Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals

Journal of Pharmacological and Toxicological Methods

Volumn 53, Issue 1, 2006, Pages 20-29

  Sturgeon, Sharelle A ^a   Jones, Catherine ^a   Angus, James A ^b   Wright, Christine E ^b  

^a Kinacia Pty Ltd   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Arterial thrombosis; Carotid artery; Cyclic flow reductions; Electrolytic; Folts; Methods; Mouse; Rabbit; Rat; Stenosis

Indexed keywords

8 (4 FLUORO 2 METHYLPHENOXY) 2 MORPHOLIN 4 YLQUINOLIN 4(1H)ONE; ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; DIMETHYL SULFOXIDE; FIBRIN; FIBRINOGEN RECEPTOR ANTAGONIST; GPI 562; PHOSPHOINOSITIDE 3 KINASE INHIBITOR; PROPYLENE GLYCOL; TGX 155; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INJURY; ARTERY THROMBOSIS; ARTICLE; CAROTID ARTERY FLOW; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG EFFECT; DRUG RESEARCH; DRUG SCREENING; ELECTROLYSIS; ENDOTHELIUM INJURY; EXPERIMENTAL ANIMAL; FEMALE; MALE; MOUSE; NONHUMAN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; RABBIT; RAT; REPRODUCIBILITY; THROMBOGENESIS;

ANIMALS; ASPIRIN; BENZYLAMINES; CAROTID ARTERIES; CAROTID ARTERY THROMBOSIS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ELECTRIC STIMULATION; FIBRINOLYTIC AGENTS; MALE; MICE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; REPRODUCIBILITY OF RESULTS; TICLOPIDINE; TIME FACTORS;

ANIMALIA; CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS; THROMBUS;

EID: 30144444264     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2005.06.006     Document Type: Article

References (49)

