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Volumn 374, Issue 1-2, 2013, Pages 1-11

VSL#3 probiotics exerts the anti-inflammatory activity via PI3k/Akt and NF-κB pathway in rat model of DSS-induced colitis

Author keywords

Inflammatory bowel disease; NF B; PI3K Akt; Probiotic; Ulcerative colitis

Indexed keywords

CYCLOOXYGENASE 2; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 6; MYELOPEROXIDASE; PLACEBO; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; VSL3; WORTMANNIN;

EID: 84871986920     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1488-3     Document Type: Article
Times cited : (138)

References (66)
  • 1
    • 77957868697 scopus 로고    scopus 로고
    • New insights into IBD epidemiology: Are there any lessons for treatment?
    • 20926864 10.1159/000320394
    • Bernstein CN (2010) New insights into IBD epidemiology: are there any lessons for treatment? Dig Dis 28(3):406-410
    • (2010) Dig Dis , vol.28 , Issue.3 , pp. 406-410
    • Bernstein, C.N.1
  • 2
    • 77957600507 scopus 로고    scopus 로고
    • Chronic inflammatory bowel disease: Crohn's disease and ulcerative colitis
    • 20432590
    • Fiasse R, Denis MA, Dewit O (2010) Chronic inflammatory bowel disease: Crohn's disease and ulcerative colitis. J Pharm Belg 1:1-9
    • (2010) J Pharm Belg , vol.1 , pp. 1-9
    • Fiasse, R.1    Denis, M.A.2    Dewit, O.3
  • 3
    • 1542295995 scopus 로고    scopus 로고
    • Probiotics, irritable bowel syndrome, and inflammatory bowel disease
    • 12846937 10.1007/s11938-003-0020-y
    • Floch MH (2003) Probiotics, irritable bowel syndrome, and inflammatory bowel disease. Curr Treat Options Gastroenterol 6(4):283-288
    • (2003) Curr Treat Options Gastroenterol , vol.6 , Issue.4 , pp. 283-288
    • Floch, M.H.1
  • 4
    • 77955411137 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Longterm management
    • 20848988
    • Leske D, Hoffmann JC (2010) Inflammatory bowel disease: longterm management. MMW Fortschr Med 152(28-30):40-42
    • (2010) MMW Fortschr Med , vol.152 , Issue.28-30 , pp. 40-42
    • Leske, D.1    Hoffmann, J.C.2
  • 5
    • 0019004788 scopus 로고
    • Pathology of inflammatory bowel disease
    • 7380171 1:STN:280:DyaL3c3gt1CjsQ%3D%3D
    • Morson BC (1980) Pathology of inflammatory bowel disease. Gastroenterol Jpn 15(2):184-187
    • (1980) Gastroenterol Jpn , vol.15 , Issue.2 , pp. 184-187
    • Morson, B.C.1
  • 7
    • 33747455627 scopus 로고    scopus 로고
    • Anti-inflammatory effect of diammonium glycyrrhizinate in a rat model of ulcerative colitis
    • 16874877
    • Yuan H, Ji WS, Wu KX, Jiao JX, Sun LH, Feng YT (2006) Anti-inflammatory effect of diammonium glycyrrhizinate in a rat model of ulcerative colitis. World J Gastroenterol 12(28):4578-4581
    • (2006) World J Gastroenterol , vol.12 , Issue.28 , pp. 4578-4581
    • Yuan, H.1    Ji, W.S.2    Wu, K.X.3    Jiao, J.X.4    Sun, L.H.5    Feng, Y.T.6
  • 8
    • 77951674908 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate
    • 10.1155/2010/943516 20300439 10.1155/2010/943516
    • Choi SY, Hur SJ, An CS, Jeon YH, Jeoung YJ, Bak JP, Lim BO (2010) Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate. J Biomed Biotechnol 2010:943516. doi: 10.1155/2010/943516
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 943516
    • Choi, S.Y.1    Hur, S.J.2    An, C.S.3    Jeon, Y.H.4    Jeoung, Y.J.5    Bak, J.P.6    Lim, B.O.7
  • 9
    • 44949119375 scopus 로고    scopus 로고
    • Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice
    • 10.1038/bjp.2008.137 18536734 10.1038/bjp.2008.137 1:CAS:528: DC%2BD1cXmvFWisL8%3D
    • Islam MS, Murata T, Fujisawa M, Nagasaka R, Ushio H, Bari AM, Hori M, Ozaki H (2008) Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice. Br J Pharmacol 154(4):812-824. doi: 10.1038/bjp.2008.137
    • (2008) Br J Pharmacol , vol.154 , Issue.4 , pp. 812-824
