메뉴 건너뛰기




Volumn 11, Issue 1, 2015, Pages 45-54

Fracture healing: Mechanisms and interventions

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; PARATHYROID HORMONE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT OSTEOGENIC PROTEIN 1; RECOMBINANT PLATELET DERIVED GROWTH FACTOR BB; WNT PROTEIN;

EID: 84925503883     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2014.164     Document Type: Review
Times cited : (1292)

References (101)
  • 1
    • 0026769957 scopus 로고
    • Regulation of fracture repair by growth factors
    • Bolander, M. E. Regulation of fracture repair by growth factors. Proc. Soc. Exp. Biol. Med. 200, 165-170 (1992).
    • (1992) Proc. Soc. Exp. Biol. Med. , vol.200 , pp. 165-170
    • Bolander, M.E.1
  • 2
    • 0031734171 scopus 로고    scopus 로고
    • The cell and molecular biology of fracture healing
    • Einhorn, T. A. The cell and molecular biology of fracture healing. Clin. Orthop. Relat. Res. 355 (Suppl.), S7-S21 (1998).
    • (1998) Clin. Orthop. Relat. Res. , vol.355 , pp. S7-S21
    • Einhorn, T.A.1
  • 3
    • 0032841147 scopus 로고    scopus 로고
    • Does adult fracture repair recapitulate embryonic skeletal formation?
    • Ferguson, C., Alpern, E., Miclau, T. & Helms, J. A. Does adult fracture repair recapitulate embryonic skeletal formation? Mech. Dev. 87, 57-66 (1999).
    • (1999) Mech. Dev. , vol.87 , pp. 57-66
    • Ferguson, C.1    Alpern, E.2    Miclau, T.3    Helms, J.A.4
  • 4
    • 0037376627 scopus 로고    scopus 로고
    • Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation
    • Gerstenfeld, L. C., Cullinane, D. M., Barnes, G. L., Graves, D. T. & Einhorn, T. A. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J. Cell Biochem. 88, 873-884 (2003).
    • (2003) J. Cell Biochem. , vol.88 , pp. 873-884
    • Gerstenfeld, L.C.1    Cullinane, D.M.2    Barnes, G.L.3    Graves, D.T.4    Einhorn, T.A.5
  • 5
    • 0032008025 scopus 로고    scopus 로고
    • Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair
    • Vortkamp, A. et al. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech. Dev. 71, 65-76 (1998).
    • (1998) Mech. Dev. , vol.71 , pp. 65-76
    • Vortkamp, A.1
  • 6
    • 67649823758 scopus 로고    scopus 로고
    • Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes
    • Bais, M. et al. Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PLoS ONE 4, e5393 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e5393
    • Bais, M.1
  • 7
    • 33644877907 scopus 로고    scopus 로고
    • Overview of the fracture healing cascade
    • Phillips, A. M. Overview of the fracture healing cascade. Injury 36 (Suppl. 3), 55-57 (2005).
    • (2005) Injury , vol.36 , pp. 55-57
    • Phillips, A.M.1
  • 9
    • 0035208929 scopus 로고    scopus 로고
    • Prevention of fracture healing in rats by an inhibitor of angiogenesis
    • Hausman, M. R., Schaffler, M. B. & Majeska, R. J. Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone 29, 560-564 (2001).
    • (2001) Bone , vol.29 , pp. 560-564
    • Hausman, M.R.1    Schaffler, M.B.2    Majeska, R.J.3
  • 10
    • 0030069507 scopus 로고    scopus 로고
    • Endothelial stimulating angiogenic factor in early fracture healing
    • Kurdy, N. M., Weiss, J. B. & Bate, A. Endothelial stimulating angiogenic factor in early fracture healing. Injury 27, 143-145 (1996).
    • (1996) Injury , vol.27 , pp. 143-145
    • Kurdy, N.M.1    Weiss, J.B.2    Bate, A.3
  • 11
    • 0031981097 scopus 로고    scopus 로고
    • Programmed removal of chondrocytes during endochondral fracture healing
    • Young, L. F., Choi, Y. W., Behrens, F. F., DeFouw, D. O. & Einhorn, T. A. Programmed removal of chondrocytes during endochondral fracture healing. J. Orthop. Res. 6, 144-149 (1998).
    • (1998) J. Orthop. Res. , vol.6 , pp. 144-149
    • Young, L.F.1    Choi, Y.W.2    Behrens, F.F.3    DeFouw, D.O.4    Einhorn, T.A.5
  • 12
    • 0042978778 scopus 로고    scopus 로고
    • Impaired fracture healing in the absence of TNF-α signaling: The role of TNF-α in endochondral cartilage resorption
    • Gerstenfeld, L. C. et al. Impaired fracture healing in the absence of TNF-α signaling: the role of TNF-α in endochondral cartilage resorption. J. Bone Miner. Res. 18, 1584-1592 (2003).
