Cold-induced injury to lung epithelial cells can be inhibited by iron chelators - implications for lung preservation

European Journal of Cardio-thoracic Surgery

Volumn 40, Issue 4, 2011, Pages 948-955

  Pizanis, Nikolaus ^a   Gillner, Sebastian ^a   Kamler, Markus ^a   de Groot, Herbert ^a   Jakob, Heinz ^a   Rauen, Ursula ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Hypothermic storage; Iron chelator; Lung transplantation; Oxidative cell injury; Preservation solution

Indexed keywords

2,2' BIPYRIDINE; CELSIOR; DEFEROXAMINE MESYLATE; HTK SOLUTION; IRON CHELATING AGENT; LACTATE DEHYDROGENASE; LK 614; LOW POTASSIUM DEXTRAN; PRESERVATION SOLUTION; UNCLASSIFIED DRUG;

ARTICLE; CELL DAMAGE; CELL METABOLISM; CELL PROTECTION; COLD INJURY; CONTROLLED STUDY; CRYOPRESERVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IRON CHELATION; LIPID PEROXIDATION; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; WARMING;

2,2'-DIPYRIDYL; CELL DEATH; COLD TEMPERATURE; DEFEROXAMINE; EPITHELIAL CELLS; HUMANS; IRON CHELATING AGENTS; LIPID PEROXIDATION; LUNG; MICROSCOPY, PHASE-CONTRAST; ORGAN PRESERVATION; ORGAN PRESERVATION SOLUTIONS; REWARMING; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 80052962696     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1016/j.ejcts.2011.01.052     Document Type: Article

References (25)

1. Fisher A.B., Dodia C., Ayene I., al-Mehdi A. Ischemia-reperfusion injury to the lung. Ann NY Acad Sci 1994, 723:197-207.
2. Naka Y., Roy D.K., Smerling A.J., Michler R.E., Smith C.R., Stern D.M., Oz M.C., Pinsky D.J. Inhaled nitric oxide fails to confer the pulmonary protection provided by distal stimulation of the nitric oxide pathway at the level of cyclic guanosine monophosphate. J Thorac Cardiovasc Surg 1995, 110(5):1434-1440.
3. Fehrenbach H., Schepelmann D., Albes J.M., Bando T., Fischer F., Fehrenbach A., Stolte N., Wahlers T., Richter J. Pulmonary ischemia/reperfusion injury: a quantitative study of structure and function in isolated heart-lungs of the rat. Anat Rec 1999, 255(1):84-89.
4. Moore T.M., Khimenko P.L., Taylor A.E. Restoration of normal pH triggers ischemia-reperfusion injury in lung by Na+/H+ exchange activation. Am J Physiol 1995, 269(4 Pt 2):1501-1505.
5. Rauen U., de Groot H. New insights into the cellular and molecular mechanisms of cold storage injury. Invest Med 2004, 52:299-309.
6. Rauen U., de Groot H. Cold-induced release of reactive oxygen species as a decisive mediator of hypothermia injury to cultured liver cells. Free Radic Biol Med 1998, 24:1316-1323.
7. Rauen U., Polzar B., Stephan H., Mannherz H.G., de Groot H. Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. FASEB J 1999, 13:155-168.
8. Rauen U., de Groot H. Mammalian cell injury induced by hypothermia - the emerging role for reactive oxygen species. Biol Chem 2002, 383(3-4):477-488.
9. Salahudeen A.K. Cold ischemic injury of transplanted kidneys: new insights from experimental studies. Am J Physiol Renal Physiol 2004, 287:F181-F187.
10. Rauen U., Kerkweg U., Weisheit D., Petrat F., Sustmann R., de Groot H. Cold-induced apoptosis of hepatocytes: mitochondrial permeability transition triggered by nonmitochondrial chelatable iron. Free Radic Biol Med 2003, 35:1664-1678.
11. Kerkweg U., Jacob M., de Groot H., Mannherz H.G., Rauen U. Cold-induced apoptosis of rat liver endothelial cells: contribution of mitochondrial alterations. Transplantation 2003, 76(3):501-508.
12. Hochachka P.W. Defense strategies against hypoxia and hypothermia. Science 1986, 231:234-241.
13. Clavien P.A., Harvey P.R.C., Strasberg S.M. Preservation and reperfusion injuries in liver allografts. An overview and synthesis of current studies. Transplantation 1992, 53:957-978.
14. Torres R.L., Martins L.K., Picoral M., Auzani J., Fernandes T.R., Torres I.L., Ferreira M.B., Andrade C.F., Belló-Klein A., Cardoso P.F. The potential protective effect of low potassium dextran against lipid peroxidation in a rat lung transplantation model. Thorac Cardiovasc Surg 2009, 57(5):309-311.
15. Rauen U., de Groot H. Inherent toxicity of organ preservation solutions to cultured hepatocytes. Cryobiology 2008, 56(1):88-92.
16. Fukuse T., Hirata T., Ishikawa S., Shoji T., Yoshimura T., Chen Q., Matsukura T., Hanaoka N., Wada H. Optimal alveolar oxygen concentration for cold storage of the lung. Transplantation 2001, 72(2):300-304.
17. Laubach V.E., Kron I.L. Pulmonary inflammation after lung transplantation. Surgery 2009, 146(1):1-4.
18. Lama V.N. Update in lung transplantation 2008. Am J Respir Crit Care Med 2009, 179(9):759-764.
19. Rauen U., Klempt S., de Groot H. Histidine-induced injury to cultured liver cells, effects of histidine derivatives and of iron chelators. Cell Mol Life Sci 2007, 64(2):192-205.
20. Wu K., Türk T.R., Rauen U., Su S., Feldkamp T., de Groot H., Wiswedel I., Baba H.A., Kribben A., Witzke O. Prolonged cold storage using a new histidine-tryptophan-ketoglutarate-based preservation solution in isogeneic cardiac mouse grafts. Eur Heart J 2011, 32(4):509-516.
21. Radovits T., Lin L.N., Zotkina J., Koch A., Rauen U., Köhler G., Karck M., Szabó G. Endothelial dysfunction after long-term cold storage in HTK organ preservation solutions: effects of iron chelators and N-alpha-acetyl-L-histidine. J Heart Lung Transplant 2008, 27(2):208-216.
22. O'Neill C.A., Fu L.W., Halliwell B., Longhurst J.C. Hydroxyl radical production during myocardial ischemia and reperfusion in cats. Am J Physiol 1996, 271(2 Pt 2):H660-H667.
23. Stegemann J., Hirner A., Rauen U., Minor T. Gaseous oxygen persufflation or oxygenated machine perfusion with Custodiol-N for long-term preservation of ischemic rat livers?. Cryobiology 2009, 58(1):45-51.
24. Loganathan S., Radovits T., Hirschberg K., Korkmaz S., Koch A., Karck M., Szabó G. Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury. J Thorac Cardiovasc Surg 2010, 139(4):1048-1056.
25. Cardella J.A., Keshavjee S., Mourgeon E., Cassivi S.D., Fischer S., Isowa N., Slutsky A., Liu M. A novel cell culture model for studying ischemia-reperfusion injury in lung transplantation. J Appl Physiol 2000, 89(4):1553-1560.