Neuroprotectant FK506 inhibits glutamate-induced apoptosis of astrocytes in vitro and in vivo

Journal of Neurochemistry

Volumn 99, Issue 3, 2006, Pages 965-975

  Szydlowska, Kinga ^a   Zawadzka, Malgorzata ^a   Kaminska, Bozena ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

Apoptosis; Astrocyte death; FK506; Glutamate; Ischaemia; Mitochondria

Indexed keywords

CALCINEURIN; CASPASE; DNA FRAGMENT; GLUTAMIC ACID; IMMUNOSUPPRESSIVE AGENT; NEUROPROTECTIVE AGENT; TACROLIMUS;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN ISCHEMIA; CELL INTERACTION; CELL NUCLEUS; CELL ULTRASTRUCTURE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORPUS STRIATUM; DNA DETERMINATION; ENERGY METABOLISM; ENZYME ACTIVATION; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE POTENTIAL; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL MEMBRANE; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; ASTROCYTES; BLOTTING, WESTERN; CASPASES; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DNA FRAGMENTATION; ENZYME ACTIVATION; EXCITATORY AMINO ACID ANTAGONISTS; FLUORESCENT DYES; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; IN SITU NICK-END LABELING; INDOLES; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA; NEUROPROTECTIVE AGENTS; RATS; REPERFUSION INJURY; TACROLIMUS; TETRAZOLIUM SALTS; THIAZOLES;

ANIMALIA;

EID: 33750085875     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04136.x     Document Type: Article

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