    • Islam, M.S.1    Murata, T.2    Fujisawa, M.3    Nagasaka, R.4    Ushio, H.5    Bari, A.M.6    Hori, M.7    Ozaki, H.8
  • 10
    • 33745727051 scopus 로고    scopus 로고
    • Plant originated glycoprotein has anti-oxidative and anti-inflammatory effects on dextran sulfate sodium-induced colitis in mouse
    • 10.1007/s11373-006-9083-9 16586048 10.1007/s11373-006-9083-9 1:CAS:528:DC%2BD28XpsVCisbs%3D
    • Oh PS, Lim KT (2006) Plant originated glycoprotein has anti-oxidative and anti-inflammatory effects on dextran sulfate sodium-induced colitis in mouse. J Biomed Sci 13(4):549-560. doi: 10.1007/s11373-006-9083-9
    • (2006) J Biomed Sci , vol.13 , Issue.4 , pp. 549-560
    • Oh, P.S.1    Lim, K.T.2
  • 11
    • 0028345981 scopus 로고
    • Pathology of chronic inflammatory bowel disease in children
    • 8003743 10.1016/S0950-3528(06)80018-7 1:STN:280:DyaK2c3nt1Skug%3D%3D
    • Domizio P (1994) Pathology of chronic inflammatory bowel disease in children. Baillieres Clin Gastroenterol 8(1):35-63
    • (1994) Baillieres Clin Gastroenterol , vol.8 , Issue.1 , pp. 35-63
    • Domizio, P.1
  • 14
    • 77957603468 scopus 로고    scopus 로고
    • The role of bacteria in the pathogenesis of inflammatory bowel disease
    • 10.5009/gnl.2010.4.3.295 20981205 10.5009/gnl.2010.4.3.295 1:CAS:528:DC%2BC3cXhsFCnsrjE
    • Friswell M, Campbell B, Rhodes J (2010) The role of bacteria in the pathogenesis of inflammatory bowel disease. Gut Liver 4(3):295-306. doi: 10.5009/gnl.2010.4.3.295
    • (2010) Gut Liver , vol.4 , Issue.3 , pp. 295-306
    • Friswell, M.1    Campbell, B.2    Rhodes, J.3
  • 15
    • 77649150349 scopus 로고    scopus 로고
    • Update on the role of probiotics in the therapy of pediatric inflammatory bowel disease
    • 20383890 10.1586/eci.09.70 1:CAS:528:DC%2BD1MXhsFKgtbvN
    • Guandalini S (2010) Update on the role of probiotics in the therapy of pediatric inflammatory bowel disease. Expert Rev Clin Immunol 6(1):47-54
    • (2010) Expert Rev Clin Immunol , vol.6 , Issue.1 , pp. 47-54
    • Guandalini, S.1
  • 16
    • 77249179697 scopus 로고    scopus 로고
    • Guidance for substantiating the evidence for beneficial effects of probiotics: Probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome
    • 10.3945/jn.109.113746 20107148 10.3945/jn.109.113746 1:CAS:528: DC%2BC3cXnsVyqsL8%3D
    • Haller D, Antoine JM, Bengmark S, Enck P, Rijkers GT, Lenoir-Wijnkoop I (2010) Guidance for substantiating the evidence for beneficial effects of probiotics: probiotics in chronic inflammatory bowel disease and the functional disorder irritable bowel syndrome. J Nutr 140(3):690S-697S. doi: 10.3945/jn.109.113746
    • (2010) J Nutr , vol.140 , Issue.3
    • Haller, D.1    Antoine, J.M.2    Bengmark, S.3    Enck, P.4    Rijkers, G.T.5    Lenoir-Wijnkoop, I.6
  • 17
    • 70449505391 scopus 로고    scopus 로고
    • Therapeutic options to modulate barrier defects in inflammatory bowel disease
    • 10.1159/000233283 19897959 10.1159/000233283
    • Hering NA, Schulzke JD (2009) Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig Dis 27(4):450-454. doi: 10.1159/000233283
    • (2009) Dig Dis , vol.27 , Issue.4 , pp. 450-454
    • Hering, N.A.1    Schulzke, J.D.2
  • 18
    • 77949619014 scopus 로고    scopus 로고
    • Probiotics
    • 10.2146/ajhp090168 20208051 10.2146/ajhp090168 1:CAS:528: DC%2BC3cXkvVOnu74%3D
    • Williams NT (2010) Probiotics. Am J Health Syst Pharm 67(6):449-458. doi: 10.2146/ajhp090168
    • (2010) Am J Health Syst Pharm , vol.67 , Issue.6 , pp. 449-458
    • Williams, N.T.1
  • 19
    • 67650311571 scopus 로고    scopus 로고
    • Probiotic preparation VSL#3 induces remission in children with mild to moderate acute ulcerative colitis: A pilot study
    • 10.1002/ibd.20816 19067432 10.1002/ibd.20816
    • Huynh HQ, deBruyn J, Guan L, Diaz H, Li M, Girgis S, Turner J, Fedorak R, Madsen K (2009) Probiotic preparation VSL#3 induces remission in children with mild to moderate acute ulcerative colitis: a pilot study. Inflamm Bowel Dis 15(5):760-768. doi: 10.1002/ibd.20816
