메뉴 건너뛰기




Volumn 19, Issue 19, 2013, Pages 5300-5309

CTLA-4 and PD-1/PD-L1 blockade: New immunotherapeutic modalities with durable clinical benefit in melanoma patients

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BMS 936559; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DACARBAZINE; GLYCOPROTEIN GP 100; IPILIMUMAB; LAMBROLIZUMAB; MDX 1105; MONOCLONAL ANTIBODY; NIVOLUMAB; PD 1 MONOCLONAL ANTIBODY; PD L1 MONOCLONAL ANTIBODY; PLACEBO; PROGRAMMED DEATH 1 RECEPTOR; TICILIMUMAB; UNCLASSIFIED DRUG;

EID: 84886443514     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0143     Document Type: Article
Times cited : (573)

References (89)
  • 1
    • 0032471712 scopus 로고    scopus 로고
    • Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: Identification of the antigens mediating response
    • Rosenberg SA, Yang JC, White DE, Steinberg SM. Durability of complete responses in patients with metastatic cancer treated with high-dose interleukin-2: identification of the antigens mediating response. Ann Surg 1998;228:307-19.
    • (1998) Ann Surg , vol.228 , pp. 307-319
    • Rosenberg, S.A.1    Yang, J.C.2    White, D.E.3    Steinberg, S.M.4
  • 2
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP, Fisher RI, Weiss G, Margolin K, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 1999;17:2105-16.
    • (1999) J Clin Oncol , vol.17 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3    Fisher, R.I.4    Weiss, G.5    Margolin, K.6
  • 3
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res 2011;17:4550-7.
    • (2011) Clin Cancer Res , vol.17 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3    Kammula, U.S.4    Hughes, M.S.5    Phan, G.Q.6
  • 5
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 7
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, O'Day S, M DJ, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26.
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O'Day, S.4    Dj, M.5    Garbe, C.6
  • 10
    • 33646794392 scopus 로고    scopus 로고
    • Checkpoint blockade in cancer immunotherapy
    • Korman AJ, Peggs KS, Allison JP. Checkpoint blockade in cancer immunotherapy. Adv Immunol 2006;90:297-339.
    • (2006) Adv Immunol , vol.90 , pp. 297-339
    • Korman, A.J.1    Peggs, K.S.2    Allison, J.P.3
  • 13
    • 84859499803 scopus 로고    scopus 로고
    • Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells
    • Karman J, Jiang JL, Gumlaw N, Zhao H, Campos-Rivera J, Sancho J, et al. Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells. J Biol Chem 2012;287:11098-107.
    • (2012) J Biol Chem , vol.287 , pp. 11098-11107
    • Karman, J.1    Jiang, J.L.2    Gumlaw, N.3    Zhao, H.4    Campos-Rivera, J.5    Sancho, J.6
  • 14
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 2012;24:207-12.
    • (2012) Curr Opin Immunol , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 15
    • 84862882003 scopus 로고    scopus 로고
    • Tumor immunotherapy directed at PD-1
    • Ribas A. Tumor immunotherapy directed at PD-1. N Engl J Med 2012;366:2517-9.
    • (2012) N Engl J Med , vol.366 , pp. 2517-2519
    • Ribas, A.1
  • 16
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 2009;206:1717-25.
    • (2009) J Exp Med , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 17
    • 55949083407 scopus 로고    scopus 로고
    • Anti-cytotoxic T-lymphocyte antigen-4 antibody: The first in an emerging class of immunomodulatory antibodies for cancer treatment
    • Fong L, Small EJ. Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. J Clin Oncol 2008;26:5275-83.
    • (2008) J Clin Oncol , vol.26 , pp. 5275-5283
    • Fong, L.1    Small, E.J.2
  • 18
    • 32644467549 scopus 로고    scopus 로고
    • Antitumor activity in melanoma and anti-self responses in a phase i trial with the anti-cytotoxic T lymphocyteassociated antigen 4 monoclonal antibody CP-675,206
    • Ribas A, Camacho LH, Lopez-Berestein G, Pavlov D, Bulanhagui CA, Millham R, et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyteassociated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol 2005;23:8968-77.
