Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse

Archives of General Psychiatry

Volumn 54, Issue 4, 1997, Pages 364-374

  Bremner, J Douglas ^a,b,c   Innis, Robert B ^a,b,c   Salomon, Ronald M ^a,c   Staib, Lawrence H ^a   Ng, Chin K ^a,c,d   Miller, Helen L ^a,c   Bronen, Richard A ^a   Krystal, John H ^a,b,c   Duncan, James ^a   Rich, Dayton ^c,d   Price, Lawrence H ^a   Malison, Robert ^a   Dey, Holley ^a,c,d   Soufer, Robert ^a,c,d   Charney, Dennis S ^a,b,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b National Center for Posttraumatic Stress Disorder   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^d Yale/Vet Aff Positron Emission T   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN;

ADULT; AGED; ARTICLE; BRAIN METABOLISM; BRAIN REGION; CLINICAL ARTICLE; DEPRESSION; FEMALE; HUMAN; MALE; ORBITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; RELAPSE; THALAMUS;

EID: 0030944433     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.1997.01830160092012     Document Type: Article

References (84)

1. Mann JJ, Arango V, Marzuk PM, Theccanat S, Reis DJ. Evidence for the 5-HT hypothesis of suicide: a review of post-mortem studies. Br J Psychiatry. 1989; 155(suppl 8):7-14.
2. Risch SC, Nemeroff CB. Neurochemical alterations of serotonergic neuronal systems in depression. J Clin Psychiatry. 1992;53(suppl):3-7.
3. Maes M, Melzer HY. The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ, eds. Psychopharmacology: The Fourth Generation of Progress. New York, NY: Raven Press; 1995:933-944.
4. Charney DS, Delgado PL, Price LH, Heninger GR. The receptor sensitivity hypothesis of antidepressant action: a review of antidepressant effects on serotonin function. In: Brown S-L, van Praag H, eds. The Role of Serotonin in Psychiatric Disorders. New York, NY: Brunner/Mazel Inc; 1991:29-56.
5. Asberg M, Bertilsson L, Martensson B, Scalia Tomba GP, Thoren P, Traskman-Bendz L. CSF monoamine metabolites in melancholia. Acta Psychiatr Scand. 1984;69:201-219.
6. Asberg M, Thoren P, Traskman L, Bertilsson L, Ringberger V. 'Serotonin depression': a biological subgroup within the affective disorders? Science. 1976; 191:478-480.
7. Jones JS, Stanley B, Mann JJ, Frances AJ, Guido JR, Traskman-Bendz L, Winchel R, Brown RP, Stanley M. CSF 5-HIAA and HVA concentrations in elderly depressed patients who attempted suicide. Am J Psychiatry. 1990;147:1225-1227.
8. Mann JJ, McBride A, Anderson GM, Mieczkowski TA. Platelet and whole blood serotonin content in depressed inpatients: correlations with acute and lifetime psychopathology. Biol Psychiatry. 1992;32:243-257.
9. 2 and β-adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiatry. 1986;43:954-959.
10. 2 binding sites in frontal cortex of suicide victims. Lancet. 1983;1:214-216.
11. 2 and α-adrenergic receptor binding sites in the brain of suicide victims. Arch Gen Psychiatry. 1990;47:1038-1047.
12. Ferrier IN, McKeith IG, Cross AJ, Perry EK, Candy JM, Pemy RH. Postmortem neurochemical studies in depression. Ann N Y Acad Sci. 1986;487:128-142.
13. 2 receptors in suicide victims: violence of death, depression and effects of antidepressant medication. Brain Res. 1994;642:281-289.
14. Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB, Mohs RC, Davis KL. Serotonergic studies in patients with affective and personality disorders. Arch Gen Psychiatry. 1989;46:587-599.
15. Heninger GR, Charney DS, Sternberg DE. Serotonergic function in depression: prolactin response to intravenous tryptophan in depressed patients and healthy subjects. Arch Gen Psychiatry. 1984;41:398-402.
16. Price LH, Charney DS, Delgado PL, Heninger GR. Serotonin function and depression: neuroendocrine and mood responses to intravenous L-tryptophan in depressed patients and healthy comparison subjects. Arch Gen Psychiatry. 1991; 148:1518-1526.
17. Baldessarini RJ. Treatment of depression by altering monoamine metabolism: precursors and metabolic inhibitors. Psychopharmacol Bull. 1984;2: 224-239.
