Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells

Cancer Letters

Volumn 361, Issue 1, 2015, Pages 39-48

  Stuhldreier, Fabian ^a   Kassel, Stefanie ^a   Schumacher, Lena ^a   Wesselborg, Sebastian ^a   Proksch, Peter ^a   Fritz, Gerhard ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Acute myeloid leukemia; Anthrayclines; Cell death; DNA damage response; Natural compounds; Spongean alkaloids

Indexed keywords

AAPTAMINE; AEROPLYSININ 1; ALKALOID; CHECKPOINT KINASE 2; DAUNORUBICIN; HISTONE H2AX; HISTONE H3; PROTEIN P16; PROTEIN P21; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ACETONITRILE DERIVATIVE; AEROPLYSININ I; ANTINEOPLASTIC ANTIBIOTIC; CYCLOHEXENE DERIVATIVE; NAPHTHYRIDINE DERIVATIVE;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG TRANSPORT; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC50; LEUKEMIA CELL; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; CELL CYCLE; CELL PROLIFERATION; DRUG EFFECTS; DRUG POTENTIATION; FLOW CYTOMETRY; GENETICS; LEUKEMIA, MYELOID, ACUTE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL CULTURE;

ACETONITRILES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CYCLOHEXENES; DAUNORUBICIN; DNA DAMAGE; DRUG SYNERGISM; FLOW CYTOMETRY; HUMANS; LEUKEMIA, MYELOID, ACUTE; NAPHTHYRIDINES; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 84925247267     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2015.02.030     Document Type: Article

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