Curvature dynamics of α-Synuclein familial Parkinson disease mutants. Molecular simulations of the Micelle-and Bilayer-bound forms

Journal of Biological Chemistry

Volumn 284, Issue 11, 2009, Pages 7177-7189

  Perlmutter, Jason D ^a   Braun, Anthony R ^a   Sachs, Jonathan N ^a,b  

^a University of Minnesota   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMISTIC MOLECULAR DYNAMICS SIMULATIONS; BI-LAYER; BIOLOGICAL ENVIRONMENTS; FIBRILLAR AGGREGATES; MOLECULAR SIMULATIONS; NEURODEGENERATIVE DISEASE; PARKINSON DISEASE; PUTATIVE FUNCTIONS; SECONDARY STRUCTURES; STRUCTURE AND DYNAMICS; SURFACE AREA; SYNAPTIC VESICLE; SYNUCLEIN; WILD TYPES;

BINDING SITES; DETERGENTS; DIFFUSERS (OPTICAL); DYNAMICS; HYDROGEN; LIPID BILAYERS; MICELLES; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

HYDROGEN BONDS;

ALPHA SYNUCLEIN; DIOLEOYLPHOSPHATIDYLSERINE; THREONINE; DODECYL SULFATE SODIUM;

ARTICLE; CONTROLLED STUDY; FAMILIAL DISEASE; HYDROGEN BOND; LIPID BILAYER; MICELLE; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTANT; MUTATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; WILD TYPE; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; PARKINSONISM; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; HUMANS; LIPID BILAYERS; MICELLES; MODELS, MOLECULAR; MUTATION, MISSENSE; PARKINSONIAN DISORDERS; PROTEIN STRUCTURE, SECONDARY; SODIUM DODECYL SULFATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65449137602     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808895200     Document Type: Article

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