Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses

Journal of Immunology

Volumn 186, Issue 9, 2011, Pages 5497-5505

  Brown, Kelly L ^a,b   Poon, Grace F T ^b   Birkenhead, Darlene ^b   Pena, Olga M ^b   Falsafi, Reza ^b   Dahlgren, Claes ^a   Karlsson, Anna ^a   Bylund, Johan ^a   Hancock, Robert E W ^b   Johnson, Pauline ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; GAMMA INTERFERON; INTERLEUKIN 4; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFICACY; DRUG SELECTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; POLARIZATION; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL DIFFERENTIATION; CELL SEPARATION; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; INFLAMMATION; MACROPHAGES; MICE; MICE, INBRED C57BL; NITRIC OXIDE; PHAGOCYTOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79955527970     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002508     Document Type: Article

References (42)

1. Mantovani, A., A. Sica, S. Sozzani, P. Allavena, A. Vecchi, and M. Locati. 2004. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25: 677-686. (Pubitemid 39457982)
2. Gordon, S., and P. R. Taylor. 2005. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5: 953-964.
3. Mosser, D. M., and J. P. Edwards. 2008. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8: 958-969.
4. Pollard, J. W. 2009. Trophic macrophages in development and disease. Nat. Rev. Immunol. 9: 259-270.
5. Gordon, S., and F. O. Martinez. 2010. Alternative activation of macrophages: mechanism and functions. Immunity 32: 593-604.
6. Martinez, F. O., L. Helming, and S. Gordon. 2009. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27: 451-483.
7. Gordon, S. 2003. Alternative activation of macrophages. Nat. Rev. Immunol. 3: 23-35.
8. Soehnlein, O., and L. Lindbom. 2010. Phagocyte partnership during the onset and resolution of inflammation. Nat. Rev. Immunol. 10: 427-439.
9. Mantovani, A., A. Sica, and M. Locati. 2005. Macrophage polarization comes of age. Immunity 23: 344-346. (Pubitemid 41443435)
10. Nijnik, A., and R. E. W. Hancock. 2009. The roles of cathelicidin LL-37 in immune defences and novel clinical applications. Curr. Opin. Hematol. 16: 41-47.
11. Doss, M., M. R. White, T. Tecle, and K. L. Hartshorn. 2010. Human defensins and LL-37 in mucosal immunity. J. Leukoc. Biol. 87: 79-92.
12. Peyssonnaux, C., A. T. Boutin, A. S. Zinkernagel, V. Datta, V. Nizet, and R. S. Johnson. 2008. Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J. Invest. Dermatol. 128: 1964-1968.
13. Liu, P. T., S. Stenger, D. H. Tang, and R. L. Modlin. 2007. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J. Immunol. 179: 2060-2063.
14. Wang, T. T., F. P. Nestel, V. Bourdeau, Y. Nagai, Q. Wang, J. Liao, L. Tavera- Mendoza, R. Lin, J. W. Hanrahan, S. Mader, and J. H. White. 2004. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. [Published erratum appears in 2004 J. Immunol. 173: 6489.] J. Immunol. 173: 2909-2912.
15. Islam, D., L. Bandholtz, J. Nilsson, H. Wigzell, B. Christensson, B. Agerberth, and G. Gudmundsson. 2001. Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat. Med. 7: 180-185.
16. Frohm, M., B. Agerberth, G. Ahangari, M. Stâhle-Bäckdahl, S. Lidén, H. Wigzell, and G. H. Gudmundsson. 1997. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J. Biol. Chem. 272: 15258-15263.
17. Ong, P. Y., T. Ohtake, C. Brandt, I. Strickland, M. Boguniewicz, T. Ganz, R. L. Gallo, and D. Y. Leung. 2002. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347: 1151-1160.
18. Schaller-Bals, S., A. Schulze, and R. Bals. 2002. Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection. Am. J. Respir. Crit. Care Med. 165: 992-995.
19. Bals, R., D. J. Weiner, R. L. Meegalla, and J. M. Wilson. 1999. Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. J. Clin. Invest. 103: 1113-1117.
20. Schauber, J., and R. L. Gallo. 2008. Antimicrobial peptides and the skin immune defense system. J. Allergy Clin. Immunol. 122: 261-266.
21. Yang, D., O. Chertov, and J. J. Oppenheim. 2001. Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37). J. Leukoc. Biol. 69: 691-697.
22. Filewod, N. C., J. Pistolic, and R. E. Hancock. 2009. Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to proinflammatory stimuli. FEMS Immunol. Med. Microbiol. 56: 233-240.
