An update on transforming growth factor-β (TGF-β): Sources, types, functions and clinical applicability for cartilage/bone healing

Journal of Cellular Physiology

Volumn 226, Issue 12, 2011, Pages 3094-3103

  Patil, A S ^a   Sable, R B ^a   Kothari, R M ^b  

^a Bharati Vidyapeeth University Dental College and Hospital   (India)

^b Bharati Vidyapeeth Deemed University   (India)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; HETERODIMER; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3;

BONE; CARTILAGE; CARTILAGE CELL; CELL CYCLE; CELL DENSITY; CELL DIFFERENTIATION; CELL TYPE; GLYCOSYLATION; HEALING; HOMEOSTASIS; HUMAN; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSAMINATION; WOUND HEALING; X RAY CRYSTALLOGRAPHY;

ANIMALS; BONE AND BONES; CARTILAGE; CHONDROCYTES; CHONDROGENESIS; FRACTURE HEALING; HUMANS; OSTEOGENESIS; PROTEIN CONFORMATION; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 80053156520     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22698     Document Type: Short Survey

References (54)

1. Asanbaeva A, Masuda K, Eugene J-M, Thonar A, Klisch M, Robert LS. 2008. Regulation of immature cartilage growth by IGF-I, TGF-β1, BMP-7 and PDGF-AB: Role of metabolic balance between fixed charge and collagen network. Biomech Model Mechanobiol 7: 263-276.
2. Blumenfeld I, Laufer D, Livne E. 1997. Effects of transforming growth factor-b1 and IL-1a on matrix synthesis in osteoarthritic cartilage of the temporo-mandibular joint in aged mice. Mech Ageing Dev 95: 101-111.
3. Blumenfeld I, Livne E. 1999. The role of transforming growth factor (TGF-β), insulin-like growth factor (IGF)-1 and interleukin (IL)-1 in osteoarthritis and aging of joints. Exp Gerontol 34: 821-829.
4. Bujia J, Pitzke P, Kastenbauer E, Wilmes E, Hammer C. 1996. Effect of growth factors on matrix synthesis by human nasal chondrocytes cultured in monolayer and in agar. Eur Arch Otorhinolaryngol 253: 336-340.
5. D'Angelo M, Billings PC, Pacifici M, Leboy PS, Kirsch T. 2001. Authentic matrix vesicles contain active metalloproteases (MMP). A role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta. J Biol Chem 276: 11347-11353.
6. Davidson EN, van der Kraan PM, van den Berg WB. 2007. TGF-β and osteoarthritis. Osteoarthritis Cartilage 15: 597-604.
7. de Haart WJ, van Osch GJ, Verhaar JA. 1999. Effect of TGF beta-2, b FGF and L-ascorbic acid on bovine articular chondrocytes. Acta Orthop Scand 70: 55-61.
8. Delatte M, von der Hoff JW, Nottet SJ, Clerck De HJ, Kuijpers-Jagtman AM. 2005. Growth regulation of the rat mandibular condyle and femoral head by TGF-β1, FGF-2 and IGF-1. Eur J Orthod 27: 17-26.
9. Edwards DR, Murphy G, Reynolds JJ, Whitman SE, Docherty AJP, Angel P, Heath JK. 1987. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 6: 1899-1904.
10. Elder BD, Athanasiou KA. 2009. Systematic assessment of growth factor treatment on biochemical and biomechanical properties of engineered articular cartilage constructs. Osteoarthritis Cartilage 17: 114-123.
11. Galéra P, Vivien D, Pronost S, Bonaventure J, Rédini F, Loyau G. 1992. Transforming growth factor-beta 1 (TGF-beta 1) up-regulation of collagen type II in primary cultures of rabbit articular chondrocytes (RAC) involves increased mRNA levels without affecting mRNA stability and procollagen processing. J Cell Physiol 153: 596-606.
12. Goldring MB, Tsuchimochi K, Ijiri K. 2006. The control of chondrogenesis. J Cell Biochem 97: 33-44.
13. Grimaud E, Heymann D, Redini F. 2002. Recent advances in TGF β effect on chondrocyte metabolism: Potential therapeutic roles of TGF β in cartilage disorders. Cytokines Growth Factors Rev 13: 241-257.
14. Gruber HE, Fisher EC Jr, Desai B, Stasky AA, Hoelscher G, Hanley EN Jr. 1997. Human invertebral disc cells from the annulus: Three dimensional culture in agarose or alginate and responsiveness to TGF-beta 1. Exp Cell Res 232: 13-21.
