANSCRIPTION; GLYCOLYSIS; HUMAN; MAMMAL CELL; METABOLISM; MOLECULAR INTERACTION; NATURAL SELECTION; NEOPLASM; NONHUMAN; PROKARYOTIC CELL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; SENESCENCE;

ANIMALS; CELL AGING; DNA DAMAGE; DNA REPAIR; HUMANS; TIME FACTORS;

PROKARYOTA;

EID: 84867435039     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201200092     Document Type: Article

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