    • (2005) J Clin Oncol , vol.23 , pp. 8968-8977
    • Ribas, A.1    Camacho, L.H.2    Lopez-Berestein, G.3    Pavlov, D.4    Bulanhagui, C.A.5    Millham, R.6
  • 19
    • 70249083099 scopus 로고    scopus 로고
    • What is the role of cytotoxic T lymphocyteassociated antigen 4 blockade in patients with metastatic melanoma?
    • Robert C, Ghiringhelli F. What is the role of cytotoxic T lymphocyteassociated antigen 4 blockade in patients with metastatic melanoma? Oncologist 2009;14:848-61.
    • (2009) Oncologist , vol.14 , pp. 848-861
    • Robert, C.1    Ghiringhelli, F.2
  • 20
    • 61349114199 scopus 로고    scopus 로고
    • Ipilimumab: Controversies in its development, utility and autoimmune adverse events
    • Weber J. Ipilimumab: controversies in its development, utility and autoimmune adverse events. Cancer Immunol Immunother 2009;58: 823-30.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 823-830
    • Weber, J.1
  • 21
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • Ribas A, Kefford R, Marshall MA, Punt CJ, Haanen JB, Marmol M, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol 2013;31:616-22.
    • (2013) J Clin Oncol , vol.31 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3    Punt, C.J.4    Haanen, J.B.5    Marmol, M.6
  • 23
    • 84859393995 scopus 로고    scopus 로고
    • CTLA-4 blockade with ipilimumab: Long-term follow-up of 177 patients with metastatic melanoma
    • Prieto PA, Yang JC, Sherry RM, Hughes MS, Kammula US, White DE, et al. CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma. Clin Cancer Res 2012;18: 2039-47.
    • (2012) Clin Cancer Res , vol.18 , pp. 2039-2047
    • Prieto, P.A.1    Yang, J.C.2    Sherry, R.M.3    Hughes, M.S.4    Kammula, U.S.5    White, D.E.6
  • 24
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • Attia P, Phan GQ, Maker AV, Robinson MR, Quezado MM, Yang JC, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 2005;23:6043-53.
    • (2005) J Clin Oncol , vol.23 , pp. 6043-6053
    • Attia, P.1    Phan, G.Q.2    Maker, A.V.3    Robinson, M.R.4    Quezado, M.M.5    Yang, J.C.6
  • 25
    • 27844458057 scopus 로고    scopus 로고
    • Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: A phase I/II study
    • Maker AV, Phan GQ, Attia P, Yang JC, Sherry RM, Topalian SL, et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol 2005;12:1005-16.
    • (2005) Ann Surg Oncol , vol.12 , pp. 1005-1016
    • Maker, A.V.1    Phan, G.Q.2    Attia, P.3    Yang, J.C.4    Sherry, R.M.5    Topalian, S.L.6
  • 26
  • 27
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A 2003;100:8372-7.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3    Hwu, P.4    Topalian, S.L.5    Schwartzentruber, D.J.6
  • 28
    • 84880310548 scopus 로고    scopus 로고
    • Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials
    • Wolchok JD, Weber JS, Maio M, Neyns B, Harmankaya K, Chin K, et al. Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials. Ann Oncol 2013; 24:2174-80.
    • (2013) Ann Oncol , vol.24 , pp. 2174-2180
    • Wolchok, J.D.1    Weber, J.S.2    Maio, M.3    Neyns, B.4    Harmankaya, K.5    Chin, K.6
  • 29
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
    • Wolchok JD, Neyns B, Linette G, Negrier S, Lutzky J, Thomas L, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 2010;11:155-64.
    • (2010) Lancet Oncol , vol.11 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3    Negrier, S.4    Lutzky, J.5    Thomas, L.6
  • 30
    • 77955256254 scopus 로고    scopus 로고
    • Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: A multicenter singlearm phase II study
    • O'Day SJ, Maio M, Chiarion-Sileni V, Gajewski TF, Pehamberger H, Bondarenko IN, et al. Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter singlearm phase II study. Ann Oncol 2010;21:1712-7.
