Acute tryptophan depletion in accordance with body weight: Influx of amino acids across the blood-brain barrier

Journal of Neural Transmission

Volumn 119, Issue 9, 2012, Pages 1037-1045

  Dingerkus, V L S ^a,b   Gaber, T J ^a,b   Helmbold, K ^a,b   Bubenzer, S ^a,b   Eisert, A ^a   Sanchez C L ^a,b   Zepf, F D ^a,b,c  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b JARA Translational Brain Medicine   (Germany)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Acute tryptophan depletion; Blood brain barrier; Influx rates; Moja De; Serotonin; Tryptophan

Indexed keywords

AMINO ACID; SEROTONIN; TRYPTOPHAN;

ACUTE TRYPTOPHAN DEPLETION; ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; ARTICLE; BINDING COMPETITION; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BODY WEIGHT; CALCULATION; CENTRAL NERVOUS SYSTEM; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MENTAL DISEASE; METHODOLOGY; MICHAELIS MENTEN KINETICS; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); TRYPTOPHAN BRAIN LEVEL;

ADULT; AMINO ACIDS; ANALYSIS OF VARIANCE; BLOOD-BRAIN BARRIER; BODY WEIGHT; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; TIME FACTORS; TRYPTOPHAN; YOUNG ADULT;

EID: 84867337997     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0793-z     Document Type: Article

References (43)

