메뉴 건너뛰기




Volumn 60, Issue 6, 2015, Pages 845-853

Green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (LL-37) to reduce the LPS-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts

Author keywords

Cathelicidin; Cranberry; Epithelial cell; Fibroblast; Green tea; Periodontal disease

Indexed keywords

VACCINIUM MACROCARPON;

EID: 84924974527     PISSN: 00039969     EISSN: 18791506     Source Type: Journal    
DOI: 10.1016/j.archoralbio.2015.02.021     Document Type: Article
Times cited : (40)

References (55)
  • 1
    • 84876319818 scopus 로고    scopus 로고
    • Periodontitis: A host-mediated disruption of microbial homeostasis. Unlearning learned concepts
    • P.M. Bartold, and T.E. Van Dyke Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts Periodontology 2000 62 2013 203 217
    • (2013) Periodontology 2000 , vol.62 , pp. 203-217
    • Bartold, P.M.1    Van Dyke, T.E.2
  • 2
    • 0033143084 scopus 로고    scopus 로고
    • Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: Occurrence and treatment
    • J. Slots, and M. Ting Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment Periodontology 2000 20 1999 82 121
    • (1999) Periodontology 2000 , vol.20 , pp. 82-121
    • Slots, J.1    Ting, M.2
  • 4
    • 84886303778 scopus 로고    scopus 로고
    • MyD88 is essential for alveolar bone loss induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide in mice
    • M.F. Madeira, C.M. Queiroz-Junior, D. Cisalpino, S.M. Werneck, H. Kikuchi, and O. Fujise MyD88 is essential for alveolar bone loss induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide in mice Mol Oral Microbiol 28 2013 415 424
    • (2013) Mol Oral Microbiol , vol.28 , pp. 415-424
    • Madeira, M.F.1    Queiroz-Junior, C.M.2    Cisalpino, D.3    Werneck, S.M.4    Kikuchi, H.5    Fujise, O.6
  • 5
    • 0031114710 scopus 로고    scopus 로고
    • Secretion of IL-1 beta, TNF-alpha, IL-8 and IL-1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria
    • A. Yoshimura, Y. Hara, T. Kaneko, and I. Kato Secretion of IL-1 beta, TNF-alpha, IL-8 and IL-1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria J Periodontal Res 32 1997 279 286
    • (1997) J Periodontal Res , vol.32 , pp. 279-286
    • Yoshimura, A.1    Hara, Y.2    Kaneko, T.3    Kato, I.4
  • 6
    • 0027686868 scopus 로고
    • Tissues and cells of the periodontium
    • T.M. Hassell Tissues and cells of the periodontium Periodontology 2000 3 1993 9 38
    • (1993) Periodontology 2000 , vol.3 , pp. 9-38
    • Hassell, T.M.1
  • 7
    • 84888017840 scopus 로고    scopus 로고
    • The induction expression of human β-defensins in gingival epithelial cells and fibroblasts
    • J. Liu, X. Du, J. Chen, L. Hu, and L. Chen The induction expression of human β-defensins in gingival epithelial cells and fibroblasts Arch Oral Biol 58 2013 1415 1421
    • (2013) Arch Oral Biol , vol.58 , pp. 1415-1421
    • Liu, J.1    Du, X.2    Chen, J.3    Hu, L.4    Chen, L.5
  • 8
    • 84881509396 scopus 로고    scopus 로고
    • Defensins and LL-37: A review of function in the gingival epithelium
    • A. Greer, C. Zenobia, and R.P. Darveau Defensins and LL-37: a review of function in the gingival epithelium Periodontology 2000 63 2013 67 79
    • (2013) Periodontology 2000 , vol.63 , pp. 67-79
    • Greer, A.1    Zenobia, C.2    Darveau, R.P.3
  • 10
    • 0034283216 scopus 로고    scopus 로고
    • The role of cationic antimicrobial peptides in innate host defences
    • R.E. Hancock, and G. Diamond The role of cationic antimicrobial peptides in innate host defences Trends Microbiol 8 2000 402 410