    • (2003) J. Bone Miner. Res. , vol.18 , pp. 1584-1592
    • Gerstenfeld, L.C.1
  • 13
    • 53149122903 scopus 로고    scopus 로고
    • Revascularisation during fracture healing with soft tissue injury
    • Melnyk, M., Henke, T., Claes, L. & Augat, P. Revascularisation during fracture healing with soft tissue injury. Arch. Orthop. Trauma Surg. 128, 1159-1165 (2008).
    • (2008) Arch. Orthop. Trauma Surg. , vol.128 , pp. 1159-1165
    • Melnyk, M.1    Henke, T.2    Claes, L.3    Augat, P.4
  • 14
    • 84882793174 scopus 로고    scopus 로고
    • Endostatin inhibits callus remodeling during fracture healing in mice
    • Holstein, J. H. et al. Endostatin inhibits callus remodeling during fracture healing in mice. J. Orthop. Res. 31, 1579-1584 (2013).
    • (2013) J. Orthop. Res. , vol.31 , pp. 1579-1584
    • Holstein, J.H.1
  • 15
    • 0034999587 scopus 로고    scopus 로고
    • Expression of osteoprotegerin, receptor activator of NF-κB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing
    • Kon, T. et al. Expression of osteoprotegerin, receptor activator of NF-κB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J. Bone Miner. Res. 16, 1004-1014 (2001).
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 1004-1014
    • Kon, T.1
  • 16
    • 0034087699 scopus 로고    scopus 로고
    • Role of fracture hematoma and periosteum during fracture healing in rats: Interaction of fracture hematoma and the periosteum in the initial step of the healing process
    • Ozaki, A., Tsunoda, M., Kinoshita, S. & Saura, R. Role of fracture hematoma and periosteum during fracture healing in rats: interaction of fracture hematoma and the periosteum in the initial step of the healing process. J. Orthop. Sci. 5, 64-70 (2005).
    • (2005) J. Orthop. Sci. , vol.5 , pp. 64-70
    • Ozaki, A.1    Tsunoda, M.2    Kinoshita, S.3    Saura, R.4
  • 17
    • 22544469122 scopus 로고    scopus 로고
    • Fracture hematoma is a potent proinflammatory mediator of neutrophil function
    • Timlin, M. D. et al. Fracture hematoma is a potent proinflammatory mediator of neutrophil function. J. Trauma 58, 1223-1229 (2005).
    • (2005) J. Trauma , vol.58 , pp. 1223-1229
    • Timlin, M.D.1
  • 18
    • 0031713691 scopus 로고    scopus 로고
    • Altered T cell cytokine production following mechanical trauma
    • Meert, K. L., Ofenstein, J. P. & Sarnaik, A. P. Altered T cell cytokine production following mechanical trauma. Ann. Clin. Lab. Sci. 28, 283-288 (1998).
    • (1998) Ann. Clin. Lab. Sci. , vol.28 , pp. 283-288
    • Meert, K.L.1    Ofenstein, J.P.2    Sarnaik, A.P.3
  • 19
    • 84901272669 scopus 로고    scopus 로고
    • REG cells in fracture healing as characterized in the Fas-deficient (lpr) mouse model of lupus
    • REG cells in fracture healing as characterized in the Fas-deficient (lpr) mouse model of lupus. J. Bone Miner. Res. 29, 1478-1491 (2014).
    • (2014) J. Bone Miner. Res. , vol.29 , pp. 1478-1491
    • Al-Sebaei, M.O.1
  • 20
    • 36348977575 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stromal cells
    • Nauta, A. J. & Fibbe, W. E. Immunomodulatory properties of mesenchymal stromal cells. Blood 110, 3499-3506 (2007).
    • (2007) Blood , vol.110 , pp. 3499-3506
    • Nauta, A.J.1    Fibbe, W.E.2
  • 21
  • 22
    • 47249127693 scopus 로고    scopus 로고
    • A functional role for soluble HLA-G. antigens in immune modulation mediated by mesenchymal stromal cells
    • Rizzo, R. et al. A functional role for soluble HLA-G. antigens in immune modulation mediated by mesenchymal stromal cells. Cytotherapy 10, 364-375 (2008).
    • (2008) Cytotherapy , vol.10 , pp. 364-375
    • Rizzo, R.1
  • 23
    • 47949099102 scopus 로고    scopus 로고
    • Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumor-associated antigens
    • Morandi, F. et al. Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumor-associated antigens. Stem Cells 26, 1275-1287 (2008).
    • (2008) Stem Cells , vol.26 , pp. 1275-1287
    • Morandi, F.1
  • 24
    • 84901022651 scopus 로고    scopus 로고
    • Osteodifferentiated mesenchymal stem cells from bone marrow and adipose tissue express HLA-G. and display immunomodulatory properties in HLA-mismatched settings: Implications in bone repair therapy
    • Montespan, F., Deschaseaux, F., Sensébé, L., Carosella, E. D., Rouas-Freiss, N. Osteodifferentiated mesenchymal stem cells from bone marrow and adipose tissue express HLA-G. and display immunomodulatory properties in HLA-mismatched settings: implications in bone repair therapy. J. Immunol. Res. 2014, 23034 (2014).
