Non-culturable bioaerosols in indoor settings: Impact on health and molecular approaches for detection

Atmospheric Environment

Volumn 110, Issue , 2015, Pages 45-53

  Blais Lecours, Pascale ^a   Perrott, Phillipa ^a   Duchaine, Caroline ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Archaea; Bacteria; Bioaerosols; Culturable microorganisms; Culture independent; Molecular methods; Risk assessment; Virus

Indexed keywords

AEROSOLS; AIR QUALITY; HEALTH; MICROBIOLOGY; MICROORGANISMS; RISK ASSESSMENT; VIRUSES;

ARCHAEA; BIOAEROSOLS; CULTURABLE MICROORGANISMS; CULTURE TECHNIQUES; DETECTION AND QUANTIFICATIONS; MICROBIAL BURDENS; MOLECULAR APPROACH; MOLECULAR METHODS;

BACTERIA;

AEROSOL; AGAR; AIR QUALITY; DETECTION METHOD; HEALTH IMPACT; INDOOR AIR; MOLECULAR ANALYSIS; PROKARYOTE; PUBLIC HEALTH; RISK ASSESSMENT; VIRUS;

AEROSOL; AIR QUALITY; AIRBORNE BACTERIUM; ARCHAEON; ARTICLE; ATYPICAL MYCOBACTERIUM; BACTERIUM DETECTION; BIOAEROSOL; HEALTH IMPACT ASSESSMENT; HUMAN; MICROORGANISM DETECTION; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; RISK ASSESSMENT; SEASONAL VARIATION; VIRUS;

BACTERIA (MICROORGANISMS);

EID: 84925444983     PISSN: 13522310     EISSN: 18732844     Source Type: Journal    
DOI: 10.1016/j.atmosenv.2015.03.039     Document Type: Article

References (166)

1. Abd-Elall A.M., Mohamed M.E., Awadallah M.A. Potential airborne microbial hazards for workers on dairy and beef cattle farms in Egypt. Vet. Ital. 2009, 45(2):275-285.
2. Adams R.I., Miletto M., Lindow S.E., Taylor J.W., Bruns T.D. Airborne bacterial communities in residences: similarities and differences with fungi. PLoS One 2014, 9(3):e91283.
3. Albrecht A., Witzenberger R., Bernzen U., Jackel U. Detection of airborne microbes in a composting facility by cultivation based and cultivation-independent methods. Ann. Agric. Environ. Med. 2007, 14(1):81-85.
4. Allers T., Mevarech M. Archaeal genetics - the third way. Nat. Rev. Genet. 2005, 6(1):58-73.
5. Alvarado C.S., Gandara A., Flores C., Perez H.R., Green C.F., Hurd W.W., Gibbs S.G. Seasonal changes in airborne fungi and bacteria at a dairy cattle concentrated animal feeding operation in the southwest United States. J.Environ. Health 2009, 71(9):40-44.
6. Alvarez A.J., Buttner M.P., Toranzos G.A., Dvorsky E.A., Toro A., Heikes T.B., Mertikas-Pifer L.E., Stetzenbach L.D. Use of solid-phase PCR for enhanced detection of airborne microorganisms. Appl. Environ. Microbiol. 1994, 60(1):374-376.
7. Amann R.I., Ludwig W., Schleifer K.H. Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol. Rev. 1995, 59(1):143-169.
8. ATS Respiratory Health Hazards in Agriculture. American Thoracic Society, Medical Section of the American Lung Association 1998.
9. Baker G.C., Smith J.J., Cowan D.A. Review and re-analysis of domain-specific 16S primers. J.Microbiol. Methods 2003, 55(3):541-555.
10. Bauer H., Fuerhacker M., Zibuschka F., Schmid H., Puxbaum H. Bacteria and fungi in aerosols generated by two different types of wastewater treatment plants. Water Res. 2002, 36(16):3965-3970.
11. Bettoncelli G., Blasi F., Brusasco V., Centanni S., Corrado A., De Benedetto F., De Michele F., Di Maria G.U., Donner C.F., Falcone F., Mereu C., Nardini S., Pasqua F., Polverino M., Rossi A., Sanguinetti C.M. The clinical and integrated management of COPD. An official document of AIMAR (Interdisciplinary Association for Research in Lung Disease), AIPO (Italian Association of Hospital Pulmonologists), SIMER (Italian Society of Respiratory Medicine), SIMG (Italian Society of General Medicine). Multidiscip. Respir. Med. 2014, 9(1):25.
12. Bholah R., Subratty A.H. Indoor biological contaminants and symptoms of sick building syndrome in office buildings in Mauritius. Int. J. Environ. Health Res. 2002, 12(1):93-98.
13. Blais Lecours P., Duchaine C., Taillefer M., Tremblay C., Veillette M., Cormier Y., Marsolais D. Immunogenic properties of archaeal species found in bioaerosols. PLoS One 2011, 6(8):e23326.