    • (2000) Trends Microbiol , vol.8 , pp. 402-410
    • Hancock, R.E.1    Diamond, G.2
  • 11
    • 33748935159 scopus 로고    scopus 로고
    • LL-37, the only human member of the cathelicidin family of antimicrobial peptides
    • U.H. Durr, U.S. Sudheendra, and A. Ramamoorthy LL-37, the only human member of the cathelicidin family of antimicrobial peptides Biochim Biophys Acta 1758 2006 1408 1425
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1408-1425
    • Durr, U.H.1    Sudheendra, U.S.2    Ramamoorthy, A.3
  • 12
    • 0031686776 scopus 로고    scopus 로고
    • Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils
    • J. Turner, Y. Cho, N.N. Dinh, A.J. Waring, and R.I. Lehrer Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils Antimicrob Agents Chemother 42 1998 2206 2214
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2206-2214
    • Turner, J.1    Cho, Y.2    Dinh, N.N.3    Waring, A.J.4    Lehrer, R.I.5
  • 13
    • 78649605533 scopus 로고    scopus 로고
    • Suppressive effect of the antimicrobial peptide LL-37 on expression of IL-6, IL-8 and CXCL10 induced by Porphyromonas gingivalis cells and extracts in human gingival fibroblasts
    • M. Inomata, T. Into, and Y. Murakami Suppressive effect of the antimicrobial peptide LL-37 on expression of IL-6, IL-8 and CXCL10 induced by Porphyromonas gingivalis cells and extracts in human gingival fibroblasts Eur J Oral Sci 118 2010 574 581
    • (2010) Eur J Oral Sci , vol.118 , pp. 574-581
    • Inomata, M.1    Into, T.2    Murakami, Y.3
  • 14
    • 79955527970 scopus 로고    scopus 로고
    • Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses
    • K.L. Brown, G.F. Poon, D. Birkenhead, O.M. Pena, R. Falsafi, and C. Dahlgren Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses J Immunol 186 2011 5497 5505
    • (2011) J Immunol , vol.186 , pp. 5497-5505
    • Brown, K.L.1    Poon, G.F.2    Birkenhead, D.3    Pena, O.M.4    Falsafi, R.5    Dahlgren, C.6
  • 15
    • 77954144593 scopus 로고    scopus 로고
    • Effect of the antimicrobial peptide LL-37 on Toll-like receptors 2-, 3- and 4-triggered expression of IL-6, IL-8 and CXCL10 in human gingival fibroblasts
    • T. Into, M. Inomata, K. Shibata, and Y. Murakami Effect of the antimicrobial peptide LL-37 on Toll-like receptors 2-, 3- and 4-triggered expression of IL-6, IL-8 and CXCL10 in human gingival fibroblasts Cell Immunol 264 2010 104 109
    • (2010) Cell Immunol , vol.264 , pp. 104-109
    • Into, T.1    Inomata, M.2    Shibata, K.3    Murakami, Y.4
  • 16
    • 33644978944 scopus 로고    scopus 로고
    • Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action
    • Y. Rosenfeld, N. Papo, and Y. Shai Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action J Biol Chem 281 2006 1636 1643
    • (2006) J Biol Chem , vol.281 , pp. 1636-1643
    • Rosenfeld, Y.1    Papo, N.2    Shai, Y.3
  • 18
    • 84855522617 scopus 로고    scopus 로고
    • Antimicrobial peptides in periodontal innate defense
    • S.U. Gorr Antimicrobial peptides in periodontal innate defense Front Oral Biol 15 2012 84 98
    • (2012) Front Oral Biol , vol.15 , pp. 84-98
    • Gorr, S.U.1
  • 19
    • 72449155528 scopus 로고    scopus 로고
    • Saliva enables the antimicrobial activity of LL-37 in the presence of proteases of Porphyromonas gingivalis
    • M. Gutner, S. Chaushu, D. Balter, and G. Bachrach Saliva enables the antimicrobial activity of LL-37 in the presence of proteases of Porphyromonas gingivalis Infect Immun 77 2009 5558 5563
    • (2009) Infect Immun , vol.77 , pp. 5558-5563
    • Gutner, M.1    Chaushu, S.2    Balter, D.3    Bachrach, G.4