    • (2009) Inflamm Bowel Dis , vol.15 , Issue.5 , pp. 760-768
    • Huynh, H.Q.1    Debruyn, J.2    Guan, L.3    Diaz, H.4    Li, M.5    Girgis, S.6    Turner, J.7    Fedorak, R.8    Madsen, K.9
  • 20
    • 71949112397 scopus 로고    scopus 로고
    • Inflammatory bowel disease, gut bacteria and probiotic therapy
    • 10.1016/j.ijmm.2009.08.004 19800289 10.1016/j.ijmm.2009.08.004 1:CAS:528:DC%2BC3cXjt1ajsL4%3D
    • Reiff C, Kelly D (2010) Inflammatory bowel disease, gut bacteria and probiotic therapy. Int J Med Microbiol 300(1):25-33. doi: 10.1016/j.ijmm.2009. 08.004
    • (2010) Int J Med Microbiol , vol.300 , Issue.1 , pp. 25-33
    • Reiff, C.1    Kelly, D.2
  • 21
    • 79952445253 scopus 로고    scopus 로고
    • The effect of exopolysaccharide-producing probiotic strains on gut oxidative damage in experimental colitis
    • 10.1007/s10620-010-1362-7 20683661 10.1007/s10620-010-1362-7
    • Sengul N, Isik S, Aslim B, Ucar G, Demirbag AE (2011) The effect of exopolysaccharide-producing probiotic strains on gut oxidative damage in experimental colitis. Dig Dis Sci 56(3):707-714. doi: 10.1007/s10620-010-1362-7
    • (2011) Dig Dis Sci , vol.56 , Issue.3 , pp. 707-714
    • Sengul, N.1    Isik, S.2    Aslim, B.3    Ucar, G.4    Demirbag, A.E.5
  • 22
    • 78650107219 scopus 로고    scopus 로고
    • Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis
    • 10.1002/ibd.21366 20564535 10.1002/ibd.21366
    • Uronis JM, Arthur JC, Keku T, Fodor A, Carroll IM, Cruz ML, Appleyard CB, Jobin C (2011) Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis. Inflamm Bowel Dis 17(1):289-297. doi: 10.1002/ibd.21366
    • (2011) Inflamm Bowel Dis , vol.17 , Issue.1 , pp. 289-297
    • Uronis, J.M.1    Arthur, J.C.2    Keku, T.3    Fodor, A.4    Carroll, I.M.5    Cruz, M.L.6    Appleyard, C.B.7    Jobin, C.8
  • 23
    • 79952115400 scopus 로고    scopus 로고
    • Probiotic therapy using live combined bifidobacterium, lactobacillus and enterococcus for experimental colitis in rats model
    • 20646418
    • Wan YM, Zhu YQ, Xia B, Luo J (2010) Probiotic therapy using live combined bifidobacterium, lactobacillus and enterococcus for experimental colitis in rats model. Zhonghua Nei Ke Za Zhi 49(5):418-421
    • (2010) Zhonghua Nei Ke Za Zhi , vol.49 , Issue.5 , pp. 418-421
    • Wan, Y.M.1    Zhu, Y.Q.2    Xia, B.3    Luo, J.4
  • 24
    • 76749125943 scopus 로고    scopus 로고
    • Multistep mechanism of probiotic bacterium, the effect on innate immune system
    • 10.1002/mnfr.200800591 19998380 10.1002/mnfr.200800591 1:CAS:528:DC%2BC3cXhs1amur4%3D
    • Amit-Romach E, Uni Z, Reifen R (2010) Multistep mechanism of probiotic bacterium, the effect on innate immune system. Mol Nutr Food Res 54(2):277-284. doi: 10.1002/mnfr.200800591
    • (2010) Mol Nutr Food Res , vol.54 , Issue.2 , pp. 277-284
    • Amit-Romach, E.1    Uni, Z.2    Reifen, R.3
  • 25
    • 70350337980 scopus 로고    scopus 로고
    • A probiotic strain of Escherichia coli, Nissle 1917, given orally exerts local and systemic anti-inflammatory effects in lipopolysaccharide-induced sepsis in mice
    • 10.1111/j.1476-5381.2009.00270.x 19486007 10.1111/j.1476-5381.2009.00270. x 1:CAS:528:DC%2BD1MXhtVChu7bE
    • Arribas B, Rodriguez-Cabezas ME, Camuesco D, Comalada M, Bailon E, Utrilla P, Nieto A, Concha A, Zarzuelo A, Galvez J (2009) A probiotic strain of Escherichia coli, Nissle 1917, given orally exerts local and systemic anti-inflammatory effects in lipopolysaccharide-induced sepsis in mice. Br J Pharmacol 157(6):1024-1033. doi: 10.1111/j.1476-5381.2009.00270.x
    • (2009) Br J Pharmacol , vol.157 , Issue.6 , pp. 1024-1033
    • Arribas, B.1    Rodriguez-Cabezas, M.E.2    Camuesco, D.3    Comalada, M.4    Bailon, E.5    Utrilla, P.6    Nieto, A.7    Concha, A.8    Zarzuelo, A.9    Galvez, J.10