15. Henson FM, Schofield PN, Jeffcott LB. 1997. Expression of transforming growth factor-beta 1 in normal and dyschondroplastic articular growth cartilage of the young horse. Equine Vet 29: 434-439.
16. Hinton RJ, Carlson DS. 2005. Regulation of growth in mandibular condylar cartilage. Semin Orthod 11: 209-218.
17. Hirota Y, Tsukazaki T, Yonekura A, Miyazaki Y, Osaki M, Shindo H. 2000. Activation of specific MEK-ERK cascade is necessary for TGF- signaling and crosstalk with PKA and PKC pathways in cultured articular chondrocytes. Osteoarthritis Cartilage 8: 241-248.
18. Holland TA, Bodde WH, Cuijpers JI, Baggett LS, Tabata J, Mikos AG, Jansen JA. 2007. Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair. Osteoarthritis Cartilage 15: 187-197.
19. Hui W, Rowan AD, Cawston T. 2001. Modulation of expression of matrix metalloproteinases by TGF-β1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-α. Cytokine 16: 31-35.
20. Inoue H, Kato Y, Ivamoto M, Hiraki Y, Sakuda M, Suzuki F. 1989. Stimulation of cartilage-matrix proteoglycan synthesis by morphologically transformed chondrocytes grown in the presence of fibroblast growth factor and transforming growth factor-beta. J Cell Physiol 138: 329-337.
21. Itoh S, Itoh F, Goumans MJ, Dijke PT. 2000. Signaling of transforming growth factor-β family members through Smad proteins. Eur J Biochem 267: 6954-6967.
22. Johns DE, Athanasiou KA. 2008. Growth factor effects on costal chondrocytes for tissue engineering fibrocartilage. Cell Tissue Res 333: 439-447.
23. Joyce ME, Roberts AB, Sporn MB, Bolander ME. 1990. Transforming growth factor -β and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol 110: 2195-2207.
24. Kraan P, van der Vitters E, van den Berg W. 1992. Differential effect of transforming growth factor-beta on freshly isolated and cultured articular chondrocytes. J Rheumatol 19: 140-145.
25. Lee JD, Hwang O, Kim SW, Han S. 1997. Primary cultured chondrocytes of different origins respond differently to bFGF and TGF-beta. Life Sci 61: 293-299.
26. Loser RF, Pacione CA, Chubinskaya S. 2003. The combination of insulin like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes. Arthritis Rheum. 48: 2188-2196.
27. Maeda S, Dean DD, Gay I, Schwartz Z, Boyan BD. 2001. Activation of latent transforming growth factor beta 1 by stromelysin in extracts of growth plate chondrocyte-derived matrix vesicles. J Bone Min Res 16: 1281-1290.
28. Mao JJ, Giannobile WV, Helms JA, Hollister SJ, Krebsbach PH, Longaker MT, Shi S. 2006. Craniofacial tissue engineering by stem cells. J Dent Res 85: 966-979.
29. Matsumura T, Whelan MC, Li XQ, Trippel SB. 2000. Regulation by IGF-I and TGF-beta 1 of Swarm-rat chondrosarcoma chondrocytes. J Orthop Res 18: 351-355.
30. Miyazaki Y, Tsukazaki T, Hirota Y, Yonekura A, Osaki M, Shindo H. 2000. Dexamethasone inhibition of TGF-beta-induced cell growth and type II collagen mRNA expression through ERK-integrated AP-1 activity in cultured rat articular chondrocytes. Osteoarthritis Cartilage 8: 378-385.
31. Moroco JR, Hinton R, Buschang P, Milam SB, Iacopino SM. 1997. Type II collagen and TGF- βs in developing and aging porcine mandibular condylar cartilage: immune-histo-chemical studies. Cell Tissue Res 289: 119-124.
32. Mulherkar L, Kothari RM, Vaidya VG. 1972. Study of catheptic activity and acid phosphatase activity during development and metamorphosis of D. melanogaster Wilhelm Raux Arch Entwickl-Mech Org 171: 195-199.
33. Nasatsky E, Azran E, Dean DD, Boyan BD, Schwartz Z. 2000. Parathyroid hormone and transforming growth factor-beta 1 coregulate chondrocyte differentiation in vitro Endocrine 13: 305-313.
34. Oka K, Oka S, Hosokawa R, Bringas P, Brokhoff HC, Nonaka K, Chai Y. 2008. TGF-β mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandibular development. Develop Biol 321: 303-309.
