Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes

GLIA

Volumn 63, Issue 5, 2015, Pages 736-753

  Ju, Won Kyu ^a,d   Kim, Keun Young ^a,d   Noh, You Hyun ^a   Hoshijima, Masahiko ^a,b   Lukas, Thomas J ^c   Ellisman, Mark H ^a   Weinreb, Robert N ^a   Perkins, Guy A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d NONE

Author keywords

Excitotoxicity; Glaucoma; Mitochondrial fission; Optic nerve head astrocyte

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 1 L1; DYNAMIN; DYNAMIN RELATED PROTEIN 1; ENHANCED GREEN FLUORESCENT PROTEIN; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMIC ACID; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SERINE; UNCLASSIFIED DRUG; ALDH1L1 PROTEIN, HUMAN; AMINO ACID RECEPTOR BLOCKING AGENT; N METHYLASPARTIC ACID;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTOLYSOSOME; AUTOPHAGOSOME; BACTERIAL ARTIFICIAL CHROMOSOME; BRAIN MITOCHONDRION; CELL COUNT; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; EXCITOTOXICITY; FEMALE; GLAUCOMA; GLIA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MIDDLE AGED; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL VOLUME DENSITY; MOUSE; NERVE DEGENERATION; NERVE FIBER; NEUROPROTECTION; NONHUMAN; OPTIC NERVE; OPTIC NERVE HEAD ASTROCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSGENIC ANIMAL; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INTRAOCULAR PRESSURE; MITOCHONDRION; OPTIC DISK; PATHOLOGY; PHYSIOLOGY; RETINA GANGLION CELL; TRANSGENIC MOUSE; ULTRASTRUCTURE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALDEHYDE DEHYDROGENASE; ANIMALS; ASTROCYTES; CELL COUNT; CELLS, CULTURED; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; GLAUCOMA; GLUTAMIC ACID; HUMANS; INTRAOCULAR PRESSURE; MEMANTINE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; N-METHYLASPARTATE; OPTIC DISK; RETINAL GANGLION CELLS;

EID: 84925100005     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22781     Document Type: Article

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