14. Blais Lecours P., Veillette M., Marsolais D., Cormier Y., Kirychuk S., Duchaine C. Archaea des bioaérosols de fermes laitières, de poulaillers et d'usines d'épuration des eaux usées : leur rÔle dans l'inflammation pulmonaire 2014, IRSST, R-827.
15. Blais Lecours P., Veillette M., Marsolais D., Duchaine C. Characterization of bioaerosols from dairy barns: reconstructing the puzzle of occupational respiratory diseases using molecular approaches. Appl. Environ. Microbiol. 2012, 78(9):3242-3248.
16. Bonetta S., Bonetta S., Mosso S., Sampo S., Carraro E. Assessment of microbiological indoor air quality in an Italian office building equipped with an HVAC system. Environ. Monit. Assess. 2010, 161(1-4):473-483.
17. Bonifait L., Veillette M., Letourneau V., Grenier D., Duchaine C. Detection of Streptococcus suis in bioaerosols of swine confinement buildings. Appl. Environ. Microbiol. 2014, 80(11):3296-3304.
18. Bouillard L., Michel O., Dramaix M., Devleeschouwer M. Bacterial contamination of indoor air, surfaces, and settled dust, and related dust endotoxin concentrations in healthy office buildings. Ann. Agric. Environ. Med. 2005, 12(2):187-192.
19. Bouillard L.A., Devleeschouwer M.J., Michel O. Characteristics of the home bacterial contamination and endotoxin related release. J.Pharm. Belg. 2006, 61(2):63-66.
20. Bridges C.B., Kuehnert M.J., Hall C.B. Transmission of influenza: implications for control in health care settings. Clin. Infect. Dis. 2003, 37(8):1094-1101.
21. Brochier-Armanet C., Forterre P., Gribaldo S. Phylogeny and evolution of the Archaea: one hundred genomes later. Curr. Opin. Microbiol. 2011, 14(3):274-281.
22. Bru-Adan V., Wery N., Moletta-Denat M., Boiron P., Delgenes J.P., Godon J.J. Diversity of bacteria and fungi in aerosols during screening in a green waste composting plant. Curr. Microbiol. 2009, 59(3):326-335.
23. Bunger J., Westphal G., Monnich A., Hinnendahl B., Hallier E., Muller M. Cytotoxicity of occupationally and environmentally relevant mycotoxins. Toxicology 2004, 202(3):199-211.
24. Carducci A., Federigi I., Verani M. Virus occupational exposure in solid waste processing facilities. Ann. Occup. Hyg. 2013, 57(9):1115-1127.
25. Cayer M.P., Veillette M., Pageau P., Hamelin R., Bergeron M.J., Meriaux A., Cormier Y., Duchaine C. Identification of mycobacteria in peat moss processing plants: application of molecular biology approaches. Can. J. Microbiol. 2007, 53(1):92-99.
26. Chalupka S. Control banding for risk management of source chemical agents and other occupational hazards. AAOHN J. Official J. Am. Assoc. Occup. Health Nurses 2010, 58(9):404.
27. Chang C.W., Chung H., Huang C.F., Su H.J. Exposure of workers to airborne microorganisms in open-air swine houses. Appl. Environ. Microbiol. 2001, 67(1):155-161.
28. Chen K., Pachter L. Bioinformatics for whole-genome shotgun sequencing of microbial communities. PLoS Comput Biol. 2005, 1(2):106-112.
29. Cohen H., White E.M. Metalworking fluid mist occupational exposure limits: a discussion of alternative methods. J.Occup. Environ. Hyg. 2006, 3(9):501-507.
30. Cormier Y., Assayag E., Tremblay G. Viral infection enhances lung response to Micropolyspora faeni. Am. J. Ind. Med. 1994, 25(1):79-80.
31. Cormier Y., Israel-Assayag E., Fournier M., Tremblay G.M. Modulation of experimental hypersensitivity pneumonitis by Sendai virus. J.Lab. Clin. Med. 1993, 121(5):683-688.
32. Corzo C.A., Culhane M., Dee S., Morrison R.B., Torremorell M. Airborne detection and quantification of swine influenza a virus in air samples collected inside, outside and downwind from swine barns. PLoS One 2013, 8(8):e71444.
33. Dakhama A., Hegele R.G., Laflamme G., Israel-Assayag E., Cormier Y. Common respiratory viruses in lower airways of patients with acute hypersensitivity pneumonitis. Am. J. Respir. Crit. Care Med. 1999, 159(4 Pt 1):1316-1322.
34. Dasaraju P.V., Liu C. Medical Microbiology 1996, Galveston (TX).
35. Dosman J.A., Fukushima Y., Senthilselvan A., Kirychuk S.P., Lawson J.A., Pahwa P., Cormier Y., Hurst T., Barber E.M., Rhodes C.S. Respiratory response to endotoxin and dust predicts evidence of inflammatory response in volunteers in a swine barn. Am. J. Ind. Med. 2006, 49(9):761-766.
