Subnormothermic machine perfusion for preservation of porcine kidneys in a donation after circulatory death model

Transplant International

Volumn 27, Issue 10, 2014, Pages 1097-1106

  Hoyer, Dieter P ^a   Gallinat, Anja ^a   Swoboda, Sandra ^a   Wohlschläger, Jeremias ^a   Rauen, Ursula ^a   Paul, Andreas ^a   Minor, Thomas ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

donation after circulatory death; kidney; machine perfusion; subnormothermia; temperature

Indexed keywords

BETA ACTIN; CASPASE 3; CREATININE; SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CIRCULATORY DEATH; CONTROLLED STUDY; CREATININE CLEARANCE; CRYOPRESERVATION; DEATH; EXPERIMENTAL PIG; FEMALE; IN VITRO STUDY; INTERMETHOD COMPARISON; ISCHEMIA; ISOLATED KIDNEY; KIDNEY BLOOD FLOW; KIDNEY CELL; KIDNEY FUNCTION; KIDNEY PERFUSION; KIDNEY PRESERVATION; KIDNEY TRANSPLANTATION; NONHUMAN; OXYGEN CONSUMPTION; OXYGENATED HYPOTHERMIC MACHINE PERFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM EXCRETION; SUBNORMOTHERMIC MACHINE PERFUSION; URINARY EXCRETION; URINE VOLUME; UROLOGICAL PROCEDURE; ANIMAL; DISEASE MODEL; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; KIDNEY; ORGAN PRESERVATION; PATHOLOGY; PERFUSION; PIG; POSTMORTEM CHANGE; PROCEDURES; RANDOMIZATION; SENSITIVITY AND SPECIFICITY; SHOCK; SURGERY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CRYOPRESERVATION; DISEASE MODELS, ANIMAL; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TRANSPLANTATION; ORGAN PRESERVATION; PERFUSION; POSTMORTEM CHANGES; RANDOM ALLOCATION; SENSITIVITY AND SPECIFICITY; SHOCK; SWINE;

EID: 84925388140     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12389     Document Type: Article

References (56)

