Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine

Chemical Biology and Drug Design

Volumn 71, Issue 3, 2008, Pages 205-215

  Bowling, John J ^a   Pennaka, Hari K ^a   Ivey, Kelly ^a   Wahyuono, Subagus ^b   Kelly, Michelle ^c   Schinazi, Raymond F ^d   Valeriote, Frederick A ^e   Graves, David E ^f   Hamann, Mark T ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b GADJAH MADA UNIVERSITY   (Indonesia)

^c NATIONAL INSTITUTE OF WATER AND ATMOSPHERIC RESEARCH   (New Zealand)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HENRY FORD HEALTH SYSTEM   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Aaptamine; Alkaloid; Anti HIV; Cytotoxicity; DNA binding; Infectious diseases; Natural products

Indexed keywords

1,6 BISISOAAPTAMINE HEXANE; 1N (3 METHYLBUTYL)AAPTAMINE; 1N BUTYLAAPTAMINE; 1N DODECYLAAPTAMINE; 1N ETHYLAAPTAMINE; 1N HEPTYLAAPTAMINE; 1N METHYLAAPTAMINE; 1N NONYLAAPTAMINE; 1N PROPYLAAPTAMINE; 1N,4N DIDODECYLAAPTAMINE; 4N (3 METHYLBUTYL)AAPTAMINE; 4N BUTYLAAPTAMINE; 4N ETHYLAAPTAMINE; 4N HEPTYLAAPTAMINE; 4N HEXADECYLAAPTAMINE; 4N HEXYLAAPTAMINE; 4N METHYLAAPTAMINE; 4N NONYLAAPTAMINE; 4N PROPYLAAPTAMINE; 9 O METHYLSULFONYLISOAAPTAMINE; 9 O OCTYLSULFONYLISOAAPTAMINE; 9 O PHENYLSULFONYLISOAAPTAMINE; 9 O PROPYLSULFONYLISOAAPTAMINE; AAPTAMINE; AMPHOTERICIN B; DNA; INTERCALATING AGENT; ISOAAPTAMINE; N [2 (DIETHYLAMINO)ETHYL] 9 AMINOACRIDINE 4 CARBOXAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISK DIFFUSION; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR; ULTRAVIOLET SPECTROSCOPY; VALIDATION STUDY;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; BIOLOGICAL PRODUCTS; DNA; DRUG EVALUATION, PRECLINICAL; MARINE BIOLOGY; NAPHTHYRIDINES; PORIFERA; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

KOBUS;

EID: 38849152333     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00628.x     Document Type: Article

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