    • (2010) Ann Oncol , vol.21 , pp. 1712-1717
    • O'Day, S.J.1    Maio, M.2    Chiarion-Sileni, V.3    Gajewski, T.F.4    Pehamberger, H.5    Bondarenko, I.N.6
  • 31
    • 69949095926 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patientswith unresectable stage III or IV melanoma
    • Weber J, Thompson JA, Hamid O, Minor D, Amin A, Ron I, et al. A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patientswith unresectable stage III or IV melanoma. Clin Cancer Res 2009;15:5591-8.
    • (2009) Clin Cancer Res , vol.15 , pp. 5591-5598
    • Weber, J.1    Thompson, J.A.2    Hamid, O.3    Minor, D.4    Amin, A.5    Ron, I.6
  • 32
    • 42949105127 scopus 로고    scopus 로고
    • Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
    • Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, et al. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci U S A 2008;105:3005-10.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 3005-3010
    • Hodi, F.S.1    Butler, M.2    Oble, D.A.3    Seiden, M.V.4    Haluska, F.G.5    Kruse, A.6
  • 33
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • Hodi FS, Mihm MC, Soiffer RJ, Haluska FG, Butler M, Seiden MV, et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci U S A 2003; 100:4712-7.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4712-4717
    • Hodi, F.S.1    Mihm, M.C.2    Soiffer, R.J.3    Haluska, F.G.4    Butler, M.5    Seiden, M.V.6
  • 34
    • 80053648839 scopus 로고    scopus 로고
    • Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
    • Yuan J, Adamow M, Ginsberg BA, Rasalan TS, Ritter E, Gallardo HF, et al. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Proc Natl Acad Sci U S A 2011;108:16723-8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 16723-16728
    • Yuan, J.1    Adamow, M.2    Ginsberg, B.A.3    Rasalan, T.S.4    Ritter, E.5    Gallardo, H.F.6
  • 35
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002;8:793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 36
    • 84859157752 scopus 로고    scopus 로고
    • Tim-3, a negative regulator of anti-tumor immunity
    • Anderson AC. Tim-3, a negative regulator of anti-tumor immunity. Curr Opin Immunol 2012;24:213-6.
    • (2012) Curr Opin Immunol , vol.24 , pp. 213-216
    • Anderson, A.C.1
  • 38
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9:162-74.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 40
    • 0036214017 scopus 로고    scopus 로고
    • The B7 family of ligands and its receptors: New pathways for costimulation and inhibition of immune responses
    • Carreno BM, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol 2002;20:29-53.
    • (2002) Annu Rev Immunol , vol.20 , pp. 29-53
    • Carreno, B.M.1    Collins, M.2
  • 43
    • 65349083187 scopus 로고    scopus 로고
    • Negative regulators of T-cell activation: Potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
    • Pentcheva-Hoang T, Corse E, Allison JP. Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections. Immunol Rev 2009; 229:67-87.
    • (2009) Immunol Rev , vol.229 , pp. 67-87
    • Pentcheva-Hoang, T.1    Corse, E.2    Allison, J.P.3
  • 44
    • 84863011810 scopus 로고    scopus 로고
    • Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy
    • Flies DB, Sandler BJ, Sznol M, Chen L. Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy. Yale J Biol Med 2011;84:409-21.
    • (2011) Yale J Biol Med , vol.84 , pp. 409-421
    • Flies, D.B.1    Sandler, B.J.2    Sznol, M.3    Chen, L.4
  • 45
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127ra37.
    • (2012) Sci Transl Med , vol.4
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6
  • 46
    • 84880732199 scopus 로고    scopus 로고
    • Survival and long-term follow-up of safety and response in patients (pts) with advanced melanoma (MEL) in a phase i trial of nivolumab (anti-PD-1; BMS-936558; ONO-4538)
    • (suppl; abstr CRA9006)
    • Sznol M KH, Hodi FS, McDermott DF, Carvajal RD, Lawrence DP, Topalian SL, et al. Survival and long-term follow-up of safety and response in patients (pts) with advanced melanoma (MEL) in a phase I trial of nivolumab (anti-PD-1; BMS-936558; ONO-4538). J Clin Oncol 2013 (suppl; abstr CRA9006).
