메뉴 건너뛰기




Volumn 28, Issue 6, 2014, Pages 1003-1015

Clinical relevance of Helicobacter pylori vacA and cagA genotypes in gastric carcinoma

Author keywords

CagA; Gastric carcinoma; Genotypes; Helicobacter pylori; VacA; Virulence factors

Indexed keywords

CAGA PROTEIN; INTERLEUKIN 1BETA; UNCLASSIFIED DRUG; VACUOLATING CYTOTOXIN A; VACUOLATING TOXIN; VIRULENCE FACTOR; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI; VACA PROTEIN, HELICOBACTER PYLORI;

EID: 84925226060     PISSN: 15216918     EISSN: 15321916     Source Type: Journal    
DOI: 10.1016/j.bpg.2014.09.004     Document Type: Review
Times cited : (56)

References (126)
  • 2
    • 12644292106 scopus 로고
    • The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification
    • Lauren P. The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965;64: 31-49.
    • (1965) Acta Pathol Microbiol Scand , vol.64 , pp. 31-49
    • Lauren, P.1
  • 3
    • 0029082877 scopus 로고
    • New elements for an updated classification of the carcinomas of the stomach
    • Carneiro F, Seixas M, Sobrinho-Simoes M. New elements for an updated classification of the carcinomas of the stomach. Pathol Res Pract 1995;191: 571-84.
    • (1995) Pathol Res Pract , vol.191 , pp. 571-584
    • Carneiro, F.1    Seixas, M.2    Sobrinho-Simoes, M.3
  • 4
    • 0028694306 scopus 로고
    • Schistosomes liver flukes and Helicobacter pylori. IARC working group on the evaluation of carcinogenic risks to humans
    • IARC. Lyon, 7-14 June 1994
    • IARC. Schistosomes, liver flukes and Helicobacter pylori. IARC working group on the evaluation of carcinogenic risks to humans. Lyon, 7-14 June 1994. IARC Monogr Eval Carcinog Risks Hum 1994;61: 1-241.
    • (1994) IARC Monogr Eval Carcinog Risks Hum , vol.61 , pp. 1-241
  • 5
    • 77952903266 scopus 로고    scopus 로고
    • Helicobacter pylori: Gastric cancer and beyond
    • Polk DB, Peek Jr. RM. Helicobacter pylori: Gastric cancer and beyond. Nat Rev Cancer 2010;10: 403-14.
    • (2010) Nat Rev Cancer , vol.10 , pp. 403-414
    • Polk, D.B.1    Peek, R.M.2
  • 6
    • 0027065034 scopus 로고
    • Human gastric carcinogenesis: A multistep and multifactorial process - First American Cancer Society Award Lecture on cancer epidemiology and prevention
    • Correa P. Human gastric carcinogenesis: A multistep and multifactorial process - First American Cancer Society Award Lecture on cancer epidemiology and prevention. Cancer Res 1992;52: 6735-40.
    • (1992) Cancer Res , vol.52 , pp. 6735-6740
    • Correa, P.1
  • 7
    • 84859589351 scopus 로고    scopus 로고
    • Management of Helicobacter pylori infection - The Maastricht IV/florence consensus report
    • Malfertheiner P, Megraud F, O'Morain CA, Atherton J, Axon AT, Bazzoli F, et al. Management of Helicobacter pylori infection - The Maastricht IV/florence consensus report. Gut 2012;61: 646-64.
    • (2012) Gut , vol.61 , pp. 646-664
    • Malfertheiner, P.1    Megraud, F.2    O'Morain, C.A.3    Atherton, J.4    Axon, A.T.5    Bazzoli, F.6
  • 8
    • 0142117212 scopus 로고    scopus 로고
    • Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    • Gonzalez CA, Pera G, Agudo A, Palli D, Krogh V, Vineis P, et al. Smoking and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 2003;107: 629-34.
    • (2003) Int J Cancer , vol.107 , pp. 629-634
    • Gonzalez, C.A.1    Pera, G.2    Agudo, A.3    Palli, D.4    Krogh, V.5    Vineis, P.6
  • 9
    • 9144220789 scopus 로고    scopus 로고
    • Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: A randomized controlled trial
    • Wong BC, Lam SK,Wong WM, Chen JS, Zheng TT, Feng RE, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: A randomized controlled trial. JAMA 2004;291: 187-94.
    • (2004) JAMA , vol.291 , pp. 187-194
    • Wong, B.C.1    Lam, S.K.2    Wong, W.M.3    Chen, J.S.4    Zheng, T.T.5    Feng, R.E.6
  • 10
    • 14144249629 scopus 로고    scopus 로고
    • Salt, salted food intake, and risk of gastric cancer: Epidemiologic evidence
    • Tsugane S. Salt, salted food intake, and risk of gastric cancer: Epidemiologic evidence. Cancer Sci 2005;96: 1-6.
    • (2005) Cancer Sci , vol.96 , pp. 1-6
    • Tsugane, S.1
  • 12
  • 13
    • 0042667008 scopus 로고    scopus 로고
    • A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
    • Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003;125: 364-71.
    • (2003) Gastroenterology , vol.125 , pp. 364-371
    • Machado, J.C.1    Figueiredo, C.2    Canedo, P.3    Pharoah, P.4    Carvalho, R.5    Nabais, S.6
  • 14
    • 0034793044 scopus 로고    scopus 로고
    • Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    • Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, et al. Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 2001;121: 823-9.
    • (2001) Gastroenterology , vol.121 , pp. 823-829
    • Machado, J.C.1    Pharoah, P.2    Sousa, S.3    Carvalho, R.4    Oliveira, C.5    Figueiredo, C.6
  • 15
    • 54949110598 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)
    • Crusius JB, Canzian F, Capella G, Pena AS, Pera G, Sala N, et al. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Ann Oncol 2008;19: 1894-902.
    • (2008) Ann Oncol , vol.19 , pp. 1894-1902
    • Crusius, J.B.1    Canzian, F.2    Capella, G.3    Pena, A.S.4    Pera, G.5    Sala, N.6
  • 16
    • 79251525848 scopus 로고    scopus 로고
    • Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses
    • Persson C, Canedo P, Machado JC, El-Omar EM, Forman D. Polymorphisms in inflammatory response genes and their association with gastric cancer: A HuGE systematic review and meta-analyses. Am J Epidemiol 2011;173: 259-70.