  • 26
    • 14844349149 scopus 로고    scopus 로고
    • Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells
    • 15749854
    • Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M (2005) Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol 174(6):3237-3246
    • (2005) J Immunol , vol.174 , Issue.6 , pp. 3237-3246
    • Di Giacinto, C.1    Marinaro, M.2    Sanchez, M.3    Strober, W.4    Boirivant, M.5
  • 27
    • 77949331692 scopus 로고    scopus 로고
    • Saccharomyces boulardii reduced intestinal inflammation in mice model of 2,4,6-trinitrobencene sulfonic acid induced colitis: Based on microarray
    • 20098065 10.4166/kjg.2010.55.1.33
    • Lee SK, Kim HJ, Chi SG (2010) Saccharomyces boulardii reduced intestinal inflammation in mice model of 2,4,6-trinitrobencene sulfonic acid induced colitis: based on microarray. Korean J Gastroenterol 55(1):33-45
    • (2010) Korean J Gastroenterol , vol.55 , Issue.1 , pp. 33-45
    • Lee, S.K.1    Kim, H.J.2    Chi, S.G.3
  • 29
    • 79960844328 scopus 로고    scopus 로고
    • Treatment with Bifidobacterium bifidum 17 partially protects mice from Th1-driven inflammation in a chemically induced model of colitis
    • 10.1016/j.ijfoodmicro.2010.12.020 21257218
    • Philippe D, Heupel E, Blum-Sperisen S, Riedel CU (2010) Treatment with Bifidobacterium bifidum 17 partially protects mice from Th1-driven inflammation in a chemically induced model of colitis. Int J Food Microbiol. doi: 10.1016/j.ijfoodmicro.2010.12.020
    • (2010) Int J Food Microbiol
    • Philippe, D.1    Heupel, E.2    Blum-Sperisen, S.3    Riedel, C.U.4
  • 30
    • 22744438084 scopus 로고    scopus 로고
    • VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis
    • 10.1111/j.1572-0241.2005.41794.x 15984978 10.1111/j.1572-0241.2005.41794. x
    • Bibiloni R, Fedorak RN, Tannock GW, Madsen KL, Gionchetti P, Campieri M, De Simone C, Sartor RB (2005) VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis. Am J Gastroenterol 100(7):1539-1546. doi: 10.1111/j.1572-0241.2005.41794.x
    • (2005) Am J Gastroenterol , vol.100 , Issue.7 , pp. 1539-1546
    • Bibiloni, R.1    Fedorak, R.N.2    Tannock, G.W.3    Madsen, K.L.4    Gionchetti, P.5    Campieri, M.6    De Simone, C.7    Sartor, R.B.8
  • 31
    • 33747384568 scopus 로고    scopus 로고
    • VSL#3 probiotic mixture: A review of its use in chronic inflammatory bowel diseases
    • 16903771 10.2165/00003495-200666100-00006 1:CAS:528:DC%2BD28XpvFWku7w%3D
    • Chapman TM, Plosker GL, Figgitt DP (2006) VSL#3 probiotic mixture: a review of its use in chronic inflammatory bowel diseases. Drugs 66(10):1371-1387
    • (2006) Drugs , vol.66 , Issue.10 , pp. 1371-1387
    • Chapman, T.M.1    Plosker, G.L.2    Figgitt, D.P.3
  • 32
    • 77954423238 scopus 로고    scopus 로고
    • VSL#3 improves symptoms in children with irritable bowel syndrome: A multicenter, randomized, placebo-controlled, double-blind, crossover study
    • 10.1097/MPG.0b013e3181ca4d95 20453678 10.1097/MPG.0b013e3181ca4d95
    • Guandalini S, Magazzu G, Chiaro A, La Balestra V, Di Nardo G, Gopalan S, Sibal A, Romano C, Canani RB, Lionetti P, Setty M (2010) VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study. J Pediatr Gastroenterol Nutr 51(1):24-30. doi: 10.1097/MPG.0b013e3181ca4d95
    • (2010) J Pediatr Gastroenterol Nutr , vol.51 , Issue.1 , pp. 24-30
    • Guandalini, S.1    Magazzu, G.2    Chiaro, A.3    La Balestra, V.4    Di Nardo, G.5    Gopalan, S.6    Sibal, A.7    Romano, C.8    Canani, R.B.9    Lionetti, P.10    Setty, M.11
  • 33
    • 79952342457 scopus 로고    scopus 로고
    • VSL#3 and remission in active ulcerative colitis: Larger studies required
    • 10.1038/ajg.2010.451 21378771 10.1038/ajg.2010.451
    • Jackson EL, Hamlin PJ, Ford AC (2011) VSL#3 and remission in active ulcerative colitis: larger studies required. Am J Gastroenterol 106(3):547. doi: 10.1038/ajg.2010.451