36. Douwes J., Thorne P., Pearce N., Heederik D. Bioaerosol health effects and exposure assessment: progress and prospects. Ann. Occup. Hyg. 2003, 47(3):187-200.
37. Dridi B., Fardeau M.L., Ollivier B., Raoult D., Drancourt M. The antimicrobial resistance pattern of cultured human methanogens reflects the unique phylogenetic position of archaea. J.Antimicrob. Chemother. 2011, 66(9):2038-2044.
38. Duchaine C., Meriaux A., Brochu G., Cormier Y. Airborne microflora in Quebec dairy farms: lack of effect of bacterial hay preservatives. Am. Ind. Hyg. Assoc. J. 1999, 60(1):89-95.
39. Duchaine C., Meriaux A., Thorne P.S., Cormier Y. Assessment of particulates and bioaerosols in eastern Canadian sawmills. AIHAJ 2000, 61(5):727-732.
40. Dutil S., Meriaux A., de Latremoille M.C., Lazure L., Barbeau J., Duchaine C. Measurement of airborne bacteria and endotoxin generated during dental cleaning. J.Occup. Environ. Hyg. 2009, 6(2):121-130.
41. Dutil S., Veillette M., Meriaux A., Lazure L., Barbeau J., Duchaine C. Aerosolization of mycobacteria and legionellae during dental treatment: low exposure despite dental unit contamination. Environ. Microbiol. 2007, 9(11):2836-2843.
42. Dybwad M., Skogan G., Blatny J.M. Temporal variability of the bioaerosol background at a subway station: concentration level, size distribution and diversity of airborne bacteria. Appl. Environ. Microbiol. 2014, 80(1):257-270.
43. Eduard W. Exposure to non-infectious microorganisms and endotoxins in agriculture. Ann. Agric. Environ. Med. 1997, 4:179-186.
44. Eduard W., Heederik D. Methods for quantitative assessment of airborne levels of noninfectious microorganisms in highly contaminated work environments. Am. Ind. Hyg. Assoc. J. 1998, 59(2):113-127.
45. Eduard W., Heederik D., Duchaine C., Green B.J. Bioaerosol exposure assessment in the workplace: the past, present and recent advances. J.Environ. Monit. 2012, 14(2):334-339.
46. Falkinham J.O. Mycobacterial aerosols and respiratory disease. Emerg. Infect. Dis. 2003, 9(7):763-767.
47. Falkinham J.O. Surrounded by mycobacteria: nontuberculous mycobacteria in the human environment. J.Appl. Microbiol. 2009, 107(2):356-367.
48. Fallschissel K., Klug K., Kampfer P., Jackel U. Detection of airborne bacteria in a German turkey house by cultivation-based and molecular methods. Ann. Occup. Hyg. 2010, 54(8):934-943.
49. Fogelmark B., Lacey J., Rylander R. Experimental allergic alveolitis after exposure to different microorganisms. Int. J. Exp. Pathol. 1991, 72(4):387-395.
50. Forterre P., Brochier C., Philippe H. Evolution of the Archaea. Theor. Popul. Biol. 2002, 61(4):409-422.
51. Frankel M., Beko G., Timm M., Gustavsen S., Hansen E.W., Madsen A.M. Seasonal variations of indoor microbial exposures and their relation to temperature, relative humidity, and air exchange rate. Appl. Environ. Microbiol. 2012, 78(23):8289-8297.
52. Gandolfi I., Bertolini V., Ambrosini R., Bestetti G., Franzetti A. Unravelling the bacterial diversity in the atmosphere. Appl. Microbiol. Biotechnol. 2013, 97(11):4727-4736.
53. Gattinger A., Hofle M.G., Schloter M., Embacher A., Bohme F., Munch J.C., Labrenz M. Traditional cattle manure application determines abundance, diversity and activity of methanogenic Archaea in arable European soil. Environ. Microbiol. 2007, 9(3):612-624.
54. Gaüzère C., Godon J.J., Blanquart H., Stéphanie F., Moularat S., Robine E., Moletta-Denat M. 'Core species' in three sources of indoor air belonging to the human micro-environment to the exclusion of outdoor air. Sci. Total Environ. 2014, 485-486:508-517.
55. Gilbert Y., Veillette M., Duchaine C. Airborne bacteria and antibiotic resistance genes in hospital rooms. Aerobiologia 2010, 26(3):185-194.
56. Gilbert Y., Veillette M., Duchaine C. Metalworking fluids biodiversity characterization. J.Appl. Microbiol. 2010, 108(2):437-449.
57. Gilbert Y., Veillette M., Meriaux A., Lavoie J., Cormier Y., Duchaine C. Metalworking fluid-related aerosols in machining plants. J.Occup. Environ. Hyg. 2010, 7(5):280-289.
58. Girard M., Lacasse Y., Cormier Y. Hypersensitivity pneumonitis. Allergy 2009, 64(3):322-334.
59. Glazer C.S., Martyny J.W., Lee B., Sanchez T.L., Sells T.M., Newman L.S., Murphy J., Heifets L., Rose C.S. Nontuberculous mycobacteria in aerosol droplets and bulk water samples from therapy pools and hot tubs. J.Occup. Environ. Hyg. 2007, 4(11):831-840.