35. Pepper MS. 1997. Transforming growth factor-beta: Vasculogenesis, angiogenesis and vessel wall integrity. Cytokines Growth Factor Rev 8: 21-43.
36. Qi WN, Scully SP. 1998. Effect of type II collagen in chondrocyte response to TGF-beta 1 regulation. Exp Cell Res 241: 142-150.
37. Ramamurthy V, Upadhyay CM, Kothari RM. 1991. An optimized protocol for the preparation and application of acid protease. J Biotechnol 21: 187-196.
38. Rédini F, Daireaux M, Mauviel A, Galéra P, Loyau G, Pujol J.-P. 1991. Characterization of proteoglycans synthesized by rabbit articular chondrocytes in response to transforming growth factor-β (TGF-β). Biochim Biophys Acta 1093: 196-206.
39. Reinholz GG, Fitzsimmons JS, Casper ME, Ruesink TJ, Chung HW, Schagemann JC, O'Driscoll SW. 2009. Rejuvenation of periosteal chondrogenesis using local growth factor injection. Osteoarthritis Cartilage 17: 723-734.
40. Robey PG, Young MF, Flanders KC, Roche NS, Kondaiah P, Reddi AH, Termine JD, Sporn MB, Roberts AB. 1987. Osteoblast synthesize and respond to transforming growth factor-type β (TGF-β) in vitro J Cell Biol 105: 457-463.
41. Roman-Blas JA, Stokes DG, Jimenez SA. 2007. Modulation of TGF- β signaling by pro-inflammatory cytokines in articular chondrocytes. Osteoarthritis Cartilage 15: 1367-1382.
42. Schmidmaier G, Wildemann B, Heeger J, Belein T, Flyvbjerg A, Bail HJ, Raschke M. 2002. Improvement of fracture healing by systemic administration of growth hormone and local application of insulin-like growth factor-1 and transforming growth factor-β1. Bone 31: 165-172.
43. Seko Y, Tanaka Y, Tokoro T. 1995. Influence of bFGF as a potent growth stimulator and TGF-beta as a growth regulator on sclera chondrocytes and scleral fibroblasts in vitro Ophthalmic Res 27: 144-152.
44. Shah DN, Nehete PN, Kothari RM. 1986. Isolation of B. licheniformis mutant for stable production profiles of alkaline protease. Biotechnol Letts 8: 103-106.
45. Sporn MB, Roberts AB. 1992. Transforming growth factor-β: Recent progress and new challenges. J Cell Biol 119: 1017-1021.
46. Sporn MB, Roberts AB, Wakefield LM, Crombrugghe BD. 1987. Some recent advances in the chemistry and biology of transforming growth factor -beta. J Cell Biol 105: 1039-1045.
47. Sviri GE, Blumenfeld I, Livne E. 2000. Differential metabolic responses to local administration of TGF β and IGF 1 in temporomandibular joint cartilage of aged mice. Arch Gerontol Geriatrics 31: 159-176.
48. Thompson NL, Flanders KC, Smith JM, Ellingsworth LR, Roberts AB, Sporn MB. 1989. Expression of transforming growth factor-β1 in specific cells and tissues of adult and neonatal mice. J Cell Biol 108: 661-669.
49. Tuli R, Tuli S, Nandi S, Huang X, Manner PA, Hozack WJ. 2003. Transforming growth factor- β mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen activated protein kinase and Wnt signaling cross-talk. J Biol Chem 278: 41227-41236.
50. van Osch GJ, van den Berg WB, Hunziker EB, Hauselmann HJ. 1998. Differential effects of IGF-I and TGF beta-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes. Osteoarthritis Cartilage 6: 187-195.
51. von den Hoff JW, Delatte M. 2008. Interplay of mechanical loading and growth factors in the mandibular condyle. Arch Oral Biol 53: 709-715.
52. Webster. 2008. Webster's New World Medical Dictionary. Wiley Publishing, Inc. USA.
53. Yaeger PC, Masi TL, de Ortiz JL, Binette F, Tubo R, McPherson JM. 1997. Synergistic action of transforming growth factor-beta and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytes. Exp Cell Res 237: 318-325.
54. Yonekura A, Osaki M, Hirota Y, Tsukazaki T, Miyazaki Y, Matsumoto T. 1999. Transforming growth factor-beta stimulates articular chondrocyte cell growth through p44/42 MAP kinase (ERK) activation. Endocr J 46: 545-553.