Alcohol consumption and antitumor immunity: Dynamic changes from activation to accelerated deterioration of the immune system

Advances in Experimental Medicine and Biology

Volumn 815, Issue , 2015, Pages 313-331

  Zhang, Hui ^a   Zhu, Zhaohui ^a   Zhang, Faya ^a   Meadows, Gary G ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Alcohol; Antitumor immunity; B16BL6 melanoma; Metastasis; NK cells; NKT cells; Survival; T cells

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; INTERLEUKIN 4; NATURAL KILLER CELL RECEPTOR NKG2A BLOCKING AGENT; PROGRAMMED DEATH 1 RECEPTOR BLOCKING AGENT; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; ALCOHOL;

ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CANCER GROWTH; CANCER IMMUNOLOGY; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER MODEL; CANCER PATIENT; CANCER SURVIVAL; CARCINOGENESIS; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE COURSE; DRINKING BEHAVIOR; HUMAN; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; IMMUNOSURVEILLANCE; LUNG METASTASIS; LYMPHOCYTE PROLIFERATION; MALIGNANT NEOPLASTIC DISEASE; MEDICAL RESEARCH; MELANOMA; METABOLITE; METASTASIS INHIBITION; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; SIGNAL TRANSDUCTION; STEADY STATE; SUBCUTANEOUS TISSUE TUMOR; SUPPRESSOR CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TUMOR IMMUNITY; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; EXPERIMENTAL MELANOMA; IMMUNE SYSTEM; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; TOXICITY;

MUS;

ALCOHOL DRINKING; ANIMALS; B-LYMPHOCYTES; ETHANOL; IMMUNE SYSTEM; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MELANOMA, EXPERIMENTAL; MICE; T-LYMPHOCYTES;

EID: 84925339967     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-09614-8_18     Document Type: Article

References (81)

