Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers

Journal of Psychopharmacology

Volumn 26, Issue 11, 2012, Pages 1434-1442

  Roiser, Jonathan P ^a,b,c   Levy, Jamey ^b   Fromm, Stephen J ^b   Goldman, David ^d   Hodgkinson, Colin A ^d   Hasler, Gregor ^b   Sahakian, Barbara J ^c,e   Drevets, Wayne C ^b,f  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f LAUREATE INSTITUTE FOR BRAIN RESEARCH   (United States)

Author keywords

acute tryptophan depletion; Depression; emotional processing; functional magnetic resonance imaging (fMRI); serotonin transporter polymorphism (5 HTTLPR)

Indexed keywords

SEROTONIN TRANSPORTER; TRYPTOPHAN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTIONALITY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENOTYPE; HIPPOCAMPUS; HUMAN; MAJOR DEPRESSION; MALE; MOOD CHANGE; MUTATOR GENE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEPLETION; SEROTONIN TRANSPORTER GENE; SEROTONINERGIC SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE;

ADULT; AFFECT; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; EMOTIONS; FEMALE; GENOTYPE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRYPTOPHAN; YOUNG ADULT;

EID: 84867554612     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881112442789     Document Type: Article

References (47)

1. Canli T, Qiu M, Omura K, et al. Neural correlates of epigenesis. Proc Natl Acad Sci U S A. 2006 ; 103: 16033-16038
2. Caspi A, Hariri AR, Holmes A, et al. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry. 2010 ; 167: 509-527
3. Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003 ; 301: 386-389
4. Clarke H, Flint J, Attwood AS, et al. Association of the 5- HTTLPR genotype and unipolar depression: a meta-analysis. Psychol Med. 2010 ; 40: 1767-1778
5. Drevets WC, Price JL, Furey ML. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct. 2008 ; 213: 93-118
6. Drevets WC, Price JL, Simpson JR, et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997 ; 386: 824-827
7. Elliott R, Rubinsztein JS, Sahakian BJ, et al. Selective attention to emotional stimuli in a verbal go/no-go task: an fMRI study. Neuroreport. 2000 ; 11: 1739-1744
8. Elliott R, Rubinsztein JS, Sahakian BJ, et al. The neural basis of mood-congruent processing biases in depression. Arch Gen Psychiatry. 2002 ; 59: 597-604
9. Engels WR. Exact tests for Hardy-Weinberg proportions. Genetics. 2009 ; 183: 1431-1441
10. Erickson K, Drevets WC, Clark L, et al. Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder. Am J Psychiatry. 2005 ; 162: 2171-2173
11. Fournier JC, DeRubeis RJ, Shelton RC, et al. Prediction of response to medication and cognitive therapy in the treatment of moderate to severe depression. J Consult Clin Psychol. 2009 ; 77: 775-787
12. Frodl T, Reinhold E, Koutsouleris N, et al. Childhood stress, serotonin transporter gene and brain structures in major depression. Neuropsychopharmacology. 2010 ; 35: 1383-1390
13. Furst P, Pollack L, Graser TA, et al. Appraisal of four pre-column derivatization methods for the high-performance liquid chromatographic determination of free amino acids in biological materials. J Chromatogr. 1990 ; 499: 557-569
14. Harmer CJ, Goodwin GM, Cowen PJ. Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action. Br J Psychiatry. 2009 ; 195: 102-108
15. Heils A, Teufel A, Petri S, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996 ; 66: 2621-2624
16. Hu XZ, Lipsky RH, Zhu G, et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet. 2006 ; 78: 815-826
17. Hu XZ, Rush AJ, Charney D, et al. Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. Arch Gen Psychiatry. 2007 ; 64: 783-792
18. Kato M, Serretti A. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry. 2010 ; 15: 473-500
19. Kendler KS, Kessler RC, Neale MC, et al. The prediction of major depression in women: toward an integrated etiologic model. Am J Psychiatry. 1993 ; 150: 1139-1148
