Rimonabant precipitates anxiety in rats withdrawn from palatable food: Role of the central Amygdala

Neuropsychopharmacology

Volumn 38, Issue 12, 2013, Pages 2498-2507

  Blasio, Angelo ^a   Iemolo, Attilio ^a   Sabino, Valentina ^a   Petrosino, Stefania ^b   Steardo, Luca ^c   Rice, Kenner C ^d   Orlando, Pierangelo ^e   Iannotti, Fabio Arturo ^b   Di Marzo, Vincenzo ^b   Zorrilla, Eric P ^f   Cottone, Pietro ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CNR   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^e INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

compulsive eating; eating disorders; endocannabinoids; obesity; SR141716A; withdrawal

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; RIMONABANT;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANOREXIA; ANXIETY; ARTICLE; BODY WEIGHT; CENTRAL NUCLEUS (AMYGDALA); CONTROLLED STUDY; DIET; DRUG EFFECT; FEMALE; FOOD INTAKE; GENE EXPRESSION; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WEIGHT CHANGE; WEIGHT REDUCTION;

AMYGDALA; ANIMALS; ANOREXIA; ANTI-OBESITY AGENTS; ANXIETY; ARACHIDONIC ACIDS; BODY WEIGHT; CANNABINOID RECEPTOR ANTAGONISTS; CORTICOSTERONE; DIET; DIETARY SUCROSE; ENDOCANNABINOIDS; FEMALE; GLYCERIDES; PIPERIDINES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1;

EID: 84888379168     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.153     Document Type: Article

References (57)