1. Nelson DE et al (2013) Alcohol-attributable cancer deaths and years of potential life lost in the United States. Am J Public Health 103(4):641–648
2. Boffetta P, Hashibe M (2006) Alcohol and cancer. Lancet Oncol 7(2):149–156
3. Haas SL, Ye W, Lohr JM (2012) Alcohol consumption and digestive tract cancer. Curr Opin Clin Nutr Metab Care 15(5):457–467
4. Berstad P et al (2008) Alcohol intake and breast cancer risk among young women. Breast Cancer Res Treat 108(1):113–120
5. Longnecker MP et al (1995) Risk of breast cancer in relation to lifetime alcohol consumption. J Natl Cancer Inst 87(12):923–929
6. Brooks PJ, Zakhari S (2013) Moderate alcohol consumption and breast cancer in women: from epidemiology to mechanisms and interventions. Alcohol Clin Exp Res 37(1):23–30
7. Thrift AP et al (2012) The infl uence of prediagnostic demographic and lifestyle factors on esophageal squamous cell carcinoma survival. Int J Cancer 131(5):E759–E768
8. Mayne ST et al (2009) Alcohol and tobacco use prediagnosis and postdiagnosis, and survival in a cohort of patients with early stage cancers of the oral cavity, pharynx, and larynx. Cancer Epidemiol Biomarkers Prev 18(12):3368–3374
9. Jerjes W et al (2012) The effect of tobacco and alcohol and their reduction/cessation on mortality in oral cancer patients: short communication. Head Neck Oncol 4:6
10. Wu IC et al (2012) Substance use (alcohol, areca nut and cigarette) is associated with poor prognosis of esophageal squamous cell carcinoma. PLoS One 8(2):e55834
11. Wang JB et al (2012) Attributable causes of esophageal cancer incidence and mortality in China. PLoS One 7(8):e42281
12. Newcomb PA et al (2013) Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes. J Clin Oncol 31(16):1939–1946
13. Kwan ML et al (2012) Postdiagnosis alcohol consumption and breast cancer prognosis in the after breast cancer pooling project. Cancer Epidemiol Biomarkers Prev 22(1):32–41
14. Harris HR, Bergkvist L, Wolk A (2012) Alcohol intake and mortality among women with invasive breast cancer. Br J Cancer 106(3):592–595
15. Flatt SW et al (2010) Low to moderate alcohol intake is not associated with increased mortality after breast cancer. Cancer Epidemiol Biomarkers Prev 19(3):681–688
16. McDonald PA et al (2002) Breast cancer survival in African American women: is alcohol consumption a prognostic indicator? Cancer Causes Control 13(6):543–549
17. Weaver AM et al (2013) Alcohol intake over the life course and breast cancer survival in Western New York exposures and breast cancer (WEB) study: quantity and intensity of intake. Breast Cancer Res Treat 139(1):245–253
18. Holm M et al (2013) Pre-diagnostic alcohol consumption and breast cancer recurrence and mortality: results from a prospective cohort with a wide range of variation in alcohol intake. Int J Cancer 132(3):686–694
19. Barnett GC et al (2008) Risk factors for the incidence of breast cancer: do they affect survival from the disease? J Clin Oncol 26(20):3310–3316
20. Morton LM et al (2005) Alcohol consumption and risk of non-Hodgkin lymphoma: a pooled analysis. Lancet Oncol 6(7):469–476
21. Tramacere I et al (2012) Alcohol drinking and non-Hodgkin lymphoma risk: a systematic review and a meta-analysis. Ann Oncol 23(11):2791–2798
22. Gapstur SM et al (2012) Alcohol intake and the incidence of non-Hodgkin lymphoid neoplasms in the cancer prevention study II nutrition cohort. Am J Epidemiol 176(1):60–69
23. Geyer SM et al (2010) Smoking, alcohol use, obesity, and overall survival from non-Hodgkin lymphoma: a population-based study. Cancer 116(12):2993–3000
24. Talamini R et al (2008) The impact of tobacco smoking and alcohol drinking on survival of patients with non-Hodgkin lymphoma. Int J Cancer 122(7):1624–1629
25. Battaglioli T et al (2006) Cigarette smoking and alcohol consumption as determinants of survival in non-Hodgkin’s lymphoma: a population-based study. Ann Oncol 17(8):1283–1289
26. Meadows GG et al (1993) Alcohol consumption suppresses metastasis of B16-BL6 melanoma in mice. Clin Exp Metastasis 11:191–199
27. Blank SE, Meadows GG (1996) Ethanol modulates metastatic potential of B16BL6 melanoma and host responses. Alcohol Clin Exp Res 20:624–628
28. Szabo G, Mandrekar P (2009) A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res 33(2):220–232
29. Cook RT (1998) Alcohol abuse, alcoholism, and damage to the immune system—a review. Alcohol Clin Exp Res 22(9):1927–1941
30. Cook RT et al (1991) Activated CD-8 cells and HLA DR expression in alcoholics without overt liver disease. J Clin Immunol 11:246–253
31. Song K et al (2002) Chronic ethanol consumption by mice results in activated splenic T cells. J Leukoc Biol 72:1109–1116
32. Laso FJ et al (2007) Chronic alcohol consumption is associated with changes in the distribution, immunophenotype, and the infl ammatory cytokine secretion profi le of circulating dendritic cells. Alcohol Clin Exp Res 31(5):846–854
33. Zhang H, Meadows GG (2005) Chronic alcohol consumption in mice increases the proportion of peripheral memory T cells by homeostatic proliferation. J Leukoc Biol 78(5):1070–1080
34. Abdallah RM, Starkey JR, Meadows GG (1988) Toxicity of chronic high alcohol intake on mouse natural killer cell activity. Res Commun Chem Pathol Pharmacol 59:245–258
35. Núñez NP, Carter PA, Meadows GG (2002) Alcohol consumption promotes body weight loss in melanoma-bearing mice. Alcohol Clin Exp Res 26:617–626
36. Zhang H, Meadows GG (2008) Chronic alcohol consumption perturbs the balance between thymus-derived and bone marrow-derived natural killer cells in the spleen. J Leukoc Biol 83(1):41–47
37. Weber JS et al (1987) Immunotherapy of a murine tumor with interleukin 2. Increased sensitivity after MHC class I gene transfection. J Exp Med 166(6):1716–1733
38. Winter H et al (2001) Immunotherapy of melanoma: a dichotomy in the requirement for IFN-gamma in vaccine-induced antitumor immunity versus adoptive immunotherapy. J Immunol 166(12):7370–7380
