Extracorporeal machine liver perfusion: Are we warming up?

Current Opinion in Organ Transplantation

Volumn 17, Issue 2, 2012, Pages 143-147

  Hessheimer, Amelia J ^a   Fondevila, Constantino ^a   García Valdecasas, Juan C ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

donation after cardiac death; hypothermic perfusion; machine liver perfusion; normothermic extracorporeal membrane oxygenation; normothermic perfusion; subnormothermic perfusion

Indexed keywords

CELL DAMAGE; CELL ENERGY; CRYOPRESERVATION; ENDOTHELIUM CELL; EXTRACORPOREAL CIRCULATION; HUMAN; INDUCED HYPOTHERMIA; KUPFFER CELL; LIVER CELL; LIVER GRAFT; LIVER PERFUSION; MACHINE; NONHUMAN; REVIEW;

HUMANS; LIVER; LIVER TRANSPLANTATION; ORGAN PRESERVATION; PERFUSION; TEMPERATURE; TRANSPLANTS;

EID: 84858754352     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e328351082a     Document Type: Review

References (45)

1. Tsuchihashi S, Fondevila C, Shaw GD, et al. Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation. J Immunol 2006; 176:616-624. (Pubitemid 43023310)
2. Fondevila C, Shen XD, Duarte S, et al. Cytoprotective effects of a cyclic RGD peptide in steatotic liver cold ischemia and reperfusion injury. Am J Transplant 2009; 9:2240-2250.
3. Fondevila C, Busuttil RW, Kupiec-Weglinski JW. Hepatic ischemia/ reperfusion injury-a fresh look. Exp Mol Pathol 2003; 74:86-93. (Pubitemid 36438656)
4. Fondevila C, Shen XD, Tsuchihashi S, et al. The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury. Liver Transpl 2008; 14:1133-1141.
5. Hamada T, Fondevila C, Busuttil RW, Coito AJ. Metalloproteinase-9 deficiency protects against hepatic ischemia/reperfusion injury. Hepatology 2008; 47:186-198. (Pubitemid 351171056)
6. Belzer FO, Ashby BS, Gulyassy PF, Powell M. Successful seventeen-hour preservation and transplantation of human-cadaver kidney. N Engl J Med 1968; 278:608-610.
7. Fuller BJ, Lee CY. Hypothermic perfusion preservation: the future of organ preservation revisited? Cryobiology 2007; 54:129-145. (Pubitemid 46528446)
8. Opelz G, Terasaki PI. Advantage of cold storage over machine perfusion for preservation of cadaver kidneys. Transplantation 1982; 33:64-68. (Pubitemid 12162773)
9. Halloran P, Aprile M. A randomized prospective trial of cold storage versus pulsatile perfusion for cadaver kidney preservation. Transplantation 1987; 43:827-832. (Pubitemid 17084258)
10. Changani KK, Fuller BJ, Bryant DJ, et al. Noninvasive assessment of ATP regeneration potential of the preserved donor liver. A 31P MRS study in pig liver. J Hepatol 1997; 26:336-342. (Pubitemid 27077433)
11. Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009; 360:7-19.
12. Jochmans I, Moers C, Smits JM, et al. Machine perfusion versus cold storage for the preservation of kidneys donated after cardiac death: a multicenter, randomized, controlled trial. Ann Surg 2010; 252:756-764.
13. Belzer FO, Ashby BS, Huang JS, Dunphy JE. Etiology of rising perfusion pressure in isolated organ perfusion. Ann Surg 1968; 168:382-391.
14. Hansen TN, Dawson PE, Brockbank KG. Effects of hypothermia upon endothelial cells: mechanisms and clinical importance. Cryobiology 1994; 31:101-106. (Pubitemid 124011121)
15. Xu H, Lee CY, Clemens MG, Zhang JX. Prolonged hypothermic machine perfusion preserves hepatocellular function but potentiates endothelial cell dysfunction in rat livers. Transplantation 2004; 77:1676-1682. (Pubitemid 38780533)
16. Jain S, Xu H, Duncan H, et al. Ex-vivo study of flow dynamics and endothelial cell structure during extended hypothermic machine perfusion preservation of livers. Cryobiology 2004; 48:322-332. (Pubitemid 38638616)
17. Carles J, Fawaz R, Hamoudi NE, et al. Preservation of human liver grafts in UW solution. Ultrastructural evidence for endothelial and Kupffer cell activation during cold ischemia and after ischemia-reperfusion. Liver 1994; 14:50-56. (Pubitemid 24089308)
18. Niwano M, Arii S, Monden K, et al. Amelioration of sinusoidal endothelial cell damage by Kupffer cell blockade during cold preservation of rat liver. J Surg Res 1997; 72:36-48. (Pubitemid 27446634)
19. Lichtman SN, Lemasters JJ. Role of cytokines and cytokine-producing cells in reperfusion injury to the liver. Semin Liver Dis 1999; 19:171-187.
20. Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant 2010; 10:372-381.
