Amino acid challenge and depletion techniques in human functional neuroimaging studies: An overview

Amino Acids

Volumn 47, Issue 4, 2015, Pages 651-683

  Biskup, C S ^a,b   Gaber, T ^a,b   Helmbold, K ^a,b   Bubenzer Busch, S ^a,b   Zepf, F D ^a,b,c,d  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b JARA Translational Brain Medicine   (Germany)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d DEPARTMENT OF HEALTH   (Australia)

Author keywords

Amino acids; fMRI; PET; Phenylalanine; Tryptophan; Tyrosine

Indexed keywords

AMINO ACID; DOPAMINE;

ANIMAL; BRAIN; FUNCTIONAL NEUROIMAGING; HUMAN; METABOLISM; RADIOGRAPHY;

AMINO ACIDS; ANIMALS; BRAIN; DOPAMINE; FUNCTIONAL NEUROIMAGING; HUMANS;

EID: 84925512174     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-015-1919-z     Document Type: Review

References (151)

1. Agren H, Reibring L (1994) PET studies of presynaptic monoamine metabolism in depressed patients and healthy volunteers. Pharmacopsychiatry 27:2-6
2. Allen PP, Cleare AJ, Lee F et al (2006) Effect of acute tryptophan depletion on pre-frontal engagement. Psychopharmacology 187:486-497. doi: 10.1007/s00213-006-0444-x
3. Alonso R, Agharanya JC, Wurtman RJ (1980) Tyrosine loading enhances catecholamine excretion by rats. J Neural Transm 49:31-43
4. Altman HJ, Normile HJ, Galloway MP et al (1990) Enhanced spatial discrimination learning in rats following 5,7-DHT-induced serotonergic deafferentation of the hippocampus. Brain Res 518:61-66
5. Anderson IM, Richell RA, Bradshaw CM (2003) The effect of acute tryptophan depletion on probabilistic choice. J Psychopharmacol 17:3-7
6. Arce E, Simmons AN, Lovero KL et al (2008) Escitalopram effects on insula and amygdala BOLD activation during emotional processing. Psychopharmacology 196:661-672. doi: 10.1007/s00213-007-1004-8
7. Asberg M, Thorén P, Träskman L et al (1976) "Serotonin depression" - a biochemical subgroup within the affective disorders? Science 191:478-480
8. Barratt ES, Adams PM, Poffenbarger PL et al (1976) Effects of rapid depletion of phenylalanine and tyrosine on sleep and behavior. Pharmacol Biochem Behav 5:47-53
9. Bergström KA, Halldin C, Hall H et al (1997) In vitro and in vivo characterisation of nor-beta-CIT: a potential radioligand for visualisation of the serotonin transporter in the brain. Eur J Nucl Med 24:596-601
10. Biggio G, Fadda F, Fanni P et al (1974) Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sci 14:1321-1329
11. Biskup CS, Sánchez CL, Arrant A et al (2012) Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6 J and BALB/cJ mice. PLoS One 7:e35916. doi: 10.1371/journal.pone.0035916
12. Bjork JM, Grant SJ, Chen G, Hommer DW (2014) Dietary tyrosine/phenylalanine depletion effects on behavioral and brain signatures of human motivational processing. Neuropsychopharmacology 39:595-604. doi: 10.1038/npp.2013.232
13. Blokland A, Lieben C, Deutz NEP (2002) Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat. J Psychopharmacol 16:39-49
14. Bremner JD, Innis RB, Salomon RM et al (1997) Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Arch Gen Psychiatry 54:364-374
15. Büchel C, Morris J, Dolan RJ, Friston KJ (1998) Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron 20:947-957
16. Carli M, Reader TA (1997) Regulation of central serotonin transporters by chronic lithium: an autoradiographic study. Synapse 27:83-89. doi: 10.1002/(SICI)1098-2396(199709)27:1<83:AID-SYN9>3.0.CO;2-9