60. Golofit-Szymczak M., Gorny R.L. Bacterial and fungal aerosols in air-conditioned office buildings in Warsaw, Poland-the winter season. Int. J. Occup. Saf. Ergon. 2010, 16(4):465-476.
61. Gora A., Mackiewicz B., Krawczyk P., Golec M., Skorska C., Sitkowska J., Cholewa G., Larsson L., Jarosz M., Wojcik-Fatla A., Dutkiewicz J. Occupational exposure to organic dust, microorganisms, endotoxin and peptidoglycan among plants processing workers in Poland. Ann. Agric. Environ. Med. 2009, 16(1):143-150.
62. Gorny R.L. Filamentous microorganisms and their fragments in indoor air-a review. Ann. Agric. Environ. Med. 2004, 11(2):185-197.
63. Gorny R.L., Szponar B., Larsson L., Pehrson C., Prazmo Z., Dutkiewicz J. Metalworking fluid bioaerosols at selected workplaces in a steelworks. Am. J. Ind. Med. 2004, 46(4):400-403.
64. Goyer N., Lavoie J., Lazure L., Marchand G. Les bioaérosols en milieu de travail : guide d'évaluation, de contrÔle et de prévention 2001, IRSST.
65. Hall C.B. Respiratory syncytial virus and parainfluenza virus. N.Engl. J. Med. 2001, 344(25):1917-1928.
66. Hallier C., Williams D.W., Potts A.J., Lewis M.A. Apilot study of bioaerosol reduction using an air cleaning system during dental procedures. Br. Dent. J. 2010, 209(8):E14.
67. Harrison A.M., Bonville C.A., Rosenberg H.F., Domachowske J.B. Respiratory syncytical virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation. Am. J. Respir. Crit. Care Med. 1999, 159(6):1918-1924.
68. Hoffmann E., Stech J., Guan Y., Webster R.G., Perez D.R. Universal primer set for the full-length amplification of all influenza A viruses. Arch. Virol. 2001, 146(12):2275-2289.
69. Hong P.Y., Li X., Yang X., Shinkai T., Zhang Y., Wang X., Mackie R.I. Monitoring airborne biotic contaminants in the indoor environment of pig and poultry confinement buildings. Environ. Microbiol. 2012, 14(6):1420-1431.
70. Hubad B., Lapanje A. The efficient method for simultaneous monitoring of the culturable as well as nonculturable airborne microorganisms. PLoS One 2013, 8(12):e82186.
71. Huttunen K., Ruotsalainen M., Iivanainen E., Torkko P., Katila M., Hirvonen M. Inflammatory responses in RAW264.7 macrophages caused by mycobacteria isolated from moldy houses. Environ. Toxicol. Pharmacol. 2000, 8(4):237-244.
72. Jaakkola J.J., Heinonen O.P. Shared office space and the risk of the common cold. Eur. J. Epidemiol. 1995, 11(2):213-216.
73. Just N., Blais Lecours P., Marcoux-Voiselle M., Kirychuk S., Veillette M., Singh B., Duchaine C. Archaeal characterization of bioaerosols from cage-housed and floor-housed poultry operations. Can. J. Microbiol. 2013, 59(1):46-50.
74. Kandler O., Konig H. Cell wall polymers in Archaea (Archaebacteria). Cell. Mol. Life Sci. 1998, 54(4):305-308.
75. Kates M. Archaebacterial lipids: structure, biosynthesis and function. Biochem. Soc. Symp. 1992, 58:51-72.
76. Kaushik R., Balasubramanian R. Discrimination of viable from non-viable gram-negative bacterial pathogens in airborne particles using propidium monoazide-assisted qPCR. Sci. Total Environ. 2013, 449:237-243.
77. Khelaifia S., Raoult D., Drancourt M. Aversatile medium for cultivating methanogenic archaea. PLoS One 2013, 8(4):e61563.
78. Kim K.Y., Kim Y.S., Kim D., Kim H.T. Exposure level and distribution characteristics of airborne bacteria and fungi in Seoul metropolitan subway stations. Ind. Health 2011, 49(2):242-248.
79. Kirkhorn S.R., Garry V.F. Agricultural lung diseases. Environ. Health Perspect. 2000, 4(108 Suppl.l):705-712.
80. Kullman G.J., Thorne P.S., Waldron P.F., Marx J.J., Ault B., Lewis D.M., Siegel P.D., Olenchock S.A., Merchant J.A. Organic dust exposures from work in dairy barns. Am. Ind. Hyg. Assoc. J. 1998, 59(6):403-413.
81. Laitinen S., Kangas J., Kotimaa M., Liesivuori J., Martikainen P.J., Nevalainen A., Sarantila R., Husman K. Workers' exposure to airborne bacteria and endotoxins at industrial wastewater treatment plants. Am. Ind. Hyg. Assoc. J. 1994, 55(11):1055-1060.