1. Aceto MD, Scates SM, Martin BB (2001). Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2. Eur J Pharmacol 416: 75-81. (Pubitemid 32244437)
2. Avena NM, Rada P, Hoebel BG (2008). EviDEnce for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 32: 20-39. (Pubitemid 350160955)
3. Basso AM, Spina M, Rivier J, Vale W, Koob GF (1999). Corticotropin- releasing factor antagonist attenuates the "anxiogenic-like" effect in the DEfensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats. Psychopharmacology (Berl) 145: 21-30.
4. Belin D, Mar AC, Dalley JW, Robbins TW, Everitt BJ (2008). High impulsivity predicts the switch to compulsive cocaine-taking. Science 320: 1352-1355. (Pubitemid 351929473)
5. Blasio A, Steardo L, Sabino V, Cottone P (2013). Opioid system in the medial prefrontal cortex mediates binge-like eating. Addict Biol (doi:10.1111/adb.12033).
6. Caille S, Parsons LH (2006). Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway. Neuropsychopharmacology 31: 804-813.
7. Corwin RL, Grigson PS (2009). Symposium overview-Food addiction: fact or fiction J Nutr 139: 617-619.
8. Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB et al (2009a). CRF system recruitment mediates dark siDE of compulsive eating. Proc Natl Acad Sci USA 106: 20016-20020.
9. Cottone P, Sabino V, Steardo L, Zorrilla EP (2008). Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats. Am J Physiol Regul Integr Comp Physiol 295: R1066-R1076.
10. Cottone P, Sabino V, Steardo L, Zorrilla EP (2009b). Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food. Psychoneuroendocrinology 34(1): 38-49.
11. Davis JF, Loos M, Di Sebastiano AR, Brown JL, Lehman MN, Coolen LM (2010). Lesions of the medial prefrontal cortex cause maladaptive sexual behavior in male rats. Biol Psychiatry 67: 1199-1204.
12. DE Vries TJ, Shaham Y, Homberg JR, Crombag H, Schuurman K, Dieben J et al (2001). A cannabinoid mechanism in relapse to cocaine seeking. Nat Med 7: 1151-1154. (Pubitemid 33010025)
13. Di Marzo V, Matias I (2005). Endocannabinoid control of food intake and energy balance. Nat Neurosci 8: 585-589. (Pubitemid 40594198)
14. Di Marzo V, Piscitelli F, Mechoulam R (2011). Cannabinoids and endocannabinoids in metabolic disorDErs with focus on diabetes. Handb Exp Pharmacol 203: 75-104.
15. Dore R, Iemolo A, Smith KL, Wang X, Cottone P, Sabino V (2013a). CRF Mediates the Anxiogenic and Anti-Rewarding, But Not the Anorectic Effects of PACAP. Neuropsychopharmacology (doi:10.1038/npp.2013.113).
16. Dore R, Valenza M, Wang X, Rice KC, Sabino V, Cottone P (2013b). The inverse agonist of CB receptor SR141716 blocks compulsive eating of palatable food. Addict Biol (doi:10.1111/adb.12056).
17. Engeli S (2012). Central and peripheral cannabinoid receptors as therapeutic targets in the control of food intake and body weight. Handb Exp Pharmacol 209: 357-381.
18. Epstein DH, Shaham Y (2010). Cheesecake-eating rats and the question of food addiction. Nat Neurosci 13: 529-531.
19. Freedland CS, Poston JS, Porrino LJ (2000). Effects of SR141716A, a central cannabinoid receptor antagonist, on food-maintained responding. Pharmacol Biochem Behav 67: 265-270. (Pubitemid 32000832)
20. Gaetani S, Kaye WH, Cuomo V, Piomelli D (2008). Role of endocannabinoids and their analogues in obesity and eating disorDErs. Eat Weight Disord 13: e42-e48.
21. George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH et al (2007). CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-DEpenDEnt rats. Proc Natl Acad Sci USA 104: 17198-17203. (Pubitemid 350211014)
22. Gessa GL, Orru A, Lai P, Maccioni P, Lecca R, Lobina C et al (2006). Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats. Psychopharmacology (Berl) 185: 248-254. (Pubitemid 43363621)
23. Goldberg SR, Schuster CR (1969). Nalorphine: increased sensitivity of monkeys formerly DEpenDEnt on morphine. Science 166: 1548-1549.
24. Grimaldi P, Orlando P, Di Siena S, Lolicato F, Petrosino S, Bisogno T et al (2009). The endocannabinoid system and pivotal role of the CB2 receptor in mouse spermatogenesis. Proc Natl Acad Sci USA 106: 11131-11136.
25. Hagan MM, Moss DE (1997). Persistence of binge-eating patterns after a history of restriction with intermittent bouts of refeeding on palatable food in rats: implications for bulimia nervosa. Int J Eat Disord 22: 411-420. (Pubitemid 27459521)
26. Haller J, Varga B, LeDEnt C, Barna I, Freund TF (2004). ContextDEpenDEnt effects of CB1 cannabinoid gene disruption on anxietylike and social behaviour in mice. Eur J Neurosci 19: 1906-1912. (Pubitemid 38482578)
27. Iemolo A, Blasio A St, Cyr SA, Jiang F, Rice KC, Sabino V et al (2013). CRF-CRF receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food. Neuropsychopharmacology (doi:10.1038/npp. 2013.147).
