Chronic Stress Induces Anxiety via an Amygdalar Intracellular Cascade that Impairs Endocannabinoid Signaling

Neuron

Volumn 85, Issue 6, 2015, Pages 1319-1331

  Qin, Zhaohong ^a   Zhou, Xun ^a   Pandey, Nihar R ^a   Vecchiarelli, Haley A ^b   Stewart, Chloe A ^a   Zhang, Xia ^c,d   Lagace, Diane C ^d   Brunel, Jean Michel ^e   Béïque, Jean Claude ^d   Stewart, Alexandre F R ^d,f,g   Hill, Matthew N ^b   Chen, Hsiao Huei ^a,d,g  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c ROYAL OTTAWA HOSPITAL   (Canada)

^d UNIVERSITY OF OTTAWA   (Canada)

^e AIX MARSEILLE UNIVERSITY   (France)

^f UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^g UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; ENDOCANNABINOID; GLUCOCORTICOID RECEPTOR ANTAGONIST; GLUTAMATE RECEPTOR 5; LIM DOMAIN ONLY 4 PROTEIN; LIM PROTEIN; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AFFECTING AGENT; LMO4 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; BEAM BREAK TEST; CELL TRANSPORT; CHRONIC STRESS; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL TEST; FEAR; FEMALE; LIGHT DARK PREFERENCE; MALE; MAZE TEST; MOUSE; NERVE CELL; NONHUMAN; NOVELTY SUPPRESSED FEEDING TEST; OPEN FIELD TEST; PALMITOYLATION; PASSIVE AVOIDANCE TEST; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REINFORCEMENT; SIGNAL TRANSDUCTION; ANIMAL; ANXIETY; CYTOPLASM; GENETICS; INTRACELLULAR SPACE; KNOCKOUT MOUSE; MENTAL STRESS; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMYGDALA; ANIMALS; ANXIETY; CANNABINOID RECEPTOR MODULATORS; CYTOPLASM; ENDOCANNABINOIDS; INTRACELLULAR SPACE; LIM DOMAIN PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTOR, CANNABINOID, CB1; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL;

EID: 84925326770     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2015.02.015     Document Type: Article

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