17. Carlsson M, Carlsson A (1988) In vivo evidence for a greater brain tryptophan hydroxylase capacity in female than in male rats. Naunyn Schmiedebergs Arch Pharmacol 338:345-349
18. Carretti N, Florio P, Bertolin A et al (2005) Serum fluctuations of total and free tryptophan levels during the menstrual cycle are related to gonadotrophins and reflect brain serotonin utilization. Hum Reprod 20:1548-1553. doi: 10.1093/humrep/deh795
19. Chance WT, Foley-Nelson T, Nelson JL, Fischer JE (1990) Tyrosine loading increases dopamine metabolite concentrations in the brain. Pharmacol Biochem Behav 35:195-199
20. Charney DS, Drevets WC (2002) The Neurobiological Basis of Anxiety Disorders. In: Davis K, Charney DS, Coyle J, Nemeroff C (eds) Neuropsychopharmacol. Fifth Gener, Prog, pp 900-930
21. Clark L, Roiser JP, Cools R et al (2005) Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity. Psychopharmacology 182:570-578. doi: 10.1007/s00213-005-0104-6
22. Clarke HF, Robbins TW, Roberts AC (2008) Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex. J Neurosci 28:10972-10982. doi: 10.1523/JNEUROSCI.1521-08.2008
23. Coccaro EF, Kavoussi RJ, Trestman RL et al (1997) Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness. Psychiatry Res 73:1-14
24. Cools R, Blackwell A, Clark L et al (2005a) Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity. Neuropsychopharmacology 30:1362-1373. doi: 10.1038/sj.npp.1300704
25. Cools R, Calder AJ, Lawrence AD et al (2005b) Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces. Psychopharmacology 180:670-679. doi: 10.1007/s00213-005-2215-5
26. Coull JT, Hwang HJ, Leyton M, Dagher A (2012) Dopamine precursor depletion impairs timing in healthy volunteers by attenuating activity in putamen and supplementary motor area. J Neurosci 32:16704-16715. doi: 10.1523/JNEUROSCI.1258-12.2012
27. Cowen P, Sherwood AC (2013) The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression. J Psychopharmacol 27:575-583. doi: 10.1177/0269881113482531
28. 11C]raclopride study in humans. Br J Psychiatry 199:391-397. doi: 10.1192/bjp.bp.110.084178
29. Crockett MJ, Clark L, Robbins TW (2009) Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans. J Neurosci 29:11993-11999. doi: 10.1523/JNEUROSCI.2513-09.2009
30. Daly E, Deeley Q, Hallahan B et al (2010) Effects of acute tryptophan depletion on neural processing of facial expressions of emotion in humans. Psychopharmacology 210:499-510. doi: 10.1007/s00213-010-1850-7
31. Daly EM, Deeley Q, Ecker C et al (2012) Serotonin and the neural processing of facial emotions in adults with autism: an fMRI study using acute tryptophan depletion. Arch Gen Psychiatry 69:1003-1013. doi: 10.1001/archgenpsychiatry.2012.513
32. Davis M, Whalen PJ (2001) The amygdala: vigilance and emotion. Mol Psychiatry 6:13-34
33. Daw ND, Kakade S, Dayan P (2002) Opponent interactions between serotonin and dopamine. Neural Netw 15:603-616
34. De Boer SF, Lesourd M, Mocaer E, Koolhaas JM (1999) Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: a comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. J Pharmacol Exp Ther 288:1125-1133
35. Delgado PL, Price LH, Miller HL, Salomon RM, Aghajanian GK, Heniger GR, CHarney DS (1994) Serotonin and the neurobiology of depression, Effects of tryptophan depletion in drug-free depressed patients. Arch Gen Psych 51(11):865-874
36. Demisch L, Kewitz A, Schmeck K et al (2002) Methodology of rapid tryptophan depletion (RTD): impact of gender and body weight. Eur Arch Psych Clin Neurosci 252:25