18. Cowen PJEM, Charig EM, Fraser S, Elliott JM. Platelet 5-HT receptor binding during depressive illness and tricyclic antidepressant treatment. J Affect Disord. 1989;13:45-50.
19. Maes M, Vandewoude M, Schotte C, Martin M, D'Hondt P, Scharpe S, Blockx P. The decreased availability of L-tryptophan in depressed females: clinical and biological correlates. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14: 903-919.
20. Meltzer HY. Role of serotonin in depression. Ann N Y Acad Sci. 1990;600: 486-499.
21. Moller SE, Kirk L, Fremming KH. Plasma amino acids as an index for subgroups in manic depressive psychosis: correlation to effect of tryptophan. Psychopharmacology. 1976;49:205-213.
22. Moller SE, Kirk L, Honore P. Relationship between plasma ratio of tryptophan to competing amino acids and the response to L-tryptophan treatment in endogenous depressed patients. J Affect Disord. 1980;2:47-59.
23. Moller SEP, Honore P, Larsen OB. Tryptophan and tyrosine ratios to neutral amino acids in endogenous depression: relation to antidepressant response to amitriptyline and lithium plus L-tryptophan. J Affect Disord. 1983;5:67-79.
24. De Meyer MK, Shea PA, Hendrie HC, Yoshimura NN. Plasma tryptophan and five other amino acids in depressed and normal subjects. Arch Gen Psychiatry. 1981;38:642-646.
25. Joseph M, Brewerton T, Reus V, Stebbins B. Plasma L-tryptophan/neutral amino acid ratio and dexamethasone suppression in depression. Psychiatry Res. 1984; 11:185-192.
26. Maes M, De Ruyter M, Claes R, Bosma G, Suy E. The cortisol responses to 5-hydroxytryptophan, orally, in depressive inpatients. J Affect Disord. 1987; 13:23-30.
27. Moller SE, Odum K, Kirk L, Bjerre M, Fog-Moller F, Knudsen A. Plasma tyrosine/ neutral amino acid ratio correlated with clinical response to nortriptyline in endogenously depressed patients. J Affect Disord. 1985;9:223-229.
28. Maes M, Maes L, Suy E. Symptom profiles of biological markers in depression: a multivariate study. Psychoneuroendocrinology. 1990;15:29-37.
29. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR. Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry. 1990;47:411-418.
30. Delgado PL, Price LH, Miller HL, Salomon RM, Aghajanian GK, Heninger GR, Charney DS. Serotonin and the neurobiology of depression: effects of tryptophan depletion in drug-free depressed patients. Arch Gen Psychiatry. 1994; 51:865-874.
31. Biggio G, Fadda F, Fanni P, Tagliamonte A, Gesse GL. Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acetic acid by a tryptophan-free diet. Life Sci. 1974;14:1321-1329.
32. Moja EA, Cipollo P, Castoldi D, Tofanetti O. Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats. Life Sci. 1989;44:971-976.
33. Young SN, Ervin FR, Pihl RO, Finn P. Biochemical aspects of tryptophan depletion in primates. Psychopharmacology (Berl). 1989;98:508-511.
34. Young SN, Smith SE, Pihl RO, Ervin FR. Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology (Berl). 1985;87:173-177.
35. Smith SE, Pihl RO, Young SN, Ervin FR. A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males. Psychopharmacology (Berl). 1987;91:451-457.
36. Delgado PL, Charney DS, Price LH, Landis H, Heninger GR. Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjects. Life Sci. 1989;45:2323-2332.
37. Heninger GR, Delgado PL, Charney DS, Price LH, Aghajanian GK. Tryptophan-deficient diet and amino acid drink deplete plasma tryptophan and induce a relapse of depression in susceptible patients. J Chem Neuroanatomy. 1992; 5:347-348.
38. Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN. Mood-lowering effect of tryptophan depletion: enhanced susceptibility in young men at risk for major affective disorders. Arch Gen Psychiatry. 1994;51:687-697.
39. George MS, Ketter TA, Post RM. Prefrontal cortex dysfunction in clinical depression. Depression. 1994;2:59-72.
