CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors

Biological Psychiatry

Volumn 40, Issue 11, 1996, Pages 1067-1082

  Higley, J Dee ^a,e   Mehlman, Patrick T ^b   Poland, Russell E ^c   Taub, David M ^b   Vickers, James ^d   Suomi, Stephen J ^e   Linnoila, Markku ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b Lab Animal Breeders and Services   (United States)

^c HARBOR UCLA MEDICAL CENTER   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e NIH Animal Center   (United States)

Author keywords

aggression; cerebrospinal fluid testosterne; impulsivity; nonhuman primate; serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; SEROTONIN; TESTOSTERONE;

ADOLESCENT; AGGRESSION; ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID; HUMAN; IMPULSIVENESS; MALE; PRIORITY JOURNAL; RHESUS MONKEY; VIOLENCE;

EID: 0030560890     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(95)00675-3     Document Type: Article

References (67)

1. Altmann SA (1962): A field study of the sociobiology of rhesus monkeys, Macaca mulatta. Ann N Y Acad Sci 102:338-435.
2. Apter A, van Praag HM, Plutchik R, Sevy S, Korn M, Brown SL (1990): Interrelationships among anxiety, aggression, impulsivity, and mood: A serotonergically linked cluster? Psychiatry Res 32:191-199.
3. Archer J (1991): The influence of testosterone on human aggression. Br J Psychol 82:1-28.
4. Banki CM, Arato M (1983a): Amine metabolites, neuroendocrine findings, and personality dimensions as correlates of suicidal behavior. Psychiatry Res 10:253-261.
5. Banki CM, Arato M (1983b): Relationship between cerebrospinal fluid amine metabolites, neuroendocrine findings and personality dimensions (Marke-Nyman scale factors) in psychiatric patients. Acta Psychiatr Scand 67:272-280.
6. Bertilsson L, Tybring G, Braithwaite R, Träskman-Bendz L, Âsberg M (1982): Urinary excretion of 5-hydroxyindoleacetic acid - No relationship to the level in cerebrospinal fluid. Acta Psychiatr Scand 66:190-198.
7. Booth A, Shelley G, Mazur A, Tharp G, Kittok R (1989): Testosterone, and winning and losing in human competition. Horn Behav 23:556-571.
8. Brown GL, Linnoila MI (1990): CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence. J Clin Psychiatry 51(suppl):31-43.
9. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF (1979): Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1:131-139.
10. Brown GL, Ebert MH, Goyer PF, et al (1982): Aggression, suicide, and serotonin: Relationships to CSF amine metabolites. Am J Psychiatry 139:741-746.
11. Buchanan CM, Eccles JS, Becker JB (1992): Are adolescents the victims of raging hormones: Evidence for activational effects of hormones on moods and behavior at adolescence. Psychol Bull 111:62-107.
12. Christiansen K, Knussmann R (1987): Androgen levels and components of aggressive behavior in men. Harm Behav 21:170-180.
13. Cloninger CR (1986): A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatric Dev 3:167-226.
14. Coccaro EF (1989): Central serotonin and impulsive aggression. Br J Psychiatry Suppl:52-62.
15. Coccaro EF (1992): Impulsive aggression and central serotonergic system function in humans: An example of a dimensional brain-behavior relationship. Int Clin Psychopharmacol 7:3-12.
16. Coccaro EF, Siever LJ, Klar HM, et al (1989): Serotonergic studies in patients with affective and personality disorders: Correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 46:587-599.
17. Cohen DJ, Shaywitz BA, Johnson WT, Bowers MD (1974): Biogenic amines in autistic and atypical children. Arch Gen Psychiatry 31:845-853.
18. Csernansky JG, Sheline YI (1993): Abnormalities of serotonin metabolism and nonpsychotic psychiatric disorders. Ann Clin Psychiatry 5:275-281.
19. Dabbs JM (1990): Salivary testosterone measurements: Reliability across hours, days, and weeks. Physiol Behav 1:83-86.
20. Dabbs JM, Frady RL, Carr TS, Besch NF (1987): Saliva testosterone and criminal violence in young adult prison inmates. Psychosom Med 49:174-182.