82. Lavoie J., Neesham-Grenon E., Debia M., Cloutier Y., Marchand G. Development of a Control Banding Method for Selecting Respiratory Protection against Bioaerosols 2013, IRSST.
83. Lawniczek-Walczyk A., Gorny R.L., Golofit-Szymczak M., Niesler A., Wlazlo A. Occupational exposure to airborne microorganisms, endotoxins and beta-glucans in poultry houses at different stages of the production cycle. Ann. Agric. Environ. Med. 2013, 20(2):259-268.
84. Lee J.A., Johnson J.C., Reynolds S.J., Thorne P.S., O'Shaughnessy P.T. Indoor and outdoor air quality assessment of four wastewater treatment plants. J.Occup. Environ. Hyg. 2006, 3(1):36-43.
85. Lee S.A., Adhikari A., Grinshpun S.A., McKay R., Shukla R., Reponen T. Personal exposure to airborne dust and microorganisms in agricultural environments. J.Occup. Environ. Hyg. 2006, 3(3):118-130.
86. Lee S.A., Liao C.H. Size-selective assessment of agricultural workers' personal exposure to airborne fungi and fungal fragments. Sci. Total Environ. 2014, 466-467:725-732.
87. Leung M.H., Wilkins D., Li E.K., Kong F.K., Lee P.K. Diversity and dynamics of the indoor air microbiome in an urban subway network. Appl. Environ. Microbiol. AEM 2014, 02244-02214.
88. Li L., Han Y., Liu J. Assessing genetic structure, diversity of bacterial aerosol from aeration system in an oxidation ditch wastewater treatment plant by culture methods and bio-molecular tools. Environ. Monit. Assess. 2013, 185(1):603-613.
89. Lignell U., Meklin T., Putus T., Vepsalainen A., Roponen M., Torvinen E., Reeslev M., Pennanen S., Hirvonen M.R., Kalliokoski P., Nevalainen A. Microbial exposure, symptoms and inflammatory mediators in nasal lavage fluid of kitchen and clerical personnel in schools. Int. J. Occup. Med. Environ. Health 2005, 18(2):139-150.
90. Linaker C., Smedley J. Respiratory illness in agricultural workers. Occup. Med. (Lond) 2002, 52(8):451-459.
91. Lis D.O., Ulfig K., Wlazlo A., Pastuszka J.S. Microbial air quality in offices at municipal landfills. J.Occup. Environ. Hyg. 2004, 1(2):62-68.
92. LoBue P.A., Enarson D.A., Thoen T.C. Tuberculosis in humans and its epidemiology, diagnosis and treatment in the United States. Int. J. Tuberc. Lung Dis. 2010, 14(10):1226-1232.
93. Lopardo G., Calmaggi A., Clara L., Levy Hara G., Mykietiuk A., Pryluka D., Ruvinsky S., Vujacich C., Yahni D., Bogdanowicz E., Klein M., Lopez Furst M.J., Pensotti C., Rial M.J., Scapellato P., Sociedad Argentina de I., Sociedad Argentina de P., Sociedad Argentina de and M.y.P.C M., Sociedad Argentina de Bacteriologia Consensus guidelines for the management of upper respiratory tract infections. Med. (B Aires) 2012, 72(6):484-494.
94. Louie J.K., Hacker J.K., Gonzales R., Mark J., Maselli J.H., Yagi S., Drew W.L. Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season. Clin. Infect. Dis. 2005, 41(6):822-828.
95. Maher-Sturgess S.L., Forrester N.L., Wayper P.J., Gould E.A., Hall R.A., Barnard R.T., Gibbs M.J. Universal primers that amplify RNA from all three flavivirus subgroups. Virol. J. 2008, 5:16.
96. Maron P.-A., Lejon D.P.H., Carvalho E., Bizet K., Lemanceau P., Ranjard L., Mougel C. Assessing genetic structure and diversity of airborne bacterial communities by DNA fingerprinting and 16S rDNA clone library. Atmos. Environ. 2005, 39(20):3687-3695.
97. Marras T.K., Wallace R.J., Koth L.L., Stulbarg M.S., Cowl C.T., Daley C.L. Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water. Chest 2005, 127(2):664-671.
98. Martin E., Jackel U. Characterization of bacterial contaminants in the air of a duck hatchery by cultivation based and molecular methods. J.Environ. Monit. 2011, 13(2):464-470.
99. Masclaux F.G., Hotz P., Gashi D., Savova-Bianchi D., Oppliger A. Assessment of airborne virus contamination in wastewater treatment plants. Environ. Res. 2014, 133:260-265.
100. Masclaux F.G., Sakwinska O., Charriere N., Semaani E., Oppliger A. Concentration of airborne Staphylococcus aureus (MRSA and MSSA), total bacteria, and endotoxins in pig farms. Ann. Occup. Hyg. 2013, 57(5):550-557.