37. Demoto Y, Okada G, Okamoto Y et al (2012) Neural and personality correlates of individual differences related to the effects of acute tryptophan depletion on future reward evaluation. Neuropsychobiology 65:55-64. doi: 10.1159/000328990
38. Dingerkus VLS, Gaber TJ, Helmbold K et al (2012) Acute tryptophan depletion in accordance with body weight: influx of amino acids across the blood-brain barrier. J Neural Transm 119:1037-1045. doi: 10.1007/s00702-012-0793-z
39. Drevets WC, Bogers W, Raichle ME (2002) Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 12:527-544
40. Elliott R, Sahakian BJ, Herrod JJ et al (1997) Abnormal response to negative feedback in unipolar depression: evidence for a diagnosis specific impairment. J Neurol Neurosurg Psychiatry 63:74-82
41. Ellis KA, Mehta MA, Naga Venkatesha Murthy PJ et al (2007) Tyrosine depletion alters cortical and limbic blood flow but does not modulate spatial working memory performance or task-related blood flow in humans. Hum Brain Mapp 28:1136-1149. doi: 10.1002/hbm.20339
42. Epperson C, Amin Z, Ruparel K et al (2012) Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal women. Psychoneuroendocrinology 37:372-382. doi: 10.1016/j.psyneuen.2011.07.007
43. Evers EAT, Cools R, Clark L et al (2005) Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning. Neuropsychopharmacology 30:1138-1147. doi: 10.1038/sj.npp.1300663
44. Evers EAT, van der Veen FM, Jolles J et al (2006a) Acute tryptophan depletion improves performance and modulates the BOLD response during a Stroop task in healthy females. Neuroimage 32:248-255. doi: 10.1016/j.neuroimage.2006.03.026
45. Evers EAT, van der Veen FM, van Deursen JA et al (2006b) The effect of acute tryptophan depletion on the BOLD response during performance monitoring and response inhibition in healthy male volunteers. Psychopharmacology 187:200-208. doi: 10.1007/s00213-006-0411-6
46. Fallgatter AJ, Herrmann MJ, Roemmler J et al (2004) Allelic variation of serotonin transporter function modulates the brain electrical response for error processing. Neuropsychopharmacology 29:1506-1511. doi: 10.1038/sj.npp.1300409
47. Fikke LT, Melinder A, Landrø NI (2013) The effects of acute tryptophan depletion on impulsivity and mood in adolescents engaging in non-suicidal self-injury. Hum Psychopharmacol 28:61-71. doi: 10.1002/hup.2283
48. Fish EW, Faccidomo S, Miczek KA (1999) Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 146:391-399
49. Fusar-Poli P, Allen P, Lee F et al (2007) Modulation of neural response to happy and sad faces by acute tryptophan depletion. Psychopharmacology 193:31-44. doi: 10.1007/s00213-007-0757-4
50. Gál EM, Young RB, Sherman AD (1978) Tryptophan loading: consequent effects on the synthesis of kynurenine and 5-hydroxyindoles in rat brain. J Neurochem 31:237-244
51. Gläscher J, Büchel C (2005) Formal learning theory dissociates brain regions with different temporal integration. Neuron 47:295-306. doi: 10.1016/j.neuron.2005.06.008
52. Glass JD, Selim M, Srkalovic G, Rea MA (1995) Tryptophan loading modulates light-induced responses in the mammalian circadian system. J Biol Rhythms 10:80-90
53. Goodnough DB, Baker GB (1994) 5-Hydroxytryptamine2 and beta-adrenergic receptor regulation in rat brain following chronic treatment with desipramine and fluoxetine alone and in combination. J Neurochem 62:2262-2268
54. Grabemann M, Mette C, Zimmermann M et al (2013) No clear effects of acute tryptophan depletion on processing affective prosody in male adults with ADHD. Acta Psychiatr Scand 128:142-148. doi: 10.1111/acps.12130