1. Gallinat A, Moers C, Treckmann J, et al,. Machine perfusion versus cold storage for the preservation of kidneys from donors ≥ 65 years allocated in the eurotransplant senior programme. Nephrol Dial Transplant 2012; 27: 4458.
2. Gallinat A, Moers C, Smits JM, et al,. Machine perfusion versus static cold storage in expanded criteria donor kidney transplantation: 3-year follow-up data. Transpl Int 2013; 26: E52.
3. Treckmann J, Moers C, Smits JM, et al,. Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death. Transpl Int 2011; 24: 548.
4. Kwiatkowski A, Wszoła M, Kosieradzki M, et al,. The early and long term function and survival of kidney allografts stored before transplantation by hypothermic pulsatile perfusion. A prospective randomized study. Ann Transplant 2009; 14: 14.
5. O'Callaghan JM, Morgan RD, Knight SR, Morris PJ,. Systematic review and meta-analysis of hypothermic machine perfusion versus static cold storage of kidney allografts on transplant outcomes. Br J Surg 2013; 100: 991.
6. Moers C, Smits JM, Maathuis M-HJ, et al,. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009; 360: 7.
7. Kwiatkowski A, Wszola M, Kosieradzki M, et al,. Machine perfusion preservation improves renal allograft survival. Am J Transplant 2007; 7: 1942.
8. Jochmans I, Moers C, Smits JM, et al,. Machine perfusion versus cold storage for the preservation of kidneys donated after cardiac death: a multicenter, randomized, controlled trial. Ann Surg 2010; 252: 756.
9. Matas AJ, Smith JM, Lamb KE, et al,. OPTN/SRTR 2011 Annual data report: kidney. Am J Transplant 2013; 13 (Suppl. 1): 11.
10. Salahudeen AK,. Cold ischemic injury of transplanted kidneys: new insights from experimental studies. Am J Physiol Renal Physiol 2004; 287: F181.
11. Rauen U, de Groot H,. Mammalian cell injury induced by hypothermia-the emerging role for reactive oxygen species. Biol Chem 2002; 383: 477.
12. Rauen U, Polzar B, Stephan H, Mannherz HG, de Groot H,. Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. FASEB J 1999; 13: 155.
13. Rauen U, Kerkweg U, Weisheit D, Petrat F, Sustmann R, de Groot H,. Cold-induced apoptosis of hepatocytes: mitochondrial permeability transition triggered by nonmitochondrial chelatable iron. Free Radic Biol Med 2003; 35: 1664.
14. Bartels-Stringer M, Kramers C, Wetzels JFM, Russel FGM, de Groot H, Rauen U,. Hypothermia causes a marked injury to rat proximal tubular cells that is aggravated by all currently used preservation solutions. Cryobiology 2003; 47: 82.
15. Rauen U, de Groot H,. New insights into the cellular and molecular mechanisms of cold storage injury. J Investig Med 2004; 52: 299.
16. Suzuki S, Bing H, Sugawara T, et al,. Paclitaxel prevents loss of pulmonary endothelial barrier integrity during cold preservation. Transplantation 2004; 78: 524.
17. Hall SM, Komai H, Reader J, Haworth SG,. Donor lung preservation: effect of cold preservation fluids on cultured pulmonary endothelial cells. Am J Physiol 1994; 267 (5 Pt 1): L508.
18. Mangino MJ, Tian T, Ametani M, Lindell S, Southard JH,. Cytoskeletal involvement in hypothermic renal preservation injury. Transplantation 2008; 85: 427.
19. Stefanovich P, Ezzell RM, Sheehan SJ, Tompkins RG, Yarmush ML, Toner M,. Effects of hypothermia on the function, membrane integrity, and cytoskeletal structure of hepatocytes. Cryobiology 1995; 32: 389.
20. Kosieradzki M, Rowiński W,. Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention. Transpl Proc 2008; 40: 3279.
21. Lien Y-HH, Lai L-W, Silva AL,. Pathogenesis of renal ischemia/reperfusion injury: lessons from knockout mice. Life Sci 2003; 74: 543.
22. Donnahoo KK, Shames BD, Harken AH, Meldrum DR,. Review article: the role of tumor necrosis factor in renal ischemia-reperfusion injury. J Urol 1999; 162: 196.
23. Gallinat A, Lüer B, Swoboda S, Rauen U, Paul A, Minor T,. Use of the new preservation solution Custodiol-N supplemented with dextran for hypothermic machine perfusion of the kidney. Cryobiology 2013; 66: 131.
24. Pizanis N, Petrov A, Heckmann J, et al,. A new preservation solution for lung transplantation: evaluation in a porcine transplantation model. J Heart Lung Transplant 2012; 31: 310.
25. Scherberich J, Mondorf W,. Excretion of kidney brush border antigens as a quantitative indicator of tubular damage. Curr Probl Clin Biochem 1979; 9: 281.
26. Wolf G, Scherberich J, Schoeppe W,. Peptidase-associated antigens as markers of differentiation in human kidney and renal adenocarcinoma. Cell Mol Biol 1988; 34: 311.
27. Torras J, Herrero-Fresneda I, Lloberas N, Riera M, Ma Cruzado J, Ma Grinyõ J,. Promising effects of ischemic preconditioning in renal transplantation. Kidney Int 2002; 61: 2218.
28. Meyer M, Schillinger W, Pieske B, et al,. Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation 1995; 92: 778.
29. 2+, adenine nucleotide, and calmodulin. J Biol Chem 1987; 262: 3065.