101. Matouskova I., Holy O. Bacterial contamination of the indoor air in a transplant unit. Epidemiol. Mikrobiol. Imunol. 2013, 62(4):153-159.
102. May S., Romberger D.J., Poole J.A. Respiratory health effects of large animal farming environments. J.Toxicol. Environ. Health B Crit. Rev. 2012, 15(8):524-541.
103. Meadow J., Altrichter A., Kembel S., Kline J., Mhuireach G., Moriyama M., Northcutt D., O'Connor T., Womack A., Brown G. Indoor airborne bacterial communities are influenced by ventilation, occupancy, and outdoor air source. Indoor Air 2014, 24(1):41-48.
104. Mentese S., Rad A.Y., Arisoy M., Gullu G. Multiple comparisons of organic, microbial, and fine particulate pollutants in typical indoor environments: diurnal and seasonal variations. J.Air Waste Manag. Assoc. 2012, 62(12):1380-1393.
105. Meriaux A., Cormier Y., Pageau P., Israel-Assayag E., Duchaine C. Sensitization to airborne molds and its health effects in peat moss processing plant workers. J.Occup. Environ. Hyg. 2006, 3(8):442-447.
106. Meriaux A., Pageau P., Cormier Y., Goyer N., Duchaine C. Bioaerosols in peat moss processing plants. J.Occup. Environ. Hyg. 2006, 3(8):408-417.
107. Morgan J.L., Darling A.E., Eisen J.A. Metagenomic sequencing of an invitro-simulated microbial community. PLoS One 2010, 5(4):e10209.
108. Mukoda T., Todd L.A., Sobsey M.D. PCR and gene probes for detecting bioaerosols. J.Aerosol Sci. 1994, 25(8):1523-1532.
109. Myatt T.A., Johnston S.L., Zuo Z., Wand M., Kebadze T., Rudnick S., Milton D.K. Detection of airborne rhinovirus and its relation to outdoor air supply in office environments. Am. J. Respir. Crit. Care Med. 2004, 169(11):1187-1190.
110. National Institute for Occupational Safety and Health Respiratory Disease in Agricultural Workers: Mortality and Morbidity Statistics 2007.
111. Nehme B., Gilbert Y., Letourneau V., Forster R.J., Veillette M., Villemur R., Duchaine C. Culture-independent characterization of archaeal biodiversity in swine confinement building bioaerosols. Appl. Environ. Microbiol. 2009, 75(17):5445-5450.
112. Nehme B., Letourneau V., Forster R.J., Veillette M., Duchaine C. Culture-independent approach of the bacterial bioaerosol diversity in the standard swine confinement buildings, and assessment of the seasonal effect. Environ. Microbiol. 2008, 10(3):665-675.
113. Nguyen T.M., Ilef D., Jarraud S., Rouil L., Campese C., Che D., Haeghebaert S., Ganiayre F., Marcel F., Etienne J., Desenclos J.C. Acommunity-wide outbreak of legionnaires disease linked to industrial cooling towers-how far can contaminated aerosols spread?. J.Infect. Dis. 2006, 193(1):102-111.
114. Nocker A., Cheung C.Y., Camper A.K. Comparison of propidium monoazide with ethidium monoazide for differentiation of live vs. dead bacteria by selective removal of DNA from dead cells. J.Microbiol. Methods 2006, 67(2):310-320.
115. Nonnenmann M.W., Bextine B., Dowd S.E., Gilmore K., Levin J.L. Culture-independent characterization of bacteria and fungi in a poultry bioaerosol using pyrosequencing: a new approach. J.Occup. Environ. Hyg. 2010, 7(12):693-699.
116. Nottingham P.M., Hungate R.E. Isolation of methanogenic bacteria from feces of man. J.Bacteriol. 1968, 96(6):2178-2179.
117. O'Connor D.J., Healy D.A., Sodeau J.R. The on-line detection of biological particle emissions from selected agricultural using the WISB-4 (Waveband integrated Bioaerosol Sensor) technique. Atmos. Environ. 2013, 80:415-425.
118. Oppliger A., Charriere N., Droz P.O., Rinsoz T. Exposure to bioaerosols in poultry houses at different stages of fattening; use of real-time PCR for airborne bacterial quantification. Ann. Occup. Hyg. 2008, 52(5):405-412.
119. Oppliger A., Masclaux F.G., Niculita-Hirzel H. Assessment of airborne microorganisms by real-time PCR: optimistic findings and research challenges. Front. Biosci. Sch. Ed. 2011, 3:445-453.
120. Park D.U., Yeom J.K., Lee W.J., Lee K.M. Assessment of the levels of airborne bacteria, Gram-negative bacteria, and fungi in hospital lobbies. Int. J. Environ. Res. Public Health 2013, 10(2):541-555.
121. Park H., Park H., Lee I. Microbial exposure assessment in sawmill, livestock feed industry, and metal working fluids handling industry. Saf. Health Work 2010, 1(2):183-191.