    • (2014) J. Immunol. Res. , vol.2014 , pp. 23034
    • Montespan, F.1    Deschaseaux, F.2    Sensébé, L.3    Carosella, E.D.4    Rouas-Freiss, N.5
  • 25
    • 84870342780 scopus 로고    scopus 로고
    • Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: The expression and impact of inflammatory priming
    • Najar, M. et al. Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: the expression and impact of inflammatory priming. Stem Cell Rev. 8, 1188-1198 (2012).
    • (2012) Stem Cell Rev. , vol.8 , pp. 1188-1198
    • Najar, M.1
  • 26
    • 34247645621 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A new strategy for immunosuppression?
    • Uccelli, A., Pistoia, V. & Moretta, L. Mesenchymal stem cells: a new strategy for immunosuppression? Trends Immunol. 28, 219-226 (2007).
    • (2007) Trends Immunol. , vol.28 , pp. 219-226
    • Uccelli, A.1    Pistoia, V.2    Moretta, L.3
  • 27
    • 36148989585 scopus 로고    scopus 로고
    • Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice
    • Yang, X. et al. Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice. Bone 41, 928-936 (2007).
    • (2007) Bone , vol.41 , pp. 928-936
    • Yang, X.1
  • 28
    • 79960233326 scopus 로고    scopus 로고
    • Effects of interleukin-6 ablation on fracture healing in mice
    • Wallace, A., Cooney, T. E., Englund, R. & Lubahn, J. D. Effects of interleukin-6 ablation on fracture healing in mice. J. Orthop. Res. 29, 1437-1442 (2011).
    • (2011) J. Orthop. Res. , vol.29 , pp. 1437-1442
    • Wallace, A.1    Cooney, T.E.2    Englund, R.3    Lubahn, J.D.4
  • 29
    • 84863111658 scopus 로고    scopus 로고
    • T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair
    • Nam, D. et al. T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair. PLoS ONE 7, e40044 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e40044
    • Nam, D.1
  • 30
    • 79952122953 scopus 로고    scopus 로고
    • TNF-α promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells
    • Glass, G. E. et al. TNF-α promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells. Proc. Natl Acad. Sci. USA 108, 1585-1590 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 1585-1590
    • Glass, G.E.1
  • 31
    • 38749087924 scopus 로고    scopus 로고
    • Management of infected nonunion of long bones: The last decade (1996-2006)
    • Motsitsi, N. S. Management of infected nonunion of long bones: the last decade (1996-2006). Injury 39, 55-60 (2007).
    • (2007) Injury , vol.39 , pp. 55-60
    • Motsitsi, N.S.1
  • 32
    • 73549115418 scopus 로고    scopus 로고
    • High levels of tumor necrosis factor-α contribute to accelerated loss of cartilage in diabetic fracture healing
    • Alblowi, J. et al. High levels of tumor necrosis factor-α contribute to accelerated loss of cartilage in diabetic fracture healing. Am. J. Pathol. 175, 1574-1585 (2009).
    • (2009) Am. J. Pathol. , vol.175 , pp. 1574-1585
    • Alblowi, J.1
  • 33
    • 77954693022 scopus 로고    scopus 로고
    • TNF-α mediates diabetes enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO-1
    • Kayal, J. et al. TNF-α mediates diabetes enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO-1. J. Bone Miner. Res. 25, 1604-1615 (2010).
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 1604-1615
    • Kayal, J.1
  • 34
    • 84857920401 scopus 로고    scopus 로고
    • Fracture healing under healthy and inflammatory conditions
    • Claes, L., Recknagel, S. & Ignatius, A. Fracture healing under healthy and inflammatory conditions. Nat. Rev. Rheumatol. 8, 133-143 (2012).
    • (2012) Nat. Rev. Rheumatol. , vol.8 , pp. 133-143
    • Claes, L.1    Recknagel, S.2    Ignatius, A.3
  • 35
    • 0027095675 scopus 로고
    • Immunologic studies of nonunited fractures
    • Santavirta, S. et al. Immunologic studies of nonunited fractures. Acta Orthop. Scand. 63, 579-586 (1992).
    • (1992) Acta Orthop. Scand. , vol.63 , pp. 579-586
    • Santavirta, S.1
  • 36
    • 0019868972 scopus 로고
    • Changes in some indices of cellular immunity in patients with uncomplicated and complicated healing of bone fractures
    • Askalonov, A. A. Changes in some indices of cellular immunity in patients with uncomplicated and complicated healing of bone fractures. J. Hyg. Epidemiol. Microbiol. Immunol. 25, 307-310 (1991).
    • (1991) J. Hyg. Epidemiol. Microbiol. Immunol. , vol.25 , pp. 307-310
    • Askalonov, A.A.1
  • 38
    • 0030953659 scopus 로고    scopus 로고
    • The immune microenvironment of human fracture/soft-tissue hematomas and its relationship to systemic immunity
    • Hauser, C. J. et al. The immune microenvironment of human fracture/soft-tissue hematomas and its relationship to systemic immunity. J. Trauma 42, 895-903 (1997).