    • (2011) Am J Epidemiol , vol.173 , pp. 259-270
    • Persson, C.1    Canedo, P.2    Machado, J.C.3    El-Omar, E.M.4    Forman, D.5
  • 18
    • 44449109938 scopus 로고    scopus 로고
    • Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: A meta-analysis
    • Zhang J, Dou C, Song Y, Ji C, Gu S, Xie Y, et al. Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: A meta-analysis. J Hum Genet 2008;53: 479-89.
    • (2008) J Hum Genet , vol.53 , pp. 479-489
    • Zhang, J.1    Dou, C.2    Song, Y.3    Ji, C.4    Gu, S.5    Xie, Y.6
  • 19
    • 34249048365 scopus 로고    scopus 로고
    • Helicobacter pylori evolution and phenotypic diversification in a changing host
    • Suerbaum S, Josenhans C. Helicobacter pylori evolution and phenotypic diversification in a changing host. Nat Rev Microbiol 2007;5: 441-52.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 441-452
    • Suerbaum, S.1    Josenhans, C.2
  • 20
    • 13044317274 scopus 로고    scopus 로고
    • Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity
    • Szabo I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, et al. Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. EMBO J 1999;18: 5517-27.
    • (1999) EMBO J , vol.18 , pp. 5517-5527
    • Szabo, I.1    Brutsche, S.2    Tombola, F.3    Moschioni, M.4    Satin, B.5    Telford, J.L.6
  • 22
    • 0026062034 scopus 로고
    • Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin
    • Cover TL, Puryear W, Perez-Perez GI, Blaser MJ. Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin. Infect Immun 1991;59: 1264-70.
    • (1991) Infect Immun , vol.59 , pp. 1264-1270
    • Cover, T.L.1    Puryear, W.2    Perez-Perez, G.I.3    Blaser, M.J.4
  • 23
    • 0037370481 scopus 로고    scopus 로고
    • Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori
    • Fujikawa A, Shirasaka D, Yamamoto S, Ota H, Yahiro K, Fukada M, et al. Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Nat Genet 2003;33: 375-81.
    • (2003) Nat Genet , vol.33 , pp. 375-381
    • Fujikawa, A.1    Shirasaka, D.2    Yamamoto, S.3    Ota, H.4    Yahiro, K.5    Fukada, M.6
  • 24
    • 0034388020 scopus 로고    scopus 로고
    • The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release
    • Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, et al. The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J 2000;19: 6361-70.
    • (2000) EMBO J , vol.19 , pp. 6361-6370
    • Galmiche, A.1    Rassow, J.2    Doye, A.3    Cagnol, S.4    Chambard, J.C.5    Contamin, S.6
  • 25
    • 0006534562 scopus 로고    scopus 로고
    • Vacuolating cytotoxin purified from Helicobacter pylori causes mitochondrial damage in human gastric cells
    • Kimura M, Goto S, Wada A, Yahiro K, Niidome T, Hatakeyama T, et al. Vacuolating cytotoxin purified from Helicobacter pylori causes mitochondrial damage in human gastric cells. Microb Pathog 1999;26: 45-52.
    • (1999) Microb Pathog , vol.26 , pp. 45-52
    • Kimura, M.1    Goto, S.2    Wada, A.3    Yahiro, K.4    Niidome, T.5    Hatakeyama, T.6
  • 26
  • 27
    • 84860223287 scopus 로고    scopus 로고
    • Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans
    • Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, et al. Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology 2012;142: 1160-71.
    • (2012) Gastroenterology , vol.142 , pp. 1160-1171
    • Raju, D.1    Hussey, S.2    Ang, M.3    Terebiznik, M.R.4    Sibony, M.5    Galindo-Mata, E.6
  • 28
    • 0042932364 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation
    • Gebert B, Fischer W, Weiss E, Hoffmann R, Haas R. Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 2003;301: 1099-102.
    • (2003) Science , vol.301 , pp. 1099-1102
    • Gebert, B.1    Fischer, W.2    Weiss, E.3    Hoffmann, R.4    Haas, R.5
  • 29
    • 38049076855 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets
    • Torres VJ, VanCompernolle SE, Sundrud MS, Unutmaz D, Cover TL. Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets. J Immunol 2007;179: 5433-40.
    • (2007) J Immunol , vol.179 , pp. 5433-5440
    • Torres, V.J.1    VanCompernolle, S.E.2    Sundrud, M.S.3    Unutmaz, D.4    Cover, T.L.5
  • 30
    • 0027360887 scopus 로고
    • Correlation between vacuolating cytotoxin production by Helicobacter pylori isolates in vitro and in vivo
    • Cover TL, Cao P, Lind CD, Tham KT, Blaser MJ. Correlation between vacuolating cytotoxin production by Helicobacter pylori isolates in vitro and in vivo. Infect Immun 1993;61: 5008-12.
    • (1993) Infect Immun , vol.61 , pp. 5008-5012
    • Cover, T.L.1    Cao, P.2    Lind, C.D.3    Tham, K.T.4    Blaser, M.J.5
  • 31
    • 0028308711 scopus 로고
    • Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
    • Cover TL, Tummuru MK, Cao P, Thompson SA, Blaser MJ. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 1994;269: 10566-73.
    • (1994) J Biol Chem , vol.269 , pp. 10566-10573
    • Cover, T.L.1    Tummuru, M.K.2    Cao, P.3    Thompson, S.A.4    Blaser, M.J.5
  • 32
    • 0029059733 scopus 로고
    • Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration
    • Atherton JC, Cao P, Peek Jr. RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995;270: 17771-7.
    • (1995) J Biol Chem , vol.270 , pp. 17771-17777
    • Atherton, J.C.1    Cao, P.2    Peek, R.M.3    Tummuru, M.K.4    Blaser, M.J.5    Cover, T.L.6
  • 33
    • 0034750730 scopus 로고    scopus 로고
    • A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation
    • McClain MS, Cao P, Iwamoto H, Vinion-Dubiel AD, Szabo G, Shao Z, et al. A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation. J Bacteriol 2001;183: 6499-508.
