Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 48, 2013, Pages 19615-19620

  Gong, Bin ^a   Shelite, Thomas ^a   Mei, Fang C ^a   Ha, Tuha ^a   Hu, Yaohua ^a   Xu, Guang ^a   Chang, Qing ^a   Wakamiya, Maki ^a   Ksiazek, Thomas G ^a   Boor, Paul J ^a   Bouyer, Donald H ^a   Popov, Vsevolod L ^a   Chen, Ju ^b   Walker, David H ^a   Cheng, Xiaodong ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Cyclic AMP; Epac inhibitor; Prophylaxis; Rickettsial infection; Therapeutics

Indexed keywords

ANTIPORTER; CYCLIC AMP; CYCLIC AMP RECEPTOR; ESI 09; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP PROTEIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ADHERENCE; CELL INVASION; CONTROLLED STUDY; ENDOTHELIUM CELL; FATALITY; GENE DELETION; GENE EXPRESSION; HOST CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; KNOCKOUT GENE; MALE; MOLECULAR PATHOLOGY; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RICKETTSIOSIS;

CYCLIC AMP; EPAC INHIBITOR; PROPHYLAXIS; RICKETTSIAL INFECTION; THERAPEUTICS;

ANIMALS; BACTERIAL ADHESION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HOST-PATHOGEN INTERACTIONS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDRAZONES; IMMUNOHISTOCHEMISTRY; ISOXAZOLES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RICKETTSIA INFECTIONS; SIGNAL TRANSDUCTION;

EID: 84888309422     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314400110     Document Type: Article

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