    • (1997) J. Trauma , vol.42 , pp. 895-903
    • Hauser, C.J.1
  • 39
    • 78650938516 scopus 로고    scopus 로고
    • Fracture healing is accelerated in the absence of the adaptive immune system
    • Toben, D. et al. Fracture healing is accelerated in the absence of the adaptive immune system. J. Bone Miner. Res. 26, 113-124 (2011).
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 113-124
    • Toben, D.1
  • 41
    • 66449106049 scopus 로고    scopus 로고
    • A role for gamma delta T-cells in a mouse model of fracture healing
    • Colburn, N. T., Zaal, K. J., Wang, F. & Tuan, R. A role for gamma delta T-cells in a mouse model of fracture healing. Arthritis Rheum. 60, 1694-1703 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 1694-1703
    • Colburn, N.T.1    Zaal, K.J.2    Wang, F.3    Tuan, R.4
  • 42
    • 84883614526 scopus 로고    scopus 로고
    • Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages
    • Melief, S. M. et al. Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages. Stem Cells 31, 1980-1991 (2013).
    • (2013) Stem Cells , vol.31 , pp. 1980-1991
    • Melief, S.M.1
  • 43
    • 84899474275 scopus 로고    scopus 로고
    • Immunomodulation of mesenchymal stromal cells on regulatory T cells and its possible mechanism
    • Yan, Z., Zhuansun, Y., Chen, R., Li, J. & Ran, P. Immunomodulation of mesenchymal stromal cells on regulatory T cells and its possible mechanism. Exp. Cell Res. 15, 65-74 (2014).
    • (2014) Exp. Cell Res. , vol.15 , pp. 65-74
    • Yan, Z.1    Zhuansun, Y.2    Chen, R.3    Li, J.4    Ran, P.5
  • 44
    • 0042700077 scopus 로고    scopus 로고
    • Influence of extensive muscle injury on fracture healing in rat tibia
    • Utvåg, S. E., Grundnes, O., Rindal, D. B. & Reikerås, O. Influence of extensive muscle injury on fracture healing in rat tibia. J. Orthop. Trauma 17, 430-435 (2003).
    • (2003) J. Orthop. Trauma , vol.17 , pp. 430-435
    • Utvåg, S.E.1    Grundnes, O.2    Rindal, D.B.3    Reikerås, O.4
  • 45
    • 79953812507 scopus 로고    scopus 로고
    • The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model
    • Claes, L. et al. The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model. Acta Orthop. 82, 223-227 (2011).
    • (2011) Acta Orthop. , vol.82 , pp. 223-227
    • Claes, L.1
  • 46
    • 0033968708 scopus 로고    scopus 로고
    • The influence of mechanical stimulus on the pattern of tissue differentiation in a long bone fracture - An FEM study
    • Gardner, T. N., Stoll, T., Marks, L., Mishra, S. & Knothe Tate, M. The influence of mechanical stimulus on the pattern of tissue differentiation in a long bone fracture - an FEM study. J. Biomech. 33, 415-425 (2000).
    • (2000) J. Biomech. , vol.33 , pp. 415-425
    • Gardner, T.N.1    Stoll, T.2    Marks, L.3    Mishra, S.4    Knothe Tate, M.5
  • 47
    • 0033104459 scopus 로고    scopus 로고
    • Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing
    • Claes, L. E. & Heigele, C. A. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J. Biomech. 32, 255-266 (1999).
    • (1999) J. Biomech. , vol.32 , pp. 255-266
    • Claes, L.E.1    Heigele, C.A.2
  • 48
    • 77955551563 scopus 로고    scopus 로고
    • Correlations between local strains and tissue phenotypes in an experimental model of skeletal healing
    • Morgan, E. F. et al. Correlations between local strains and tissue phenotypes in an experimental model of skeletal healing. J. Biomech. 43, 2418-2424 (2010).
    • (2010) J. Biomech. , vol.43 , pp. 2418-2424
    • Morgan, E.F.1
  • 49
    • 58649117944 scopus 로고    scopus 로고
    • Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration
    • Colnot, C. Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration. J. Bone Miner. Res. 24, 274-282 (2009).
    • (2009) J. Bone Miner. Res. , vol.24 , pp. 274-282
    • Colnot, C.1
  • 50
    • 77954760366 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair
    • Yu, Y. Y., Lieu, S., Lu, C. & Colnot, C. Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair. Bone 47, 65-73 (2010).
    • (2010) Bone , vol.47 , pp. 65-73
    • Yu, Y.Y.1    Lieu, S.2    Lu, C.3    Colnot, C.4
  • 51
    • 84055213708 scopus 로고    scopus 로고
    • Myogenic progenitors contribute to open but not closed fracture repair
    • Liu, R. et al. Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskelet. Disord. 12, 288 (2011).
    • (2011) BMC Musculoskelet. Disord. , vol.12 , pp. 288
    • Liu, R.1
  • 52
    • 0022525242 scopus 로고
    • Intramedullary reaming and nailing: Its early effects on cortical bone vascularization
    • Olerud, S. & Strömberg, L. Intramedullary reaming and nailing: its early effects on cortical bone vascularization. Orthopedics 9, 1204-1208 (1986).