    • (2013) J Clin Oncol
    • Sznol, M.K.H.1    Hodi, F.S.2    McDermott, D.F.3    Carvajal, R.D.4    Lawrence, D.P.5    Topalian, S.L.6
  • 47
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.J.5    Kefford, R.6
  • 48
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 2007; 27:111-22.
    • (2007) Immunity , vol.27 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 49
    • 77249095138 scopus 로고    scopus 로고
    • PD-L1 and PD-L2 modulate airway inflammation and iNKT-celldependent airway hyperreactivity in opposing directions
    • Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, et al. PD-L1 and PD-L2 modulate airway inflammation and iNKT-celldependent airway hyperreactivity in opposing directions. Mucosal Immunol 2010;3:81-91.
    • (2010) Mucosal Immunol , vol.3 , pp. 81-91
    • Akbari, O.1    Stock, P.2    Singh, A.K.3    Lombardi, V.4    Lee, W.L.5    Freeman, G.J.6
  • 50
    • 78049367774 scopus 로고    scopus 로고
    • Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2
    • Huber S, Hoffmann R, Muskens F, Voehringer D. Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 2010;116:3311-20.
    • (2010) Blood , vol.116 , pp. 3311-3320
    • Huber, S.1    Hoffmann, R.2    Muskens, F.3    Voehringer, D.4
  • 51
    • 84871192340 scopus 로고    scopus 로고
    • Molecular pathways: Next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1
    • Chen DS, Irving BA, Hodi FS. Molecular pathways: next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1. Clin Cancer Res 2012;18:6580-7.
    • (2012) Clin Cancer Res , vol.18 , pp. 6580-6587
    • Chen, D.S.1    Irving, B.A.2    Hodi, F.S.3
  • 52
    • 33748160137 scopus 로고    scopus 로고
    • T-cell homing specificity and plasticity: New concepts and future challenges
    • Mora JR, von Andrian UH. T-cell homing specificity and plasticity: new concepts and future challenges. Trends Immunol 2006;27:235-43.
    • (2006) Trends Immunol , vol.27 , pp. 235-243
    • Mora, J.R.1    Von Andrian, U.H.2
  • 53
    • 77950258677 scopus 로고    scopus 로고
    • Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: Lymphocyte count after 2 doses correlates with survival
    • Ku GY, Yuan J, Page DB, Schroeder SE, Panageas KS, Carvajal RD, et al. Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival. Cancer 2010; 116:1767-75.
    • (2010) Cancer , vol.116 , pp. 1767-1775
    • Ku, G.Y.1    Yuan, J.2    Page, D.B.3    Schroeder, S.E.4    Panageas, K.S.5    Carvajal, R.D.6
  • 54
    • 84878432797 scopus 로고    scopus 로고
    • Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: An early increase in lymphocyte and eosinophil counts is associated with improved survival
    • Delyon J, Mateus C, Lefeuvre D, Lanoy E, Zitvogel L, Chaput N, et al. Experience in daily practice with ipilimumab for the treatment of patients with metastatic melanoma: an early increase in lymphocyte and eosinophil counts is associated with improved survival. Ann Oncol 2013;24:1697-703.
    • (2013) Ann Oncol , vol.24 , pp. 1697-1703
    • Delyon, J.1    Mateus, C.2    Lefeuvre, D.3    Lanoy, E.4    Zitvogel, L.5    Chaput, N.6
  • 55
    • 84877093633 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control
    • Robert C, Schadendorf D, Messina M, Hodi FS, O'Day S. Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control. Clin Cancer Res 2013;19:2232-9.
    • (2013) Clin Cancer Res , vol.19 , pp. 2232-2239
    • Robert, C.1    Schadendorf, D.2    Messina, M.3    Hodi, F.S.4    O'Day, S.5
  • 56
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 2011;331:1565-70.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 57
  • 58
    • 84872514622 scopus 로고    scopus 로고
    • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
    • Lipson EJ, Sharfman WH, Drake CG, Wollner I, Taube JM, Anders RA, et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res 2013;19:462-8.
    • (2013) Clin Cancer Res , vol.19 , pp. 462-468
    • Lipson, E.J.1    Sharfman, W.H.2    Drake, C.G.3    Wollner, I.4    Taube, J.M.5    Anders, R.A.6
  • 60
    • 84155171313 scopus 로고    scopus 로고
    • Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma
    • Joseph RW, Sullivan RJ, Harrell R, Stemke-Hale K, Panka D, Manoukian G, et al. Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma. J Immunother 2012;35:66-72.
