The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function

Nature Communications

Volumn 6, Issue , 2015, Pages

  Mountford, Jessica K ^a   Petitjean, Claire ^a   Putra, Harun W Kusuma ^a   McCafferty, Jonathan A ^a   Setiabakti, Natasha M ^a   Lee, Hannah ^a   Tønnesen, Lotte L ^a   McFadyen, James D ^a   Schoenwaelder, Simone M ^a,b   Eckly, Anita ^c   Gachet, Christian ^c   Ellis, Sarah ^d   Voss, Anne K ^d,e   Dickins, Ross A ^d,e   Hamilton, Justin R ^a   Jackson, Shaun P ^a,b,f  

^a MONASH UNIVERSITY   (Australia)

^b University of Sydney   (Australia)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE C2ALPHA; UNCLASSIFIED DRUG; PIK3C2A PROTEIN, HUMAN; PIK3C2A PROTEIN, MOUSE;

BLOOD; ENZYME ACTIVITY; PHYSIOLOGY; SHEAR STRESS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; EMBRYO; FEMALE; HEMODYNAMICS; HEMOSTASIS; IN VITRO STUDY; IN VIVO STUDY; MEGAKARYOCYTE; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; SHEAR STRESS; SIGNAL TRANSDUCTION; THROMBOCYTE ADHESION; THROMBOSIS; ALLELE; ANIMAL; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CELL ADHESION; CROSS BREEDING; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; HUMAN; MECHANICAL STRESS; METABOLISM; MUTATION; PERFUSION; PHOSPHORYLATION; SHEAR STRENGTH; THROMBOCYTE; THROMBOCYTE AGGREGATION; TRANSMISSION ELECTRON MICROSCOPY;

ALLELES; ANIMALS; BLOOD PLATELETS; BONE MARROW TRANSPLANTATION; CELL ADHESION; CROSSES, GENETIC; GENE EXPRESSION REGULATION; GENOTYPE; HEMOSTASIS; HUMANS; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; MUTATION; PERFUSION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; SHEAR STRENGTH; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; THROMBOSIS;

EID: 84924943700     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7535     Document Type: Article

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