  • 20
    • 0037068959 scopus 로고    scopus 로고
    • Deficiency of antibacterial peptides in patients with morbus Kostmann: An observation study
    • K. Putsep, G. Carlsson, H.G. Boman, and M. Andersson Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study Lancet 360 2002 1144 1149
    • (2002) Lancet , vol.360 , pp. 1144-1149
    • Putsep, K.1    Carlsson, G.2    Boman, H.G.3    Andersson, M.4
  • 21
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • T.C. Chou Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies Pharmacol Rev 58 2006 621 681
    • (2006) Pharmacol Rev , vol.58 , pp. 621-681
    • Chou, T.C.1
  • 23
    • 34447530882 scopus 로고    scopus 로고
    • Bioactive compounds in cranberries and their role in prevention of urinary tract infections
    • A.B. Howell Bioactive compounds in cranberries and their role in prevention of urinary tract infections Mol Nutr Food Res 51 2007 732 737
    • (2007) Mol Nutr Food Res , vol.51 , pp. 732-737
    • Howell, A.B.1
  • 24
    • 34447515810 scopus 로고    scopus 로고
    • Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases
    • C.C. Neto Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases Mol Nutr Food Res 51 2007 652 664
    • (2007) Mol Nutr Food Res , vol.51 , pp. 652-664
    • Neto, C.C.1
  • 25
    • 0001585772 scopus 로고    scopus 로고
    • The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro
    • L.Y. Foo, Y. Lu, A.B. Howell, and N. Vorsa The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro Phytochemistry 54 2000 173 181
    • (2000) Phytochemistry , vol.54 , pp. 173-181
    • Foo, L.Y.1    Lu, Y.2    Howell, A.B.3    Vorsa, N.4
  • 26
    • 33645130043 scopus 로고    scopus 로고
    • Anti-inflammatory activity of a high-molecular-weight cranberry fraction on macrophages stimulated by lipopolysaccharides from periodontopathogens
    • C. Bodet, F. Chandad, and D. Grenier Anti-inflammatory activity of a high-molecular-weight cranberry fraction on macrophages stimulated by lipopolysaccharides from periodontopathogens J Dent Res 85 2006 235 239
    • (2006) J Dent Res , vol.85 , pp. 235-239
    • Bodet, C.1    Chandad, F.2    Grenier, D.3
  • 27
    • 33645120485 scopus 로고    scopus 로고
    • Inhibition of periodontopathogen-derived proteolytic enzymes by a high-molecular-weight fraction isolated from cranberry
    • C. Bodet, M. Piché, F. Chandad, and D. Grenier Inhibition of periodontopathogen-derived proteolytic enzymes by a high-molecular-weight fraction isolated from cranberry J Antimicrob Chemother 57 2006 685 690
    • (2006) J Antimicrob Chemother , vol.57 , pp. 685-690
    • Bodet, C.1    Piché, M.2    Chandad, F.3    Grenier, D.4
  • 28
    • 77951220630 scopus 로고    scopus 로고
    • Anti-Porphyromonas gingivalis and anti-inflammatory activities of A-type cranberry proanthocyanidins
    • V.D. La, A.B. Howell, and D. Grenier Anti-Porphyromonas gingivalis and anti-inflammatory activities of A-type cranberry proanthocyanidins Antimicrob Agents Chemother 54 2010 1778 1784
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1778-1784
    • La, V.D.1    Howell, A.B.2    Grenier, D.3
  • 29
    • 84862209489 scopus 로고    scopus 로고
    • Cranberry proanthocyanidins: Natural weapons against periodontal diseases
    • K. Feghali, M. Feldman, V.D. La, J. Santos, and D. Grenier Cranberry proanthocyanidins: natural weapons against periodontal diseases J Agric Food Chem 60 2012 5728 5735
    • (2012) J Agric Food Chem , vol.60 , pp. 5728-5735
    • Feghali, K.1    Feldman, M.2    La, V.D.3    Santos, J.4    Grenier, D.5
  • 30