    • (2012) J Immunother , vol.35 , pp. 66-72
    • Joseph, R.W.1    Sullivan, R.J.2    Harrell, R.3    Stemke-Hale, K.4    Panka, D.5    Manoukian, G.6
  • 66
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012;380:358-65.
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3    Jouary, T.4    Gutzmer, R.5    Millward, M.6
  • 67
    • 84868120907 scopus 로고    scopus 로고
    • Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, openlabel, phase 2 trial
    • Long GV, Trefzer U, Davies MA, Kefford RF, Ascierto PA, Chapman PB, et al. Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, openlabel, phase 2 trial. Lancet Oncol 2012;13:1087-95.
    • (2012) Lancet Oncol , vol.13 , pp. 1087-1095
    • Long, G.V.1    Trefzer, U.2    Davies, M.A.3    Kefford, R.F.4    Ascierto, P.A.5    Chapman, P.B.6
  • 68
    • 84864371119 scopus 로고    scopus 로고
    • Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: A phase 1 dose-escalation trial
    • Falchook GS, Lewis KD, Infante JR, Gordon MS, Vogelzang NJ, DeMarini DJ, et al. Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol 2012;13:782-9.
    • (2012) Lancet Oncol , vol.13 , pp. 782-789
    • Falchook, G.S.1    Lewis, K.D.2    Infante, J.R.3    Gordon, M.S.4    Vogelzang, N.J.5    Demarini, D.J.6
  • 69
    • 84864340896 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: A phase 1 doseescalation trial
    • Infante JR, Fecher LA, Falchook GS, Nallapareddy S, Gordon MS, Becerra C, et al. Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 doseescalation trial. Lancet Oncol 2012;13:773-81.
    • (2012) Lancet Oncol , vol.13 , pp. 773-781
    • Infante, J.R.1    Fecher, L.A.2    Falchook, G.S.3    Nallapareddy, S.4    Gordon, M.S.5    Becerra, C.6
  • 70
    • 84886425815 scopus 로고    scopus 로고
    • Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma
    • Kwong LN, Davies MA. Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma. Clin Cancer Res 2013;19: 5310-9.
    • (2013) Clin Cancer Res , vol.19 , pp. 5310-5319
    • Kwong, L.N.1    Davies, M.A.2
  • 71
    • 84872514398 scopus 로고    scopus 로고
    • BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice
    • Liu C, Peng W, Xu C, Lou Y, Zhang M, Wargo JA, et al. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res 2013; 19:393-403.
    • (2013) Clin Cancer Res , vol.19 , pp. 393-403
    • Liu, C.1    Peng, W.2    Xu, C.3    Lou, Y.4    Zhang, M.5    Wargo, J.A.6
  • 72
    • 84873336707 scopus 로고    scopus 로고
    • The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition
    • Jiang X, Zhou J, Giobbie-Hurder A, Wargo J, Hodi FS. The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition. Clin Cancer Res 2013;19:598-609.
    • (2013) Clin Cancer Res , vol.19 , pp. 598-609
    • Jiang, X.1    Zhou, J.2    Giobbie-Hurder, A.3    Wargo, J.4    Hodi, F.S.5
  • 73
    • 77954373338 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
    • Boni A, Cogdill AP, Dang P, Udayakumar D, Njauw CN, Sloss CM, et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res 2010;70: 5213-9.
    • (2010) Cancer Res , vol.70 , pp. 5213-5219
    • Boni, A.1    Cogdill, A.P.2    Dang, P.3    Udayakumar, D.4    Njauw, C.N.5    Sloss, C.M.6
  • 74
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res 2013;19:1225-31.
    • (2013) Clin Cancer Res , vol.19 , pp. 1225-1231
    • Frederick, D.T.1    Piris, A.2    Cogdill, A.P.3    Cooper, Z.A.4    Lezcano, C.5    Ferrone, C.R.6
  • 75
    • 84859807701 scopus 로고    scopus 로고
    • BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competency
    • Hong DS, Vence L, Falchook G, Radvanyi LG, Liu C, Goodman V, et al. BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competency. Clin Cancer Res 2012;18:2326-35.