40. Mayberg HS, Starkstein SE, Peyser CE, Brandt J, Dannals RF, Folstein SE. Paralimbic frontal lobe hypometabolism in depression associated with Huntington's disease. Neurology. 1992;42:1791-1797.
41. Martinot J-L, Hardy P, Feline A, Huret J-D, Mazoyer B, Attar-Levy D, Pappata S, Syrota A. Left prefrontal glucose hypometabolism in the depressed state: a confirmation. Am J Psychiatry. 1990;147:1313-1317.
42. Sackeim HA, Prohovnik I, Moeller JR, Brown RP, Apter S, Prudic J, Devanand DP, Mukherjee S. Regional cerebral blood flow in mood disorders, I: comparison of major depressives and normal controls at rest. Arch Gen Psychiatry. 1990;47:60-70.
43. Sackeim HA, Prohovnik I, Moeller JR, Mayeux R, Stern Y, Devanand DP. Regional cerebral blood flow in mood disorders, II: comparison of major depression and Alzheimer's disease. J Nucl Med. 1993;34:1090-1101.
44. Baxter LR, Phelps ME, Mazziotta JC, Schwartz JM, Gerner RH, Selin CE, Sumida RM. Cerebral metabolic rates for glucose in mood disorders. Arch Gen Psychiatry. 1985;42:441-447.
45. Baxter LR, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, Gerner RH, Smida RM. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry. 1989;46:243-249.
46. Buchsbaum MS, DeLisi LE, Holcomb H, Cappelletti J, King AC, Johnson J, Hazlett E, Dowling-Zimmerman S, Post RM, Morihisa J, Carpenter W, Cohen R, Pickar D, Weinberger DR, Margolin R, Kessler RM. Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch Gen Psychiatry. 1984;41:1159-1166.
47. 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. J Affect Disord. 1992;26:31-43.
48. Bench CJ, Fristen KJ, Brown RG, Scott LC, Frackowiak RSJ, Dolan RJ. The anatomy of melancholia: focal abnormalities of cerebral blood flow in major depression. Psychol Med. 1992;22:607-615.
49. Mayberg HS, Starkstein SE, Sadzot B, Preziosi T, Andrezejewski PL, Dannals RF, Wagner HN, Robinson RG. Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease. Ann Neurol. 1990;28:57-64.
50. Drevets WC, Raichle ME. Neuroanatomical circuits in depression: implications for treatment mechanisms. Psychopharmacol Bull. 1992;28:261-274.
51. Pardo JV, Pardo PJ, Raichle ME. Neural correlates of self-induced dysphoria. Am J Psychiatry. 1993;150:713-720.
52. George MS, Ketter TA, Parekh PI, Horwitz B, Herscovitch P. Post RM. Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry. 1995;152:341-351.
53. Mayberg HS, Lewis PJ, Regenold W, Wagner HN. Paralimbic hypoperfusion in unipolar depression. J Nucl Med. 1994;35:929-934.
54. Buchsbaum MS, Wu J, DeLisi LE, Holcomb H, Kessler R, Johnson J, King AC, Hazlett E, Langston K, Post RM. Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness. J Affect Disord. 1986;10:137-152.
55. Post RM, DeLisi LE, Holcomb HH, Uhde TW, Cohen R, Buchsbaum MS. Glucose utilization in the temporal cortex of affectively ill patients: positron emission tomography. Biol Psychiatry. 1987;22:545-553.
56. Hurwitz TA, Clark C, Murphy E, Klonoff H, Martin WRW, Pate BD. Regional cerebral glucose metabolism in major depressive disorder. Can J Psychiatry. 1990;35:684-688.
57. Ebert D, Feistel H, Barocka A. Effects of sleep deprivation on the limbic system and the frontal lobes in affective disorders: a study with Tc-99m-HMPAO SPECT. Psychiatry Res Neuroimaging. 1991;40:247-251.
58. 99mTc-exametazime into brain in major depression shown with single photon emission tomography. J Affect Disord. 1994;30:27-34.
59. 99mTc-exametazine with single photon emission tomography in major depression before and after treatment. J Affect Disord. 1993;29:245-255.
60. Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, Mendlewicz J, Lotstra F. Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry. 1994;36:381-388.
61. Wu JC, Gillin JC, Buchsbaum MS, Hershey T, Johnson JC, Bunney WE. Effect of sleep deprivation on brain metabolism of depressed patients. Am J Psychiatry. 1992;149:538-543.