    • (2001) J Bacteriol , vol.183 , pp. 6499-6508
    • McClain, M.S.1    Cao, P.2    Iwamoto, H.3    Vinion-Dubiel, A.D.4    Szabo, G.5    Shao, Z.6
  • 34
    • 20444426199 scopus 로고    scopus 로고
    • Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin
    • Torres VJ, Ivie SE, McClain MS, Cover TL. Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin. J Biol Chem 2005;280: 21107-14.
    • (2005) J Biol Chem , vol.280 , pp. 21107-21114
    • Torres, V.J.1    Ivie, S.E.2    McClain, M.S.3    Cover, T.L.4
  • 36
    • 0038712424 scopus 로고    scopus 로고
    • Determinants of non-toxicity in the gastric pathogen Helicobacter pylori
    • Letley DP, Rhead JL, Twells RJ, Dove B, Atherton JC. Determinants of non-toxicity in the gastric pathogen Helicobacter pylori. J Biol Chem 2003;278: 26734-41.
    • (2003) J Biol Chem , vol.278 , pp. 26734-26741
    • Letley, D.P.1    Rhead, J.L.2    Twells, R.J.3    Dove, B.4    Atherton, J.C.5
  • 37
    • 34548495047 scopus 로고    scopus 로고
    • A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric Cancer
    • Rhead JL, Letley DP, Mohammadi M, Hussein N, Mohagheghi MA, Eshagh Hosseini M, et al. A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric Cancer. Gastroenterology 2007; 133: 926-36.
    • (2007) Gastroenterology , vol.133 , pp. 926-936
    • Rhead, J.L.1    Letley, D.P.2    Mohammadi, M.3    Hussein, N.4    Mohagheghi, M.A.5    Eshagh Hosseini, M.6
  • 40
    • 70449631467 scopus 로고    scopus 로고
    • Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases
    • Ogiwara H, Sugimoto M, Ohno T, Vilaichone RK, Mahachai V, Graham DY, et al. Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases. J Clin Microbiol 2009;47: 3493-500.
    • (2009) J Clin Microbiol , vol.47 , pp. 3493-3500
    • Ogiwara, H.1    Sugimoto, M.2    Ohno, T.3    Vilaichone, R.K.4    Mahachai, V.5    Graham, D.Y.6
  • 41
    • 84869213164 scopus 로고    scopus 로고
    • A novel method for genotyping Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens
    • Ferreira RM, Machado JC, Letley D, Atherton JC, Pardo ML, Gonzalez CA, et al. A novel method for genotyping Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens. J Clin Microbiol 2012;50: 3983-9.
    • (2012) J Clin Microbiol , vol.50 , pp. 3983-3989
    • Ferreira, R.M.1    Machado, J.C.2    Letley, D.3    Atherton, J.C.4    Pardo, M.L.5    Gonzalez, C.A.6
  • 42
    • 77749312943 scopus 로고    scopus 로고
    • Diversity of VacA intermediate region among Helicobacter pylori strains from several regions of the world
    • Chung C, Olivares A, Torres E, Yilmaz O, Cohen H, Perez-Perez G. Diversity of VacA intermediate region among Helicobacter pylori strains from several regions of the world. J Clin Microbiol 2010;48: 690-6.
    • (2010) J Clin Microbiol , vol.48 , pp. 690-696
    • Chung, C.1    Olivares, A.2    Torres, E.3    Yilmaz, O.4    Cohen, H.5    Perez-Perez, G.6
  • 43
    • 0031032033 scopus 로고    scopus 로고
    • Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori
    • Atherton JC, Peek Jr. RM, Tham KT, Cover TL, Blaser MJ. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997;112: 92-9.
    • (1997) Gastroenterology , vol.112 , pp. 92-99
    • Atherton, J.C.1    Peek, R.M.2    Tham, K.T.3    Cover, T.L.4    Blaser, M.J.5
  • 46
    • 15644371883 scopus 로고    scopus 로고
    • Analysis of Helicobacter pylori vacA and cagA genotypes and serum antibody profile in benign and malignant gastroduodenal diseases
    • Basso D, Navaglia F, Brigato L, Piva MG, Toma A, Greco E, et al. Analysis of Helicobacter pylori vacA and cagA genotypes and serum antibody profile in benign and malignant gastroduodenal diseases. Gut 1998;43: 182-6.
    • (1998) Gut , vol.43 , pp. 182-186
    • Basso, D.1    Navaglia, F.2    Brigato, L.3    Piva, M.G.4    Toma, A.5    Greco, E.6
  • 47
    • 0034256060 scopus 로고    scopus 로고
    • The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany
    • Miehlke S, Kirsch C, Agha-Amiri K, Gunther T, Lehn N, Malfertheiner P, et al. The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany. Int J Cancer 2000;87: 322-7.
    • (2000) Int J Cancer , vol.87 , pp. 322-327
    • Miehlke, S.1    Kirsch, C.2    Agha-Amiri, K.3    Gunther, T.4    Lehn, N.5    Malfertheiner, P.6
  • 48
    • 0035120651 scopus 로고    scopus 로고
    • Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains
    • Figueiredo C, Van Doorn LJ, Nogueira C, Soares JM, Pinho C, Figueira P, et al. Helicobacter pylori genotypes are associated with clinical outcome in Portuguese patients and show a high prevalence of infections with multiple strains. Scand J Gastroenterol 2001;36: 128-35.
    • (2001) Scand J Gastroenterol , vol.36 , pp. 128-135
    • Figueiredo, C.1    Van Doorn, L.J.2    Nogueira, C.3    Soares, J.M.4    Pinho, C.5    Figueira, P.6
  • 49
    • 0037146297 scopus 로고    scopus 로고
    • Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma
    • Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, et al. Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002;94: 1680-7.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1680-1687
    • Figueiredo, C.1    Machado, J.C.2    Pharoah, P.3    Seruca, R.4    Sousa, S.5    Carvalho, R.6
  • 50
    • 0037067564 scopus 로고    scopus 로고
    • Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma
    • Ashour AA, Magalhaes PP, Mendes EN, Collares GB, de Gusmao VR, Queiroz DM, et al. Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma. FEMS Immunol Med Microbiol 2002;33: 173-8.