    • (2011) Am J Gastroenterol , vol.106 , Issue.3 , pp. 547
    • Jackson, E.L.1    Hamlin, P.J.2    Ford, A.C.3
  • 34
    • 85046981110 scopus 로고    scopus 로고
    • Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases
    • 10.4161/gmic.19245 22356855 10.4161/gmic.19245
    • Yan F, Polk DB (2012) Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases. Gut Microbes 3(1):25-28. doi: 10.4161/gmic.19245
    • (2012) Gut Microbes , vol.3 , Issue.1 , pp. 25-28
    • Yan, F.1    Polk, D.B.2
  • 35
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • 8350599 1:CAS:528:DyaK2cXhs1Smtr0%3D
    • Cooper HS, Murthy SN, Shah RS, Sedergran DJ (1993) Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69(2):238-249
    • (1993) Lab Invest , vol.69 , Issue.2 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3    Sedergran, D.J.4
  • 37
    • 34247623042 scopus 로고    scopus 로고
    • Effects of the probiotic formulation VSL#3 on colitis in weanling rats
    • 10.1097/MPG.0b013e31803bda51 17460487 10.1097/MPG.0b013e31803bda51
    • Fitzpatrick LR, Hertzog KL, Quatse AL, Koltun WA, Small JS, Vrana K (2007) Effects of the probiotic formulation VSL#3 on colitis in weanling rats. J Pediatr Gastroenterol Nutr 44(5):561-570. doi: 10.1097/MPG.0b013e31803bda51
    • (2007) J Pediatr Gastroenterol Nutr , vol.44 , Issue.5 , pp. 561-570
    • Fitzpatrick, L.R.1    Hertzog, K.L.2    Quatse, A.L.3    Koltun, W.A.4    Small, J.S.5    Vrana, K.6
  • 38
    • 0030944324 scopus 로고    scopus 로고
    • Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats
    • 9125657 10.1023/A:1018880501437 1:STN:280:DyaK2s3ntVGktg%3D%3D
    • Bjorck S, Jennische E, Dahlstrom A, Ahlman H (1997) Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats. Dig Dis Sci 42(4):824-832
    • (1997) Dig Dis Sci , vol.42 , Issue.4 , pp. 824-832
    • Bjorck, S.1    Jennische, E.2    Dahlstrom, A.3    Ahlman, H.4
  • 39
    • 47949089638 scopus 로고    scopus 로고
    • UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis
    • 10.1002/ibd.20381 18253952 10.1002/ibd.20381
    • Bailon E, Comalada M, Roman J, Michelena P, Ramis I, Merlos M, Nieto A, Concha A, Zarzuelo A, Galvez J (2008) UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis. Inflamm Bowel Dis 14(7):888-897. doi: 10.1002/ibd.20381
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.7 , pp. 888-897
    • Bailon, E.1    Comalada, M.2    Roman, J.3    Michelena, P.4    Ramis, I.5    Merlos, M.6    Nieto, A.7    Concha, A.8    Zarzuelo, A.9    Galvez, J.10
  • 40
    • 0035682240 scopus 로고    scopus 로고
    • Functional effects of dextran sulphate sodium (DSS) treatment on the longitudinal muscle of rat distal colon
    • 11844019 10.1046/j.1365-2680.2001.00218.x 1:CAS:528: DC%2BD38Xjt1ymtw%3D%3D
    • Borjesson L, Aldenborg F, Delbro DS (2001) Functional effects of dextran sulphate sodium (DSS) treatment on the longitudinal muscle of rat distal colon. J Auton Pharmacol 21(3):121-129
    • (2001) J Auton Pharmacol , vol.21 , Issue.3 , pp. 121-129
    • Borjesson, L.1    Aldenborg, F.2    Delbro, D.S.3
  • 41
    • 31544438540 scopus 로고    scopus 로고
    • The VSL# 3 probiotic mixture modifies microflora but does not heal chronic dextran-sodium sulfate-induced colitis or reinforce the mucus barrier in mice
    • 16317116 1:CAS:528:DC%2BD2MXhtlalsL3P
    • Gaudier E, Michel C, Segain JP, Cherbut C, Hoebler C (2005) The VSL# 3 probiotic mixture modifies microflora but does not heal chronic dextran-sodium sulfate-induced colitis or reinforce the mucus barrier in mice. J Nutr 135(12):2753-2761
    • (2005) J Nutr , vol.135 , Issue.12 , pp. 2753-2761
    • Gaudier, E.1    Michel, C.2    Segain, J.P.3    Cherbut, C.4    Hoebler, C.5
  • 42
    • 0026683530 scopus 로고
    • Oxygen radicals in ulcerative colitis
    • 1355459 10.1016/0891-5849(92)90079-V 1:STN:280:DyaK38zoslGlsQ%3D%3D
