Helicobacter pylori cagA and vacA genotypes as predictors of progression of gastric preneoplastic lesions: A long-term follow-up in a high-risk area in Spain

American Journal of Gastroenterology

Volumn 106, Issue 5, 2011, Pages 867-874

  González, Carlos A ^a   Figueiredo, Ceu ^b,c   Lic, C Bonet ^a   Ferreira, R M ^b,c   Pardo, M L ^d   Ruiz Liso, J M ^d   Alonso, P ^d   Sala, N ^a,e   Capella, G ^e   Sanz Anquela, J M ^f  

^a Department of Epidemiology   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c University of Porto   (Portugal)

^d Hospital Virgen del Mirón   (Spain)

^e CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^f HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; HELICOBACTER PYLORI VACCINE;

ADULT; ARTICLE; ATROPHIC GASTRITIS; BACTERIAL STRAIN; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SURVEILLANCE; ENDOSCOPY; FOLLOW UP; GENOTYPE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HIGH RISK POPULATION; HISTOLOGY; HUMAN; INTESTINE METAPLASIA; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRECANCER; PRIORITY JOURNAL; RISK; SPAIN; STOMACH BIOPSY;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BIOPSY, NEEDLE; DISEASE PROGRESSION; FEMALE; GASTRIC MUCOSA; GASTRITIS, ATROPHIC; GASTROSCOPY; GENOTYPE; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS; RISK FACTORS; STOMACH NEOPLASMS;

EID: 79955601017     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2011.1     Document Type: Article

References (31)

1. Correa P. Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol 1995; 19 (Suppl 1): S37-43.
2. Correa P, Haenszel W, Cuello C et al. A model for gastric cancer epidemiology. Lancet 1975; 2: 58-60.
3. Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 2006; 118: 3030-3044.
4. El-Omar EM, Carrington M, Chow WH et al. The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer. Nature 2001; 412: 99.
5. Figueiredo C, Machado JC, Pharoah P et al. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002; 94: 1680-1687. (Pubitemid 35446836)
6. Correa P, Schneider BG. Etiology of gastric cancer: what is new? Cancer Epidemiol Biomarkers Prev 2005; 14: 1865-1868. (Pubitemid 41161190)
7. Odenbreit S, Püls J, Sedlmaier B et al. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 2000; 287: 1497-500. (Pubitemid 30127145)
8. Huang JQ, Zheng GF, Sumanac K et al. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 2003; 125: 1636-1644. (Pubitemid 37500427)
9. Plummer M, van Doorn LJ, Franceschi S et al. Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions. J Natl Cancer Inst 2007; 99: 1328-1334. (Pubitemid 47394171)
10. Kuipers EJ, Pérez-Pérez GI, Meuwissen SG et al. Helicobacter pylori and atrophic gastritis: importance of the cagA status. J Natl Cancer Inst 1995; 87: 1777-1780.
11. Nogueira C, Figueiredo C, Carneiro F et al. Helicobacter pylori genotypes may determine gastric histopathology. Am J Pathol 2001; 158: 647-654. (Pubitemid 32158625)
12. Cover TL, Blanke SR. Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat Rev Microbiol 2005; 3: 320-332. (Pubitemid 40443725)
13. Atherton JC, Cao P, Peek RM Jr et al. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995; 270: 17771-7.
14. Instituto de Salud Carlos III, Centro Nacional de Epidemiolog í a. Madrid, Spain; http://193.146.50.130/ariadna.php.
15. González CA, Pardo ML, Ruiz Liso JM et al. Gastric cancer occurrence in preneoplastic lesions: a long term follow up in a high-risk area in Spain. Int J Cancer 2010; 127: 2654-2660.
16. Dixon MF, Genta RM, Yardley JH et al. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996; 20: 1161-1181.
17. van Doorn LJ, Figueiredo C, Rossau R et al. Typing of Helicobacter pylori vacA gene and detection of cagA gene by PCR and reverse hybridization. J Clin Microbiol 1998; 36: 1271-1276. (Pubitemid 28208012)
18. van Doorn LJ, Figueiredo C, Sanna R et al. Expanding allelic diversity of Helicobacter pylori vacA. J Clin Microbiol 1998; 36: 2597-603. (Pubitemid 28380962)
19. Bukanov NO, Berg DE. Ordered cosmid library and high-resolution physical-genetic map of Helicobacter pylori strain NCTC11638. Mol Microbiol 1994; 11: 509-523. (Pubitemid 24205463)
20. Selbach M, Moese S, Hauck CR et al. Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 2002; 277: 6775-6778. (Pubitemid 34953058)
21. Tammer I, Brandt S, Hartig R et al. Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology 2007; 132: 1309-1319. (Pubitemid 46627580)
22. Amieva MR, Vogelmann R, Covacci A et al. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 2003; 300: 1430-1434. (Pubitemid 36638162)
23. Higashi H, Tsutsumi R, Fujita A et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci USA 2002; 99: 14428-33. (Pubitemid 35257688)
24. Basso D, Zambon CF, Letley DP et al. Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology 2008; 135: 91-9. (Pubitemid 351899019)
25. Brandt S, Kwok T, Hartig R et al. NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci USA 2005; 102: 9300-9305. (Pubitemid 40923558)
26. Viala J, Chaput C, Boneca IG et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 2004; 5: 1166-1174. (Pubitemid 39549631)
27. Wiedemann T, Loell E, Mueller S et al. Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbils. PLoS One 2009; 4: e4754.
28. Telford JL, Ghiara P, Dell'Orco M et al. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 1994; 179: 1653-1658. (Pubitemid 24129582)
29. Wang F, Xia P, Wu F et al. Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells. J Biol Chem 2008; 283: 26714-25.
30. Rhead JL, Letley DP, Mohammadi M et al. A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology 2007; 133: 926-936. (Pubitemid 47374139)
31. Scholte GH, van Doorn LJ, Cats A et al. Genotyping of Helicobacter pylori in paraffin-embedded gastric biopsy specimens: relation to histological parameters and effects on therapy. Am J Gastroenterol 2002; 97: 1687-1695. (Pubitemid 34761390)