1. Biggio G, Fadda F, Fanni P, Tagliamonte A, Gessa GL (1974) Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet. Life Sci 14(7):1321-1329
2. Biskup CS, Sánchez CL, Arrant A, van Swearingen AED, Kuhn C, Zepf FD (2012) Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice. PLOS One (in press)
3. Blokland A, Prickaerts J, Honig W, de Vente J (1998) Statedependent impairment in object recognition after hippocampal NOS inhibition. Neuroreport 9(18):4205-4208
4. Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV (1997) Valvular heart disease associated with fenfluramine- phentermine. N Engl J Med 337(9):581-588. doi:10.1056/NEJM199708283370901
5. Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW, den Ouden H, Apergis-Schoute A, Campbell-Meikeljohn D, Seymour B, Sahakian BJ, Rogers RD, Robbins TW (2012) Converging evidence for central 5-HT effects in acute tryptophan depletion. Mol Psychiatry 17:121-123. doi:10.1038/mp. 2011.106
6. Dawson VL, Dawson TM (1996) Nitric oxide actions in neurochemistry. Neurochem Int 29(2):97-110
7. Demal U (1999) SKIDPIT-light screeningbogen. Universität Wien
8. Demisch L, Kewitz A, Schmeck K, Sadigorsky S, Barta S, Dierks T, Poustka F (2002) Methodology of rapid tryptophan depletion (RTD): Impact of gender and body weight. Eur Arch Psychiatry Clin Neurosci 252(Suppl 2):I/25
9. Domek-Lopacinska K, Strosznajder JB (2008) The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging. Brain Res 1216:68-77
10. Gessa GL, Tagliamonte A (1974) Possible role of free serum tryptophan in the control of brain tryptophan level and serotonin synthesis. Adv Biochem Psychopharmacol 11:119-131
11. Graham DJ, Green L (1997) Further cases of valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 337(9): 635. doi:10.1056/NEJM199708283370911
12. Kaehler ST, Singewald N, Sinner C, Philippu A (1999) Nitric oxide modulates the release of serotonin in the rat hypothalamus. Brain Res 835(2):346-349 (pii:S0006-8993(99)01599-1
13. Kelly PA, Thomas CL, Ritchie IM, Arbuthnott GW (1994) Cerebrovascular autoregulation in response to hypertension induced by NG-nitro-L-arginine methyl ester. Neuroscience 59:13-20
14. Kelly PA, Ritchie IM, Arbuthnott GW (1995) Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: Effects upon local cerebral blood flow and glucose use in the rat. J Cereb Blood Flow Metab 15:766-773
15. Kewitz A (2002) Biochemische untersuchungen zur optimierung des "Rapid Tryptophan Depletion-Test" (RTD)-eine physiologische methode zur akuten verminderung der zentralnervösen serotonin-synthese in der psychobiologischen forschung. Doctoral Thesis, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany
16. Li R, Serdula MK, Williamson DF, Bowman BA, Graham DJ, Green L (1999) Dose-effect of fenfluramine use on the severity of valvular heart disease among fen-phen patients with valvulopathy. Int J Obes Relat Metab Disord 23(9):926-928
17. Lieben CK, Blokland A, Westerink B, Deutz NE (2004) Acute tryptophan and serotonin depletion using an optimized tryptophan-free protein-carbohydrate mixture in the adult rat. Neurochem Int 44(1):9-16
18. Murad F, Mittal CK, Arnold WP, Katsuki S, Kimura H (1978) Guanylate cyclase: Activation by azide, nitro compounds, nitric oxide, and hydroxyl radical and inhibition by hemoglobin and myoglobin. Adv Cyclic Nucleotide Res 9:145-158
19. Oldendorf WH, Szabo J (1976) Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am J Physiol 230(1):94-98
20. Pardridge WM (1983) Brain metabolism: A perspective from the blood-brain barrier. Physiol Rev 63(4):1481-1535
21. Pardridge WM (1998) Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids. Neurochem Res 23: 635-644
22. Pardridge WM, Fierer G (1990) Transport of tryptophan into the brain from the circulating, albumin-bound pool in rats and rabbits. J Neurochem 54:971-976
23. Prickaerts J, de Vente J, Honig W, Steinbusch HW, Blokland A (2002a) cGMP, but not cAMP, in rat hippocampus is involved in early stages of object memory consolidation. Eur J Pharmacol 436(1-2):83-87
24. Prickaerts J, van Staveren WC, Sik A, Markerink-van Ittersum M, Niewohner U, van der Staay FJ, Blokland A, de Vente J (2002b) Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat. Neuroscience 113(2): 351-361
25. Smith QR (2000) Transport of glutamate and other amino acids at the blood-brain barrier. J Nutr 130(Suppl 4S):1016S-1122S
26. Reed RG, Burrington CM (1989) The albumin receptor effect may be due to a surface-induced conformational change in albumin. J Biol Chem 264(17):9867-9872
27. Smith QRS, Stoll J (1998) Blood-brain barrier amino acid transport. In: Pardridge WM (ed) Introduction to the blood-brain-barrier. University Press, Cambridge, pp 189-197
28. Smith QR, Momma S, Aoyagi M, Rapoport SI (1987a) Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem 49(5):1651-1658
29. Smith QR, Momma S, Aoyagi M, Rapoport SI (1987b) Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem 49:1651-1658
30. Stadler C, Zepf FD, Demisch L, Schmitt M, Landgraf M, Poustka F (2007) Influence of rapid tryptophan depletion on laboratoryprovoked aggression in children with ADHD. Neuropsychobiology 56(2-3):104-110. doi:10.1159/000112951
31. Tagliamonte A, Biggio G, Vargiu L, Gessa GL (1973) Free tryptophan in serum controls brain tryptophan level and serotonin synthesis. Life Sci II 12(6):277-287
32. van Donkelaar EL, Ferrington L, Blokland A, Steinbusch HW, Prickaerts J, Kelly PA (2009a) Acute tryptophan depletion in rats alters the relationship between cerebral blood flow and glucose metabolism independent of central serotonin. Neuroscience 163(2):683-694. doi:10.1016/j.neuroscience.2009.06.063
33. van Donkelaar EL, van den Hove DL, Blokland A, Steinbusch HW, Prickaerts J (2009b) Stress-mediated decreases in brain-derived neurotrophic factor as potential confounding factor for acute tryptophan depletion-induced neurochemical effects. Eur Neuropsychopharmacol 19(11):812-821. doi:10.1016/j.euroneuro. 2009.06.012
34. van Donkelaar EL, Blokland A, Ferrington L, Kelly PA, Steinbusch HW, Prickaerts J (2011) Mechanism of acute tryptophan depletion: Is it only serotonin? Mol Psychiatry 16(7):695-713. doi:10.1038/mp.2011.9
35. Zepf FD (2012) Principles of rapid tryptophan depletion and its use in neuropsychiatric disorders. In: D'Mello JPF (ed) Amino acids in human nutrition and health. Cabi Publishing, Oxfordshire, pp 418-426
36. Zepf FD, Poustka F (2008) 5-HT functioning and aggression in children with ADHD and disruptive behaviour disorders. Hum Psychopharmacol 23:438
37. Zepf FD, Holtmann M, Stadler C, Demisch L, Schmitt M, Wockel L, Poustka F (2008a) Diminished serotonergic functioning in hostile children with ADHD: Tryptophan depletion increases behavioural inhibition. Pharmacopsychiatry 41(2):60-65. doi: 10.1055/s-2007-1004593
38. Zepf FD, Stadler C, Demisch L, Schmitt M, Landgraf M, Poustka F (2008b) Serotonergic functioning and trait-impulsivity in attention-deficit/ hyperactivity-disordered boys (ADHD): Influence of rapid tryptophan depletion. Hum Psychopharmacol 23(1):43-51. doi:10.1002/hup.896
39. Zepf FD, Wockel L, Poustka F, Holtmann M (2008c) Diminished 5-HT functioning in CBCL pediatric bipolar disorder-profiled ADHD patients versus normal ADHD: Susceptibility to rapid tryptophan depletion influences reaction time performance. Hum Psychopharmacol 23(4):291-299. doi:10.1002/hup.934
40. Zepf FD, Holtmann M, Poustka F, Wockel L (2009a) The role of serotonin in viral hepatitis-depletion of plasma tryptophan as a potential option to reduce virus persistence and immunopathology? Med Hypotheses 72(3):367. doi:10.1016/j.mehy.2008. 09.035
41. Zepf FD, Holtmann M, Stadler C, Wockel L, Poustka F (2009b) Reduced serotonergic functioning changes heart rate in ADHD. J Neural Transm 116(1):105-108. doi:10.1007/s00702-008-0146-0
42. Zepf FD, Wöckel L, Herpertz-Dahlmann B, Poustka F, Freitag CM (2009c) Tryptophan depletion in bipolar mania: Reduction of metabolic imbalance by administration according to body weight. Bipolar Disord 11(5):557-558
43. Zepf FD, Wockel L, Poustka F, Holtmann M (2009d) Dietary tryptophan depletion according to body weight-a new treatment option in acute mania? Med Hypotheses 72(1):47-48. doi: 10.1016/j.mehy.2008.06.046