LIM domain only 4 protein promotes granulocyte colony-stimulating factor-induced signaling in neurons

Cellular and Molecular Life Sciences

Volumn 67, Issue 6, 2010, Pages 949-957

  Gomez Smith, Mariana ^a   Qin, Zhaohong ^a   Zhou , Xun ^a   Schock, Sarah C ^a   Chen, Hsiao Huei ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Cell death acetylation; GCSF; HDAC; Ischemia; Lmo4 stat3; Neurons

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; HISTONE DEACETYLASE 2; LIM DOMAIN ONLY 4 PROTEIN; LIM PROTEIN; PROTEIN P27; STAT3 PROTEIN; TRICHOSTATIN A; UNCLASSIFIED DRUG; HDAC2 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; LMO4 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ACETYLATION; ANIMAL CELL; ARTICLE; CANCER CELL; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ISCHEMIA; LIVER CELL; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; GENETICS; METABOLISM; MOUSE MUTANT; NERVE CELL; PATHOLOGY;

ANIMALS; CELLS, CULTURED; GRANULOCYTE COLONY-STIMULATING FACTOR; HEPATOCYTES; HISTONE DEACETYLASE 2; HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; NEURONS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 77949501543     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0223-z     Document Type: Article

References (42)

1. Mattson MP, Scheff SW (1994) Endogenous neuroprotection factors and traumatic brain injury: mechanisms of action and implications for therapy. J Neurotrauma 11:3-33
2. Metcalf D (1990) The colony stimulating factors. Discovery, development, and clinical applications. Cancer 65:2185-2195
3. 3. Schabitz WR, Kollmar R, Schwaninger M, Juettler E, Bardutzky J, Scholzke MN, Sommer C, Schwab S (2003) Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 34:745-751 (Pubitemid 36307405)
4. Schneider A, Kruger C, Steigleder T, Weber D, Pitzer C, Laage R, Aronowski J, Maurer MH, Gassler N, Mier W, Hasselblatt M, Kollmar R, Schwab S, Sommer C, Bach A, Kuhn HG, Schabitz WR (2005) The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 115:2083-2098
5. 5. Komine-Kobayashi M, Zhang N, Liu M, Tanaka R, Hara H, Osaka A, Mochizuki H, Mizuno Y, Urabe T (2006) Neuroprotective effect of recombinant human granulocyte colonystimulating factor in transient focal ischemia of mice. J Cereb Blood Flow Metab 26:402-413 (Pubitemid 43297921)
6. 6. Solaroglu I, Tsubokawa T, Cahill J, Zhang JH (2006) Antiapoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat. Neuroscience 143:965-974 (Pubitemid 44827523)
7. 7. Byts N, Samoylenko A, Woldt H, Ehrenreich H, Siren AL (2006) Cell type specific signalling by hematopoietic growth factors in neural cells. Neurochem Res 31:1219-1230 (Pubitemid 44701769)
8. Huang HY, Lin SZ, Kuo JS, Chen WF, Wang MJ (2007) G-CSF protects dopaminergic neurons from 6-OHDA-induced toxicity via the ERK pathway. Neurobiol Aging 28:1258-1269
9. Solaroglu I, Cahill J, Jadhav V, Zhang JH (2006) A novel neuroprotectant granulocyte-colony stimulating factor. Stroke 37:1123-1128
10. 10. Yuan ZL, Guan YJ, Chatterjee D, Chin YE (2005) Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science 307:269-273 (Pubitemid 40116244)
11. Schock SC, Xu J, Duquette PM, Qin Z, Rai PS, Lewandowski AJ, Thompson CS, Seifert EL, Harper ME, Chen HH (2008) Rescue of neurons from ischemic injury by PPARgamma requires a novel essential cofactor LMO4. J Neurosci 28:12433-12444
12. Joshi K, Lee S, Lee B, Lee JW, Lee SK (2009) LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron 61:839-851
13. Song MR, Sun Y, Bryson A, Gill GN, Evans SM, Pfaff SL (2009) Islet-to-LMO stoichiometrics control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development 136:2923-2932
14. 14. Manetopoulos C, Hansson A, Karlsson J, Jonsson JI, Axelson H (2003) The LIM-only protein LMO4 modulates the transcriptional activity of HENl. Biochem Biophys Res Commun 307:891-899 (Pubitemid 36871657)
15. 15. Kashani AH, Qiu Z, Jurata L, Lee SK, Pfaff S, Goebbels S, Nave KA, Ghosh A (2006) Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci 26:8398-8408 (Pubitemid 44309854)
16. 16. Hahm K, Sum EY, Fujiwara Y, Lindeman GJ, Visvader JE, Orkin SH (2004) Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol 24:2074-2082 (Pubitemid 38248946)
17. Tse E, Smith AJ, Hunt S, Lavenir I, Forster A, Warren AJ, Grutz G, Foroni L, Carlton MB, Colledge WH, Boehm T, Rabbitts TH (2004) Null mutation of the Lmo4 gene or a combined null mutation of the Lmol/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. Mol Cell Biol 24:2063-2073