55. Grady CL, Siebner HR, Hornboll B et al (2013) Acute pharmacologically induced shifts in serotonin availability abolish emotion-selective responses to negative face emotions in distinct brain networks. Eur Neuropsychopharmacol 23:368-378. doi: 10.1016/j.euroneuro.2012.06.003
56. Gurd JM, Cowell PE, Lux S et al (2013) fMRI and corpus callosum relationships in monozygotic twins discordant for handedness. Brain Struct Funct 218:491-509. doi: 10.1007/s00429-012-0410-9
57. Hamilton JP, Etkin A, Furman DJ et al (2012) Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of base line activation and neural response data. Am J Psychiatry 169:693-703. doi: 10.1176/appi.ajp.2012.11071105
58. Haxby J, Hoffman E, Gobbini M (2000) The distributed human neural system for face perception. Trends Cogn Sci 4:223-233
59. Haxby JV, Hoffman EA, Gobbini MI (2002) Human neural systems for face recognition and social communication. Biol Psychiatry 51:59-67
60. Helmbold K, Bubenzer S, Dahmen B et al (2013) Influence of acute tryptophan depletion on verbal declarative episodic memory in young adult females. Amino Acids 45:1207-1219. doi: 10.1007/s00726-013-1582-1
61. Helmbold K, Zvyagintsev M, Dahmen B, Bubenzer-Busch S, Gaber TJ, Crockett MJ, Klasen M, Sanchez CL, Eisert A, Konrad K, Habel U, Herpertz-Dahlmann B, Zepf FD (2015) Effects of serotonin depletion on punishment processing in the orbitofrontal and anterior cingulate cortices of healthy women. Euro Neuropsychopharmacol (accepted)
62. Hernandez G, Haines E, Rajabi H et al (2007) Predictable and unpredictable rewards produce similar changes in dopamine tone. Behav Neurosci 121:887-895. doi: 10.1037/0735-7044.121.5.887
63. Higley JD, Mehlman PT, Poland RE et al (1996) CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors. Biol Psychiatry 40:1067-1082. doi: 10.1016/S0006-3223(95)00675-3
64. Hindi Attar C, Finckh B, Büchel C (2012) The influence of serotonin on fear learning. PLoS ONE 7:e42397. doi: 10.1371/journal.pone.0042397
65. Hobson RM, Watson P, Maughan RJ (2013) Acute tryptophan depletion does not improve endurance cycling capacity in a warm environment. Amino Acids 44:983-991. doi: 10.1007/s00726-012-1429-1
66. Horacek J, Zavesicka L, Tintera J (2005) The effect of tryptophan depletion on brain activation measured by functional magnetic resonance imaging during the Stroop test in healthy subjects. Physiol Res 54:235-244
67. Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72:165-229
68. Kanwisher N, McDermott J, Chun MM (1997) The fusiform face area: a module in human extrastriate cortex specialized for face perception. J Neurosci 17:4302-4311
69. Kewitz A (2002) Biochemische untersuchungen zur Optimierung des "'Rapid Tryptophan Depletion-Test'" (RTD) - eine physiologi- sche Methode zur akuten Verminderung der zentralnervösen Serotonin-Synthese in der psychobiologischen Forschung. Johann Wolfgang Goethe-Universität, Frankfurt am Main
70. Knott V, Bisserbe J-C, Shah D et al (2013) The moderating influence of nicotine and smoking on resting-state mood and EEG changes in remitted depressed patients during tryptophan depletion. Biol Psychol 94:545-555. doi: 10.1016/j.biopsycho.2013.09.008
71. Kötting WF, Bubenzer S, Helmbold K et al (2013) Effects of tryptophan depletion on reactive aggression and aggressive decision-making in young people with ADHD. Acta Psychiatr Scand 128:114-123. doi: 10.1111/acps.12001
72. Krämer UM, Riba J, Richter S, Münte TF (2011) An fMRI study on the role of serotonin in reactive aggression. PLoS ONE 6:e27668. doi: 10.1371/journal.pone.0027668
