메뉴 건너뛰기




Volumn 38, Issue 7, 2013, Pages 772-783

The effects of probiotics on barrier function and mucosal pouch microbiota during maintenance treatment for severe pouchitis in patients with ulcerative colitis

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; ECOLOGIC; METRONIDAZOLE; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

EID: 84883486415     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.12451     Document Type: Article
Times cited : (65)

References (56)
  • 1
    • 42149148028 scopus 로고    scopus 로고
    • Review article: Restorative proctocolectomy, indications, management of complications and follow-up - A guide for gastroenterologists
    • McLaughlin SD, Clark SK, Tekkis PP, Ciclitira PJ, Nicholls RJ,. Review article: restorative proctocolectomy, indications, management of complications and follow-up-a guide for gastroenterologists. Aliment Pharmacol Ther 2008; 27: 895-909.
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 895-909
    • McLaughlin, S.D.1    Clark, S.K.2    Tekkis, P.P.3    Ciclitira, P.J.4    Nicholls, R.J.5
  • 3
    • 75449091807 scopus 로고    scopus 로고
    • Antibiotics and probiotics in chronic pouchitis: A comparative proteomic approach
    • Turroni S, Vitali B, Candela M, et al,. Antibiotics and probiotics in chronic pouchitis: a comparative proteomic approach. World J Gastroenterol 2010; 16: 30-41.
    • (2010) World J Gastroenterol , vol.16 , pp. 30-41
    • Turroni, S.1    Vitali, B.2    Candela, M.3
  • 4
    • 0029151873 scopus 로고
    • Acute pouchitis and deficiencies of fuel
    • Sagar PM, Taylor BA, Godwin P, et al,. Acute pouchitis and deficiencies of fuel. Dis Colon Rectum 1995; 38: 488-93.
    • (1995) Dis Colon Rectum , vol.38 , pp. 488-493
    • Sagar, P.M.1    Taylor, B.A.2    Godwin, P.3
  • 6
    • 3142777281 scopus 로고    scopus 로고
    • Factors associated with disease activity of pouchitis after surgery for ulcerative colitis
    • Kuisma J, Jarvinen H, Kahri A, Farkkila M,. Factors associated with disease activity of pouchitis after surgery for ulcerative colitis. Scand J Gastroenterol 2004; 39: 544-8.
    • (2004) Scand J Gastroenterol , vol.39 , pp. 544-548
    • Kuisma, J.1    Jarvinen, H.2    Kahri, A.3    Farkkila, M.4
  • 7
    • 0029156873 scopus 로고
    • Fecal bile acids, short-chain fatty acids, and bacteria after ileal pouch-anal anastomosis do not differ in patients with pouchitis
    • Sandborn WJ, Tremaine WJ, Batts KP, et al,. Fecal bile acids, short-chain fatty acids, and bacteria after ileal pouch-anal anastomosis do not differ in patients with pouchitis. Dig Dis Sci 1995; 40: 1474-83.
    • (1995) Dig Dis Sci , vol.40 , pp. 1474-1483
    • Sandborn, W.J.1    Tremaine, W.J.2    Batts, K.P.3
  • 10
    • 0034788267 scopus 로고    scopus 로고
    • The interleukin 1 receptor antagonist gene allele 2 as a predictor of pouchitis following colectomy and IPAA in ulcerative colitis
    • Carter MJ, Di Giovine FS, Cox A, et al,. The interleukin 1 receptor antagonist gene allele 2 as a predictor of pouchitis following colectomy and IPAA in ulcerative colitis. Gastroenterology 2001; 121: 805-11.
    • (2001) Gastroenterology , vol.121 , pp. 805-811
    • Carter, M.J.1    Di Giovine, F.S.2    Cox, A.3
  • 11
    • 0032912297 scopus 로고    scopus 로고
    • Crohn's disease-associated genetic marker is seen in medically unresponsive ulcerative colitis patients and may be associated with pouch-specific complications
    • Facklis K, Plevy SE, Vasiliauskas EA, et al,. Crohn's disease-associated genetic marker is seen in medically unresponsive ulcerative colitis patients and may be associated with pouch-specific complications. Dis Colon Rectum 1999; 42: 601-5.
