An fMRI study on the role of serotonin in reactive aggression

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Krämer, Ulrike M ^a   Riba, Jordi ^b   Richter, Sylvia ^c   Münte, Thomas F ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c Helmholtz Center for Neurodegenerative Diseases   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN;

ACUTE TRYPTOPHAN DEPLETION; ADULT; AGGRESSION; ARTICLE; CONTROLLED STUDY; DECISION MAKING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; INSULA; MALE; NORMAL HUMAN; PROVOCATION; QUESTIONNAIRE; RATING SCALE; REACTIVE AGGRESSION; TASK PERFORMANCE;

AGGRESSION; EMOTIONS; FEEDBACK, PSYCHOLOGICAL; GYRUS CINGULI; HUMANS; INTERPERSONAL RELATIONS; MAGNETIC RESONANCE IMAGING; MALE; PREFRONTAL CORTEX; QUESTIONNAIRES; SEROTONIN; TRYPTOPHAN; YOUNG ADULT;

EID: 81155131665     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027668     Document Type: Article

References (49)

1. Manuck SB, Kaplan JR, Lotrich FE, (2006) Brain serotonin and aggressive disposition in humans and nonhuman primates. In: Nelson RJ, editors. Biology of aggression New York Oxford University Press.
2. Olivier B, van Oorschot R, (2005) 5-HT1B receptors and aggression: a review. European Journal of Pharmacology 526: 207-217.
3. Moore TM, Scarpa A, Raine A, (2002) A meta-analysis of serotonin metabolite 5-HIAA and antisocial behavior. Aggressive Behavior 28: 299.
4. Coccaro EF, (1989) Central serotonin and impulsive aggression. British Journal of Psychiatry 52-62.
5. Higley JD, Mehlman PT, Poland RE, Taub DM, Vickers J, et al. (1996) CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors. Biological psychiatry 40: 1067-1082.
6. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, et al. (1994) Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. American Journal of Psychiatry 151: 1485-1491.
7. Saudou F, Amara DA, Dierich A, LeMeur M, Ramboz S, et al. (1994) Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 265: 1875-1878.
8. de Boer SF, Lesourd M, Mocaer E, Koolhaas JM, (1999) Selective Antiaggressive Effects of Alnespirone in Resident-Intruder Test Are Mediated via 5-Hydroxytryptamine1A Receptors: A Comparative Pharmacological Study with 8-Hydroxy-2-Dipropylaminotetralin, Ipsapirone, Buspirone, Eltoprazine, and WAY-100635. Journal of Pharmacology and Experimental Therapeutics 288: 1125-1133.
9. Fish EW, Faccidomo S, Miczek KA, (1999) Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT1B receptor agonist CP-94,253. Psychopharmacology 146: 391-399.
10. Coccaro EF, Kavoussi RJ, (1997) Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Archives of General Psychiatry 54: 1081-1088.
11. Moss HB, Yao JK, Panzak GL, (1990) Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Biological Psychiatry 28: 325-338.
12. Taylor SP, (1967) Aggressive behavior and physiological arousal as a function of provocation and the tendency to inhibit aggression. Journal of Personality 35: 297-310.
13. Bell CJ, Hood SD, Nutt DJ, (2005) Acute tryptophan depletion. Part II: clinical effects and implications. Australian and New Zealand Journal of Psychiatry 39: 565-574.
14. Hood SD, Bell CJ, Nutt DJ, (2005) Acute tryptophan depletion. Part I: rationale and methodology. Australian and New Zealand Journal of Psychiatry 39: 558-564.
15. Fusar-Poli P, Allen P, McGuire P, Placentino A, Cortesi M, et al. (2006) Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature. Psychopharmacology (Berl) 188: 131-143.
16. Cleare AJ, Bond AJ, (1995) The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects. Psychopharmacology (Berl) 118: 72-81.
17. Pihl RO, Young SN, Harden P, Plotnick S, Chamberlain B, et al. (1995) Acute effect of altered tryptophan levels and alcohol on aggression in normal human males. Psychopharmacology (Berl) 119: 353-360.
18. Bjork JM, Dougherty DM, Moeller FG, Cherek DR, Swann AC, (1999) The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a food-restricted control. Psychopharmacology (Berl) 142: 24-30.
19. Bjork JM, Dougherty DM, Moeller FG, Swann AC, (2000) Differential behavioral effects of plasma tryptophan depletion and loading in aggressive and nonaggressive men. Neuropsychopharmacology 22: 357-369.
20. Dougherty DM, Bjork JM, Marsh DM, Moeller FG, (1999) Influence of trait hostility on tryptophan depletion-induced laboratory aggression. Psychiatry Research 88: 227-232.
21. Cherek DR, (1981) Effects of smoking different doses of nicotine on human aggressive behavior. Psychopharmacology (Berl) 75: 339-345.
22. LeMarquand DG, Pihl RO, Young SN, Tremblay RE, Seguin JR, et al. (1998) Tryptophan depletion, executive functions, and disinhibition in aggressive, adolescent males. Neuropsychopharmacology 19: 333-341.
