Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity.

The Journal of biological chemistry

Volumn 277, Issue 32, 2002, Pages 28916-28922

  Niswender, Colleen M ^a   Ishihara, R Wesley ^a   Judge, Luke M ^a   Zhang, Chao ^a   Shokat, Kevan M ^a   McKnight, G Stanley ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; GLYCINE; ISOLEUCINE; ISOPROTEIN; ISOQUINOLINE DERIVATIVE; LEUCINE; LYSINE; METHIONINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; SULFONAMIDE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CATALYSIS; CELL CULTURE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME ACTIVE SITE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; IC 50; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; PLASMID; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; CATALYTIC DOMAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLYCINE; HUMANS; INHIBITORY CONCENTRATION 50; ISOLEUCINE; ISOQUINOLINES; LEUCINE; LYSINE; METHIONINE; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; PROTEIN ENGINEERING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SULFONAMIDES; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037047423     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203327200     Document Type: Article

References (0)