    • (1999) Dis Colon Rectum , vol.42 , pp. 601-605
    • Facklis, K.1    Plevy, S.E.2    Vasiliauskas, E.A.3
  • 12
    • 0028286347 scopus 로고
    • Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis
    • Madden MV, McIntyre AS, Nicholls RJ,. Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis. Dig Dis Sci 1994; 39: 1193-6.
    • (1994) Dig Dis Sci , vol.39 , pp. 1193-1196
    • Madden, M.V.1    McIntyre, A.S.2    Nicholls, R.J.3
  • 13
    • 0035167112 scopus 로고    scopus 로고
    • A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis
    • Shen B, Achkar JP, Lashner BA, et al,. A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. Inflamm Bowel Dis 2001; 7: 301-5.
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 301-305
    • Shen, B.1    Achkar, J.P.2    Lashner, B.A.3
  • 14
    • 80955180995 scopus 로고    scopus 로고
    • Intestinal microbiota in human health and disease: The impact of probiotics
    • Gerritsen J, Smidt H, Rijkers GT, de Vos WM,. Intestinal microbiota in human health and disease: the impact of probiotics. Genes Nutr 2011; 6: 209-40.
    • (2011) Genes Nutr , vol.6 , pp. 209-240
    • Gerritsen, J.1    Smidt, H.2    Rijkers, G.T.3    De Vos, W.M.4
  • 15
    • 0026531046 scopus 로고
    • Microbiologic assessment of tissue biopsy samples from ileal pouch patients
    • Onderdonk AB, Dvorak AM, Cisneros RL, et al,. Microbiologic assessment of tissue biopsy samples from ileal pouch patients. J Clin Microbiol 1992; 30: 312-7.
    • (1992) J Clin Microbiol , vol.30 , pp. 312-317
    • Onderdonk, A.B.1    Dvorak, A.M.2    Cisneros, R.L.3
  • 18
    • 33344462428 scopus 로고    scopus 로고
    • Change in the bacterial flora of pouchitis
    • Iwaya A, Iiai T, Okamoto H, et al,. Change in the bacterial flora of pouchitis. Hepatogastroenterology 2006; 53: 55-9.
    • (2006) Hepatogastroenterology , vol.53 , pp. 55-59
    • Iwaya, A.1    Iiai, T.2    Okamoto, H.3
  • 20
    • 68149168773 scopus 로고    scopus 로고
    • An assessment of bacterial dysbiosis in pouchitis using terminal restriction fragment length polymorphisms of 16S ribosomal DNA from pouch effluent microbiota
    • Lim M, Adams JD, Wilcox M, Finan P, Sagar P, Burke D,. An assessment of bacterial dysbiosis in pouchitis using terminal restriction fragment length polymorphisms of 16S ribosomal DNA from pouch effluent microbiota. Dis Colon Rectum 2009; 52: 1492-500.
    • (2009) Dis Colon Rectum , vol.52 , pp. 1492-1500
    • Lim, M.1    Adams, J.D.2    Wilcox, M.3    Finan, P.4    Sagar, P.5    Burke, D.6
  • 21
    • 77954084505 scopus 로고    scopus 로고
    • The bacteriology of pouchitis: A molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing
    • McLaughlin SD, Walker AW, Churcher C, et al,. The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing. Ann Surg 2010; 252: 90-8.
    • (2010) Ann Surg , vol.252 , pp. 90-98
    • McLaughlin, S.D.1    Walker, A.W.2    Churcher, C.3
  • 22
    • 79953890383 scopus 로고    scopus 로고
    • Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis
    • Zella GC, Hait EJ, Glavan T, et al,. Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis. Inflamm Bowel Dis 2011; 17: 1092-100.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1092-1100
    • Zella, G.C.1    Hait, E.J.2    Glavan, T.3
  • 23
    • 84859793930 scopus 로고    scopus 로고
    • Comprehensive analysis of the bacterial content of stool from patients with chronic pouchitis, normal pouches, or familial adenomatous polyposis pouches
    • Tannock GW, Lawley B, Munro K, et al,. Comprehensive analysis of the bacterial content of stool from patients with chronic pouchitis, normal pouches, or familial adenomatous polyposis pouches. Inflamm Bowel Dis 2012; 18: 925-34.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 925-934
    • Tannock, G.W.1    Lawley, B.2    Munro, K.3
  • 24
    • 84871611642 scopus 로고    scopus 로고
    • A shift from colon- to ileum-predominant bacteria in ileal-pouch feces following total proctocolectomy
    • Hinata M, Kohyama A, Ogawa H, et al,. A shift from colon- to ileum-predominant bacteria in ileal-pouch feces following total proctocolectomy. Dig Dis Sci 2012; 57: 2965-74.