73. LaBar KS, Gatenby JC, Gore JC et al (1998) Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron 20:937-945
74. Labus J, Mayer E, Jarcho J et al (2011) Acute tryptophan depletion alters the effective connectivity of emotional arousal circuitry during visceral stimuli in healthy women. Gut. doi: 10.1136/gut.2010.213447
75. Laird AR, McMillan KM, Lancaster JL et al (2005) A comparison of label-based review and ALE meta-analysis in the Stroop task. Hum Brain Mapp 25:6-21. doi: 10.1002/hbm.20129
76. Lamar M, Cutter WJ, Rubia K et al (2009) 5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletion. Neurobiol Aging 30:1135-1146. doi: 10.1016/j.neurobiolaging.2007.09.013
77. Leyton M, Dagher A, Boileau I et al (2004) Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: a PET/[11C]raclopride study in healthy men. Neuropsychopharmacology 29:427-432. doi: 10.1038/sj.npp.1300328
78. Lieben CKJ, van Oorsouw K, Deutz NEP, Blokland A (2004) Acute tryptophan depletion induced by a gelatin-based mixture impairs object memory but not affective behavior and spatial learning in the rat. Behav Brain Res 151:53-64. doi: 10.1016/j.bbr.2003.08.002
79. Macoveanu J, Hornboll B, Elliott R et al (2013) Serotonin 2A receptors, citalopram and tryptophan-depletion: a multimodal imaging study of their interactions during response inhibition. Neuropsychopharmacology 38:996-1005. doi: 10.1038/npp.2012.264
80. McClure SM, Daw ND, Montague PR (2003) A computational substrate for incentive salience. Trends Neurosci 26:423-428
81. Mehlman PT, Higley JD, Faucher I et al (1994) Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am J Psychiatry 151:1485-1491
82. Meneses A, Liy-Salmeron G (2012) Serotonin and emotion, learning and memory. Rev Neurosci 23:543-553. doi: 10.1515/revneuro-2012-0060
83. Mette C, Zimmermann M, Grabemann M et al (2013) The impact of acute tryptophan depletion on attentional performance in adult patients with ADHD. Acta Psychiatr Scand 128:124-132. doi: 10.1111/acps.12090
84. Meyers S (2000) Use of neurotransmitter precursors for treatment of depression. Altern Med Rev 5:64-71
85. Mobascher A, Warbrick T, Brinkmeyer J et al (2012) Nicotine effects on anterior cingulate cortex in schizophrenia and healthy smokers as revealed by EEG-informed fMRI. Psychiatry Res 204:168-177. doi: 10.1016/j.pscychresns.2012.09.005
86. Montgomery AJ, McTavish SFB, Cowen PJ, Grasby PM (2003) Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study. Am J Psychiatry 160:1887-1889
87. Morris JS, Smith KA, Cowen PJ et al (1999) Covariation of Activity in Habenula and Dorsal Raphé Nuclei Following Tryptophan Depletion. Neuroimage 10:163-172
88. Moss HB, Yao JK, Panzak GL (1990) Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Biol Psychiatry 28:325-338
89. Murphy FC, Michael A, Robbins TW, Sahakian BJ (2003) Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance. Psychol Med 33:455-467
90. Nagano-Saito A, Leyton M, Monchi O et al (2008) Dopamine depletion impairs frontostriatal functional connectivity during a set-shifting task. J Neurosci 28:3697-3706. doi: 10.1523/JNEUROSCI.3921-07.2008
91. Nagano-Saito A, Cisek P, Perna AS et al (2012) From anticipation to action, the role of dopamine in perceptual decision making: an fMRI-tyrosine depletion study. J Neurophysiol 108:501-512. doi: 10.1152/jn.00592.2011
92. Neumeister A, Praschak-Rieder N, Heßelmann B, Vitouch O, Rauh M, Barocka A, Kasper S (1997) Rapid tryptophan depletion in drug-free depressed patients with seasonal affective disorder. Am J Psychiatry 154(8):1153-1155