18. 18. Chen HH, Schock SC, Xu J, Safarpour F, Thompson CS, Stewart AF (2007) Extracellular ATP-dependent upregulation of the transcription cofactor LMO4 promotes neuron survival from hypoxia. Exp Cell Res 313:3106-3116 (Pubitemid 47125879)
19. 19. Chen HH, Xu J, Safarpour F, Stewart AF (2007) LMO4 mRNA stability is regulated by extracellular ATP in F11 cells. Biochem Biophys Res Commun 357:56-61 (Pubitemid 46574499)
20. 20. Novotny-Diermayr V, Lin B, Gu L, Cao X (2005) Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction. J Biol Chem. 280:12747-12757 (Pubitemid 40491095)
21. Singh RR, Barnes CJ, Talukder AH, Fuqua SA, Kumar R (2005) Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein. Cancer Res 65:10594-10601
22. 22. Sum EY, Segara D, Duscio B, Bath ML, Field AS, Sutherland RL, Lindeman GJ, Visvader JE (2005) Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer. Proc Natl Acad Sci USA. 102:7659-7664 (Pubitemid 40741027)
23. 23. Wang N, Lin KK, Lu Z, Lam KS, Newton R, Xu X, Yu Z, Gill GN, Andersen B (2007) The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells. Oncogene 26:6431-6441 (Pubitemid 47494218)
24. 24. Ou XM, Jafar-Nejad H, Starring JM, Meng JH, Lemonde S, Albert PR (2000) Novel dual repressor elements for neuronal cell-specific transcription of the rat 5-HTlA receptor gene. J Biol Chem 275:8161-8168 (Pubitemid 30159731)
25. 25. Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (2000) A role for SKIP in EBNA2 activation of CBF1-repressed promoters. J Virol 74:1939-1947 (Pubitemid 30434053)
26. Setogawa T, Shinozaki-Yabana S, Masuda T, Matsuura K, Akiyama T (2006) The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldbl. Biochem Biophys Res Commun 343:1186-1190
27. Chen HH, Kong WP, Zhang L, Ward PL, Roos RP (1995) A picornaviral protein synthesized out of frame with the polyprotein plays a key role in a virus-induced immune-mediated demyelinating disease. Nat Med 1:927-931
28. 28. Kochanek S, Clemens PR, Mitani K, Chen HH, Chan S, Caskey CT (1996) A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Natl Acad Sci USA 93:5731-5736 (Pubitemid 26190748)
29. 29. Arai M, Imai H, Koumura T, Yoshida M, Emoto K, Umeda M, Chiba N, Nakagawa Y (1999) Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells. J Biol Chem 274:4924-4933 (Pubitemid 129501508)
30. 30. Hasegawa T, Suzuki K, Sakamoto C, Ohta K, Nishiki S, Hino M, Tatsumi N, Kitagawa S (2003) Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia. Blood 101:1164-1171 (Pubitemid 36139392)
31. Sun Y, Chin YE, Weisiger E, Malter C, Tawara I, Toubai T, Gatza E, Mascagni P, Dinarello CA, Reddy P (2009) Cutting edge: negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3. J Immunol 182:5899-5903
32. 32. de Koning JP, Soede-Bobok AA, Ward AC, Schelen AM, Antonissen C, van Leeuwen D, Lowenberg B, Touw IP (2000) STAT3-m.ediated differentiation and survival, and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kipl). Oncogene 19:3290-3298 (Pubitemid 30487415)
33. 33. Akashiba H, Matsuki N, Nishiyama N (2006) p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study. Cell Mol Life Sci 63:2397-2404 (Pubitemid 44653049)
34. 34. Akashiba H, Matsuki N, Nishiyama N (2006) Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons. J Neurochem 99:733-744 (Pubitemid 44583433)
35. Yamashita T, Deguchi K, Sehara Y, Lukic-Panin V, Zhang H, Kamiya T, Abe K (2009) Therapeutic strategy for ischemic stroke. Neurochem Res 34:707-710
36. 36. Park DS, Morris EJ, Padmanabhan J, Shelanski ML, Geller HM, Greene LA (1998) Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. J Cell Biol 143:457-467 (Pubitemid 28487863)
37. 37. Ueyama C, Akashiba H, Nakayama K, Nakayama KI, Nishiyama N, Matsuki N (2007) Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration, Neuroreport 18:1781-1785 (Pubitemid 350303751)
38. Rashidian J, Iyirhiaro GO, Park DS (2007) Cell cycle machinery and stroke. Biochim Biophys Acta 1772:484-493
39. Biswas SC, Liu DX, Greene LA (2005) Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J Neurosci 25:8349-8358
40. Liu DX, Biswas SC, Greene LA (2004) B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage. J Neurosci 24:8720-8725
41. Langley B, Brochier C, Rivieccio MA (2009) Targeting histone deacetylases as a multifaceted approach to treat the diverse outcomes of stroke. Stroke 40:2899-2905
42. Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR (2008) Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(wafl/cipl) in cell cycleindependent neuroprotection. J Neurosci 28:163-176