    • (2012) Dig Dis Sci , vol.57 , pp. 2965-2974
    • Hinata, M.1    Kohyama, A.2    Ogawa, H.3
  • 25
    • 22744438084 scopus 로고    scopus 로고
    • VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis
    • Bibiloni R, Fedorak RN, Tannock GW, et al,. VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis. Am J Gastroenterol 2005; 100: 1539-46.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1539-1546
    • Bibiloni, R.1    Fedorak, R.N.2    Tannock, G.W.3
  • 26
    • 4644239296 scopus 로고    scopus 로고
    • Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
    • Kruis W, Fric P, Pokrotnieks J, et al,. Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 2004; 53: 1617-23.
    • (2004) Gut , vol.53 , pp. 1617-1623
    • Kruis, W.1    Fric, P.2    Pokrotnieks, J.3
  • 27
    • 0038185270 scopus 로고    scopus 로고
    • Prophylaxis of pouchitis onset with probiotic therapy: A double-blind, placebo-controlled trial
    • Gionchetti P, Rizzello F, Helwig U, et al,. Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 2003; 124: 1202-9.
    • (2003) Gastroenterology , vol.124 , pp. 1202-1209
    • Gionchetti, P.1    Rizzello, F.2    Helwig, U.3
  • 29
    • 26944448942 scopus 로고    scopus 로고
    • Maintenance therapy with a probiotic in antibiotic-dependent pouchitis: Experience in clinical practice
    • Shen B, Brzezinski A, Fazio VW, et al,. Maintenance therapy with a probiotic in antibiotic-dependent pouchitis: experience in clinical practice. Aliment Pharmacol Ther 2005; 22: 721-8.
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 721-728
    • Shen, B.1    Brzezinski, A.2    Fazio, V.W.3
  • 30
    • 9144254035 scopus 로고    scopus 로고
    • Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis
    • Mimura T, Rizzello F, Helwig U, et al,. Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut 2004; 53: 108-14.
    • (2004) Gut , vol.53 , pp. 108-114
    • Mimura, T.1    Rizzello, F.2    Helwig, U.3
  • 31
    • 0033860601 scopus 로고    scopus 로고
    • Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial
    • Gionchetti P, Rizzello F, Venturi A, et al,. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology 2000; 119: 305-9.
    • (2000) Gastroenterology , vol.119 , pp. 305-309
    • Gionchetti, P.1    Rizzello, F.2    Venturi, A.3
  • 32
    • 10644224177 scopus 로고    scopus 로고
    • Assessment of mucosal inflammation and blood flow in response to four weeks' intervention with probiotics in patients operated with a J-configurated ileal-pouch-anal-anastomosis (IPAA)
    • Laake KO, Line PD, Grzyb K, et al,. Assessment of mucosal inflammation and blood flow in response to four weeks' intervention with probiotics in patients operated with a J-configurated ileal-pouch-anal-anastomosis (IPAA). Scand J Gastroenterol 2004; 39: 1228-35.
    • (2004) Scand J Gastroenterol , vol.39 , pp. 1228-1235
    • Laake, K.O.1    Line, P.D.2    Grzyb, K.3
  • 34
    • 47249097557 scopus 로고    scopus 로고
    • The role of microbiota and probiotics in stress-induced gastro-intestinal damage
    • Lutgendorff F, Akkermans LM, Soderholm JD,. The role of microbiota and probiotics in stress-induced gastro-intestinal damage. Curr Mol Med 2008; 8: 282-98.
    • (2008) Curr Mol Med , vol.8 , pp. 282-298
    • Lutgendorff, F.1    Akkermans, L.M.2    Soderholm, J.D.3
  • 35
    • 79955469118 scopus 로고    scopus 로고
    • Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis
    • Wallon C, Persborn M, Jonsson M, et al,. Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis. Gastroenterology 2011; 140: 1597-607.
    • (2011) Gastroenterology , vol.140 , pp. 1597-1607
    • Wallon, C.1    Persborn, M.2    Jonsson, M.3
  • 36
    • 0034831139 scopus 로고    scopus 로고
    • Probiotic bacteria enhance murine and human intestinal epithelial barrier function
    • Madsen K, Cornish A, Soper P, et al,. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 2001; 121: 580-91.