    • Babbs CF (1992) Oxygen radicals in ulcerative colitis. Free Radic Biol Med 13(2):169-181
    • (1992) Free Radic Biol Med , vol.13 , Issue.2 , pp. 169-181
    • Babbs, C.F.1
  • 43
    • 0036093570 scopus 로고    scopus 로고
    • Biologic therapy of inflammatory bowel disease
    • 12016425 10.1053/gast.2002.33426 1:CAS:528:DC%2BD38Xlt1Cksb4%3D
    • Sandborn WJ, Targan SR (2002) Biologic therapy of inflammatory bowel disease. Gastroenterology 122(6):1592-1608
    • (2002) Gastroenterology , vol.122 , Issue.6 , pp. 1592-1608
    • Sandborn, W.J.1    Targan, S.R.2
  • 44
    • 2542455472 scopus 로고    scopus 로고
    • INOS-mediated nitric oxide production and its regulation
    • 10.1016/j.lfs.2003.10.042 15172174 10.1016/j.lfs.2003.10.042 1:CAS:528:DC%2BD2cXksVGgsL0%3D
    • Aktan F (2004) iNOS-mediated nitric oxide production and its regulation. Life Sci 75(6):639-653. doi: 10.1016/j.lfs.2003.10.042
    • (2004) Life Sci , vol.75 , Issue.6 , pp. 639-653
    • Aktan, F.1
  • 45
    • 0035158627 scopus 로고    scopus 로고
    • Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: Divergent roles of superoxide and nitric oxide
    • 11696587 10.1084/jem.194.9.1207 1:CAS:528:DC%2BD3MXot12msLc%3D
    • Krieglstein CF, Cerwinka WH, Laroux FS, Salter JW, Russell JM, Schuermann G, Grisham MB, Ross CR, Granger DN (2001) Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med 194(9):1207-1218
    • (2001) J Exp Med , vol.194 , Issue.9 , pp. 1207-1218
    • Krieglstein, C.F.1    Cerwinka, W.H.2    Laroux, F.S.3    Salter, J.W.4    Russell, J.M.5    Schuermann, G.6    Grisham, M.B.7    Ross, C.R.8    Granger, D.N.9
  • 46
    • 4544340873 scopus 로고    scopus 로고
    • Activity of inducible and neuronal nitric oxide synthases in colonic mucosa predicts progression of ulcerative colitis
    • 10.1111/j.1572-0241.2004.40065.x 15330915 10.1111/j.1572-0241.2004.40065. x 1:CAS:528:DC%2BD2cXos1egurw%3D
    • Menchen L, Colon AL, Madrigal JL, Beltran L, Botella S, Lizasoain I, Leza JC, Moro MA, Menchen P, Cos E, Lorenzo P (2004) Activity of inducible and neuronal nitric oxide synthases in colonic mucosa predicts progression of ulcerative colitis. Am J Gastroenterol 99(9):1756-1764. doi: 10.1111/j.1572-0241.2004.40065.x
    • (2004) Am J Gastroenterol , vol.99 , Issue.9 , pp. 1756-1764
    • Menchen, L.1    Colon, A.L.2    Madrigal, J.L.3    Beltran, L.4    Botella, S.5    Lizasoain, I.6    Leza, J.C.7    Moro, M.A.8    Menchen, P.9    Cos, E.10    Lorenzo, P.11
  • 47
    • 0031902251 scopus 로고    scopus 로고
    • Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease
    • 9679035 10.1016/S0016-5085(98)70196-9 1:CAS:528:DyaK1cXltl2nsr0%3D
    • Singer II, Kawka DW, Schloemann S, Tessner T, Riehl T, Stenson WF (1998) Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. Gastroenterology 115(2):297-306
    • (1998) Gastroenterology , vol.115 , Issue.2 , pp. 297-306
    • Singer, I.I.1    Kawka, D.W.2    Schloemann, S.3    Tessner, T.4    Riehl, T.5    Stenson, W.F.6
  • 48
    • 33646902166 scopus 로고    scopus 로고
    • COX-2: A pivotal enzyme in mucosal protection and resolution of inflammation
    • 10.1100/tsw.2006.122 16752007 10.1100/tsw.2006.122 1:CAS:528: DC%2BD28XnvFans7c%3D
    • Wallace JL (2006) COX-2: a pivotal enzyme in mucosal protection and resolution of inflammation. ScientificWorldJournal 6:577-588. doi: 10.1100/tsw.2006.122
    • (2006) ScientificWorldJournal , vol.6 , pp. 577-588
    • Wallace, J.L.1
  • 49
    • 33846687337 scopus 로고    scopus 로고
    • Healing impairment effect of cyclooxygenase inhibitors on dextran sulfate sodium-induced colitis in rats
    • 10.1159/000097657 17143008 10.1159/000097657 1:CAS:528: DC%2BD2sXhtFyit7k%3D
    • Tsubouchi R, Hayashi S, Aoi Y, Nishio H, Terashima S, Kato S, Takeuchi K (2006) Healing impairment effect of cyclooxygenase inhibitors on dextran sulfate sodium-induced colitis in rats. Digestion 74(2):91-100. doi: 10.1159/000097657