    • (2002) FEMS Immunol Med Microbiol , vol.33 , pp. 173-178
    • Ashour, A.A.1    Magalhaes, P.P.2    Mendes, E.N.3    Collares, G.B.4    De Gusmao, V.R.5    Queiroz, D.M.6
  • 51
    • 0032831452 scopus 로고    scopus 로고
    • Heterogeneity in the Helicobacter pylori vacA and cagA genes: Association with gastroduodenal disease in South Africa?
    • Kidd M, Lastovica AJ, Atherton JC, Louw JA. Heterogeneity in the Helicobacter pylori vacA and cagA genes: Association with gastroduodenal disease in South Africa? Gut 1999;45: 499-502.
    • (1999) Gut , vol.45 , pp. 499-502
    • Kidd, M.1    Lastovica, A.J.2    Atherton, J.C.3    Louw, J.A.4
  • 52
    • 69249099365 scopus 로고    scopus 로고
    • The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations
    • Sugimoto M, Yamaoka Y. The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations. Clin Microbiol Infect 2009;15: 835-42.
    • (2009) Clin Microbiol Infect , vol.15 , pp. 835-842
    • Sugimoto, M.1    Yamaoka, Y.2
  • 53
    • 70349673513 scopus 로고    scopus 로고
    • The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East
    • Sugimoto M, Zali MR, Yamaoka Y. The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East. Eur J Clin Microbiol Infect Dis 2009;28: 1227-36.
    • (2009) Eur J Clin Microbiol Infect Dis , vol.28 , pp. 1227-1236
    • Sugimoto, M.1    Zali, M.R.2    Yamaoka, Y.3
  • 55
    • 79955601017 scopus 로고    scopus 로고
    • Helicobacter pylori cagA and vacA genotypes as predictors of progression of gastric preneoplastic lesions: A long-term follow-up in a high-risk area in Spain
    • Gonzalez CA, Figueiredo C, Lic CB, Ferreira RM, Pardo ML, Ruiz Liso JM, et al. Helicobacter pylori cagA and vacA genotypes as predictors of progression of gastric preneoplastic lesions: A long-term follow-up in a high-risk area in Spain. Am J Gastroenterol 2011;106: 867-74.
    • (2011) Am J Gastroenterol , vol.106 , pp. 867-874
    • Gonzalez, C.A.1    Figueiredo, C.2    Lic, C.B.3    Ferreira, R.M.4    Pardo, M.L.5    Ruiz Liso, J.M.6
  • 56
    • 84866510376 scopus 로고    scopus 로고
    • Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: A meta-analysis
    • Sahara S, Sugimoto M, Vilaichone RK, Mahachai V, Miyajima H, Furuta T, et al. Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: A meta-analysis. BMC Infect Dis 2012;12: 223.
    • (2012) BMC Infect Dis , vol.12 , pp. 223
    • Sahara, S.1    Sugimoto, M.2    Vilaichone, R.K.3    Mahachai, V.4    Miyajima, H.5    Furuta, T.6
  • 57
    • 0032587923 scopus 로고    scopus 로고
    • Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: Studies in four different countries
    • Yamaoka Y, Kodama T, Gutierrez O, Kim JG, Kashima K, Graham DY. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: Studies in four different countries. J Clin Microbiol 1999;37: 2274-9.
    • (1999) J Clin Microbiol , vol.37 , pp. 2274-2279
    • Yamaoka, Y.1    Kodama, T.2    Gutierrez, O.3    Kim, J.G.4    Kashima, K.5    Graham, D.Y.6
  • 58
    • 70349135882 scopus 로고    scopus 로고
    • Analysis of virulence factors of Helicobacter pylori isolated from a Vietnamese population
    • Uchida T, Nguyen LT, Takayama A, Okimoto T, Kodama M, Murakami K, et al. Analysis of virulence factors of Helicobacter pylori isolated from a Vietnamese population. BMC Microbiol 2009;9: 175.
    • (2009) BMC Microbiol , vol.9 , pp. 175
    • Uchida, T.1    Nguyen, L.T.2    Takayama, A.3    Okimoto, T.4    Kodama, M.5    Murakami, K.6
  • 60
    • 84907303505 scopus 로고    scopus 로고
    • A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach
    • Winter JA, Letley DP, Cook KW, Rhead JL, Zaitoun AA, Ingram RJ, et al. A role for the vacuolating cytotoxin, VacA, in colonisation and Helicobacter pylori-induced metaplasia in the stomach. J Infect Dis 2014;210: 954-63.
    • (2014) J Infect Dis , vol.210 , pp. 954-963
    • Winter, J.A.1    Letley, D.P.2    Cook, K.W.3    Rhead, J.L.4    Zaitoun, A.A.5    Ingram, R.J.6
  • 61
    • 84855428342 scopus 로고    scopus 로고
    • Helicobacter pylori vacA intermediate region genotyping and progression of gastric preneoplastic lesions
    • Ferreira RM, Figueiredo C, Bonet C, Pardo ML, Liso JM, Alonso P, et al. Helicobacter pylori vacA intermediate region genotyping and progression of gastric preneoplastic lesions. Am J Gastroenterol 2012;107: 145-6.
    • (2012) Am J Gastroenterol , vol.107 , pp. 145-146
    • Ferreira, R.M.1    Figueiredo, C.2    Bonet, C.3    Pardo, M.L.4    Liso, J.M.5    Alonso, P.6
  • 62
    • 84856205336 scopus 로고    scopus 로고
    • Clinical relevance of cagA and vacA gene polymorphisms in Helicobacter pylori isolates from Senegalese patients
    • Breurec S, Michel R, Seck A, Brisse S, Come D, Dieye FB, et al. Clinical relevance of cagA and vacA gene polymorphisms in Helicobacter pylori isolates from Senegalese patients. Clin Microbiol Infect 2012;18: 153-9.