39. Maeda M et al (1998) Alcohol consumption enhances liver metastasis in colorectal carcinoma patients. Cancer 83(8):1483–1488
40. Oksuzler O et al (2009) Investigation of the synergism between alcohol consumption and herpes simplex virus in patients with laryngeal squamous cell cancers. Eur Arch Otorhinolaryngol 266(12):1977–1982
41. Wilson SD et al (2011) Zollinger-Ellison syndrome associated with a history of alcohol abuse: coincidence or consequence? Surgery 150(6):1129–1135
42. Spitzer JH et al (2000) The modulation of B16BL6 melanoma metastasis is not directly mediated by cytolytic activity of natural killer cells in alcohol-consuming mice. Alcohol Clin Exp Res 24(6):837–844
43. Zhang H et al (2011) IFN-gamma is essential for the inhibition of B16BL6 melanoma lung metastasis in chronic alcohol drinking mice. Clin Exp Metastasis 28(3):301–307
44. Dunn GP, Koebel CM, Schreiber RD (2006) Interferons, immunity and cancer immunoediting. Nat Rev Immunol 6(11):836–848
45. Savage PA, Malchow S, Leventhal DS (2013) Basic principles of tumor-associated regulatory T cell biology. Trends Immunol 34(1):33–40
46. Martin F, Apetoh L, Ghiringhelli F (2012) Controversies on the role of Th17 in cancer: a TGF-beta- dependent immunosuppressive activity? Trends Mol Med 18(12):742–749
47. Ye J, Livergood RS, Peng G (2013) The role and regulation of human Th17 cells in tumor immunity. Am J Pathol 182(1):10–20
48. DuPage M et al (2012) Expression of tumour-specifi c antigens underlies cancer immunoedit-ing. Nature 482(7385):405–409
49. Shankaran V et al (2001) IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410(6832):1107–1111
50. Kersh EN et al (2006) Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells. J Immunol 176(7):4083–4093
51. Fitzpatrick DR, Shirley KM, Kelso A (1999) Cutting edge: stable epigenetic inheritance of regional IFN-gamma promoter demethylation in CD44highCD8+ T lymphocytes. J Immunol 162(9):5053–5057
52. Winders BR, Schwartz RH, Bruniquel D (2004) A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells. J Immunol 173(12):7377–7384
53. Kambayashi T et al (2003) Memory CD8+ T cells provide an early source of IFN-gamma. J Immunol 170(5):2399–2408
54. Laso FJ et al (1999) Chronic alcoholism is associated with an imbalanced production of Th-1/ Th-2 cytokines by peripheral blood T cells. Alcohol Clin Exp Res 23(8):1306–1311
55. Zhang H, Meadows GG (2010) Chronic alcohol consumption enhances myeloid-derived suppressor cells in B16BL6 melanoma-bearing mice. Cancer Immunol Immunother 59(8): 1151–1159
56. Highfi ll SL et al (2010) Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus- host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood 116(25):5738–5747
57. Zhu X et al (2014) The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury. Ann Surg 259(1):171–178
58. Vosshenrich CA et al (2006) A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol 7(11):1217–1224
59. Vivier E et al (2008) Functions of natural killer cells. Nat Immunol 9(5):503–510
60. Vivier E et al (2012) Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol 12(4):239–252
61. Perney P et al (2003) Specifi c alteration of peripheral cytotoxic cell perforin expression in alcoholic patients: a possible role in alcohol-related diseases. Alcohol Clin Exp Res 27(11): 1825–1830
62. Meadows GG et al (1992) Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice. Alcohol Clin Exp Res 16:474–479
63. Blank SE et al (1993) Ethanol-induced changes in peripheral blood and splenic NK cells. Alcohol Clin Exp Res 17(3):561–565
64. Zhang H, Zhu Z, Meadows GG (2011) Chronic alcohol consumption decreases the percentage and number of NK cells in the peripheral lymph nodes and exacerbates B16BL6 melanoma metastasis into the draining lymph nodes. Cell Immunol 266(2):172–179
65. Chen S et al (2005) Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. J Exp Med 202(12):1679–1689
66. Inoue S et al (2006) Inhibitory effects of B cells on antitumor immunity. Cancer Res 66(15): 7741–7747
67. Yanaba K et al (2008) A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent infl ammatory responses. Immunity 28(5):639–650
68. Horikawa M et al (2011) Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. J Clin Invest 121(11):4268–4280
69. DiLillo DJ, Yanaba K, Tedder TF (2010) B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. J Immunol 184(7):4006–4016
70. Zhang H, Zhu Z, Meadows GG (2012) Chronic alcohol consumption impairs distribution and compromises circulation of B cells in B16BL6 melanoma-bearing mice. J Immunol 189(3):1340–1348
71. Parekh VV et al (2005) Glycolipid antigen induces long-term natural killer T cell anergy in mice. J Clin Invest 115(9):2572–2583
72. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5): 646–674
73. Schreiber RD, Old LJ, Smyth MJ (2011) Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 331(6024):1565–1570
74. Saberi Hosnijeh F et al (2010) Plasma cytokines and future risk of non-Hodgkin lymphoma (NHL): a case-control study nested in the Italian European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev 19(6):1577–1584
75. Parekh VV et al (2009) PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J Immunol 182(5):2816–2826
76. Kawamura T et al (2009) NKG2A inhibits invariant NKT cell activation in hepatic injury. J Immunol 182(1):250–258
77. Ota T et al (2005) IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2. Blood 106(1):184–192
78. Fourcade J et al (2010) Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specifi c CD8+ T cell dysfunction in melanoma patients. J Exp Med 207(10): 2175–2186
79. Gooden M et al (2011) HLA-E expression by gynecological cancers restrains tumor- infi ltrating CD8(+) T lymphocytes. Proc Natl Acad Sci U S A 108(26):10656–10661
80. Mortier E et al (2009) Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity 31(5):811–822
81. Ott PA, Hodi FS, Robert C (2013) CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeu-tic modalities with durable clinical benefi t in melanoma patients. Clin Cancer Res 19(19): 5300–5309