    • (2006) Digestion , vol.74 , Issue.2 , pp. 91-100
    • Tsubouchi, R.1    Hayashi, S.2    Aoi, Y.3    Nishio, H.4    Terashima, S.5    Kato, S.6    Takeuchi, K.7
  • 50
    • 0030875018 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease
    • 9219792 1:STN:280:DyaK2szmtlCquw%3D%3D
    • Hendel J, Nielsen OH (1997) Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease. Am J Gastroenterol 92(7):1170-1173
    • (1997) Am J Gastroenterol , vol.92 , Issue.7 , pp. 1170-1173
    • Hendel, J.1    Nielsen, O.H.2
  • 51
    • 0028244816 scopus 로고
    • Tumor necrosis factor: A pleiotropic cytokine and therapeutic target
    • 10.1146/annurev.med.45.1.491 8198398 10.1146/annurev.med.45.1.491 1:CAS:528:DyaK2cXivFKjtL8%3D
    • Tracey KJ, Cerami A (1994) Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu Rev Med 45:491-503. doi: 10.1146/annurev.med.45.1. 491
    • (1994) Annu Rev Med , vol.45 , pp. 491-503
    • Tracey, K.J.1    Cerami, A.2
  • 52
    • 0026101722 scopus 로고
    • Significance of interleukin-6 in patients with inflammatory bowel disease
    • 2007457 1:STN:280:DyaK3M7nslalug%3D%3D
    • Mitsuyama K, Sata M, Tanikawa K (1991) Significance of interleukin-6 in patients with inflammatory bowel disease. Gastroenterol Jpn 26(1):20-28
    • (1991) Gastroenterol Jpn , vol.26 , Issue.1 , pp. 20-28
    • Mitsuyama, K.1    Sata, M.2    Tanikawa, K.3
  • 53
    • 0031811339 scopus 로고    scopus 로고
    • Cytokine profiles of cultured microvascular endothelial cells from the human intestine
    • 9659156 10.1136/gut.42.5.635 1:CAS:528:DyaK1cXjslGgtL0%3D
    • Nilsen EM, Johansen FE, Jahnsen FL, Lundin KE, Scholz T, Brandtzaeg P, Haraldsen G (1998) Cytokine profiles of cultured microvascular endothelial cells from the human intestine. Gut 42(5):635-642
    • (1998) Gut , vol.42 , Issue.5 , pp. 635-642
    • Nilsen, E.M.1    Johansen, F.E.2    Jahnsen, F.L.3    Lundin, K.E.4    Scholz, T.5    Brandtzaeg, P.6    Haraldsen, G.7
  • 54
    • 0035834506 scopus 로고    scopus 로고
    • Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis
    • 11716848 10.1016/S0014-2999(01)01410-8 1:CAS:528:DC%2BD3MXosFOjt7g%3D
    • Bobin-Dubigeon C, Collin X, Grimaud N, Robert JM, Le Baut G, Petit JY (2001) Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis. Eur J Pharmacol 431(1):103-110
    • (2001) Eur J Pharmacol , vol.431 , Issue.1 , pp. 103-110
    • Bobin-Dubigeon, C.1    Collin, X.2    Grimaud, N.3    Robert, J.M.4    Le Baut, G.5    Petit, J.Y.6
  • 56
    • 0033948508 scopus 로고    scopus 로고
    • Lessons from genetically engineered animal models. XII. IL-10-deficient (IL)-10(-/-) mice and intestinal inflammation
    • 10859210 1:CAS:528:DC%2BD3cXks1Kntbw%3D
    • Rennick DM, Fort MM (2000) Lessons from genetically engineered animal models. XII. IL-10-deficient (IL)-10(-/-) mice and intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 278(6):G829-G833
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278 , Issue.6
    • Rennick, D.M.1    Fort, M.M.2
  • 57
    • 0038783387 scopus 로고    scopus 로고
    • Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: Control by CD4+ regulatory T cells and IL-10
    • 12847269 1:CAS:528:DC%2BD3sXltFylsr4%3D
    • Asseman C, Read S, Powrie F (2003) Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10. J Immunol 171(2):971-978
    • (2003) J Immunol , vol.171 , Issue.2 , pp. 971-978
    • Asseman, C.1    Read, S.2    Powrie, F.3
  • 58
    • 0036200314 scopus 로고    scopus 로고
    • Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice
    • 10.1006/clim.2001.5166 11890710 10.1006/clim.2001.5166 1:CAS:528:DC%2BD38Xjs1Sqtrk%3D
    • Takahashi I, Matsuda J, Gapin L, DeWinter H, Kai Y, Tamagawa H, Kronenberg M, Kiyono H (2002) Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice. Clin Immunol 102(3):237-248. doi: 10.1006/clim.2001.5166