93. Neumeister A, Nugent AC, Waldeck T et al (2004) Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch Gen Psychiatry 1-15. doi: 10.1001/archpsyc.61.8.765
94. Neumeister A, Hu X-Z, Luckenberg DA et al (2006) Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry 63:978-986
95. Nishizawa S, Benkelfat C, Young SN et al (1997) Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 94:5308-5313
96. Nugent A, Neumeister A, Goldman D et al (2008) Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion. Neuroimage 43:764-774. doi: 10.1016/j.neuroimage.2008.07.040.Serotonin
97. O'Doherty JP, Dayan P, Friston K et al (2003) Temporal difference models and reward-related learning in the human brain. Neuron 38:329-337
98. Ogawa S, Menon RS, Tank DW et al (1993) Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 64:803-812. doi: 10.1016/S0006-3495(93)81441-3
99. Park SB, Coull JT, McShane RH et al (1994) Tryptophan depletion in normal volunteers produces selective impairments in learning and memory. Neuropharmacology 33:575-588
100. Passamonti L, Crockett MJ, Apergis-Schoute AM et al (2012) Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression. Biol Psychiatry 71:36-43. doi: 10.1016/j.biopsych.2011.07.033
101. Peroutka SJ, Snyder SH (1980) Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science 210:88-90
102. Praschak-Rieder N, Hussey D, Wilson AA et al (2004) Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor-treated depression: an [(18)F] MPPF positron emission tomography study. Biol Psychiatry 56:587-591. doi: 10.1016/j.biopsych.2004.07.018
103. Praschak-Rieder N, Wilson AA, Hussey D et al (2005) Effects of tryptophan depletion on the serotonin transporter in healthy humans. Biol Psychiatry 58:825-830. doi: 10.1016/j.biopsych.2005.04.038
104. Price LH, Malison RT, McDougle CJ, Pelton GH, Heninger GR (1998) The neurobiology of tryptophan depletion in depression: effects of intravenous tryptophan infusion. Biol Psychiatry 43(5):339-347
105. Rizza V, Bousquet E, Guerrera F, De Regis M (1983) Regulation of cerebral kynurenine and 5-hydroxyindole pathways during tryptophan loading. Cephalalgia 3(Suppl 1):139-142
106. Robbins TW (2005) Chemistry of the mind: neurochemical modulation of prefrontal cortical function. J Comp Neurol 493:140-146. doi: 10.1002/cne.20717
107. Robinson OJ, Cools R, Sahakian BJ (2012) Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience. Psychopharmacology 219:599-605. doi: 10.1007/s00213-011-2410-5
108. Robinson OJ, Overstreet C, Allen PS et al (2013) The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala "aversive amplification" circuit. Neuroimage 78:217-223. doi: 10.1016/j.neuroimage.2013.03.075
109. Rogers RD, Blackshaw AJ, Middleton HC et al (1999) Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour. Psychopharmacology 146:482-491
110. Rogers RD, Tunbridge EM, Bhagwagar Z et al (2003) Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues. Neuropsychopharmacology 28:153-162. doi: 10.1038/sj.npp.1300001
111. Roiser J, Levy J, Fromm S et al (2008) The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers. Neuropsychopharmacology 33:1992-2006. doi: 10.1038/sj.npp.1301581
112. Roiser JP, Levy J, Fromm SJ et al (2009) The effects of tryptophan depletion on neural responses to emotional words in remitted depression. Biol Psychiatry 66:441-450. doi: 10.1016/j.biopsych.2009.05.002