122. Parshionikar S., Laseke I., Fout G.S. Use of propidium monoazide in reverse transcriptase PCR to distinguish between infectious and noninfectious enteric viruses in water samples. Appl. Environ. Microbiol. 2010, 76(13):4318-4326.
123. Peccia J., Hernandez M. Incorporating polymerase chain reaction-based identification, population characterization, and quantification of microorganisms into aerosol science: a review. Atmos. Environ. 2006, 40(21):3941-3961.
124. Perrott P., Smith G., Ristovski Z., Harding R., Hargreaves M. Anested real-time PCR assay has an increased sensitivity suitable for detection of viruses in aerosol studies. J.Appl. Microbiol. 2009, 106(5):1438-1447.
125. Pester M., Schleper C., Wagner M. The Thaumarchaeota: an emerging view of their phylogeny and ecophysiology. Curr. Opin. Microbiol. 2011, 14(3):300-306.
126. Poole J.A., Romberger D.J. Immunological and inflammatory responses to organic dust in agriculture. Curr. Opin. Allergy Clin. Immunol. 2012, 12(2):126-132.
127. Prussin A.J., Marr L.C., Bibby K.J. Challenges of studying viral aerosol metagenomics and communities in comparison with bacterial and fungal aerosols. FEMS Microbiol. Lett. 2014, 357(1):1-9.
128. Reynolds S.J., Black D.W., Borin S.S., Breuer G., Burmeister L.F., Fuortes L.J., Smith T.F., Stein M.A., Subramanian P., Thorne P.S., Whitten P. Indoor environmental quality in six commercial office buildings in the midwest United States. Appl. Occup. Environ. Hyg. 2001, 16(11):1065-1077.
129. Reynolds S.J., Nonnenmann M.W., Basinas I., Davidson M., Elfman L., Gordon J., Kirychuck S., Reed S., Schaeffer J.W., Schenker M.B., Schlunssen V., Sigsgaard T. Systematic review of respiratory health among dairy workers. J.Agromedicine 2013, 18(3):219-243.
130. Roy C.J., Milton D.K. Airborne transmission of communicable infection-the elusive pathway. N.Engl. J. Med. 2004, 350(17):1710-1712.
131. Roy C.J., Reed D.S. Infectious disease aerobiology: miasma incarnate. Front. Cell. Infect. Microbiol. 2012, 2:163.
132. Rylander R., Carvalheiro M.F. Airways inflammation among workers in poultry houses. Int. Arch. Occup. Environ. Health 2006, 79(6):487-490.
133. Sahlander K., Larsson K., Palmberg L. Daily exposure to dust alters innate immunity. PLoS One 2012, 7(2):e31646.
134. Schafer M.P., Fernback J.E., Ernst M.K. Detection and characterization of airborne Mycobacterium tuberculosis H37Ra particles, a surrogate for airborne pathogenic M-tuberculosis. Aerosol Sci. Technol. 1999, 30(2):161-173.
135. Schleper C., Jurgens G., Jonuscheit M. Genomic studies of uncultivated archaea. Nat. Rev. Microbiol. 2005, 3(6):479-488.
136. Sessa R., Di P.M., Schiavoni G., Santino I., Altieri A., Pinelli S., Del P.M. Microbiological indoor air quality in healthy buildings. New. Microbiol. 2002, 25(1):51-56.
137. Sferrazza Papa G.F., Pellegrino G.M., Pellegrino R. Asthma and respiratory physiology: putting lung function into perspective. Respirology 2014, 19(7):960-969.
138. Shade A., Hogan C.S., Klimowicz A.K., Linske M., McManus P.S., Handelsman J. Culturing captures members of the soil rare biosphere. Environ. Microbiol. 2012, 14(9):2247-2252.
139. Shahan T.A., Sorenson W.G., Lewis D.M. Superoxide anion production in response to bacterial lipopolysaccharide and fungal spores implicated in organic dust toxic syndrome. Environ. Res. 1994, 67(1):98-107.
140. Shelton B.G., Flanders W.D., Morris G.K. Mycobacterium sp. as a possible cause of hypersensitivity pneumonitis in machine workers. Emerg. Infect. Dis. 1999, 5(2):270-273.
141. Simon X., Duquenne P. Assessment of workers' exposure to bioaerosols in a French cheese factory. Ann. Occup. Hyg. 2014, 58(6):677-692.
142. Snell-Castro R., Godon J.J., Delgenes J.P., Dabert P. Characterisation of the microbial diversity in a pig manure storage pit using small subunit rDNA sequence analysis. FEMS Microbiol. Ecol. 2005, 52(2):229-242.
143. Sprott G.D., Patel G.B., Krishnan L. Archaeobacterial ether lipid liposomes as vaccine adjuvants. Methods Enzymol. 2003, 373:155-172.
144. Suzuki M.T., Giovannoni S.J. Bias caused by template annealing in the amplification of mixtures of 16S rRNA genes by PCR. Appl. Environ. Microbiol. 1996, 62(2):625-630.
145. Takemura T., Akashi T., Ohtani Y., Inase N., Yoshizawa Y. Pathology of hypersensitivity pneumonitis. Curr. Opin. Pulm. Med. 2008, 14(5):440-454.