    • 67651103333 scopus 로고    scopus 로고
    • Green tea (Camellia sinensis): Chemistry, traditional, medicinal uses and its pharmacological activities - A review
    • V.V. Chopade, A.A. Phatak, A.B. Upaganlawar, and A.A. Tankar Green tea (Camellia sinensis): chemistry, traditional, medicinal uses and its pharmacological activities - a review Pharmacogn Rev 3 2008 157 162
    • (2008) Pharmacogn Rev , vol.3 , pp. 157-162
    • Chopade, V.V.1    Phatak, A.A.2    Upaganlawar, A.B.3    Tankar, A.A.4
  • 31
    • 84882873168 scopus 로고    scopus 로고
    • Tea: A new perspective on health benefits
    • M. da Silva Pinto Tea: a new perspective on health benefits Food Res Int 53 2013 558 567
    • (2013) Food Res Int , vol.53 , pp. 558-567
    • Da Silva Pinto, M.1
  • 32
    • 84898454001 scopus 로고    scopus 로고
    • Effects of the tea catechin epigallocatechin gallate on Porphyromonas gingivalis biofilms
    • Y. Asahi, Y. Noiri, J. Miura, H. Maezono, M. Yamaguchi, and R. Yamamoto Effects of the tea catechin epigallocatechin gallate on Porphyromonas gingivalis biofilms J Appl Microbiol 116 2014 1164 1171
    • (2014) J Appl Microbiol , vol.116 , pp. 1164-1171
    • Asahi, Y.1    Noiri, Y.2    Miura, J.3    Maezono, H.4    Yamaguchi, M.5    Yamamoto, R.6
  • 33
    • 84856569682 scopus 로고    scopus 로고
    • Tea polyphenols inhibit rat osteoclast formation and differentiation
    • Y. Oka, S. Iwai, H. Amano, Y. Irie, K. Yatomi, and K. Ryu Tea polyphenols inhibit rat osteoclast formation and differentiation J Pharmacol Sci 118 2012 55 64
    • (2012) J Pharmacol Sci , vol.118 , pp. 55-64
    • Oka, Y.1    Iwai, S.2    Amano, H.3    Irie, Y.4    Yatomi, K.5    Ryu, K.6
  • 34
    • 79251513300 scopus 로고    scopus 로고
    • Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts
    • Y. Hosokawa, I. Hosokawa, K. Ozaki, T. Nakanishi, H. Nakae, and T. Matsuo Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts Mol Nutr Food Res 54 Suppl. 2 2010 S151 S158
    • (2010) Mol Nutr Food Res , vol.54 , pp. S151-S158
    • Hosokawa, Y.1    Hosokawa, I.2    Ozaki, K.3    Nakanishi, T.4    Nakae, H.5    Matsuo, T.6
  • 35
    • 2442509609 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells
    • D.S. Wheeler, J.D. Catravas, K. Odoms, A. Denenberg, V. Malhotra, and H.R. Wong Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells J Nutr 134 2004 1039 1044
    • (2004) J Nutr , vol.134 , pp. 1039-1044
    • Wheeler, D.S.1    Catravas, J.D.2    Odoms, K.3    Denenberg, A.4    Malhotra, V.5    Wong, H.R.6
  • 36
    • 70450267603 scopus 로고    scopus 로고
    • Epigallocatechin-3-O-gallate decreases tumor necrosis factor-alpha-induced fractalkine expression in endothelial cells by suppressing NF-kappaB
    • A.S. Lee, Y.J. Jung, D.H. Kim, T.H. Lee, K.P. Kang, and S. Lee Epigallocatechin-3-O-gallate decreases tumor necrosis factor-alpha-induced fractalkine expression in endothelial cells by suppressing NF-kappaB Cell Physiol Biochem 24 2009 503 510
    • (2009) Cell Physiol Biochem , vol.24 , pp. 503-510
    • Lee, A.S.1    Jung, Y.J.2    Kim, D.H.3    Lee, T.H.4    Kang, K.P.5    Lee, S.6
  • 37
    • 0036886860 scopus 로고    scopus 로고
    • Improvement of periodontal status by green tea catechin using a local delivery system: A clinical pilot study
    • M. Hirasawa, K. Takada, M. Makimura, and S. Otake Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study J Periodont Res 37 2002 433 438
    • (2002) J Periodont Res , vol.37 , pp. 433-438
    • Hirasawa, M.1    Takada, K.2    Makimura, M.3    Otake, S.4
  • 38
    • 0020590029 scopus 로고
    • Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains
    • R.P. Darveau, and R.E. Hancock Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains J Bacteriol 155 1983 831 838
    • (1983) J Bacteriol , vol.155 , pp. 831-838
    • Darveau, R.P.1    Hancock, R.E.2
  • 39
    • 11144353594 scopus 로고    scopus 로고
    • Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2
    • Y. Kusumoto, H. Hirano, K. Saitoh, S. Yamada, M. Takedachi, and T. Nozaki Human gingival epithelial cells produce chemotactic factors interleukin-8 and monocyte chemoattractant protein-1 after stimulation with Porphyromonas gingivalis via toll-like receptor 2 J Periodontol 75 2004 370 379
    • (2004) J Periodontol , vol.75 , pp. 370-379
    • Kusumoto, Y.1    Hirano, H.2    Saitoh, K.3    Yamada, S.4    Takedachi, M.5    Nozaki, T.6
  • 40
    • 84856645767 scopus 로고    scopus 로고
    • A novel organotypic dento-epithelial culture model: Effect of Fusobacterium nucleatum biofilm on β-defensin-2, -3, and LL-37 expression
    • U.K. Gursoy, M. Pollanen, E. Kononen, and V.J. Uitto A novel organotypic dento-epithelial culture model: effect of Fusobacterium nucleatum biofilm on β-defensin-2, -3, and LL-37 expression J Periodontol 83 2012 242 247
    • (2012) J Periodontol , vol.83 , pp. 242-247
    • Gursoy, U.K.1    Pollanen, M.2    Kononen, E.3    Uitto, V.J.4
  • 41
    • 84891372427 scopus 로고    scopus 로고
    • Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts, and host response
    • G. Hajishengallis Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response Trends Immunol 35 2014 3 11
    • (2014) Trends Immunol , vol.35 , pp. 3-11
    • Hajishengallis, G.1
  • 42
    • 33847000839 scopus 로고    scopus 로고
    • Cranberry components inhibit interleukin-6, interleukin-8, and prostaglandin e production by lipopolysaccharide-activated gingival fibroblasts
    • C. Bodet, F. Chandad, and D. Grenier Cranberry components inhibit interleukin-6, interleukin-8, and prostaglandin E production by lipopolysaccharide-activated gingival fibroblasts Eur J Oral Sci 115 2007 64 70
    • (2007) Eur J Oral Sci , vol.115 , pp. 64-70
    • Bodet, C.1    Chandad, F.2    Grenier, D.3
  • 43
    • 68249153617 scopus 로고    scopus 로고
    • Cranberry proanthocyanidins inhibit MMP production and activity
    • V.D. La, A.B. Howell, and D. Grenier Cranberry proanthocyanidins inhibit MMP production and activity J Dent Res 88 2009 627 632
    • (2009) J Dent Res , vol.88 , pp. 627-632
    • La, V.D.1    Howell, A.B.2    Grenier, D.3
  • 44
    • 84875002508 scopus 로고    scopus 로고
    • Anti-inflammatory effect of (-)-epigallocatechin-3-gallate on Porphyromonas gingivalis lipopolysaccharide-stimulated fibroblasts and stem cells derived from human periodontal ligament
    • I.H. Jung, D.E. Lee, J.H. Yun, A.R. Cho, C.S. Kim, and Y.J. You Anti-inflammatory effect of (-)-epigallocatechin-3-gallate on Porphyromonas gingivalis lipopolysaccharide-stimulated fibroblasts and stem cells derived from human periodontal ligament J Periodontal Implant Sci 42 2012 185 195
    • (2012) J Periodontal Implant Sci , vol.42 , pp. 185-195
    • Jung, I.H.1    Lee, D.E.2    Yun, J.H.3    Cho, A.R.4    Kim, C.S.5    You, Y.J.6
  • 45
    • 77951655420 scopus 로고    scopus 로고
    • Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors
    • T. Nakanishi, K. Mukai, H. Yumoto, K. Hirao, Y. Hosokawa, and T. Matsuo Anti-inflammatory effect of catechin on cultured human dental pulp cells affected by bacteria-derived factors Eur J Oral Sci 118 2010 145 150
    • (2010) Eur J Oral Sci , vol.118 , pp. 145-150