    • (2012) Clin Cancer Res , vol.18 , pp. 2326-2335
    • Hong, D.S.1    Vence, L.2    Falchook, G.3    Radvanyi, L.G.4    Liu, C.5    Goodman, V.6
  • 76
    • 78650391890 scopus 로고    scopus 로고
    • The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations
    • Comin-Anduix B, Chodon T, Sazegar H, Matsunaga D, Mock S, Jalil J, et al. The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations. Clin Cancer Res 2010;16:6040-8.
    • (2010) Clin Cancer Res , vol.16 , pp. 6040-6048
    • Comin-Anduix, B.1    Chodon, T.2    Sazegar, H.3    Matsunaga, D.4    Mock, S.5    Jalil, J.6
  • 78
    • 84877817680 scopus 로고    scopus 로고
    • Inhibition of both BRAF and MEK in BRAF(V600E) mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties
    • Ott PA, Henry T, Baranda SJ, Frleta D, Manches O, Bogunovic D, et al. Inhibition of both BRAF and MEK in BRAF(V600E) mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties. Cancer Immunol Immunother 2013;62:811-22.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 811-822
    • Ott, P.A.1    Henry, T.2    Baranda, S.J.3    Frleta, D.4    Manches, O.5    Bogunovic, D.6
  • 79
    • 84865112760 scopus 로고    scopus 로고
    • BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy
    • Koya RC, Mok S, Otte N, Blacketor KJ, Comin-Anduix B, Tumeh PC, et al. BRAF inhibitor vemurafenib improves the antitumor activity of adoptive cell immunotherapy. Cancer Res 2012;72:3928-37.
    • (2012) Cancer Res , vol.72 , pp. 3928-3937
    • Koya, R.C.1    Mok, S.2    Otte, N.3    Blacketor, K.J.4    Comin-Anduix, B.5    Tumeh, P.C.6
  • 81
    • 80052544390 scopus 로고    scopus 로고
    • A phase i trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma
    • (suppl; abstr 8511)
    • Hodi FS, Atkins DF, McDermott DF, Lawrence DP, Ibrahim N, et al. A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 2011 (suppl; abstr 8511)
    • (2011) J Clin Oncol
    • Hodi, F.S.1    Atkins, D.F.2    McDermott, D.F.3    Lawrence, D.P.4    Ibrahim, N.5
  • 82
    • 84856069688 scopus 로고    scopus 로고
    • Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma
    • Tarhini AA, Cherian J, Moschos SJ, Tawbi HA, Shuai Y, Gooding WE, et al. Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma. J Clin Oncol 2012;30:322-8.
    • (2012) J Clin Oncol , vol.30 , pp. 322-328
    • Tarhini, A.A.1    Cherian, J.2    Moschos, S.J.3    Tawbi, H.A.4    Shuai, Y.5    Gooding, W.E.6
  • 84
    • 77957980977 scopus 로고    scopus 로고
    • Regulatory T cells: Overcoming suppression of T-cell immunity
    • Golovina TN, Vonderheide RH. Regulatory T cells: overcoming suppression of T-cell immunity. Cancer J 2010;16:342-7.
    • (2010) Cancer J , vol.16 , pp. 342-347
    • Golovina, T.N.1    Vonderheide, R.H.2
  • 85
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F, Menard C, Puig PE, Ladoire S, Roux S, Martin F, et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother 2007;56:641-8.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3    Ladoire, S.4    Roux, S.5    Martin, F.6
  • 86
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A 2010;107:4275-80.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 87
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med 2013; 368:1365-6.
    • (2013) N Engl J Med , vol.368 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 89
    • 84874889330 scopus 로고    scopus 로고
    • Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination
    • Melero I, Grimaldi AM, Perez-Gracia JL, Ascierto PA. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. Clin Cancer 2013;19:997-1008.
    • (2013) Clin Cancer , vol.19 , pp. 997-1008
    • Melero, I.1    Grimaldi, A.M.2    Perez-Gracia, J.L.3    Ascierto, P.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.