    • (2001) Gastroenterology , vol.121 , pp. 580-591
    • Madsen, K.1    Cornish, A.2    Soper, P.3
  • 37
    • 33947304497 scopus 로고    scopus 로고
    • Modification of intestinal flora with multispecies probiotics reduces bacterial translocation and improves clinical course in a rat model of acute pancreatitis
    • van Minnen LP, Timmerman HM, Lutgendorff F, et al,. Modification of intestinal flora with multispecies probiotics reduces bacterial translocation and improves clinical course in a rat model of acute pancreatitis. Surgery 2007; 141: 470-80.
    • (2007) Surgery , vol.141 , pp. 470-480
    • Van Minnen, L.P.1    Timmerman, H.M.2    Lutgendorff, F.3
  • 38
    • 84867116816 scopus 로고    scopus 로고
    • Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; A randomized, double-blinded, placebo-controlled trial
    • Lamprecht M, Bogner S, Schippinger G, et al,. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. J Int Soc Sports Nutr 2012; 9: 45.
    • (2012) J Int Soc Sports Nutr , vol.9 , pp. 45
    • Lamprecht, M.1    Bogner, S.2    Schippinger, G.3
  • 40
    • 18744414535 scopus 로고    scopus 로고
    • Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon
    • Wallon C, Braaf Y, Wolving M, Olaison G, Soderholm JD,. Endoscopic biopsies in Ussing chambers evaluated for studies of macromolecular permeability in the human colon. Scand J Gastroenterol 2005; 40: 586-95.
    • (2005) Scand J Gastroenterol , vol.40 , pp. 586-595
    • Wallon, C.1    Braaf, Y.2    Wolving, M.3    Olaison, G.4    Soderholm, J.D.5
  • 41
    • 38349087186 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro
    • Wallon C, Yang PC, Keita AV, et al,. Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut 2008; 57: 50-8.
    • (2008) Gut , vol.57 , pp. 50-58
    • Wallon, C.1    Yang, P.C.2    Keita, A.V.3
  • 42
    • 0031963599 scopus 로고    scopus 로고
    • Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber
    • Soderholm JD, Hedman L, Artursson P, et al,. Integrity and metabolism of human ileal mucosa in vitro in the Ussing chamber. Acta Physiol Scand 1998; 162: 47-56.
    • (1998) Acta Physiol Scand , vol.162 , pp. 47-56
    • Soderholm, J.D.1    Hedman, L.2    Artursson, P.3
  • 43
    • 1642354455 scopus 로고    scopus 로고
    • Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats
    • Velin AK, Ericson AC, Braaf Y, Wallon C, Soderholm JD,. Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats. Gut 2004; 53: 494-500.
    • (2004) Gut , vol.53 , pp. 494-500
    • Velin, A.K.1    Ericson, A.C.2    Braaf, Y.3    Wallon, C.4    Soderholm, J.D.5
  • 44
    • 67649945513 scopus 로고    scopus 로고
    • Development and application of the human intestinal tract chip, a phylogenetic microarray: Analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults
    • Rajilic-Stojanovic M, Heilig HG, Molenaar D, et al,. Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environ Microbiol 2009; 11: 1736-51.
    • (2009) Environ Microbiol , vol.11 , pp. 1736-1751
    • Rajilic-Stojanovic, M.1    Heilig, H.G.2    Molenaar, D.3
  • 45
    • 77951977802 scopus 로고    scopus 로고
    • Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: Effective recovery of bacterial and archaeal DNA using mechanical cell lysis
    • Salonen A, Nikkila J, Jalanka-Tuovinen J, et al,. Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis. J Microbiol Methods 2010; 81: 127-34.