21. Daitzman RJ, Zuckerman M (1980): Disinhibitory sensation seeking, personality, and gonadal hormones. Person Individ Diff 1:103-110.
22. Ehrenkranz J, Bliss E, Sheard MH (1974): Plasma testosterone: Correlation with aggressive behavior and social dominance in man. Psychosom Med 36:469-475.
23. Eichelman B (1992): Aggressive behavior: From laboratory to clinic quo vadit? Arch Gen Psychiatry 49:488-492.
24. Fishbein DH, Lozovsky D, Jaffe JH (1989): Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers. Biol Psychiatry 25:1049-1066.
25. Higley JD, Suomi SJ (1996): Effect of reactivity and social competence on individual responses to severe stress in children: Investigations using nonhuman primates. In Pfeffer CR (ed), Severe Stress and Mental Disturbance in Children. Washington, DC: American Psychiatric Press, pp. 3-58.
26. Higley JD, Mehlman P, Taub D, et al (1992): Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry 49:436-441.
27. Higley JD, Linnoila M, Suomi SJ (1994): Ethological contributions: Experiential and genetic contributions to the expression and inhibition of aggression in primates. In Hersen M, Ammerman RT, Sisson L (eds), Handbook of Aggressive and Destructive Behavior In Psychiatric Patients. New York: Plenum Press, pp 17-32.
28. Higley JD, King ST, Hasert MF, Champoux M, Suomi SJ, Linnoila M (1996): Stability of interindividual differences in serotonin function and its relationship to aggressive wounding and competent social behavior in rhesus macaque females. Neuropsychopharmacology 14:67-76.
29. Kagan J (1979): The form of early development. Continuity and discontinuity in emergent competences. Arch Gen Psychiatry 36:1047-1054.
30. Kraemer GW, McKinney WT (1979): Interactions of pharmacological agents which alter biogenic amine metabolism and depression - An analysis of contributing factors within a primate model of depression. J Affect Disord 1:33-54.
31. Kruesi MJ, Rapoport JL, Hamburger S, et al (1990): Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry 47:419-426.
32. Kruesi MJ, Hibbs ED, Zahn TP, et al (1992): A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Prediction by cerebrospinal fluid 5-hydroxyindoleacetic acid, homovanillic acid, and autonomic measures? Arch Gen Psychiatry 49:429-435.
33. Lidberg L, Tuck JR, Åsberg M, Scalia-Tomba GP, Bertilsson L (1985): Homicide, suicide and CSF 5-HIAA. Acta Psychiatr Scand 71:230-236.
34. Limson R, Goldman D, Roy A, et al (1991): Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Arch Gen Psychiatry 48:437-441.
35. Lindman R, Järvinen P, Vidjeskog J (1987): Verbal interactions of aggressively and nonaggressively predisposed males in a drinking situation. Aggress Behav 13:187-196.
36. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK (1983): Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 33:2609-2614.
37. Linnoila M, DeJong J, Virkkunen M (1989): Monoamines, glucose metabolism, and impulse control. Psychopharmacol Bull 25:404-406.
38. López-Ibor JJ (1991): The functional approach of biological research in psychiatry. Acta Neurochir Suppl (Wien) 52:149-153.
39. Mattsson A, Schalling D, Olweus D, Low H, Svensson J (1980): Plasma testosterone, aggressive behavior, and personality dimensions in young male delinquents. J Am Acad Child Psychiatry 19:476-490.
40. Mazur A (1983): Hormones, aggression, and dominance in humans. In Svare BB (ed), Hormones and Aggressive Behavior. New York: Plenum Press, pp 563-576.
41. Mehlman PT, Higley JD, Faucher I, et al (1994): Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am J Psychiatry 151:1485-1491.
42. Mehlman P, Higley JD, Faucher I, et al (1995): Correlation of CSF 5-HIAA concentrations with sociality and the timing of emigration in free-ranging primates. Am J Psychiatry 152: 907-913.
43. Moss HB, Yao JK, Panzak GL (1990): Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Biol Psychiatry 28:325-338.