    • (1986) Orthopedics , vol.9 , pp. 1204-1208
    • Olerud, S.1    Strömberg, L.2
  • 53
    • 0028350795 scopus 로고
    • The vascular response to fracture micromovement
    • McCarthy, I. D. & Hughes, S. P. The vascular response to fracture micromovement. Clin. Orthop. Relat. Res. 301, 281-290 (1994).
    • (1994) Clin. Orthop. Relat. Res. , vol.301 , pp. 281-290
    • McCarthy, I.D.1    Hughes, S.P.2
  • 54
    • 0036375353 scopus 로고    scopus 로고
    • The effect of mechanical stability on local vascularization and tissue differentiation in callus healing
    • Claes, L., Eckert-Hübner, K. & Augat, P. The effect of mechanical stability on local vascularization and tissue differentiation in callus healing. J. Orthop. Res. 20, 1099-1105 (2002).
    • (2002) J. Orthop. Res. , vol.20 , pp. 1099-1105
    • Claes, L.1    Eckert-Hübner, K.2    Augat, P.3
  • 55
    • 70649108638 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in orthopaedic surgery
    • Axelrad, T. W. & Einhorn, T. A. Bone morphogenetic proteins in orthopaedic surgery. Cytokine Growth Factor Rev. 20, 481-488 (2009).
    • (2009) Cytokine Growth Factor Rev. , vol.20 , pp. 481-488
    • Axelrad, T.W.1    Einhorn, T.A.2
  • 56
    • 38849178302 scopus 로고    scopus 로고
    • Building bone to reverse osteoporosis and repair fractures
    • Khosla, S., Westendorf, J. J. & Oursler, M. J. Building bone to reverse osteoporosis and repair fractures. J. Clin. Invest. 118, 421-428 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 421-428
    • Khosla, S.1    Westendorf, J.J.2    Oursler, M.J.3
  • 57
    • 84865441732 scopus 로고    scopus 로고
    • Role of FGFs/FGFRs in skeletal development and bone regeneration
    • Du, X., Xie, Y., Xian, C. J. & Chen, L. Role of FGFs/FGFRs in skeletal development and bone regeneration. J. Cell Physiol. 227, 3731-3734 (2012).
    • (2012) J. Cell Physiol. , vol.227 , pp. 3731-3734
    • Du, X.1    Xie, Y.2    Xian, C.J.3    Chen, L.4
  • 58
    • 84887381454 scopus 로고    scopus 로고
    • Fibroblast growth factor-2, bone homeostasis and fracture repair
    • Fei, Y., Gronowicz, G. & Hurley, M. M. Fibroblast growth factor-2, bone homeostasis and fracture repair. Curr. Pharm. Des. 19, 3354-3363 (2013).
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 3354-3363
    • Fei, Y.1    Gronowicz, G.2    Hurley, M.M.3
  • 59
    • 11844281480 scopus 로고    scopus 로고
    • Sonic hedgehog gene-enhanced tissue engineering for bone regeneration
    • Edwards, P. C. et al. Sonic hedgehog gene-enhanced tissue engineering for bone regeneration. Gene Ther. 12, 75-86 (2005).
    • (2005) Gene Ther. , vol.12 , pp. 75-86
    • Edwards, P.C.1
  • 60
    • 79960004951 scopus 로고    scopus 로고
    • Enhanced bone regeneration with sequential delivery of basic fibroblast growth factor and sonic hedgehog
    • Song, K., Rao, N. J., Chen, M. L., Huang, Z. J. & Cao, Y. G. Enhanced bone regeneration with sequential delivery of basic fibroblast growth factor and sonic hedgehog. Injury 42, 796-802 (2011).
    • (2011) Injury , vol.42 , pp. 796-802
    • Song, K.1    Rao, N.J.2    Chen, M.L.3    Huang, Z.J.4    Cao, Y.G.5
  • 61
    • 40149110509 scopus 로고    scopus 로고
    • Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment
    • Barnes, G. L. et al. Stimulation of fracture-healing with systemic intermittent parathyroid hormone treatment. J. Bone Joint Surg. Am. 90 (Suppl. 1), 120-127 (2008).
    • (2008) J. Bone Joint Surg. Am. , vol.90 , pp. 120-127
    • Barnes, G.L.1
  • 62
    • 80054976274 scopus 로고    scopus 로고
    • Effects of anti-osteoporosis medications on fracture healing
    • Jørgensen, N. R. & Schwarz, P. Effects of anti-osteoporosis medications on fracture healing. Curr. Osteoporos. Rep. 9, 149-145 (2011).
    • (2011) Curr. Osteoporos. Rep. , vol.9 , pp. 149-1145
    • Jørgensen, N.R.1    Schwarz, P.2
  • 63
    • 80053156520 scopus 로고    scopus 로고
    • An update on transforming growth factor-β (TGF-β): Sources, types, functions and clinical applicability for cartilage/bone healing
    • Patil, A. S., Sable, R. B. & Kothari, R. M. An update on transforming growth factor-β (TGF-β): sources, types, functions and clinical applicability for cartilage/bone healing. J. Cell. Physiol. 226, 3094-3103 (2011).