    • (2002) Clin Immunol , vol.102 , Issue.3 , pp. 237-248
    • Takahashi, I.1    Matsuda, J.2    Gapin, L.3    Dewinter, H.4    Kai, Y.5    Tamagawa, H.6    Kronenberg, M.7    Kiyono, H.8
  • 59
    • 0037348386 scopus 로고    scopus 로고
    • Lack of interleukin-10 leads to intestinal inflammation, independent of the time at which luminal microbial colonization occurs
    • 12769442 10.1097/00054725-200303000-00002
    • Sydora BC, Tavernini MM, Wessler A, Jewell LD, Fedorak RN (2003) Lack of interleukin-10 leads to intestinal inflammation, independent of the time at which luminal microbial colonization occurs. Inflamm Bowel Dis 9(2):87-97
    • (2003) Inflamm Bowel Dis , vol.9 , Issue.2 , pp. 87-97
    • Sydora, B.C.1    Tavernini, M.M.2    Wessler, A.3    Jewell, L.D.4    Fedorak, R.N.5
  • 61
    • 0036217821 scopus 로고    scopus 로고
    • Natural products as targeted modulators of the nuclear factor-kappaB pathway
    • 11999122 10.1211/0022357021778637 1:CAS:528:DC%2BD38XjtlWgur4%3D
    • Bremner P, Heinrich M (2002) Natural products as targeted modulators of the nuclear factor-kappaB pathway. J Pharm Pharmacol 54(4):453-472
    • (2002) J Pharm Pharmacol , vol.54 , Issue.4 , pp. 453-472
    • Bremner, P.1    Heinrich, M.2
  • 62
    • 0032510832 scopus 로고    scopus 로고
    • Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene
    • 9614127 10.1074/jbc.273.24.15148 1:CAS:528:DyaK1cXktVelur0%3D
    • Taylor BS, de Vera ME, Ganster RW, Wang Q, Shapiro RA, Morris SM Jr, Billiar TR, Geller DA (1998) Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J Biol Chem 273(24):15148-15156
    • (1998) J Biol Chem , vol.273 , Issue.24 , pp. 15148-15156
    • Taylor, B.S.1    De Vera, M.E.2    Ganster, R.W.3    Wang, Q.4    Shapiro, R.A.5    Morris, Jr.S.M.6    Billiar, T.R.7    Geller, D.A.8
  • 63
    • 0035987856 scopus 로고    scopus 로고
    • Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin
    • 12095170 10.1016/S1567-5769(02)00018-8 1:CAS:528:DC%2BD38XlsFaisbo%3D
    • Garcia D, Delgado R, Ubeira FM, Leiro J (2002) Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin. Int Immunopharmacol 2(6):797-806
    • (2002) Int Immunopharmacol , vol.2 , Issue.6 , pp. 797-806
    • Garcia, D.1    Delgado, R.2    Ubeira, F.M.3    Leiro, J.4
  • 64
    • 34248198039 scopus 로고    scopus 로고
    • Preferential chemosensitization of PTEN-mutated prostate cells by silencing the Akt kinase
    • 10.1002/pros.20566 17373720 10.1002/pros.20566 1:CAS:528: DC%2BD2sXmtV2rtro%3D
    • Priulla M, Calastretti A, Bruno P, Azzariti A, Paradiso A, Canti G, Nicolin A (2007) Preferential chemosensitization of PTEN-mutated prostate cells by silencing the Akt kinase. Prostate 67(7):782-789. doi: 10.1002/pros.20566
    • (2007) Prostate , vol.67 , Issue.7 , pp. 782-789
    • Priulla, M.1    Calastretti, A.2    Bruno, P.3    Azzariti, A.4    Paradiso, A.5    Canti, G.6    Nicolin, A.7
  • 65
    • 33744457653 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
    • 10.1038/sj.leu.2404245 16642045 10.1038/sj.leu.2404245 1:CAS:528:DC%2BD28XkvVylsr4%3D
    • Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L (2006) Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 20(6):911-928. doi: 10.1038/sj.leu.2404245
    • (2006) Leukemia , vol.20 , Issue.6 , pp. 911-928
    • Martelli, A.M.1    Nyakern, M.2    Tabellini, G.3    Bortul, R.4    Tazzari, P.L.5    Evangelisti, C.6    Cocco, L.7
  • 66
    • 31344479312 scopus 로고    scopus 로고
    • Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
    • 10.1016/j.lungcan.2005.10.003 16324768 10.1016/j.lungcan.2005.10.003
    • Tang JM, He QY, Guo RX, Chang XJ (2006) Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer 51(2):181-191. doi: 10.1016/j.lungcan.2005.10.003
    • (2006) Lung Cancer , vol.51 , Issue.2 , pp. 181-191
    • Tang, J.M.1    He, Q.Y.2    Guo, R.X.3    Chang, X.J.4


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