1. S. Ashida, K. Sakuma, and Y. Abiko Antithrombotic effects of ticlopidine, acetylsalicyclic acid and dipyridamole in vascular shunt model in rats Thrombosis Research 17 1980 663 671
2. L.R. Bush, and R.J. Shebuski In vivo models of arterial thrombosis and thrombolysis Faseb Journal 4 1990 3087 3098
3. P. Carmeliet, L. Moons, J.M. Stassen, M. De Mol, A. Bouche, and J.J. van den Oord Vascular wound healing and neointima formation induced by perivascular electric injury in mice American Journal of Pathology 150 1997 761 776
4. J.P. Carteaux, A. Gast, T.B. Tschopp, and S. Roux Activated clotting time as an appropriate test to compare heparin and direct thrombin inhibitors such as hirudin or Ro 46-6240 in experimental arterial thrombosis Circulation 91 1995 1568 1574
5. T.F. Choudhri, B.L. Hoh, H.G. Zerwes, C.J. Prestigiacomo, S.C. Kim, and E.S. Connolly Jr. Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation Journal of Clinical Investigation 102 1998 1301 1310
6. B.S. Coller, J.D. Folts, L.E. Scudder, and S.R. Smith Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model Blood 68 1986 783 786
7. M. Dujovny, R. Rozario, N. Kossovsky, F.G. Diaz, and R. Segal Antiplatelet effect of dimethyl sulfoxide, barbiturates, and methyl prednisolone Annals of the New York Academy of Sciences 411 1983 234 244
8. J.D. Folts An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis Circulation 83 1991 IV-3 IV-14
9. J.D. Folts, E.B. Crowell Jr., and G.G. Rowe Platelet aggregation in partially obstructed vessels and its elimination with aspirin Circulation 54 1976 365 370
10. J.D. Folts, A.I. Schafer, J. Loscalzo, J.T. Willerson, and J.E. Muller A perspective on the potential problems with aspirin as an antithrombotic agent: A comparison of studies in an animal model with clinical trials Journal of the American College of Cardiology 33 1999 295 303
11. J.D. Folts, J. Stamler, and J. Loscalzo Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries Circulation 83 1991 2122 2127
12. J.G. Fox, L.C. Anderson, F.M. Loew, and F.W. Quimby Laboratory animal medicine 2002 Academic Press San Diego 43
13. L.G. Frederick, O.D. Suleymanov, J.A. Szalony, B.B. Taite, A.K. Salyers, and L.W. King Protective effect of oral xemilofiban in arterial thrombosis in dogs: Increased activity in combination with aspirin Circulation 98 1998 813 820
14. V. Fuster, B. Stein, J.A. Ambrose, L. Badimon, J.J. Badimon, and J.H. Chesebro Atherosclerotic plaque rupture and thrombosis. Evolving concepts Circulation 82 1990 II47 II59
15. P. Golino, G. Ambrosio, I. Pascucci, M. Ragni, E. Russolillo, and M. Chiariello Experimental carotid stenosis and endothelial injury in the rabbit: An in vivo model to study intravascular platelet aggregation Thrombosis and Haemostasis 67 1992 302 305
16. S. Guarini A highly reproducible model of arterial thrombosis in rats Journal of Pharmacological and Toxicological Methods 35 1996 101 105
17. J.M. Herbert, F. Dol, A. Bernat, R. Falotico, A. Lale, and P. Savi The antiaggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit Thrombosis and Haemostasis 80 1998 512 518
18. J. Hirsh Guidelines for antithrombotic therapy 4th ed. 2001 BC Decker Inc Hamilton, Ontario, Canada
19. S.P. Jackson, S.M. Schoenwaelder, I. Goncalves, W.S. Nesbitt, C.L. Yap, and C.E. Wright PI 3-kinase p110β: A new target for antithrombotic therapy Nature Medicine 11 2005 507 514
20. G.J. Johnson, T.R. Griggs, and L. Badimon The utility of animal models in the preclinical study of interventions to prevent human coronary artery restenosis: Analysis and recommendations Thrombosis and Haemostasis 81 1999 835 843
21. R.J. Leadley Jr., L. Chi, S.S. Rebello, and A. Gagnon Contribution of in vivo models of thrombosis to the discovery and development of novel antithrombotic agents Journal of Pharmacological and Toxicological Methods 43 2000 101 116
22. R.J. Leadley Jr., C.J. Kasiewski, J.S. Bostwick, R. Bentley, C.T. Dunwiddie, and M.H. Perrone Inhibition of repetitive thrombus formation in the stenosed canine coronary artery by enoxaparin, but not by unfractionated heparin Arteriosclerosis, Thrombosis and Vascular Biology 18 1998 908 914
23. J. Ludbrook Repeated measurements and multiple comparisons in cardiovascular research Cardiovascular Research 28 1994 303 311
24. J.J. Lynch Jr., J.J. Cook, G.R. Sitko, M.A. Holahan, D.R. Ramjit, and M.J. Mellott Nonpeptide glycoprotein IIb/IIIa inhibitors. 5. Antithrombotic effects of MK-0383 Journal of Pharmacology and Experimental Therapeutics 272 1995 20 32
25. N. Maalej, and J.D. Folts Increased shear stress overcomes the antithrombotic platelet inhibitory effect of aspirin in stenosed dog coronary arteries Circulation 93 1996 1201 1205
26. F.S. Markland, G.S. Friedrichs, S.R. Pewitt, and B.R. Lucchesi Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis Circulation 90 1994 2448 2456