    • (2011) J. Cell. Physiol. , vol.226 , pp. 3094-3103
    • Patil, A.S.1    Sable, R.B.2    Kothari, R.M.3
  • 64
    • 84880166280 scopus 로고    scopus 로고
    • Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model
    • Virk, M. S. et al. Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model. J. Bone Joint Surg. Am. 95, 694-701 (2013).
    • (2013) J. Bone Joint Surg. Am. , vol.95 , pp. 694-701
    • Virk, M.S.1
  • 65
    • 84868290353 scopus 로고    scopus 로고
    • Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases
    • Ke, H. Z., Richards, W. G. Li, X. & Ominsky, M. S. Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocr. Rev. 33, 747-783 (2012).
    • (2012) Endocr. Rev. , vol.33 , pp. 747-783
    • Ke, H.Z.1    Richards, W.G.2    Li, X.3    Ominsky, M.S.4
  • 66
    • 84861726292 scopus 로고    scopus 로고
    • The role of BMPs in bone anabolism and their potential targets SOST and DKK1
    • Kamiya, N. The role of BMPs in bone anabolism and their potential targets SOST and DKK1. Curr. Mol. Pharmacol. 5, 153-163 (2012).
    • (2012) Curr. Mol. Pharmacol. , vol.5 , pp. 153-163
    • Kamiya, N.1
  • 67
    • 38749144432 scopus 로고    scopus 로고
    • Enhanced chondrogenesis and Wnt signaling in PTH treated fractures
    • Kakar, S. et al. Enhanced chondrogenesis and Wnt signaling in PTH treated fractures. J. Bone Miner. Res. 22, 1903-1912 (2007).
    • (2007) J. Bone Miner. Res. , vol.22 , pp. 1903-1912
    • Kakar, S.1
  • 68
    • 84873558051 scopus 로고    scopus 로고
    • Wnt signaling in bone homeostasis and disease: From human mutations to treatments
    • Baron, R. & Kneissel, M. Wnt signaling in bone homeostasis and disease: from human mutations to treatments. Nat. Med. 19, 179-192 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 179-192
    • Baron, R.1    Kneissel, M.2
  • 69
    • 84864083460 scopus 로고    scopus 로고
    • Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation
    • Fei, Y. & Hurley, M. M. Role of fibroblast growth factor 2 and Wnt signaling in anabolic effects of parathyroid hormone on bone formation. J. Cell. Physiol. 227, 3539-3545 (2012).
    • (2012) J. Cell. Physiol. , vol.227 , pp. 3539-3545
    • Fei, Y.1    Hurley, M.M.2
  • 70
    • 16844379581 scopus 로고    scopus 로고
    • Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34)
    • Alkhiary, Y. M. et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J. Bone Joint Surg. Am. 87, 731-741 (2005).
    • (2005) J. Bone Joint Surg. Am. , vol.87 , pp. 731-741
    • Alkhiary, Y.M.1
  • 71
    • 0001760985 scopus 로고
    • Fundamental aspects of fracture treatment
    • Yasuda, I. Fundamental aspects of fracture treatment. J. Kyoto Med. Soc. 4, 395-406 (1953).
    • (1953) J. Kyoto Med. Soc. , vol.4 , pp. 395-406
    • Yasuda, I.1
  • 72
    • 0019364230 scopus 로고
    • A multicenter study of the treatment of non-union with constant direct current
    • Brighton, C. T. et al. A multicenter study of the treatment of non-union with constant direct current. J. Bone Joint Surg. Am. 63, 2-13 (1981).
    • (1981) J. Bone Joint Surg. Am. , vol.63 , pp. 2-13
    • Brighton, C.T.1
  • 73
    • 0019829689 scopus 로고
    • Current concepts review. The treatment of non-unions with electricity
    • Brighton, C. T. Current concepts review. The treatment of non-unions with electricity. J. Bone Joint Surg. Am. 63, 847-851 (1981).
    • (1981) J. Bone Joint Surg. Am. , vol.63 , pp. 847-851
    • Brighton, C.T.1
  • 74
    • 0028303704 scopus 로고
    • A prospective, double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones
    • Scott, G. & King, J. B. A prospective, double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones. J. Bone Joint Surg. Am. 76, 820-826 (1994).
    • (1994) J. Bone Joint Surg. Am. , vol.76 , pp. 820-826
    • Scott, G.1    King, J.B.2
  • 75
    • 0025306654 scopus 로고
    • A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures
    • Sharrard, W. J. A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures. J. Bone Joint Surg. Am. 72, 347-355 (1990).
    • (1990) J. Bone Joint Surg. Am. , vol.72 , pp. 347-355
    • Sharrard, W.J.1
  • 76
    • 55849116660 scopus 로고    scopus 로고
    • Electrical stimulation for long-bone fracture-healing: A meta-analysis of randomized controlled trials
    • Mollon, B., da Silva, V., Busse, J. W., Einhorn, T. A. & Bhandari, M. Electrical stimulation for long-bone fracture-healing: a meta-analysis of randomized controlled trials. J. Bone Joint Surg. Am. 90, 2322-2330 (2008).