23. Zuyderduyn, S., D. K. Ninaber, P. S. Hiemstra, and K. F. Rabe. 2006. The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells. J. Allergy Clin. Immunol. 117: 1328-1335.
24. Scott, M. G., D. J. Davidson, M. R. Gold, D. Bowdish, and R. E. W. Hancock. 2002. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J. Immunol. 169: 3883-3891.
25. Yu, J., N. Mookherjee, K. Wee, D. M. E. Bowdish, J. Pistolic, Y. Li, L. Rehaume, and R. E. W. Hancock. 2007. Host defense peptide LL-37, in synergy with in- flammatory mediator IL-1beta, augments immune responses by multiple pathways. J. Immunol. 179: 7684-7691.
26. Scott, M. G., A. C. Vreugdenhil, W. A. Buurman, R. E. Hancock, and M. R. Gold. 2000. Cutting edge: cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein. J. Immunol. 164: 549-553.
27. Mookherjee, N., K. L. Brown, D. M. Bowdish, S. Doria, R. Falsafi, K. Hokamp, F. M. Roche, R. Mu, G. H. Doho, J. Pistolic, et al. 2006. Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J. Immunol. 176: 2455-2464. (Pubitemid 43201696)
28. Nijnik, A., J. Pistolic, A. Wyatt, S. Tam, and R. E. W. Hancock. 2009. Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs. J. Immunol. 183: 5788-5798.
29. Kandler, K., R. Shaykhiev, P. Kleemann, F. Klescz, M. Lohoff, C. Vogelmeier, and R. Bals. 2006. The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands. Int. Immunol. 18: 1729-1736.
30. Cirioni, O., A. Giacometti, R. Ghiselli, C. Bergnach, F. Orlando, C. Silvestri, F. Mocchegiani, A. Licci, B. Skerlavaj, M. Rocchi, et al. 2006. LL-37 protects rats against lethal sepsis caused by gram-negative bacteria. Antimicrob. Agents Chemother. 50: 1672-1679.
31. Carretero, M., M. J. Escámez, M. García, B. Duarte, A. Holguín, L. Retamosa, J. L. Jorcano, M. D. Río, and F. Larcher. 2008. In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37. J. Invest. Dermatol. 128: 223-236.
32. Koczulla, R., G. von Degenfeld, C. Kupatt, F. Krötz, S. Zahler, T. Gloe, K. Issbrücker, P. Unterberger, M.Zaiou,C. Lebherz, et al. 2003.An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 111: 1665-1672.
33. Brown, K. L., K. Christenson, A. Karlsson, C. Dahlgren, and J. Bylund. 2009. Divergent effects on phagocytosis by macrophage-derived oxygen radicals. J. Innate Immun. 1: 592-598.
34. Dahlgren, C., and A. Karlsson. 1999. Respiratory burst in human neutrophils. J. Immunol. Methods 232: 3-14. (Pubitemid 30017761)
35. Scott, M. G., E. Dullaghan, N. Mookherjee, N. Glavas, M. Waldbrook, A. Thompson, A. Wang, K. Lee, S. Doria, P. Hamill, et al. 2007. An anti-infective peptide that selectively modulates the innate immune response. Nat. Biotechnol. 25: 465-472.
36. Nijnik, A., L. Madera, S. Ma, M. Waldbrook, M. R. Elliott, D. M. Easton, M. L. Mayer, S. C. Mullaly, J. Kindrachuk, H. Jenssen, and R. E. Hancock. 2010. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J. Immunol. 184: 2539-2550.
37. Zughaier, S. M., W. M. Shafer, and D. S. Stephens. 2005. Antimicrobial peptides and endotoxin inhibit cytokine and nitric oxide release but amplify respiratory burst response in human and murine macrophages. Cell. Microbiol. 7: 1251-1262.
38. Nagaoka, I., S. Hirota, F. Niyonsaba, M. Hirata, Y. Adachi, H. Tamura, S. Tanaka, and D. Heumann. 2002. Augmentation of the lipopolysaccharide- neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin. Diagn. Lab. Immunol. 9: 972-982.
39. Rosenfeld, Y., N. Papo, and Y. Shai. 2006. Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action. J. Biol. Chem. 281: 1636-1643.
40. van der Does, A. M., H. Beekhuizen, B. Ravensbergen, T. Vos, T. H. Ottenhoff, J. T. van Dissel, J. W. Drijfhout, P. S. Hiemstra, and P. H. Nibbering. 2010. LL-37 directs macrophage differentiation toward macrophages with a proin- flammatory signature. J. Immunol. 185: 1442-1449.
41. Hu, B., J. H. Jennings, J. Sonstein, J. Floros, J. C. Todt, T. Polak, and J. L. Curtis. 2004. Resident murine alveolar and peritoneal macrophages differ in adhesion of apoptotic thymocytes. Am. J. Respir. Cell Mol. Biol. 30: 687-693.
42. Barlow, P. G., P. E. Beaumont, C. Cosseau, A. Mackellar, T. S. Wilkinson, R. E. Hancock, C. Haslett, J. R. Govan, A. J. Simpson, and D. J. Davidson. 2010. The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium. Am. J. Respir. Cell Mol. Biol. 43: 692-702.