21. van der PA, Maathuis MH, Hart NA, et al. The Groningen hypothermic liver perfusion pump: functional evaluation of a new machine perfusion system. Ann Biomed Eng 2006; 34:1924-1934. (Pubitemid 44770845)
22. Hart NA, der van PA, Leuvenink HG, et al. Determination of an adequate perfusion pressure for continuous dual vessel hypothermic machine perfusion of the rat liver. Transpl Int 2007; 20:343-352.
23. de Rougemont, Breitenstein S, Leskosek B, et al. One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death. Ann Surg 2009; 250:674-683.
24. Vairetti M, Ferrigno A, Carlucci F, et al. Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase? Liver Transpl 2009; 15:20-29.
25. Olschewski P, Gass P, Ariyakhagorn V, et al. The influence of storage temperature during machine perfusion on preservation quality of marginal donor livers. Cryobiology 2010; 60:337-343.
26. Tolboom H, Izamis ML, Sharma N, et al. Subnormothermic machine perfusion at both 20 degrees C and 30 degrees C recovers ischemic rat livers for successful transplantation. J Surg Res 2011. [Epub ahead of print]
27. Schon MR, Kollmar O, Wolf S, et al. Liver transplantation after organ preservation with normothermic extracorporeal perfusion. Ann Surg 2001; 233:114-123. (Pubitemid 32042781)
28. St Peter SD, Imber CJ, Lopez I, et al. Extended preservation of nonheartbeating donor livers with normothermic machine perfusion. Br J Surg 2002; 89:609-616. (Pubitemid 34415612)
29. Butler AJ, Rees MA, Wight DG, et al. Successful extracorporeal porcine liver perfusion for 72 hr. Transplantation 2002; 73:1212-1218. (Pubitemid 34454265)
30. Brockmann J, Reddy S, Coussios C, et al. Normothermic perfusion: a new paradigm for organ preservation. Ann Surg 2009; 250:1-6.
31. Gonzalez FX, Garcia-Valdecasas JC, Lopez-Boado MA, et al. Adenine nucleotide liver tissue concentrations from nonheart-beating donor pigs and organ viability after liver transplantation. Transplant Proc 1997; 29:3480-3481. (Pubitemid 28008561)
32. Valero R, Garcia-Valdecasas JC, Tabet J, et al. Hepatic blood flow and oxygen extraction ratio during normothermic recirculation and total body cooling as viability predictors in nonheart-beating donor pigs. Transplantation 1998; 66:170-176. (Pubitemid 28369995)
33. Garcia-Valdecasas JC, Tabet J, Valero R, et al. Liver conditioning after cardiac arrest: the use of normothermic recirculation in an experimental animal model. Transpl Int 1998; 11:424-432. (Pubitemid 28554598)
34. Net M, Valero R, Almenara R, et al. The effect of normothermic recirculation is mediated by ischemic preconditioning in NHBD liver transplantation. Am J Transplant 2005; 5:2385-2392.
35. Kootstra G, Daemen JH, Oomen AP. Categories of nonheart-beating donors. Transplant Proc 1995; 27:2893-2894.
36. Fondevila C, Hessheimer AJ, Ruiz A, et al. Liver transplant using donors after unexpected cardiac death: novel preservation protocol and acceptance criteria. Am J Transplant 2007; 7:1849-1855. (Pubitemid 46905436)
37. Fondevila C, Garcia-Valdecasas JC. Liver transplantation from donors after cardiac death. Dig Liver Dis Suppl 2009; 3:82-87.
38. Fondevila C. Is extracorporeal support becoming the new standard for the preservation of DCD grafts? Am J Transplant 2010; 10:1341-1342.
39. Fondevila C, Hessheimer AJ, Flores E, et al. Applicability and results of Maastricht type 2 donation after cardiac death liver transplantation. Am J Transplant 2011. [Epub ahead of print]
40. Fondevila C, Hessheimer AJ, Maathuis MH, et al. Superior preservation of DCD livers with continuous normothermic perfusion. Ann Surg 2011; 254:1000-1007.
41. Reddy SP, Bhattacharjya S, Maniakin N, et al. Preservation of porcine nonheart-beating donor livers by sequential cold storage and warm perfusion. Transplantation 2004; 77:1328-1332. (Pubitemid 38668423)
42. Reddy S, Greenwood J, Maniakin N, et al. Nonheart-beating donor porcine livers: the adverse effect of cooling. Liver Transpl 2005; 11:35-38. (Pubitemid 40124440)
43. Dutkowski P, de Rougemont, Clavien PA. Machine perfusion for 'marginal' liver grafts. Am J Transplant 2008; 8:917-924. (Pubitemid 351537756)
44. Foley DP, Fernandez LA, Leverson G, et al. Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center. Ann Surg 2011; 253:817-825.
45. Jay CL, Lyuksemburg V, Ladner DP, et al. Ischemic cholangiopathy after controlled donation after cardiac death liver transplantation: a meta-analysis. Ann Surg 2011; 253:259-264.