    • (2008) J. Bone Joint Surg. Am. , vol.90 , pp. 2322-2330
    • Mollon, B.1    Da Silva, V.2    Busse, J.W.3    Einhorn, T.A.4    Bhandari, M.5
  • 77
    • 0028214665 scopus 로고
    • Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound
    • Heckman, J., Ryaby, J. McCabe, J., Frey, J. J. & Kilcoyne, R. F. Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J. Bone Joint Surg. Am. 76, 26-34 (1994).
    • (1994) J. Bone Joint Surg. Am. , vol.76 , pp. 26-34
    • Heckman, J.1    Ryaby, J.2    McCabe, J.3    Frey, J.J.4    Kilcoyne, R.F.5
  • 78
    • 0004831866 scopus 로고
    • The effect of low power specifically programmed ultrasound on the healing time of fresh fractures using a Colles' model
    • Kristiansen, T. K. The effect of low power specifically programmed ultrasound on the healing time of fresh fractures using a Colles' model. J. Orthop. Trauma 4, 227-228 (1990).
    • (1990) J. Orthop. Trauma , vol.4 , pp. 227-228
    • Kristiansen, T.K.1
  • 79
    • 84859008181 scopus 로고    scopus 로고
    • Low intensity pulsed ultrasonography for fractures: Systematic review of randomized controlled trials
    • Busse, J. W. et al. Low intensity pulsed ultrasonography for fractures: systematic review of randomized controlled trials. BMJ 338, 351-360 (2009).
    • (2009) BMJ , vol.338 , pp. 351-360
    • Busse, J.W.1
  • 81
    • 21444445838 scopus 로고    scopus 로고
    • Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells
    • Hernigou, P. Poignard, A., Beaujean, F. & Rouard, H. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J. Bone Joint Surg. Am. 87, 1430-1437 (2005).
    • (2005) J. Bone Joint Surg. Am. , vol.87 , pp. 1430-1437
    • Hernigou, P.1    Poignard, A.2    Beaujean, F.3    Rouard, H.4
  • 82
    • 78649581478 scopus 로고    scopus 로고
    • A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo-controlled trial
    • Kawaguchi, H. et al. A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: a randomized, placebo-controlled trial. J. Bone Miner. Res. 12, 2735-2743 (2010).
    • (2010) J. Bone Miner. Res. , vol.12 , pp. 2735-2743
    • Kawaguchi, H.1
  • 83
    • 84883707381 scopus 로고    scopus 로고
    • Recombinant human platelet-derived growth factor-BB and β-tricalcium phosphate (rhPDGF-BB/ β-TCP): An alternative to autogenous bone graft
    • North American Ortrhopedic Foot and Ankle Study Group
    • DiGiovanni, C. W. et al. Recombinant human platelet-derived growth factor-BB and β-tricalcium phosphate (rhPDGF-BB/ β-TCP): an alternative to autogenous bone graft. North American Ortrhopedic Foot and Ankle Study Group. J. Bone Joint Surg. Am. 95, 1184-1192 (2013).
    • (2013) J. Bone Joint Surg. Am. , vol.95 , pp. 1184-1192
    • DiGiovanni, C.W.1
  • 84
    • 0035222452 scopus 로고    scopus 로고
    • Osteogenic protein-1 (bone morphogenetic protein-7) in the treatement of tibial nonunions
    • Friedlaender, G. E. et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatement of tibial nonunions. J. Bone Joint Surg. Am. 83 (Suppl. 1), S151-S158 (2001).
    • (2001) J. Bone Joint Surg. Am. , vol.83 , pp. S151-S158
    • Friedlaender, G.E.1
  • 85
    • 84926290600 scopus 로고    scopus 로고
    • Blue Cross & Blue Shield of Mississippi. Bone morphogenetic protein [online], http://www.bcbsms.com/com/bcbsms/apps/ policysearch/views/viewpolicy.php?&noprint=yes&path=%2Fpolicy%2Femed%2Fbone-morphogenetic-protein.html (2014).
    • (2014) Bone Morphogenetic Protein [Online]
  • 86
    • 0036899744 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients
    • BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) study group
    • Govender, S. et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) study group. J. Bone Joint Surg. Am. 84, 2123-2134 (2002).
    • (2002) J. Bone Joint Surg. Am. , vol.84 , pp. 2123-2134
    • Govender, S.1
  • 87
    • 84893153887 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture: A double-blind, randomized, controlled phase I-II/III trial
    • Lyon, T. et al. Efficacy and safety of recombinant human bone morphogenetic protein-2/calcium phosphate matrix for closed tibial diaphyseal fracture: a double-blind, randomized, controlled phase I-II/III trial. J. Bone Joint Surg. Am. 95, 2088-2096 (2013).
    • (2013) J. Bone Joint Surg. Am. , vol.95 , pp. 2088-2096
    • Lyon, T.1
  • 88
    • 79959579500 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2: A randomized trial in open tibial fractures treated with reamed nail fixation
    • Aro, H. T. et al. Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation. J. Bone Joint Surg. Am. 93, 801-808 (2011).