    • Nakanishi, T.1    Mukai, K.2    Yumoto, H.3    Hirao, K.4    Hosokawa, Y.5    Matsuo, T.6
  • 46
    • 84908604484 scopus 로고    scopus 로고
    • Green tea extract and its major constituent, epigallocatechin-3-gallate, induce epithelial beta-defensin secretion and prevent beta-defensin degradation by Porphyromonas gingivalis
    • T.B. Lombardo Bedran, K. Feghali, L. Zhao, D.M. Palomari Spolidorio, and D. Grenier Green tea extract and its major constituent, epigallocatechin-3-gallate, induce epithelial beta-defensin secretion and prevent beta-defensin degradation by Porphyromonas gingivalis J Periodontal Res 49 2014 615 623
    • (2014) J Periodontal Res , vol.49 , pp. 615-623
    • Lombardo Bedran, T.B.1    Feghali, K.2    Zhao, L.3    Palomari Spolidorio, D.M.4    Grenier, D.5
  • 47
    • 28644448792 scopus 로고    scopus 로고
    • Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis
    • B. Kurtis, G. Tuter, M. Serdar, P. Akdemir, C. Uygur, and E. Firatli Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis J Periodontol 76 2005 1849 1855
    • (2005) J Periodontol , vol.76 , pp. 1849-1855
    • Kurtis, B.1    Tuter, G.2    Serdar, M.3    Akdemir, P.4    Uygur, C.5    Firatli, E.6
  • 48
    • 84876732005 scopus 로고    scopus 로고
    • Comparative evaluation of cytokines in gingival crevicular fluid and saliva of patients with aggressive periodontitis
    • Y. Yue, Q. Liu, C. Xu, W.T. Loo, M. Wang, and G. Wen Comparative evaluation of cytokines in gingival crevicular fluid and saliva of patients with aggressive periodontitis Int J Biol Markers 28 2013 108 112
    • (2013) Int J Biol Markers , vol.28 , pp. 108-112
    • Yue, Y.1    Liu, Q.2    Xu, C.3    Loo, W.T.4    Wang, M.5    Wen, G.6
  • 49
    • 0032468328 scopus 로고    scopus 로고
    • Cytokine expression in periodontal health and disease
    • H. Okada, and S. Murakami Cytokine expression in periodontal health and disease Crit Rev Oral Biol Med 9 1998 248 266
    • (1998) Crit Rev Oral Biol Med , vol.9 , pp. 248-266
    • Okada, H.1    Murakami, S.2
  • 50
    • 0032974306 scopus 로고    scopus 로고
    • The potential role of chemokines and inflammatory cytokines in periodontal disease progression
    • D.T. Graves The potential role of chemokines and inflammatory cytokines in periodontal disease progression Clin Infect Dis 28 1999 482 490
    • (1999) Clin Infect Dis , vol.28 , pp. 482-490
    • Graves, D.T.1
  • 52
    • 84862727906 scopus 로고    scopus 로고
    • Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
    • J.A.C. de Souza, C. Rossa, G.P. Garlet, A.V. Nogueira, and J.A. Cirelli Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease J Appl Oral Sci 20 2012 128 138
    • (2012) J Appl Oral Sci , vol.20 , pp. 128-138
    • De Souza, J.A.C.1    Rossa, C.2    Garlet, G.P.3    Nogueira, A.V.4    Cirelli, J.A.5
  • 54
    • 84863994253 scopus 로고    scopus 로고
    • Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages
    • M. Feldman, and D. Grenier Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages J Appl Microbiol 113 2012 438 447
    • (2012) J Appl Microbiol , vol.113 , pp. 438-447
    • Feldman, M.1    Grenier, D.2
  • 55
    • 0036217821 scopus 로고    scopus 로고
    • Natural products as targeted modulators of the nuclear factor-kappaB pathway
    • P. Bremner, and M. Heinrich Natural products as targeted modulators of the nuclear factor-kappaB pathway J Pharm Pharmacol 54 2002 453 472
    • (2002) J Pharm Pharmacol , vol.54 , pp. 453-472
    • Bremner, P.1    Heinrich, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.