Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions

ACS Chemical Neuroscience

Volumn 6, Issue 3, 2015, Pages 403-416

  Tsigelny, Igor F ^a,b,c   Sharikov, Yuriy ^a   Kouznetsova, Valentina L ^a,b   Greenberg, Jerry P ^a   Wrasidlo, Wolf ^b   Overk, Cassia ^c   Gonzalez, Tania ^c   Trejo, Margarita ^c   Spencer, Brian ^c   Kosberg, Kori ^c   Masliah, Eliezer ^c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

membrane interactions; molecular dynamics; neurodegeneration; oligomers; Synuclein; synuclein mutants

Indexed keywords

ALPHA SYNUCLEIN; MUTANT PROTEIN; PROTEIN A30P; PROTEIN A53T; PROTEIN E35K; PROTEIN E46K; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRON MICROSCOPY; IMMUNOLOCALIZATION; MEMBRANE BINDING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MUTANT; NERVE CELL MEMBRANE; NONHUMAN; OLIGOMERIZATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN SECONDARY STRUCTURE; RAT; WESTERN BLOTTING; ANIMAL; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; NEUROBLASTOMA; NONLINEAR SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ALPHA-SYNUCLEIN; ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; COMPUTER SIMULATION; HUMANS; MAGNETIC RESONANCE IMAGING; MODELS, MOLECULAR; NEUROBLASTOMA; NONLINEAR DYNAMICS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; TRANSFECTION;

EID: 84925599754     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500332w     Document Type: Article

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