23. Wingrove J, Bond AJ, Cleare AJ, (1999) Tryptophan enhancement/depletion and reactions to failure on a cooperative computer game. Neuropsychopharmacology 21: 755-764.
24. Rogers RD, Tunbridge EM, Bhagwagar Z, Drevets WC, Sahakian BJ, et al. (2003) Tryptophan depletion alters the decision-making of healthy volunteers through altered processing of reward cues. Neuropsychopharmacology 28: 153-162.
25. Talbot PS, Watson DR, Barrett SL, Cooper SJ, (2006) Rapid tryptophan depletion improves decision-making cognition in healthy humans without affecting reversal learning or set shifting. Neuropsychopharmacology 31: 1519-1525.
26. Evers EA, Cools R, Clark L, van der Veen FM, Jolles J, et al. (2005) Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning. Neuropsychopharmacology 30: 1138-1147.
27. Cools R, Blackwell A, Clark L, Menzies L, Cox S, et al. (2005) Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity. Neuropsychopharmacology 30: 1362-1373.
28. Crockett MJ, Clark L, Tabibnia G, Lieberman MD, Robbins TW, (2008) Serotonin modulates behavioral reactions to unfairness. Science 320: 1739.
29. Blair R, (2004) The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain and Cognition 55: 198-208.
30. Anderson SW, Bechara A, Damasio H, Tranel D, Damasio AR, (1999) Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nature Neuroscience 2: 1032-1037.
31. Krämer UM, Jansma H, Tempelmann C, Münte TF, (2007) Tit-for-tat: The neural basis of reactive aggression. NeuroImage 38: 203-211.
32. Lotze M, Veit R, Anders S, Birbaumer N, (2007) Evidence for a different role of the ventral and dorsal medial prefrontal cortex for social reactive aggression: An interactive fMRI study. Neuroimage 34: 470-478.
33. Crockett MJ, (2009) The Neurochemistry of Fairness. Annals of the New York Academy of Sciences 1167: 76-86.
34. Arce E, Simmons AN, Lovero KL, Stein MB, Paulus MP, (2008) Escitalopram effects on insula and amygdala BOLD activation during emotional processing. Psychopharmacology 196: 661-672.
35. Rubinow DR, Schmidt PJ, Roca CA, (1998) Estrogen-serotonin interactions: implications for affective regulation. Biol Psychiatry 44: 839-850.
36. Carpenter LL, Anderson GM, Pelton GH, Gudin JA, Kirwin PD, et al. (1998) Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology 19: 26-35.
37. Williams WA, Shoaf SE, Hommer D, Rawlings R, Linnoila M, (1999) Effects of acute tryptophan depletion on plasma and cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in normal volunteers. Journal of Neurochemistry 72: 1641-1647.
38. Hampel R, Selg H, (1975) Fragebogen zur Erfassung von Aggressivitätsfaktoren. Goettingen Hogrefe.
39. Bond A, Lader M, (1986) A method to elicit aggressive feelings and behaviour via provocation. Biological Psychology 22: 69-79.
40. Talairach J, Tournoux P, (1988) Co-planar Stereotaxic Atlas of the Human Brain: An Approach to Medical Cerebral Imaging. New York Thieme Medical Publishers.
41. Krämer UM, Büttner S, Roth G, Münte TF, (2008) Trait aggressiveness modulates neurophysiological correlates of laboratory-induced reactive aggression in humans. Journal of Cognitive Neuroscience 20: 1464-1477.
42. Hennig J, Reuter M, Netter P, Burk C, Landt O, (2005) Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism. Behavioral Neuroscience 119: 16-25.
43. Carver CS, Johnson SL, Joormann J, (2009) Two-Mode Models of Self-Regulation as a Tool for Conceptualizing Effects of the Serotonin System in Normal Behavior and Diverse Disorders. Current directions in psychological science: a journal of the American Psychological Society 18: 195-199.
44. Roiser JP, Levy J, Fromm SJ, Wang H, Hasler G, et al. (2008) The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 33: 1992-2006.
45. Dougherty DD, Shin LM, Alpert NM, Pitman RK, Orr SP, et al. (1999) Anger in healthy men: a PET study using script-driven imagery. Biological Psychiatry 46: 466-472.
46. Phillips ML, Young AW, Senior C, Brammer M, Andrew C, et al. (1997) A specific neural substrate for perceiving facial expressions of disgust. Nature 389: 495-498.
47. Sanfey AG, Rilling JK, Aronson JA, Nystrom LE, Cohen JD, (2003) The neural basis of economic decision-making in the Ultimatum Game. Science 300: 1755-1758.
48. Seymour B, Singer T, Dolan R, (2007) The neurobiology of punishment. Nature Reviews Neuroscience 8: 300-311.
49. Krämer UM, Kopyciok RP, Richter S, Münte TF, (2009) Oscillatory brain activity related to control mechanisms during laboratory-induced reactive aggression. Frontiers in Behavioral Neuroscience 3: 46.