    • (2012) Clin Microbiol Infect , vol.18 , pp. 153-159
    • Breurec, S.1    Michel, R.2    Seck, A.3    Brisse, S.4    Come, D.5    Dieye, F.B.6
  • 64
    • 0029963677 scopus 로고    scopus 로고
    • Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
    • Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci U S A 1996;93: 14648-53.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14648-1453
    • Censini, S.1    Lange, C.2    Xiang, Z.3    Crabtree, J.E.4    Ghiara, P.5    Borodovsky, M.6
  • 66
    • 79953725979 scopus 로고    scopus 로고
    • Architecture of the Helicobacter pylori Cag-type IV secretion system
    • Terradot L, Waksman G. Architecture of the Helicobacter pylori Cag-type IV secretion system. FEBS J 2011;278: 1213-22.
    • (2011) FEBS J , vol.278 , pp. 1213-1222
    • Terradot, L.1    Waksman, G.2
  • 67
    • 17344379177 scopus 로고    scopus 로고
    • Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion
    • Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 2000;287: 1497-500.
    • (2000) Science , vol.287 , pp. 1497-1500
    • Odenbreit, S.1    Puls, J.2    Sedlmaier, B.3    Gerland, E.4    Fischer, W.5    Haas, R.6
  • 69
    • 34249090814 scopus 로고    scopus 로고
    • Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
    • Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, et al. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 2007;447: 330-3.
    • (2007) Nature , vol.447 , pp. 330-333
    • Saadat, I.1    Higashi, H.2    Obuse, C.3    Umeda, M.4    Murata-Kamiya, N.5    Saito, Y.6
  • 70
    • 58249083314 scopus 로고    scopus 로고
    • Helicobacter pylori CagA phosphorylationindependent function in epithelial proliferation and inflammation
    • Suzuki M, Mimuro H, Kiga K, Fukumatsu M, Ishijima N, Morikawa H, et al. Helicobacter pylori CagA phosphorylationindependent function in epithelial proliferation and inflammation. Cell Host Microbe 2009;5: 23-34.
    • (2009) Cell Host Microbe , vol.5 , pp. 23-34
    • Suzuki, M.1    Mimuro, H.2    Kiga, K.3    Fukumatsu, M.4    Ishijima, N.5    Morikawa, H.6
  • 71
    • 21544441173 scopus 로고    scopus 로고
    • NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein
    • Brandt S, Kwok T, Hartig R, Konig W, Backert S. NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci U S A 2005;102: 9300-5.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9300-9305
    • Brandt, S.1    Kwok, T.2    Hartig, R.3    Konig, W.4    Backert, S.5
  • 72
    • 0036809776 scopus 로고    scopus 로고
    • Grb2 is a key mediator of Helicobacter pylori CagA protein activities
    • Mimuro H, Suzuki T, Tanaka J, Asahi M, Haas R, Sasakawa C. Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell 2002;10: 745-55.
    • (2002) Mol Cell , vol.10 , pp. 745-755
    • Mimuro, H.1    Suzuki, T.2    Tanaka, J.3    Asahi, M.4    Haas, R.5    Sasakawa, C.6
  • 73
    • 0036892969 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation
    • Hirata Y, Maeda S, Mitsuno Y, Tateishi K, Yanai A, Akanuma M, et al. Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation. Gastroenterology 2002;123: 1962-71.
    • (2002) Gastroenterology , vol.123 , pp. 1962-1971
    • Hirata, Y.1    Maeda, S.2    Mitsuno, Y.3    Tateishi, K.4    Yanai, A.5    Akanuma, M.6
  • 74
    • 0036510363 scopus 로고    scopus 로고
    • Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    • Selbach M, Moese S, Hauck CR, Meyer TF, Backert S. Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 2002;277: 6775-8.
    • (2002) J Biol Chem , vol.277 , pp. 6775-6778
    • Selbach, M.1    Moese, S.2    Hauck, C.R.3    Meyer, T.F.4    Backert, S.5
  • 75
    • 34247255905 scopus 로고    scopus 로고
    • Activation of Abl by Helicobacter pylori: A novel kinase for CagA and crucial mediator of host cell scattering
    • Tammer I, Brandt S, Hartig R, Konig W, Backert S. Activation of Abl by Helicobacter pylori: A novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology 2007;132: 1309-19.
    • (2007) Gastroenterology , vol.132 , pp. 1309-1319
    • Tammer, I.1    Brandt, S.2    Hartig, R.3    Konig, W.4    Backert, S.5
  • 76
    • 34249308195 scopus 로고    scopus 로고
    • Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility
    • Poppe M, Feller SM, Romer G, Wessler S. Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. Oncogene 2007;26: 3462-72.
    • (2007) Oncogene , vol.26 , pp. 3462-3472
    • Poppe, M.1    Feller, S.M.2    Romer, G.3    Wessler, S.4
  • 77
    • 0035162820 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells
    • Backert S, Moese S, Selbach M, Brinkmann V, Meyer TF. Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Mol Microbiol 2001;42: 631-44.
    • (2001) Mol Microbiol , vol.42 , pp. 631-644
    • Backert, S.1    Moese, S.2    Selbach, M.3    Brinkmann, V.4    Meyer, T.F.5
  • 78
    • 20744458702 scopus 로고    scopus 로고
    • EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in Mammalian cells
    • Higashi H, Yokoyama K, Fujii Y, Ren S, Yuasa H, Saadat I, et al. EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in Mammalian cells. J Biol Chem 2005;280: 23130-7.
    • (2005) J Biol Chem , vol.280 , pp. 23130-23137
    • Higashi, H.1    Yokoyama, K.2    Fujii, Y.3    Ren, S.4    Yuasa, H.5    Saadat, I.6
  • 79
    • 78650196039 scopus 로고    scopus 로고
    • Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein
    • Hatakeyama M. Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein. Cancer Sci 2011;102: 36-43.
    • (2011) Cancer Sci , vol.102 , pp. 36-43
    • Hatakeyama, M.1
  • 80
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A 2002;99: 14428-33.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14428-14433
    • Higashi, H.1    Tsutsumi, R.2    Fujita, A.3    Yamazaki, S.4    Asaka, M.5    Azuma, T.6
  • 81
    • 33646016600 scopus 로고    scopus 로고
    • Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA
    • Naito M, Yamazaki T, Tsutsumi R, Higashi H, Onoe K, Yamazaki S, et al. Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. Gastroenterology 2006;130: 1181-90.