146. Tham K.W., Zuraimi M.S. Size relationship between airborne viable bacteria and particles in a controlled indoor environment study. Indoor Air 2005, 9(15 Suppl.l):48-57.
147. Thorne P.S., Adamcakova-Dodd A., Kelly K.M., O'Neill M.E., Duchaine C. Metalworking fluid with mycobacteria and endotoxin induces hypersensitivity pneumonitis in mice. Am. J. Respir. Crit. Care Med. 2006, 173(7):759-768.
148. Tringe S.G., Zhang T., Liu X., Yu Y., Lee W.H., Yap J., Yao F., Suan S.T., Ing S.K., Haynes M., Rohwer F., Wei C.L., Tan P., Bristow J., Rubin E.M., Ruan Y. The airborne metagenome in an indoor urban environment. PLoS One 2008, 3(4):e1862.
149. Tsai F.C., Macher J.M. Concentrations of airborne culturable bacteria in 100 large US office buildings from the BASE study. Indoor Air 2005, 9(15 Suppl.l):71-81.
150. Turgeon N., McNicoll F., Toulouse M., Liav A., Barbeau J., Ho J., Grund C., Duchaine C. Neuraminidase activity as a potential enzymatic marker for rapid detection of airborne viruses. Aerosol Sci. Technol. 2011, 45(2):183-195.
151. Vadrot C., Bex V., Mouilleseaux A., Squinazi F., Darbord J.C. Detection of Mycobacterium tuberculosis complex by PCR in hospital air samples. J.Hosp. Infect. 2004, 58(4):262-267.
152. van Kampen V., Deckert A., Hoffmeyer F., Taeger D., Brinkmann E., Bruning T., Raulf-Heimsoth M., Bunger J. Symptoms, spirometry, and serum antibody concentrations among compost workers exposed to organic dust. J.Toxicol. Environ. Health A 2012, 75(8-10):492-500.
153. Veillette M., Page G., Thorne P.S., Duchaine C. Real-time PCR quantification of Mycobacterium immunogenum in used metalworking fluids. J.Occup. Environ. Hyg. 2008, 5(12):755-760.
154. Veillette M., Thorne P.S., Gordon T., Duchaine C. Six month tracking of microbial growth in a metalworking fluid after system cleaning and recharging. Ann. Occup. Hyg. 2004, 48(6):541-546.
155. Verreault D., Gendron L., Rousseau G.M., Veillette M., Masse D., Lindsley W.G., Moineau S., Duchaine C. Detection of airborne lactococcal bacteriophages in cheese manufacturing plants. Appl. Environ. Microbiol. 2011, 77(2):491-497.
156. Verreault D., Letourneau V., Gendron L., Masse D., Gagnon C.A., Duchaine C. Airborne porcine circovirus in Canadian swine confinement buildings. Vet. Microbiol. 2010, 141(3-4):224-230.
157. Vesper S., McKinstry C., Hartmann C., Neace M., Yoder S., Vesper A. Quantifying fungal viability in air and water samples using quantitative PCR after treatment with propidium monoazide (PMA). J.Microbiol. Methods 2008, 72(2):180-184.
158. Wang-Li L., Li Q., Byfield G.E. Identification of bioaerosols released from an egg production facility in the Southeast United States. Environ. Eng. Sci. 2013, 30(1):2-10.
159. Whitehead T.R., Cotta M.A. Phylogenetic diversity of methanogenic archaea in swine waste storage pits. FEMS Microbiol. Lett. 1999, 179(2):223-226.
160. Woese C.R., Kandler O., Wheelis M.L. Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. Proc. Natl. Acad. Sci. U. S. A. 1990, 87(12):4576-4579.
161. Wolfe R.S. Techniques for cultivating methanogens. Methods Enzymol. 2011, 494:1-22.
162. Zalk D.M., Heussen G.H. Banding the world together; the global growth of control banding and qualitative occupational risk management. Saf. Health Work 2011, 2(4):375-379.
163. Zejda J.E., Barber E., Dosman J.A., Olenchock S.A., McDuffie H.H., Rhodes C., Hurst T. Respiratory health status in swine producers relates to endotoxin exposure in the presence of low dust levels. J.Occup. Med. 1994, 36(1):49-56.
164. Zhang F., Turgeon N., Toulouse M., Duchaine C., Li D. Asimple and rapid fluorescent neuraminidase enzymatic assay on a microfluidic chip. Diagn. Microbiol. Infect. Dis. 2012, 74(3):263-266.
165. Zhiping W., Malmberg P., Larsson B.M., Larsson K., Larsson L., Saraf A. Exposure to bacteria in swine-house dust and acute inflammatory reactions in humans. Am. J. Respir. Crit. Care Med. 1996, 154(5):1261-1266.
166. Zukiewicz-Sobczak W.A. The role of fungi in allergic diseases. Postepy Dermatol Alergol. 2013, 30(1):42-45.