Sensitive and Simultaneous Determination of 5-Methylcytosine and Its Oxidation Products in Genomic DNA by Chemical Derivatization Coupled with Liquid Chromatography-Tandem Mass Spectrometry Analysis

Analytical Chemistry

Volumn 87, Issue 6, 2015, Pages 3445-3452

  Tang, Yang ^a,c   Zheng, Shu Jian ^a   Qi, Chu Bo ^a,b   Feng, Yu Qi ^a   Yuan, Bi Feng ^a  

^a WUHAN UNIVERSITY   (China)

^b HUBEI CANCER HOSPITAL   (China)

^c CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CHEMICAL ANALYSIS; CHEMICAL DETECTION; CHEMICAL MODIFICATION; CHEMICAL REACTIONS; DIAGNOSIS; DNA; ELECTROSPRAY IONIZATION; GENES; HISTOLOGY; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; OXIDATION; SPECTROMETRY; TISSUE; TUMORS;

5-HYDROXYMETHYLCYTOSINE; CHEMICAL DERIVATIZATION; COLORECTAL CARCINOMA; DETECTION SENSITIVITY; EPIGENETIC REGULATION; LIQUID CHROMATOGRAPHY ELECTROSPRAY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; SIMULTANEOUS DETERMINATIONS;

CHROMATOGRAPHY;

5 METHYLCYTOSINE; DNA; KETONE;

CHEMISTRY; COLORECTAL TUMOR; DNA METHYLATION; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; HUMAN; HUMAN GENOME; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; OXIDATION REDUCTION REACTION; PATHOLOGY; PROCEDURES; TANDEM MASS SPECTROMETRY; TIME;

5-METHYLCYTOSINE; CHROMATOGRAPHY, LIQUID; COLORECTAL NEOPLASMS; DNA; DNA METHYLATION; GENOME, HUMAN; HUMANS; KETONES; LIMIT OF DETECTION; OXIDATION-REDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 84924942223     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac504786r     Document Type: Article

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