    • (2006) Gastroenterology , vol.130 , pp. 1181-1190
    • Naito, M.1    Yamazaki, T.2    Tsutsumi, R.3    Higashi, H.4    Onoe, K.5    Yamazaki, S.6
  • 82
    • 4143096988 scopus 로고    scopus 로고
    • Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori
    • Argent RH, Kidd M, Owen RJ, Thomas RJ, Limb MC, Atherton JC. Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. Gastroenterology 2004;127: 514-23.
    • (2004) Gastroenterology , vol.127 , pp. 514-523
    • Argent, R.H.1    Kidd, M.2    Owen, R.J.3    Thomas, R.J.4    Limb, M.C.5    Atherton, J.C.6
  • 83
    • 38949199463 scopus 로고    scopus 로고
    • Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse
    • Ohnishi N, Yuasa H, Tanaka S, Sawa H, Miura M, Matsui A, et al. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A 2008;105: 1003-8.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 1003-1008
    • Ohnishi, N.1    Yuasa, H.2    Tanaka, S.3    Sawa, H.4    Miura, M.5    Matsui, A.6
  • 84
    • 70350743132 scopus 로고    scopus 로고
    • Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice
    • Miura M, Ohnishi N, Tanaka S, Yanagiya K, Hatakeyama M. Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice. Int J Cancer 2009;125: 2497-504.
    • (2009) Int J Cancer , vol.125 , pp. 2497-2504
    • Miura, M.1    Ohnishi, N.2    Tanaka, S.3    Yanagiya, K.4    Hatakeyama, M.5
  • 85
    • 0029043658 scopus 로고
    • Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
    • Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55: 2111-5.
    • (1995) Cancer Res , vol.55 , pp. 2111-2115
    • Blaser, M.J.1    Perez-Perez, G.I.2    Kleanthous, H.3    Cover, T.L.4    Peek, R.M.5    Chyou, P.H.6
  • 86
    • 0030975595 scopus 로고    scopus 로고
    • Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection
    • Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997;40: 297-301.
    • (1997) Gut , vol.40 , pp. 297-301
    • Parsonnet, J.1    Friedman, G.D.2    Orentreich, N.3    Vogelman, H.4
  • 88
  • 90
    • 0344197110 scopus 로고    scopus 로고
    • Meta-analysis of the relationship between cagA seropositivity and gastric cancer
    • Huang JQ, Zheng GF, Sumanac K, Irvine EJ, Hunt RH. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 2003;125: 1636-44.
    • (2003) Gastroenterology , vol.125 , pp. 1636-1644
    • Huang, J.Q.1    Zheng, G.F.2    Sumanac, K.3    Irvine, E.J.4    Hunt, R.H.5
  • 92
    • 0029561158 scopus 로고
    • Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains
    • Peek Jr. RM, Miller GG, Tham KT, Perez-Perez GI, Zhao X, Atherton JC, et al. Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab Invest 1995;73: 760-70.
    • (1995) Lab Invest , vol.73 , pp. 760-770
    • Peek, R.M.1    Miller, G.G.2    Tham, K.T.3    Perez-Perez, G.I.4    Zhao, X.5    Atherton, J.C.6
  • 93
    • 0025807183 scopus 로고
    • Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology
    • Crabtree JE, Taylor JD, Wyatt JI, Heatley RV, Shallcross TM, Tompkins DS, et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 1991;338: 332-5.
    • (1991) Lancet , vol.338 , pp. 332-335
    • Crabtree, J.E.1    Taylor, J.D.2    Wyatt, J.I.3    Heatley, R.V.4    Shallcross, T.M.5    Tompkins, D.S.6
  • 95
    • 33745666700 scopus 로고    scopus 로고
    • Systematic review and meta-analysis: Importance of CagA status for successful eradication of Helicobacter pylori infection
    • Suzuki T, Matsuo K, Sawaki A, Ito H, Hirose K, Wakai K, et al. Systematic review and meta-analysis: Importance of CagA status for successful eradication of Helicobacter pylori infection. Aliment Pharmacol Ther 2006;24: 273-80.
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 273-280
    • Suzuki, T.1    Matsuo, K.2    Sawaki, A.3    Ito, H.4    Hirose, K.5    Wakai, K.6
  • 96
    • 79953125222 scopus 로고    scopus 로고
    • Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer
    • Batista SA, Rocha GA, Rocha AM, Saraiva IE, Cabral MM, Oliveira RC, et al. Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer. BMC Microbiol 2011;11: 61.
    • (2011) BMC Microbiol , vol.11 , pp. 61
    • Batista, S.A.1    Rocha, G.A.2    Rocha, A.M.3    Saraiva, I.E.4    Cabral, M.M.5    Oliveira, R.C.6
  • 97
    • 84860282568 scopus 로고    scopus 로고
    • The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma
    • Ferreira RM, Machado JC, Leite M, Carneiro F, Figueiredo C. The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinoma. Histopathology 2012;60: 992-8.
    • (2012) Histopathology , vol.60 , pp. 992-998
    • Ferreira, R.M.1    Machado, J.C.2    Leite, M.3    Carneiro, F.4    Figueiredo, C.5
  • 98
    • 77950958214 scopus 로고    scopus 로고
    • CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions
    • Sicinschi LA, Correa P, Peek RM, Camargo MC, Piazuelo MB, Romero-Gallo J, et al. CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin Microbiol Infect 2009;16: 369-78.
    • (2009) Clin Microbiol Infect , vol.16 , pp. 369-378
    • Sicinschi, L.A.1    Correa, P.2    Peek, R.M.3    Camargo, M.C.4    Piazuelo, M.B.5    Romero-Gallo, J.6
  • 99
    • 73449093843 scopus 로고    scopus 로고
    • Analysis of 30-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population
    • Shokrzadeh L, Baghaei K, Yamaoka Y, Dabiri H, Jafari F, Sahebekhtiari N, et al. Analysis of 30-end variable region of the cagA gene in Helicobacter pylori isolated from Iranian population. J Gastroenterol Hepatol 2009;25: 172-7.
    • (2009) J Gastroenterol Hepatol , vol.25 , pp. 172-177
    • Shokrzadeh, L.1    Baghaei, K.2    Yamaoka, Y.3    Dabiri, H.4    Jafari, F.5    Sahebekhtiari, N.6
  • 100
    • 77955959294 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis
    • Acosta N, Quiroga A, Delgado P, Bravo MM, Jaramillo C. Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis. World J Gastroenterol 2010;16: 3936-43.
