PIKfyve, a class III PI Kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in toll-like receptor signaling

Chemistry and Biology

Volumn 20, Issue 7, 2013, Pages 912-921

  Cai, Xinming ^a   Xu, Yongyao ^a   Cheung, Atwood K ^a   Tomlinson, Ronald C ^a,f   Alcázar Román, Abel ^b   Murphy, Leon ^a   Billich, Andreas ^c   Zhang, Bailin ^a,f   Feng, Yan ^a   Klumpp, Martin ^c   Rondeau, Jean Michel ^c   Fazal, Aleem N ^a   Wilson, Christopher J ^a   Myer, Vic ^a   Joberty, Gerard ^d   Bouwmeester, Tewis ^c,d   Labow, Mark A ^a   Finan, Peter M ^a   Porter, Jeffrey A ^a   Ploegh, Hidde L ^e   Baird, Daniel ^a   De Camilli, Pietro ^b   Tallarico, John A ^a   Huang, Qian ^a   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d GLAXOSMITHKLINE   (United Kingdom)

^e WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^f Sanofi Aventis US LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APILIMOD; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 23; PHOSPHOTRANSFERASE; PIKFYVE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; ENZYME INHIBITION; GENE INACTIVATION; GENE REPRESSION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CYTOKINES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-12; INTERLEUKIN-23; MICE; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BINDING; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TOLL-LIKE RECEPTORS; TRIAZINES;

EID: 84880888092     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2013.05.010     Document Type: Article

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