Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer

BMC Microbiology

Volumn 11, Issue , 2011, Pages

  Batista, Sérgio A ^a   Rocha, Gifone A ^a   Rocha, Andreia M C ^a   Saraiva, Ivan E B ^a   Cabral, Mnica M D A ^a   Oliveira, Rodrigo C ^b   Queiroz, Dulciene M M ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CAGA PROTEIN; PEPSINOGEN I; BACTERIAL ANTIGEN; BACTERIAL DNA; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI;

ADULT; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BRAZIL; CANCER RISK; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DUODENUM ULCER; ENZYME BLOOD LEVEL; ETHNICITY; FEMALE; GASTRITIS; GENETIC POLYMORPHISM; GENOTYPE; HELICOBACTER PYLORI; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE REPEAT; POPULATION RESEARCH; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; AGED; CHEMISTRY; DNA SEQUENCE; GENETICS; HELICOBACTER INFECTION; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PATHOGENICITY; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; STOMACH TUMOR;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

ADULT; AGED; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BRAZIL; DNA, BACTERIAL; DUODENAL ULCER; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MIDDLE AGED; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SEQUENCE ANALYSIS, DNA; STOMACH NEOPLASMS;

EID: 79953125222     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-11-61     Document Type: Article

References (41)

1. The Prevalence of Helicobacter-pylori Infection in Different Countries. RE Pounder D Ng, Aliment Pharm Therap 1995 9 33 39
2. Helicobacter-pylori and Duodenal-Ulcer - Evidence Suggesting Causation. F Megraud H Lamouliatte, Digest Dis Sci 1992 37 5 769 772 10.1007/BF01296437 1563322
3. Helicobacter pylori infection and the risk of gastric carcinoma. J Parsonnet GD Friedman DP Vandersteen Y Chang JH Vogelman N Orentreich RK Sibley, N Engl J Med 1991 325 16 1127 1131 10.1056/NEJM199110173251603 1891020
4. Helicobacter-pylori-Associated Gastritis and Primary B-Cell Gastric Lymphoma. AC Wotherspoon C Ortizhidalgo MR Falzon PG Isaacson, Lancet 1991 338 8776 1175 1176 10.1016/0140-6736(91)92035-Z 1682595
5. IL1RN polymorphic gene and cagA-positive status independently increase the risk of noncardia gastric carcinoma. GA Rocha JB Guerra AMC Rocha IEB Saraiva DA da Silva CA de Oliveira DMM Queiroz, Int J Cancer 2005 115 5 678 683 10.1002/ijc.20935 15704154 (Pubitemid 40776689)
6. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. JC Machado C Figueiredo P Canedo P Pharoah R Carvalho S Nabais CC Alves ML Campos LJ Van Doorn C Caldas,, et al. Gastroenterology 2003 125 2 364 371 10.1016/S0016-5085(03)00899-0 12891537 (Pubitemid 36929416)
7. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. EM El-Omar CS Rabkin MD Gammon TL Vaughan HA Risch JB Schoenberg JL Stanford ST Mayne J Goedert WJ Blot,, et al. Gastroenterology 2003 124 5 1193 1201 10.1016/S0016-5085(03)00157-4 12730860 (Pubitemid 36531795)
8. Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. JC Machado P Pharoah S Sousa R Carvalho C Oliveira C Figueiredo A Amorim R Seruca C Caldas F Carneiro,, et al. Gastroenterology 2001 121 4 823 829 10.1053/gast.2001.28000 11606496 (Pubitemid 32959393)
9. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. EM El-Omar M Carrington WH Chow KEL McColl JH Bream HA Young J Herrera J Lissowska CC Yuan N Rothman,, et al. Nature 2000 404 6776 398 402 10.1038/35006081 10746728 (Pubitemid 30164342)
10. Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. AMY Nomura GI Perez-Perez J Lee G Stemmermann MJ Blaser, Am J Epidemiol 2002 155 11 1054 1059 10.1093/aje/155.11.1054 12034584 (Pubitemid 34587489)
11. cagA-positive Helicobacter pylori and risk for developing gastric carcinoma in Brazil. DMM Queiroz EN Mendes GA Rocha AMR Oliveira CA Oliveira PP Magalhaes SB Moura MMDA Cabral AMMF Nogueira, Int J Cancer 1998 78 2 135 139 10.1002/(SICI)1097-0215(19981005)78:2<135::AID-IJC1>3.0.CO;2-# 9754640 (Pubitemid 28443165)
12. Infection with Helicobacter-pylori Strains Possessing Caga Is Associated with an Increased Risk of Developing Adenocarcinoma of the Stomach. MJ Blaser GI Perezperez H Kleanthous TL Cover RM Peek PH Chyou GN Stemmermann A Nomura, Cancer Res 1995 55 10 2111 2115 7743510
13. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. H Higashi R Tsutsumi S Muto T Sugiyama T Azuma M Asaka M Hatakeyama, Science 2002 295 5555 683 686 10.1126/science.1067147 11743164 (Pubitemid 34111828)
14. Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. M Naito T Yamazaki R Tsutsumi H Higashi K Onoe S Yamazaki T Azuma M Hatakeyama, Gastroenterology 2006 130 4 1181 1190 10.1053/j.gastro.2005.12.038 16618412
15. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. T Azuma S Yamazaki A Yamakawa M Ohtani A Muramatsu H Suto Y Ito M Dojo Y Yamazaki M Kuriyama,, et al. J Infect Dis 2004 189 5 820 827 10.1086/381782 14976598 (Pubitemid 38328182)
16. Analysis of the 3 ' variable region of the cagA gene of Helicobacter pylori isolated in Koreans. KD Choi N Kim DH Lee JM Kim JS Kim HC Jung IS Song, Digest Dis Sci 2007 52 4 960 966 10.1007/s10620-005-9030-z 17342405 (Pubitemid 46481231)
17. Characterization of CagA variable region of Helicobacter pylori isolates from Chinese patients. YL Zhu S Zheng Q Du KD Qian PC Fang, World J Gastroenterol 2005 11 6 880 884 15682486 (Pubitemid 40298093)
18. Relationship between the cagA 3 ' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH. Y Yamaoka HMT El-Zimaity O Gutierrez N Figura JK Kim T Kodama K Kashima DY Graham, Gastroenterology 1999 117 2 342 349 10.1053/gast.1999.0029900342 10419915 (Pubitemid 29352942)
19. Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. D Basso CF Zambon DP Letley A Stranges A Marchet JL Rhead S Schiavon G Guariso M Ceroti D Nitti,, et al. Gastroenterology 2008 135 1 91 99 10.1053/j.gastro.2008.03.041 18474244 (Pubitemid 351899019)
20. Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. RH Argent M Kidd RJ Owen RJ Thomas MC Limb JC Atherton, Gastroenterology 2004 127 2 514 523 10.1053/j.gastro.2004.06.006 15300584 (Pubitemid 39091900)
21. CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. LA Sicinschi P Correa RM Peek MC Camargo MB Piazuelo J Romero-Gallo SS Hobbs U Krishna A Delgado R Mera,, et al. Clin Microbiol Infect 2010 16 4 369 378 10.1111/j.1469-0691.2009.02811.x 19456839
22. Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis. N Acosta A Quiroga P Delgado MM Bravo C Jaramillo, World J Gastroentero 2010 16 31 3936 3943 10.3748/wjg.v16.i31.3936
23. Lack of association between Helicobater pylori infection with dupA-positive strains and gastroduodenal diseases in Brazilian patients. LI Gomes GA Rocha AMC Rocha TF Soares CA Oliveira PFS Bittencourt DMM Queiroz, Int J Med Microbiol 2008 298 3-4 223 230 10.1016/j.ijmm.2007.05.006 17897881 (Pubitemid 351318366)
24. Geographic distribution of vacA allelic types of Helicobacter pylori. LJ van Doorn C Figueiredo F Mégraud S Pena P Midolo DM Queiroz F Carneiro B Vanderborght MD Pegado R Sanna W De Boer PM Schneeberger P Correa EK Ng J Atherton MJ Blaser WG Quint, Gastroenterology 1999 116 4 823 830 10.1016/S0016-5085(99)70065-X 10092304 (Pubitemid 29153530)