27. T.B. McClanahan, G.W. Hicks, D.P. Ignasiak, R. Bousley, T.E. Mertz, and P. Juneau The antithrombotic effects of CI-1028, an orally bioavailable direct thrombin inhibitor, in a canine model of venous and arterial thrombosis Journal of Thrombosis and Thrombolysis 10 2000 277 284
28. A. Merino, M. Cohen, J.J. Badimon, V. Fuster, and L. Badimon Synergistic action of severe wall injury and shear forces on thrombus formation in arterial stenosis: Definition of a thrombotic shear rate threshold Journal of the American College of Cardiology 24 1994 1091 1097
29. J.L. Moake, N.A. Turner, N.A. Stathopoulos, L. Nolasco, and J.D. Hellums Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin Blood 71 1988 1366 1374
30. S.A. Mousa, R. Kapil, and D.X. Mu Intravenous and oral antithrombotic efficacy of the novel platelet GPIIb/IIIa antagonist roxifiban (DMP754) and its free acid form, XV459 Arteriosclerosis, Thrombosis and Vascular Biology 19 1999 2535 2541
31. A.M. Nolan Pharmacology of analgesic drugs P.A. Flecknell A. Waterman-Pearson In pain management in animals 2000 W B Saunders Edinburgh 42 43
32. B. Ouaknine-Orlando, C.M. Samama, B. Riou, P. Bonnin, J.J. Guillosson, and J.L. Beaumont Role of the hematocrit in a rabbit model of arterial thrombosis and bleeding Anesthesiology 90 1999 1454 1461
33. D.G. Pace, J.L. Kovacs, and L.R. Klevans Dimethyl sulfoxide inhibits platelet aggregation in partially obstructed canine coronary vessels Annals of the New York Academy of Sciences 411 1983 352 356
34. J. Parris, P. Fournau, M. Granero, and C. Veins Antithrombotic effect of very low doses of acetylsalicylic acid in rats Thrombosis Research 28 1983 313 321
35. R.B. Philp, M.L. Paul, J.J. Killackey, and B.A. Killackey The influence of dose, time of administration, body temperature and salicylate kinetics on the antithrombotic action of acetylsalicylic acid in male rats Haemostasis 13 1983 42 52
36. S. Roux, J.P. Carteaux, P. Hess, L. Falivene, and J.P. Clozel Experimental carotid thrombosis in the guinea pig Thrombosis and Haemostasis 71 1994 252 256
37. P. Salvati, L. Dho, G. Ukmar, L. Vaga, O. Rimoldi, and C. Patrono A comparative evaluation of thromboxane receptor blockade, thromboxane synthase inhibition and both in animal models of arterial thrombosis Journal of Pharmacology and Experimental Therapeutics 269 1994 238 245
38. W.A. Schumacher, T.E. Steinbacher, C.L. Heran, J.R. Megill, and S.K. Durham Effects of antithrombotic drugs in a rat model of aspirin-insensitive arterial thrombosis Thrombosis and Haemostasis 69 1993 509 514
39. P.J. Sharis, C.P. Cannon, and J. Loscalzo The antiplatelet effects of ticlopidine and clopidogrel Annals of Internal Medicine 129 1998 394 405
40. T.J. Shetler, B.D. Bailey, J.A. Jakubowski, and C.V. Jackson Intravenous administration of the glycoprotein IIb-IIIa receptor antagonist 7E3 induces reperfusion of an acute thrombotic occlusion of the canine coronary artery Thrombosis Research 90 1998 95 100
41. M. Shimazawa, Y. Takiguchi, K. Umemura, K. Kondo, and M. Nakashima Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022 European Journal of Pharmacology 328 1997 183 189
42. J. Strony, A. Beaudoin, D. Brands, and B. Adelman Analysis of shear stress and hemodynamic factors in a model of coronary artery stenosis and thrombosis American Journal of Physiology 265 1993 H1787 H1796
43. S. Tsuji, M. Sugimoto, S. Miyata, M. Kuwahara, S. Kinoshita, and A. Yoshioka Real-time analysis of mural thrombus formation in various platelet aggregation disorders: Distinct shear-dependent roles of platelet receptors and adhesive proteins under flow Blood 94 1999 968 975
44. N.A. Turner, J.L. Moake, and L.V. McIntire Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow Blood 98 2001 3340 3345
45. S. Uchiyama, M. Yamazaki, S. Maruyama, M. Handa, Y. Ikeda, and M. Fukuyama Shear-induced platelet aggregation in cerebral ischemia Stroke 25 1994 1547 1551
46. J.-P. Valentin, S. Vieu, F. Bertolino, P. Faure, and G. John Differential involvement of serotonin 2A/C and thromboxane A2/prostanoid receptors in high- vs low-shear rate arterial thrombosis in rabbits Journal of Pharmacology and Experimental Therapeutics 280 1997 761 769
47. C.E. Wright, J.A. Angus, and P.I. Korner Vascular amplifier properties in renovascular hypertension in conscious rabbits. Hindquarter responses to constrictor and dilator stimuli Hypertension 9 1987 122 131
48. C.E. Wright, J.A. Angus, and P.I. Korner Structural factors increase blood pressure through the interaction of resistance vessel geometry with neurohumoral and local factors: Estimates in rabbits with renal cellophane-wrap hypertension with intact effectors and during neurohumoral blockade Journal of Hypertension 20 2002 471 483
49. IIbβ3 Blood 99 2002 151 158