44. Olweus D (1984): Development of stable aggressive reaction patterns in males. Adv Study Aggress 1:103-137.
45. Olweus D (1986): Aggression and hormones: Behavioral relationship with testosterone and adrenaline. In Olweus D, Block J, Radke-Yarrow M (eds), Development of Antisocial and Prosocial Behavior. New York: Academic Press, pp 51-72.
46. Olweus D, Mattsson A, Schalling D, Löw H (1980): Testosterone, aggression, physical, and personality dimensions in normal adolescent males. Psychosom Med 42:253-269.
47. Olweus D, Mattsson A, Schalling D, Löw H (1988): Circulating testosterone levels and aggression in adolescent males: A causal analysis. Psychosom Med 50:261-272.
48. Pardridge WM (1986): Serum bioavailability of sex steroid hormones. Clin Endocrinol Metab 15:259-278.
49. Rahe RH, Karson S, Howard NS, Rubin RT, Poland RE (1990): Psychological and physiological assessments on American hostages freed from captivity in Iran. Psychosom Med 52:1-16.
50. Raleigh MJ, McGuire MT (1994): Serotonin, aggression, and violence in vervet monkeys. In Masters RD, McGuire MT (eds), The Neurotransmitter Revolution. Carbondale, IL: Southern Illinois University Press, pp 129-145.
51. Raleigh MJ, Brammer GL, McGuire MT (1983): Male dominance, serotonergic systems, and the behavioral and physiological effects of drugs in vervet monkeys (Cercopithecus aethiops sabaeus). In Miczek KA (ed), Ethopharmacology: Primate Models of Neuropsychiatric Disorders. New York: Liss, pp 185-197.
52. Raleigh MJ, McGuire MT, Brammer GL, Pollack DB, Yuwiler A (1991): Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Res 559:181-190.
53. Rejeski WJ, Brubaker PH, Herb RA, Kaplan JR, Koritnik D (1988): Anabolic steroids and aggressive behavior in cynomolgus monkeys. J Behav Med 11:95-105.
54. Rejeski WJ, Gregg E, Kaplan JR, Manuck SB (1990): Anabolic-androgenic steroids: Effects on social behavior and baseline heart rate. Health Psychol 9:774-791.
55. Richards SM (1974): The concept of dominance and methods of assessment. Anim Behav 22:914-930.
56. Riddle MA, Anderson GM, McIntosh S, Harcherik DF, Shaywitz BA, Cohen DJ (1986): Cerebrospinal fluid monoamine precursor and metabolic levels in children treated for leukemia: Age and sex effects and individual variability. Biol Psychiatry 21:69-83.
57. Rose RM, Holaday JW, Bernstein IS (1971): Plasma testosterone, dominance rank and aggressive behaviour in male rhesus monkeys. Nature 231:366-368.
58. Roy A, Adinoff B, Linnoila M (1988): Acting out hostility in normal volunteers: Negative correlation with levels of 5HIAA in cerebrospinal fluid. Psychiatry Res 24:187-194.
59. Sannikka E, Terho P, Suominen J, Santti R (1983): Testosterone concentrations in human seminal plasma and saliva and its correlation with non-protein-bound and total testosterone levels in serum. Int J Androl 6:319-330.
60. Scaramella TJ, Brown WA (1978): Serum testosterone and aggressiveness in hockey players. Psychosom Med 40:262-265.
61. Scheinin M, Chang WH, Kirk KL, Linnoila M (1983): Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. Anal Biochem 131:246-253.
62. Soubrié P (1986): Reconciling the role of central serotonin neurons in human and animal behavior. Behav Brain Sci 9:319-364.
63. Stein DJ, Hollander E, Liebowitz MR (1993): Neurobiology of impulsivity and the impulse control disorders. J Neuropsychiatry Clin Neurosci 5:9-17.
64. Träskman-Bendz L, Åsberg M, Bertilsson L, Thoren P (1984): CSF monoamine metabolites of depressed patients during illness and other recovery. Acta Psychiatr Scand 69(Suppl): 333-342.
65. Virkkunen M, De Jong J, Bartko J, et al (1989): Relationship of psychobiological variables to recidivism in violent offenders and impulsive fire setters. A follow-up study. Arch Gen Psychiatry 46:600-603.
66. Virkkunen M, Kallio E, Rawlings R, et al (1994a): Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 51:28-33.
67. Virkkunen M, Rawlings R, Tokola R, et al (1994b): CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 51:20-27.