20. Kriegeskorte N, Lindquist MA, Nichols TE, et al. Everything you never wanted to know about circular analysis, but were afraid to ask. J Cereb Blood Flow Metab. 2010 ; 30: 1551-1557
21. Lenzinger E, Neumeister A, Praschak-Rieder N, et al. Behavioral effects of tryptophan depletion in seasonal affective disorder associated with the serotonin transporter gene?. Psychiatry Res. 1999 ; 85: 241-246
22. Maldjian JA, Laurienti PJ, Kraft RA, et al. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 2003 ; 19: 1233-1239
23. Moreno FA, Rowe DC, Kaiser B, et al. Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Mol Psychiatry. 2002 ; 7: 213-216
24. Munafo MR, Brown SM, Hariri AR. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry. 2008 ; 63: 852-857
25. Munafo MR, Durrant C, Lewis G, et al. Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry. 2009a ; 65: 211-219
26. Munafo MR, Freimer NB, Ng W, et al. 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet. 2009b ; 150B: 271-281
27. Murphy FC, Sahakian BJ, Rubinsztein JS, et al. Emotional bias and inhibitory control processes in mania and depression. Psychol Med. 1999 ; 29: 1307-1321
28. Murphy FC, Smith KA, Cowen PJ, et al. The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Psychopharmacology (Berl). 2002 ; 163: 42-53
29. Murray GK, Corlett PR, Fletcher PC. The neural underpinnings of associative learning in health and psychosis: how can performance be preserved when brain responses are abnormal?. Schizophr Bull. 2010 ; 36: 465-471
30. Neumeister A, Hu XZ, Luckenbaugh DA, et al. Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry. 2006 ; 63: 978-986
31. Neumeister A, Konstantinidis A, Stastny J, et al. Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression. Arch Gen Psychiatry. 2002 ; 59: 613-620
32. Neumeister A, Nugent AC, Waldeck T, et al. Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch Gen Psychiatry. 2004 ; 61: 765-773
33. Ongur D, Price JL. The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereb Cortex. 2000 ; 10: 206-219
34. Pezawas L, Meyer-Lindenberg A, Drabant EM, et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci. 2005 ; 8: 828-834
35. Pierucci-Lagha A, Feinn R, Modesto-Lowe V, et al. Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence. Psychopharmacology (Berl). 2004 ; 171: 340-348
36. Risch N, Herrell R, Lehner T, et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. 2009 ; 301: 2462-2471
37. Roiser JP, Blackwell AD, Cools R, et al. Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion. Neuropsychopharmacology. 2006 ; 31: 2264-2272
38. Roiser JP, Levy J, Fromm SJ, et al. The effects of tryptophan depletion on neural responses to emotional words in remitted depression. Biol Psychiatry. 2009 ; 66: 441-450
39. Roiser JP, Levy J, Fromm SJ, et al. The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers. Neuropsychopharmacology. 2008 ; 33: 1992-2006
40. Ruhe HG, Mason NS, Schene AH. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry. 2007 ; 12: 331-359
41. Serretti A, Kato M, De Ronchi D, et al. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry. 2007 ; 12: 247-257
42. Silbersweig D, Clarkin JF, Goldstein M, et al. Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder. Am J Psychiatry. 2007 ; 164: 1832-1841
43. Spitzer MB, Gibbon M, Williams JBW Stuctured Clinical Interview for DSM-IV-TR, Research Version, Patient Edition. (SCID-I/P). New York: Biometrics Research, New York State Biometrics Institute ; 2002 :
44. Sterne JA, Davey Smith G. Sifting the evidence-what's wrong with significance tests?. BMJ. 2001 ; 322: 226-231
45. Strange BA, Dolan RJ. Anterior medial temporal lobe in human cognition: memory for fear and the unexpected. Cogn Neuropsychiatry. 2006 ; 11: 198-218
46. Taylor MJ, Sen S, Bhagwagar Z. Antidepressant response and the serotonin transporter gene-linked polymorphic region. Biol Psychiatry. 2010 ; 68: 536-543
47. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry. 2010 ; 15: 18-22