113. Roiser JP, Levy J, Fromm SJ et al (2012) Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers. J Psychopharmacol 26:1434-1442. doi: 10.1177/0269881112442789
114. Rossion B, Schiltz C, Crommelinck M (2003) The functionally defined right occipital and fusiform "face areas" discriminate novel from visually familiar faces. Neuroimage 19:877-883
115. Rubia K, Lee F, Cleare AJ et al (2005) Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI. Psychopharmacology 179:791-803. doi: 10.1007/s00213-004-2116-z
116. Rubinow DR, Schmidt PJ, Roca CA (1998) Estrogen-serotonin interactions: implications for affective regulation. Biol Psychiatry 44:839-850
117. Sacher J, Rabiner EA, Clark M et al (2012) Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study. J Cereb Blood Flow Metab 32:443-446. doi: 10.1038/jcbfm.2011.184
118. Salomon RM, Cowan RL, Rogers BP et al (2011) Time series fMRI measures detect changes in pontine raphé following acute tryptophan depletion. Psychiatry Res 191:112-121. doi: 10.1016/j.pscychresns.2010.10.007
119. Sambeth A, Blokland A, Harmer CJ et al (2007) Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studies. Neurosci Biobehav Rev 31:516-529. doi: 10.1016/j.neubiorev.2006.11.009
120. Sánchez CL, Van Swearingen AED, Arrant AE et al (2014) Dietary manipulation of serotonergic and dopaminergic function in C57BL/6 J mice with amino acid depletion mixtures. J Neural Transm 121:153-162. doi: 10.1007/s00702-013-1083-0
121. Schultz W, Dayan P, Montague PR (1997) A neural substrate of prediction and reward. Science 275:1593-1599
122. Seeman P (2013) Are dopamine D2 receptors out of control in psychosis? Prog Neuropsychopharmacol Biol Psychiatry 46:146-152. doi: 10.1016/j.pnpbp.2013.07.006
123. Seymour B, Daw ND, Roiser JP et al (2012a) Serotonin selectively modulates reward value in human decision-making. J Neurosci 32:5833-5842. doi: 10.1523/JNEUROSCI.0053-12.2012
124. Seymour KE, Chronis-Tuscano A, Halldorsdottir T et al (2012b) Emotion regulation mediates the relationship between ADHD and depressive symptoms in youth. J Abnorm Child Psychol 40:595-606. doi: 10.1007/s10802-011-9593-4
125. Sharma A, Couture J (2014) A review of the pathophysiology, etiology, and treatment of attention-deficit hyperactivity disorder (ADHD). Ann Pharmacother 48:209-225. doi: 10.1177/1060028013510699
126. Siegle GJ, Steinhauer SR, Thase ME et al (2002) Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry 51:693-707
127. Smith KA, Morris JS, Friston KJ et al (1999) Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion. Br J Psychiatry 174:525-529. doi: 10.1192/bjp.174.6.525
128. Stein DJ (2008) Depression, anhedonia, and psychomotor symptoms: the role of dopaminergic neurocircuitry. CNS Spectr 13:561-565
129. Stroop JR (1935) Studies of interference in serial verbal reactions. J Exp Psychol 18:643-662. doi: 10.1037/h0054651
130. Stuber GD, Klanker M, de Ridder B et al (2008) Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science 321:1690-1692. doi: 10.1126/science.1160873
131. Sutton R, Barto M (1998) Reinforcement learning: an introduction. The MIT Press, Cambridge
132. Taffe MA, Huitrón-Resendiz S, Schroeder R et al (2003) MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys. Pharmacol Biochem Behav 76:141-152
133. 11C-DASB in healthy humans. Synapse 55:164-175. doi: 10.1002/syn.20105
134. Talbot PS, Slifstein M, Hwang D-R et al (2012) Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone. Neuroimage 59:271-285. doi: 10.1016/j.neuroimage.2011.07.001