25. DNA sequence analysis of cagA 3 ' motifs of Helicobacter pylori strains from patients with peptic ulcer diseases. BA Salih BK Bolek S Arikan, J Med Microbiol 2010 59 2 144 148 10.1099/jmm.0.014894-0 19850704
26. Oncogenic mechanisms of the Helicobacter pylori CagA protein. M Hatakeyama, Nat Rev Cancer 2004 4 9 688 694 10.1038/nrc1433 15343275 (Pubitemid 39215067)
27. Variants of the 3' region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases. Y Yamaoka T Kodama K Kashima DY Graham AR Sepulveda, J Clin Microbiol 1998 36 8 2258 2263 9666002 (Pubitemid 28324077)
28. Helicobacter pylori virulence factors as tools to study human migrations. DM Queiroz RP Cunha IE Saraiva AM Rocha, Toxicon 2010 56 7 1193 1197 10.1016/j.toxicon.2010.01.018 20144640
29. Color and genomic ancestry in Brazilians. FC Parra RC Amado JR Lambertucci J Rocha CM Antunes SDJ Pena, P Natl Acad Sci USA 2003 100 1 177 182 10.1073/pnas.0126614100 (Pubitemid 36078048)
30. Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. A study in relatives of patients with pernicious anemia. IM Samloff K Varis T Ihamaki M Siurala JI Rotter, Gastroenterology 1982 83 1Pt2 204 209 7084603 (Pubitemid 12121596)
31. Pathology of gastric intestinal metaplasia: clinical implications. P Correa MB Piazuelo KT Wilson, Am J Gastroenterol 2010 105 3 493 498 10.1038/ajg.2009.728 20203636
32. Helicobacter pylori genetic diversity and risk of human disease. MJ Blaser DE Berg, J Clin Invest 2001 107 7 767 773 10.1172/JCI12672 11285290 (Pubitemid 32274024)
33. Natural variation in populations of persistently colonizing bacteria affect human host cell phenotype. RA Aras Y Lee SK Kim D Israel RM Peek MJ Blaser, J Infect Dis 2003 188 4 486 496 10.1086/377098 12898434 (Pubitemid 37011799)
34. Indicator medium for isolation of Campylobacter pylori. DM Queiroz EN Mendes GA Rocha, J Clin Microbiol 1987 25 12 2378 2379 3429628 (Pubitemid 18008773)
35. Simple carbolfuchsin staining for showing C pylori and other spiral bacteria in gastric mucosa. GA Rocha DM Queiroz EN Mendes AP Lage AJ Barbosa, J Clin Pathol 1989 42 9 1004 1005 10.1136/jcp.42.9.1004 2794073 (Pubitemid 19225471)
36. Classification and grading of gastritis. The updated Sydney system. International Workshop on the Histopathology of Gastritis, Houston 1994. MF Dixon RM Genta JH Yardley,, et al. Am J Surg Pathol 1996 20 10 1161 1181 10.1097/00000478-199610000-00001 8827022
37. The two histological main types of gastric cancer: diffuse and so-called intestinal type carcinoma. P Lauren, Acta Pathol Microbiol Scand 1965 64 31 49 14320675
38. Sensitive Detection of Helicobacter-pylori by Using Polymerase Chain-Reaction. CL Clayton H Kleanthous PJ Coates DD Morgan S Tabaqchali, Journal of Clinical Microbiology 1992 30 1 192 200 1734052
39. Hepatic Helicobacter species identified in bile and gallbladder tissue from Chileans with chronic cholecystitis. JG Fox FE Dewhirst Z Shen Y Feng NS Taylor BJ Paster RL Ericson CN Lau P Correa JC Araya,, et al. Gastroenterology 1998 114 4 755 763 10.1016/S0016-5085(98)70589-X 9516396 (Pubitemid 28160410)
40. Detection of Helicobacter pylori gene expression in human gastric mucosa. RM Peek Jr GG Miller KT Tham GI Perez-Perez TL Cover JC Atherton GD Dunn MJ Blaser, J Clin Microbiol 1995 33 1 28 32 7699060 (Pubitemid 24382392)
41. Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. SM Kelly MC Pitcher SM Farmery GR Gibson, Gastroenterology 1994 107 6 1671 1674 7958677 (Pubitemid 24357619)