30. Thuillier R, Allain G, Celhay O, et al,. Benefits of active oxygenation during hypothermic machine perfusion of kidneys in a preclinical model of deceased after cardiac death donors. J Surg Res 2013; 184: 1174.
31. Doorschodt BM, Schreinemachers MCJM, Behbahani M, et al,. Hypothermic machine perfusion of kidney grafts: which pressure is preferred? Ann Biomed Eng 2011; 39: 1051.
32. Liu Q, Bruns H, Schultze D, et al,. HTK-N, a modified HTK solution, decreases preservation injury in a model of microsteatotic rat liver transplantation. Langenbecks Arch Surg 2012; 397: 1323.
33. Pizanis N, Gillner S, Kamler M, de Groot H, Jakob H, Rauen U,. Cold-induced injury to lung epithelial cells can be inhibited by iron chelators-implications for lung preservation. Eur J Cardiothorac Surg 2011; 40: 948.
34. Wille T, de Groot H, Rauen U,. Improvement of the cold storage of blood vessels with a vascular preservation solution. Study in porcine aortic segments. J Vasc Surg 2008; 47: 422.
35. Stegemann J, Hirner A, Rauen U, Minor T,. Use of a new modified HTK solution for machine preservation of marginal liver grafts. J Surg Res 2010; 160: 155.
36. Rauen U, de Groot H,. Inherent toxicity of organ preservation solutions to cultured hepatocytes. Cryobiology 2008; 56: 88.
37. Rauen U, Klempt S, de Groot H,. Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelators. Cell Mol Life Sci 2007; 64: 192.
38. Wu K, Türk TR, Rauen U, et al,. Prolonged cold storage using a new histidine-tryptophan-ketoglutarate-based preservation solution in isogeneic cardiac mouse grafts. Eur Heart J 2011; 32: 509.
39. Gill J, Dong J, Eng M, Landsberg D, Gill JS,. Pulsatile perfusion reduces the risk of delayed graft function in deceased donor kidney transplants, irrespective of donor type and cold ischemic time. Transplantation 2014; 97: 668.
40. De Vries EE, Hoogland ERP, Winkens B, Snoeijs MG, van Heurn LWE,. Renovascular resistance of machine-perfused DCD kidneys is associated with primary nonfunction. Am J Transplant 2011; 11: 2685.
41. Jochmans I, Moers C, Smits JM, et al,. The prognostic value of renal resistance during hypothermic machine perfusion of deceased donor kidneys. Am J Transplant 2011; 11: 2214.
42. Guarrera JV, Goldstein MJ, Samstein B, et al,. "When good kidneys pump badly": outcomes of deceased donor renal allografts with poor pulsatile perfusion characteristics. Transpl Int 2010; 23: 444.
43. Karhumäki P, Tiitinen SL, Turpeinen H, Parkkinen J,. Inhibition of ERK1/2 activation by phenolic antioxidants protects kidney tubular cells during cold storage. Transplantation 2007; 83: 948.
44. Olschewski P, Gass P, Ariyakhagorn V, et al,. The influence of storage temperature during machine perfusion on preservation quality of marginal donor livers. Cryobiology 2010; 60: 337.
45. Tolboom H, Izamis M-L, Sharma N, et al,. Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation. J Surg Res 2012; 175: 149.
46. Minor T, Efferz P, Fox M, Wohlschlaeger J, Lüer B,. Controlled oxygenated rewarming of cold stored liver grafts by thermally graduated machine perfusion prior to reperfusion. Am J Transplant 2013; 13: 1450.
47. Hessheimer AJ, Fondevila C, García-Valdecasas JC,. Extracorporeal machine liver perfusion: are we warming up? Curr Opin Organ Transplant 2012; 18: 143.
48. Fondevila C, Hessheime AJ, Maathuis M-HJ, et al,. Hypothermic oxygenated machine perfusion in porcine donation after circulatory determination of death liver transplant. Transplantation 2012; 94: 22.
49. Minor T, Sitzia M, Dombrowski F,. Kidney transplantation from non-heart-beating donors after oxygenated low-flow machine perfusion preservation with histidine-tryptophan-ketoglutarate solution. Transpl Int 2005; 17: 707.
50. McAnulty JF, Huang XQ,. The effect of simple hypothermic preservation with trolox and ascorbate on lipid peroxidation in dog kidneys. Cryobiology 1996; 33: 217.
51. Gallinat A, Fox M, Lüer B, Efferz P, Paul A, Minor T,. Role of pulsatility in hypothermic reconditioning of porcine kidney grafts by machine perfusion after cold storage. Transplantation 2013; 96: 538.
52. Gores GJ, Nieminen AL, Wray BE, Herman B, Lemasters JJ,. Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death. J Clin Invest 1989; 83: 386.
53. Gores GJ, Nieminen AL, Fleishman KE, Dawson TL, Herman B, Lemasters JJ,. Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes. Am J Physiol 1988; 255 (3 Pt 1): C315.
54. Daemen M, de Vries B, Buurman WA,. Apoptosis and inflammation in renal reperfusion injury. Transplantation 2002; 73: 1693.
55. Daemen M, van de Ven MW, Heineman E, Buurman WA,. Involvement of endogenous interleukin-10 and tumor necrosis factor-alpha in renal ischemia-reperfusion injury. Transplantation 1999; 67: 792.
56. Sadis C, Teske G, Stokman G, et al,. Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway. PLoS ONE 2007; 2: e469.