    • (2010) J Microbiol Methods , vol.81 , pp. 127-134
    • Salonen, A.1    Nikkila, J.2    Jalanka-Tuovinen, J.3
  • 47
    • 33747443136 scopus 로고    scopus 로고
    • Increased bacterial permeation in long-lasting ileoanal pouches
    • Kroesen AJ, Leistenschneider P, Lehmann K, et al,. Increased bacterial permeation in long-lasting ileoanal pouches. Inflamm Bowel Dis 2006; 12: 736-44.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 736-744
    • Kroesen, A.J.1    Leistenschneider, P.2    Lehmann, K.3
  • 48
    • 45749135141 scopus 로고    scopus 로고
    • Permanently increased mucosal permeability in patients with backwash ileitis after ileoanal pouch for ulcerative colitis
    • Kroesen AJ, Dullat S, Schulzke JD, Fromm M, Buhr HJ,. Permanently increased mucosal permeability in patients with backwash ileitis after ileoanal pouch for ulcerative colitis. Scand J Gastroenterol 2008; 43: 704-11.
    • (2008) Scand J Gastroenterol , vol.43 , pp. 704-711
    • Kroesen, A.J.1    Dullat, S.2    Schulzke, J.D.3    Fromm, M.4    Buhr, H.J.5
  • 49
    • 44649139179 scopus 로고    scopus 로고
    • Increased uptake of non-pathogenic E. Coli via the follicle-associated epithelium in longstanding ileal Crohn's disease
    • Keita AV, Salim SY, Jiang T, et al,. Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease. J Pathol 2008; 215: 135-44.
    • (2008) J Pathol , vol.215 , pp. 135-144
    • Keita, A.V.1    Salim, S.Y.2    Jiang, T.3
  • 50
    • 0036203968 scopus 로고    scopus 로고
    • Sulfate-reducing bacteria colonize pouches formed for ulcerative colitis but not for familial adenomatous polyposis
    • Duffy M, O'Mahony L, Coffey JC, et al,. Sulfate-reducing bacteria colonize pouches formed for ulcerative colitis but not for familial adenomatous polyposis. Dis Colon Rectum 2002; 45: 384-8.
    • (2002) Dis Colon Rectum , vol.45 , pp. 384-388
    • Duffy, M.1    O'Mahony, L.2    Coffey, J.C.3
  • 52
    • 0036875710 scopus 로고    scopus 로고
    • Variable response to probiotics in two models of experimental colitis in rats
    • Shibolet O, Karmeli F, Eliakim R, et al,. Variable response to probiotics in two models of experimental colitis in rats. Inflamm Bowel Dis 2002; 8: 399-406.
    • (2002) Inflamm Bowel Dis , vol.8 , pp. 399-406
    • Shibolet, O.1    Karmeli, F.2    Eliakim, R.3
  • 53
    • 0034828502 scopus 로고    scopus 로고
    • Expression of cytokines, inducible nitric oxide synthase, and matrix metalloproteinases in pouchitis: Effects of probiotic treatment
    • Ulisse S, Gionchetti P, D'Alo S, et al,. Expression of cytokines, inducible nitric oxide synthase, and matrix metalloproteinases in pouchitis: effects of probiotic treatment. Am J Gastroenterol 2001; 96: 2691-9.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2691-2699
    • Ulisse, S.1    Gionchetti, P.2    D'Alo, S.3
  • 54
    • 0036272254 scopus 로고    scopus 로고
    • Review article: Treatment of mild to moderate ulcerative colitis and pouchitis
    • Gionchetti P, Amadini C, Rizzello F, Venturi A, Campieri M,. Review article: treatment of mild to moderate ulcerative colitis and pouchitis. Aliment Pharmacol Ther 2002; 16 (Suppl. 4): 13-9.
    • (2002) Aliment Pharmacol Ther , vol.16 , Issue.SUPPL. 4 , pp. 13-19
    • Gionchetti, P.1    Amadini, C.2    Rizzello, F.3    Venturi, A.4    Campieri, M.5
  • 55
    • 34347330287 scopus 로고    scopus 로고
    • Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: A randomized, double-blind trial
    • Rayes N, Seehofer D, Theruvath T, et al,. Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial. Ann Surg 2007; 246: 36-41.
    • (2007) Ann Surg , vol.246 , pp. 36-41
    • Rayes, N.1    Seehofer, D.2    Theruvath, T.3
  • 56
    • 11844284850 scopus 로고    scopus 로고
    • Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation - A randomized, double-blind trial
    • Rayes N, Seehofer D, Theruvath T, et al,. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation-a randomized, double-blind trial. Am J Transplant 2005; 5: 125-30.
    • (2005) Am J Transplant , vol.5 , pp. 125-130
    • Rayes, N.1    Seehofer, D.2    Theruvath, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.