    • (2011) J. Bone Joint Surg. Am. , vol.93 , pp. 801-808
    • Aro, H.T.1
  • 89
    • 84879165716 scopus 로고    scopus 로고
    • Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: A meta-analysis of individual-participant data
    • Simmonds, M. C. et al. Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data. Ann. Intern. Med. 158, 877-879 (2013).
    • (2013) Ann. Intern. Med. , vol.158 , pp. 877-879
    • Simmonds, M.C.1
  • 90
    • 77953473271 scopus 로고    scopus 로고
    • Teriparatide for acceleration of fracture repair in humans: A prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures
    • Aspenberg, P. et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J. Bone Miner. Res. 24, 404-414 (2010).
    • (2010) J. Bone Miner. Res. , vol.24 , pp. 404-414
    • Aspenberg, P.1
  • 91
    • 80052871434 scopus 로고    scopus 로고
    • Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women
    • Peichl, P., Holzer, L. A., Maier, R. & Holzer, G. Parathyroid hormone 1-84 accelerates fracture - healing in pubic bones of elderly osteoporotic women. J. Bone Joint Surg. Am. 93, 1583-1587 (2011).
    • (2011) J. Bone Joint Surg. Am. , vol.93 , pp. 1583-1587
    • Peichl, P.1    Holzer, L.A.2    Maier, R.3    Holzer, G.4
  • 92
    • 34548306408 scopus 로고    scopus 로고
    • Mechanisms of anabolic therapies for osteoporosis
    • Canalis, E., Giustina, A. & Bilezikian, J. P. Mechanisms of anabolic therapies for osteoporosis. N. Engl. J. Med. 357, 905-916 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 905-916
    • Canalis, E.1    Giustina, A.2    Bilezikian, J.P.3
  • 93
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden, L. M. et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346, 1513-1521 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1513-1521
    • Boyden, L.M.1
  • 94
    • 18444400214 scopus 로고    scopus 로고
    • A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population
    • Staehling-Hampton, K. et al. A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. Am. J. Med. Genet. 110, 144-152 (2002).
    • (2002) Am. J. Med. Genet. , vol.110 , pp. 144-152
    • Staehling-Hampton, K.1
  • 95
    • 0041630893 scopus 로고    scopus 로고
    • The natural history of sclerosteosis
    • Hamersma, H., Gardner, J. & Beighton, P. The natural history of sclerosteosis. Clin. Genet. 63, 192-197 (2003).
    • (2003) Clin. Genet. , vol.63 , pp. 192-197
    • Hamersma, H.1    Gardner, J.2    Beighton, P.3
  • 96
    • 77956822573 scopus 로고    scopus 로고
    • Sclerostin antibody treatment enhances metaphyseal bone healing in rats
    • Agholme, F., Li, X. Isaksson, H., Ke, H. Z. & Aspenberg, P. Sclerostin antibody treatment enhances metaphyseal bone healing in rats. J. Bone Miner. Res. 24, 2412-2418 (2012).
    • (2012) J. Bone Miner. Res. , vol.24 , pp. 2412-2418
    • Agholme, F.1    Li, X.2    Isaksson, H.3    Ke, H.Z.4    Aspenberg, P.5
  • 97
    • 84865509876 scopus 로고    scopus 로고
    • Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectromized rats
    • McDonald, M. M. et al. Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectromized rats. J. Orthop. Res. 30, 1541-1548 (2012).
    • (2012) J. Orthop. Res. , vol.30 , pp. 1541-1548
    • McDonald, M.M.1
  • 98
    • 84865490988 scopus 로고    scopus 로고
    • Strongly enhanced levels of sclerostin during human fracture healing
    • Sarahrudi, K., Thomas, A., Albrecht, C. & Aharinejad, S. Strongly enhanced levels of sclerostin during human fracture healing. J. Orthop. Res. 30, 1549-1155 (2012).
    • (2012) J. Orthop. Res. , vol.30 , pp. 1549-11155
    • Sarahrudi, K.1    Thomas, A.2    Albrecht, C.3    Aharinejad, S.4
  • 99
    • 84893044528 scopus 로고    scopus 로고
    • Romosozumab in postmenopausal women with low bone mineral density
    • McClung, M. R. Romosozumab in postmenopausal women with low bone mineral density. N. Engl. J. Med. 370, 412-420 (2014).
    • (2014) N. Engl. J. Med. , vol.370 , pp. 412-420
    • McClung, M.R.1
  • 100
    • 84555178502 scopus 로고    scopus 로고
    • Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction
    • Takahata, M., Schwarz, E. M., Chen, T., O'Keefe, R. J. & Awad, H. A. Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction. J. Bone Miner. Res. 27, 26-37 (2012).
    • (2012) J. Bone Miner. Res. , vol.27 , pp. 26-37
    • Takahata, M.1    Schwarz, E.M.2    Chen, T.3    O'Keefe, R.J.4    Awad, H.A.5
  • 101
    • 57049163000 scopus 로고    scopus 로고
    • Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing
    • Morgan, E. F. et al. Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing. Bone 43, 1031-1038 (2008).
    • (2008) Bone , vol.43 , pp. 1031-1038
    • Morgan, E.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.