    • (2010) World J Gastroenterol , vol.16 , pp. 3936-3943
    • Acosta, N.1    Quiroga, A.2    Delgado, P.3    Bravo, M.M.4    Jaramillo, C.5
  • 101
    • 0031878592 scopus 로고    scopus 로고
    • Variants of the 30 region of the cagA gene in Helicobacter pylori isolates from patients with different H. Pylori-associated diseases
    • Yamaoka Y, Kodama T, Kashima K, Graham DY, Sepulveda AR. Variants of the 30 region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases. J Clin Microbiol 1998;36: 2258-63.
    • (1998) J Clin Microbiol , vol.36 , pp. 2258-2263
    • Yamaoka, Y.1    Kodama, T.2    Kashima, K.3    Graham, D.Y.4    Sepulveda, A.R.5
  • 102
    • 0032815340 scopus 로고    scopus 로고
    • Relationship between the cagA 30 repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH
    • Yamaoka Y, El-Zimaity HM, Gutierrez O, Figura N, Kim JG, Kodama T, et al. Relationship between the cagA 30 repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH. Gastroenterology 1999;117: 342-9.
    • (1999) Gastroenterology , vol.117 , pp. 342-349
    • Yamaoka, Y.1    El-Zimaity, H.M.2    Gutierrez, O.3    Figura, N.4    Kim, J.G.5    Kodama, T.6
  • 103
    • 2942590733 scopus 로고    scopus 로고
    • Meta-analysis of the relationship between CagA seropositivity and gastric cancer
    • author reply 7-8
    • Azuma T, Ohtani M, Yamazaki Y, Higashi H, Hatakeyama M. Meta-analysis of the relationship between CagA seropositivity and gastric cancer. Gastroenterology 2004;126: 1926-7. author reply 7-8.
    • (2004) Gastroenterology , vol.126 , pp. 1926-1927
    • Azuma, T.1    Ohtani, M.2    Yamazaki, Y.3    Higashi, H.4    Hatakeyama, M.5
  • 104
    • 84927925369 scopus 로고    scopus 로고
    • Molecular typing of Helicobacter pylori
    • In: Achtman M Suerbaum S, editors. Wymondham, UK: Horizon Scientific Press
    • van Doorn LJ, Figueiredo C, Quint WGV. Molecular typing of Helicobacter pylori. In: Achtman M, Suerbaum S, editors. Helicobacter pylori: Molecular and cellular biology. Wymondham, UK: Horizon Scientific Press; 2001. p. 293-310.
    • (2001) Helicobacter Pylori: Molecular and Cellular Biology , pp. 293-310
    • Van Doorn, L.J.1    Figueiredo, C.2    Quint, W.G.V.3
  • 105
    • 15444357984 scopus 로고    scopus 로고
    • Helicobacter pylori adhesin binding fucosylated histoblood group antigens revealed by retagging
    • Ilver D, Arnqvist A, Ogren J, Frick IM, Kersulyte D, Incecik ET, et al. Helicobacter pylori adhesin binding fucosylated histoblood group antigens revealed by retagging. Science 1998;279: 373-7.
    • (1998) Science , vol.279 , pp. 373-377
    • Ilver, D.1    Arnqvist, A.2    Ogren, J.3    Frick, I.M.4    Kersulyte, D.5    Incecik, E.T.6
  • 107
    • 33646339116 scopus 로고    scopus 로고
    • Multiple chromosomal loci for the babA gene in Helicobacter pylori
    • Hennig EE, Allen JM, Cover TL. Multiple chromosomal loci for the babA gene in Helicobacter pylori. Infect Immun 2006;74: 3046-51.
    • (2006) Infect Immun , vol.74 , pp. 3046-3051
    • Hennig, E.E.1    Allen, J.M.2    Cover, T.L.3
  • 109
    • 1242319255 scopus 로고    scopus 로고
    • Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques
    • Solnick JV, Hansen LM, Salama NR, Boonjakuakul JK, Syvanen M. Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques. Proc Natl Acad Sci U S A 2004;101: 2106-11.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2106-2111
    • Solnick, J.V.1    Hansen, L.M.2    Salama, N.R.3    Boonjakuakul, J.K.4    Syvanen, M.5
  • 110
    • 0033607258 scopus 로고    scopus 로고
    • Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin
    • Gerhard M, Lehn N, Neumayer N, Boren T, Rad R, Schepp W, et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc Natl Acad Sci U S A 1999;96: 12778-83.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12778-12783
    • Gerhard, M.1    Lehn, N.2    Neumayer, N.3    Boren, T.4    Rad, R.5    Schepp, W.6
  • 111
    • 33750553565 scopus 로고    scopus 로고
    • Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia
    • Erzin Y, Koksal V, Altun S, Dobrucali A, Aslan M, Erdamar S, et al. Prevalence of Helicobacter pylori vacA, cagA, cagE, iceA, babA2 genotypes and correlation with clinical outcome in Turkish patients with dyspepsia. Helicobacter 2006;11: 574-80.
    • (2006) Helicobacter , vol.11 , pp. 574-580
    • Erzin, Y.1    Koksal, V.2    Altun, S.3    Dobrucali, A.4    Aslan, M.5    Erdamar, S.6
  • 112
    • 33750699685 scopus 로고    scopus 로고
    • Helicobacter pylori HopH (OipA) and bacterial pathogenicity: Genetic and functional genomic analysis of hopH gene polymorphisms
    • Dossumbekova A, Prinz C, Mages J, Lang R, Kusters JG, Van Vliet AH, et al. Helicobacter pylori HopH (OipA) and bacterial pathogenicity: Genetic and functional genomic analysis of hopH gene polymorphisms. J Infect Dis 2006;194: 1346-55.