135. Taylor SP (1967) Aggressive behavior and physiological arousal as a function of provocation and the tendency to inhibit aggression. J Pers 35:297-310
136. Udo de Haes JI, Bosker FJ, Van Waarde A et al (2002) 5-HT(1A) receptor imaging in the human brain: effect of tryptophan depletion and infusion on [(18)F]MPPF binding. Synapse 46:108-115. doi: 10.1002/syn.10134
137. Van der Veen FM, Evers EAT, van Deursen JA et al (2006) Acute tryptophan depletion reduces activation in the right hippocampus during encoding in an episodic memory task. Neuroimage 31:1188-1196. doi: 10.1016/j.neuroimage.2006.01.014
138. Van der Veen FM, Evers EAT, Deutz NEP, Schmitt JAJ (2007) Effects of acute tryptophan depletion on mood and facial emotion perception related brain activation and performance in healthy women with and without a family history of depression. Neuropsychopharmacology 32:216-224. doi: 10.1038/sj.npp.1301212
139. Varnäs K, Halldin C, Hall H (2004) Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum Brain Mapp 22:246-260. doi: 10.1002/hbm.20035
140. Von Polier GG, Biskup CS, Kötting WF et al (2014) Change in electrodermal activity after acute tryptophan depletion associated with aggression in young people with attention deficit hyperactivity disorder (ADHD). J Neural Transm 121:451-455. doi: 10.1007/s00702-013-1119-5
141. Walderhaug E, Lunde H, Nordvik JE et al (2002) Lowering of serotonin by rapid tryptophan depletion increases impulsiveness in normal individuals. Psychopharmacology 164:385-391. doi: 10.1007/s00213-002-1238-4
142. Walker SC, Robbins TW, Roberts AC (2009) Differential contributions of dopamine and serotonin to orbitofrontal cortex function in the marmoset. Cereb Cortex 19:889-898. doi: 10.1093/cercor/bhn136
143. Walters JK, Davis M, Sheard MH (1979) Tryptophan-free diet: effects on the acoustic startle reflex in rats. Psychopharmacology 62:103-109
144. Wang L, Mullette-Gillman OA, Gadde KM et al (2009) The effect of acute tryptophan depletion on emotional distraction and subsequent memory. Soc Cogn Affect Neurosci 4:357-368. doi: 10.1093/scan/nsp025
145. Williams JHG, Perrett DI, Waiter GD, Pechey S (2007) Differential effects of tryptophan depletion on emotion processing according to face direction. Soc Cogn Affect Neurosci 2:264-273. doi: 10.1093/scan/nsm021
146. Yacubian J, Gläscher J, Schroeder K et al (2006) Dissociable systems for gain- and loss-related value predictions and errors of prediction in the human brain. J Neurosci 26:9530-9537. doi: 10.1523/JNEUROSCI.2915-06.2006
147. Yatham LN, Liddle P, Shiah I-S et al (2001) Effects of rapid tryptophan depletion on brain 5-HT2 receptors: a PET study. Br J Psychiatry 178:448-453. doi: 10.1192/bjp.178.5.448
148. Yatham LN, Liddle PF, Sossi V et al (2012) Positron emission tomography study of the effects of tryptophan depletion on brain serotonin(2) receptors in subjects recently remitted from major depression. Arch Gen Psychiatry 69:601-609. doi: 10.1001/archgenpsychiatry.2011.1493
149. Young SN, Smith SE, Pihl RO, Ervin FR (1985) Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 87:173-177
150. Zepf FD, Landgraf M, Biskup CS et al (2013) No effect of acute tryptophan depletion on verbal declarative memory in young persons with ADHD. Acta Psychiatr Scand 128:133-141. doi: 10.1111/acps.12089
151. Zimmermann P, Mohr C, Spangler G (2009) Genetic and attachment influences on adolescents' regulation of autonomy and aggressiveness. J Child Psychol Psychiatry 50:1339-1347. doi: 10.1111/j.1469-7610.2009.02158.x