62. Nobler MS, Sackeim HA, Prohovnik I, Moeller JR, Mukherjee S, Schnur DB, Prudic J, Devanand DP. Regional cerebral blood flow in mood disorders, III: treatment and clinical response. Arch Gen Psychiatry. 1994;51: 884-897.
63. Ebert D, Feistel H, Barocka A, Kaschka W. Increased limbic flow and total sleep deprivation in major depression with melancholia. Psychol Res. 1994;5:101-109.
64. Rubin E, Sackeim HA, Nobler MS, Moeller JR. Brain imaging studies of antidepressant treatments. Psychiatry Ann. 1994;24:653-658.
65. Ring RA, Bench CJ, Trimble MR, Brooks DJ, Frackowiak RSJ, Dolan RJ. Depression in Parkinson's disease: a positron emission study. Br J Psychiatry. 1994;165:333-339.
66. Baxter LR, Phelps ME, Mazziotta JC, Guze BH, Schwartz JM, Selin CE. Local cerebral glucose metabolic rates in obsessive-compulsive disorder: a comparison with rates in unipolar depression and normal controls. Arch Gen Psychiatry. 1987;44:211-218.
67. Cudennec A, Duverger D, Serrano A, Scatton B, MacKenzie ET. Influence of ascending serotonergic pathways on glucose use in the conscious rat brain, II; effects of electrical stimulation of the rostral raphe nuclei. Brain Res. 1988; 444:227-246.
68. Bonvento G, Lacombe P, MacKenzie ET, Seylaz J. Effects of dorsal raphe stimulation on cerebral glucose utilization in the anesthetized rat. Brain Res. 1991; 567:325-327.
69. Kapur S, Meyer J, Wilson AA, Houle S, Brown GM. Modulation of cortical neuronal activity by a serotonergic agent: a PET study in humans. Brain Res. 1994; 646:292-294.
70. Spitzer RL, Williams JBW, Gibbon M. Structured Clinical Interview for DSM-III-R. New York: New York State Psychiatric Institute, Biometrics Research Department; 1987.
71. Delgado PL, Price LH, Miller HL, Salomon RM, Licinio J, Krystal JH, Heninger GR, Charney DS. Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression. Psychopharmacol Bull. 1991;27: 321-330.
72. Mulaney NA, Gould LK, Hartz RK, Hitchens RE, Wong WH, Bristow D, Adler S, Philippe EA, Bendrien B, Sanders M, Gibbs B. Design and performance of Posicam 6.5 BGO Positron camera. J Nucl Med. 1990;31:610-616.
73. Brownell GL, Kearfott KJ, Kairento A-L, Elmaleh DR, Alpert NM, Correia JA, Wechsler L, Ackerman RH. Quantitation of regional cerebral glucose metabolism. J Comput Assist Tomagr. 1983;7:919-924.
74. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M. The [14]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977;28:897-916.
75. Huang S, Phelps ME, Hoffman EF, Kuhl DE. Error sensitivity of fluorodeoxyglucose method for measurement of cerebral rate of glucose. J Cereb Blood Flow Metab. 1981;1:391-401.
76. Robb RA, Hanson DP, Karwoski RA, Larson AG, Workman EL, Stacy MC. Analyze: a comprehensive, operator-interactive software package for multidimensional medical image display and analysis. Comput Med Imaging Graph. 1989;13:433-454.
77. Jiang H, Robb RA, Holton KS. A new approach to 3-D registration of multimodality medical images by surface matching. In: Robb R, ed. Proceedings of the Second Conference on Visual Biomedical Computing. Bellingham, Wash: SPIE; 1992;1808:196-213.
78. Zubal IG, Zhang L, Tagare B, Duncan JS. 3-D registration of SPECT and MRI brain images. J Nucl Med. 1993;34:187.
79. Duvernoy H. The Human Brain: Surface Three-Dimensional Anatomy and MRI. New York, NY: Springer-Verlag NY Inc; 1991.
80. 18F]fluoro-2-deoxy-D-glucose. J Cereb Blood Flow Metab. 1992;12:281-290.
81. Bartlett EJ, Brodie JD, Wolf AP, Christman DR, Laska E, Meissner M. Reproducibility of cerebral glucose metabolic measurements in resting human subjects. J Cereb Blood Flow Metab. 1988;8:502-512.
82. Baxter LR. PET studies of cerebral function in major depression and obsessive-compulsive disorder: the emerging prefrontal cortex consensus. Ann Clin Psychiatry. 1991;3:103-109.
83. Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9: 357-381.
84. Clark CM, Klonoff H, Tyhurst JS, Ruth T, Adam M, Rogers J, Harrop R, Martin W, Pate B. Regional cerebral glucose metabolism in identical twins. Neuropsychologia. 1988;26:615-621.