28. Iemolo A, Valenza M, Tozier L, Knapp CM, Kornetsky C, Steardo L et al (2012). Withdrawal from chronic, intermittent access to a highly palatable food induces DEpressive-like behavior in compulsive eating rats. Behav Pharmacol 23: 593-602.
29. Johnson PM, Kenny PJ (2010). Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 13: 635-641.
30. Kirkham TC (2009). Cannabinoids and appetite: food craving and food pleasure. Int Rev Psychiatry 21: 163-171.
31. Koga Y, Inukai T (1981). Characterization of withdrawal syndrome of morphine-DEpenDEnt rats prepared by intermittent infusion technique. Psychopharmacology (Berl) 73: 230-235. (Pubitemid 11104036)
32. Koob GF (2009). Neurobiological substrates for the dark siDE of compulsivity in addiction. Neuropharmacology 56(Suppl 1): 18-31.
33. Koob GF, Volkow ND (2010). Neurocircuitry of addiction. Neuropsychopharmacology 35: 217-238.
34. Kupferschmidt DA, Klas PG, Erb S (2012a). Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization. Br J Pharmacol 167: 196-206.
35. Kupferschmidt DA, Newman AE, Boonstra R, Erb S (2012b). Antagonism of cannabinoid 1 receptors reverses the anxietylike behavior induced by central injections of corticotropinreleasing factor and cocaine withdrawal. Neuroscience 204: 125-133.
36. Liu J, Schulteis G (2004). Brain reward DEficits accompany naloxone-precipitated withdrawal from acute opioid DEpenDEnce. Pharmacol Biochem Behav 79: 101-108. (Pubitemid 39237708)
37. Lukas SE, Griffiths RR (1982). Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro 15-1788) after 7 days of diazepam. Science 217: 1161-1163. (Pubitemid 12069040)
38. Malin DH, Lake JR, Carter VA, Cunningham JS, Hebert KM, Conrad DL et al (1994). The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat. Psychopharmacology (Berl) 115: 180-184. (Pubitemid 24207780)
39. Moreira FA, Grieb M, Lutz B (2009). Central siDE-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and DEpression. Best Pract Res Clin Endocrinol Metab 23: 133-144.
40. Navarro M, Carrera MR, Fratta W, ValverDE O, Cossu G, Fattore L et al (2001). Functional interaction between opioid and cannabinoid receptors in drug self-administration. J Neurosci 21: 5344-5350. (Pubitemid 32622960)
41. Pacher P, Batkai S, Kunos G (2006). The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58: 389-462. (Pubitemid 44394908)
42. Parylak SL, Cottone P, Sabino V, Rice KC, Zorrilla EP (2012). Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses. Physiol Behav 107: 231-242.
43. Parylak SL, Koob GF, Zorrilla EP (2011). The dark siDE of food addiction. Physiol Behav 104: 149-156.
44. Patel S, Hillard CJ (2008). Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. Eur J Neurosci 27: 2821-2829. (Pubitemid 351832221)
45. Patel S, Roelke CT, RaDEmacher DJ, Hillard CJ (2005). Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling. Eur J Neurosci 21: 1057-1069. (Pubitemid 40461057)
46. Paterson NE, Markou A (2004). Prolonged nicotine DEpenDEnce associated with extenDEd access to nicotine self-administration in rats. Psychopharmacology (Berl) 173: 64-72. (Pubitemid 38591148)
47. Pellegrino A (1979). A stereotaxic atlas of the rat brain. Plenum: New York.
48. Roche M, O'Connor E, Diskin C, Finn DP (2007). The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats. Eur J Neurosci 26: 2643-2653. (Pubitemid 350050435)
49. Rodriguez DE Fonseca F, Carrera MR, Navarro M, Koob GF, Weiss F (1997). Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science 276: 2050-2054. (Pubitemid 27443612)
50. Rosenberg HC, Chiu TH (1982). An antagonist-induced benzodiazepine abstinence syndrome. Eur J Pharmacol 81: 153-157. (Pubitemid 12087626)
51. Rothwell PE, Thomas MJ, Gewirtz JC (2012). Protracted manifestations of acute DEpenDEnce after a single morphine exposure. Psychopharmacology (Berl) 219: 991-998.
52. Sabino V, Cottone P, Steardo L, Schmidhammer H, Zorrilla EP (2007). 14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. Psychopharmacology (Berl) 192: 537-546. (Pubitemid 46870748)
53. Schulteis G, Yackey M, Risbrough V, Koob GF (1998). Anxiogeniclike effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze. Pharmacol Biochem Behav 60: 727-731. (Pubitemid 28341934)
54. Sidhpura N, Parsons LH (2011). Endocannabinoid-mediated synaptic plasticity and addiction-related behavior. Neuropharmacology 61: 1070-1087.
55. Tsuda M, Suzuki T, Misawa M (1998). NMDA receptor antagonists potently suppress the spontaneous withdrawal signs induced by discontinuation of long-term diazepam treatment in Fischer 344 rats. Brain Res 790: 82-90. (Pubitemid 28234491)
56. ValverDE O, Maldonado R, Valjent E, Zimmer AM, Zimmer A (2000). Cannabinoid withdrawal syndrome is reduced in preproenkephalin knock-out mice. J Neurosci 20: 9284-9289. (Pubitemid 32042932)
57. Vaughn LK, Mantsch JR, Vranjkovic O, Stroh G, Lacourt M, Kreutter M et al (2012). Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways. Neuroscience 204: 117-124.