    • (2006) J Infect Dis , vol.194 , pp. 1346-1355
    • Dossumbekova, A.1    Prinz, C.2    Mages, J.3    Lang, R.4    Kusters, J.G.5    Van Vliet, A.H.6
  • 113
    • 0034691065 scopus 로고    scopus 로고
    • A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori
    • Yamaoka Y, Kwon DH, Graham DY. A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori. Proc Natl Acad Sci U S A 2000;97: 7533-8.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7533-7538
    • Yamaoka, Y.1    Kwon, D.H.2    Graham, D.Y.3
  • 114
    • 0036320265 scopus 로고    scopus 로고
    • Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production
    • Yamaoka Y, Kikuchi S, el-Zimaity HM, Gutierrez O, Osato MS, Graham DY. Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production. Gastroenterology 2002;123: 414-24.
    • (2002) Gastroenterology , vol.123 , pp. 414-424
    • Yamaoka, Y.1    Kikuchi, S.2    El-Zimaity, H.M.3    Gutierrez, O.4    Osato, M.S.5    Graham, D.Y.6
  • 115
    • 80054946132 scopus 로고    scopus 로고
    • Helicobacter pylori outer membrane proteins on gastric mucosal interleukin 6 and 11 expression in Mongolian gerbils
    • Sugimoto M, Ohno T, Graham DY, Yamaoka Y. Helicobacter pylori outer membrane proteins on gastric mucosal interleukin 6 and 11 expression in Mongolian gerbils. J Gastroenterol Hepatol 2011;26: 1677-84.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 1677-1684
    • Sugimoto, M.1    Ohno, T.2    Graham, D.Y.3    Yamaoka, Y.4
  • 116
    • 0036746383 scopus 로고    scopus 로고
    • CagA tyrosine phosphorylation and interleukin-8 induction by Helicobacter pylori are independent from alpAB, HopZ and bab group outer membrane proteins
    • Odenbreit S, Kavermann H, Puls J, Haas R. CagA tyrosine phosphorylation and interleukin-8 induction by Helicobacter pylori are independent from alpAB, HopZ and bab group outer membrane proteins. Int J Med Microbiol 2002;292: 257-66.
    • (2002) Int J Med Microbiol , vol.292 , pp. 257-266
    • Odenbreit, S.1    Kavermann, H.2    Puls, J.3    Haas, R.4
  • 118
    • 33646772149 scopus 로고    scopus 로고
    • Helicobacter pylori outer membrane proteins and gastroduodenal disease
    • Yamaoka Y, Ojo O, Fujimoto S, Odenbreit S, Haas R, Gutierrez O, et al. Helicobacter pylori outer membrane proteins and gastroduodenal disease. Gut 2006;55: 775-81.
    • (2006) Gut , vol.55 , pp. 775-781
    • Yamaoka, Y.1    Ojo, O.2    Fujimoto, S.3    Odenbreit, S.4    Haas, R.5    Gutierrez, O.6
  • 119
    • 17144415197 scopus 로고    scopus 로고
    • Duodenal ulcer promoting gene of Helicobacter pylori
    • Lu H, Hsu PI, Graham DY, Yamaoka Y. Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology 2005;128: 833-48.
    • (2005) Gastroenterology , vol.128 , pp. 833-848
    • Lu, H.1    Hsu, P.I.2    Graham, D.Y.3    Yamaoka, Y.4
  • 120
    • 35348874205 scopus 로고    scopus 로고
    • The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America
    • Argent RH, Burette A, Miendje Deyi VY, Atherton JC. The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America. Clin Infect Dis 2007;45: 1204-6.
    • (2007) Clin Infect Dis , vol.45 , pp. 1204-1206
    • Argent, R.H.1    Burette, A.2    Miendje Deyi, V.Y.3    Atherton, J.C.4
  • 122
    • 39849086961 scopus 로고    scopus 로고
    • Lack of association between Helicobacter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients
    • Gomes LI, Rocha GA, Rocha AM, Soares TF, Oliveira CA, Bittencourt PF, et al. Lack of association between Helicobacter pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients. Int J Med Microbiol 2008; 298: 223-30.
    • (2008) Int J Med Microbiol , vol.298 , pp. 223-230
    • Gomes, L.I.1    Rocha, G.A.2    Rocha, A.M.3    Soares, T.F.4    Oliveira, C.A.5    Bittencourt, P.F.6
  • 123
    • 77955153718 scopus 로고    scopus 로고
    • Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population
    • Nguyen LT, Uchida T, Tsukamoto Y, Kuroda A, Okimoto T, Kodama M, et al. Helicobacter pylori dupA gene is not associated with clinical outcomes in the Japanese population. Clin Microbiol Infect 2010;16: 1264-9.
    • (2010) Clin Microbiol Infect , vol.16 , pp. 1264-1269
    • Nguyen, L.T.1    Uchida, T.2    Tsukamoto, Y.3    Kuroda, A.4    Okimoto, T.5    Kodama, M.6
  • 124
    • 77649174412 scopus 로고    scopus 로고
    • The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: A case-control study
    • Schmidt HM, Andres S, Kaakoush NO, Engstrand L, Eriksson L, Goh KL, et al. The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: A case-control study. Gut Pathog 2009;1: 5.
    • (2009) Gut Pathog , vol.1 , pp. 5
    • Schmidt, H.M.1    Andres, S.2    Kaakoush, N.O.3    Engstrand, L.4    Eriksson, L.5    Goh, K.L.6
  • 125
    • 84860137349 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of Helicobacter pylori dupA that lead to premature stop codons
    • Moura SB, Costa RF, Anacleto C, Rocha GA, Rocha AM, Queiroz DM. Single nucleotide polymorphisms of Helicobacter pylori dupA that lead to premature stop codons. Helicobacter 2012;17: 176-80.
    • (2012) Helicobacter , vol.17 , pp. 176-180
    • Moura, S.B.1    Costa, R.F.2    Anacleto, C.3    Rocha, G.A.4    Rocha, A.M.5    Queiroz, D.M.6
  • 126
    • 84857090761 scopus 로고    scopus 로고
    • The intact dupA cluster is a more reliable Helicobacter pylori virulence marker than dupA alone
    • Jung SW, Sugimoto M, Shiota S, Graham DY, Yamaoka Y. The intact dupA cluster is a more reliable Helicobacter pylori virulence marker than dupA alone. Infect Immun 2012;80: 381-7.
    • (2012) Infect Immun , vol.80 , pp. 381-387
    • Jung, S.W.1    Sugimoto, M.2    Shiota, S.3    Graham, D.Y.4    Yamaoka, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.