The autophagic defect in Niemann-Pick disease type C neurons differs from somatic cells and reduces neuronal viability

Neurobiology of Disease

Volumn 64, Issue , 2014, Pages 88-97

  Meske, Volker ^a   Erz, Jennifer ^a   Priesnitz, Timm ^a   Ohm, Thomas Georg ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Acidic compartment; Autophagy; Cholesterol; Neurons; Niemann Pick type C

Indexed keywords

BECLIN 1; CELL PROTEIN; CYCLODEXTRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN ULK1; RAPAMYCIN; TUBERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BIOACCUMULATION; CELL SURVIVAL; CELL VACUOLE; CELL VIABILITY; CELLULAR DISTRIBUTION; CLEARANCE; CONTROLLED STUDY; DISEASE ASSOCIATION; EMBRYO; GENE; GENE DELETION; GENE LOCATION; GENOTYPE; LYSOSOME; MOUSE; MUTATIONAL ANALYSIS; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVE FIBER C; NEUROPATHOLOGY; NIEMANN PICK DISEASE; NONHUMAN; NPC1 GENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SOMATIC CELL; STARVATION; WILD TYPE;

ACIDIC COMPARTMENT; AUTOPHAGY; CHOLESTEROL; NEURONS; NIEMANN-PICK TYPE C;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL SURVIVAL; CELLS, CULTURED; CHOLESTEROL; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; NEURONS; NIEMANN-PICK DISEASE, TYPE C; ORGANELLES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TOR SERINE-THREONINE KINASES; VACUOLES;

EID: 84892848771     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.12.018     Document Type: Article

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