Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cells

Journal of Virology

Volumn 89, Issue 7, 2015, Pages 3947-3956

  Yamaji, Reina ^a   Yamada, Shinya ^a   Le, Mai Q ^b   Li, Chengjun ^c   Chen, Hualan ^c   Qurnianingsih, Ema ^d   Nidom, Chairul A ^d   Ito, Mutsumi ^a   Sakai Tagawa, Yuko ^a   Kawaoka, Yoshihiro ^a,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b National Institute of Hygiene and Epidemiology   (Viet Nam)

^c INSTITUTE OF PLANT PROTECTION   (China)

^d AIRLANGGA UNIVERSITY   (Indonesia)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN PB2; MUTANT PROTEIN; PB2 PROTEIN, INFLUENZA VIRUS;

AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H5N1; INFLUENZA VIRUS A H5N1 CHICKEN CENTRAL JAVA UT3091 2005; INFLUENZA VIRUS A H5N1 CHICKEN VIETNAM TY31 2005; INFLUENZA VIRUS A H5N1 VIETNAM HN31676DH 2009; INFLUENZA VIRUS A H5N1 VIETNAM UT31604I 2009; INFLUENZA VIRUS A H5N1 VIETNAM UT31641II 2008; INFLUENZA VIRUS A H5N1 VIETNAM UT36236 2010; INFLUENZA VIRUS A H5N1 VIETNAM UT36250I 2010; INFLUENZA VIRUS A H5N1 VIETNAM UT36282 2010; INFLUENZA VIRUS A H5N1 VIETNAM UT36285 2010; INFLUENZA VIRUS A H5N1 WILD BIRD ANHUI 82 2005; LUNG ALVEOLUS EPITHELIUM CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PB2 GENE; PRIORITY JOURNAL; UNINDEXED SEQUENCE; VIROGENESIS; VIRUS GENE; VIRUS ISOLATION; VIRUS REPLICATION; ADAPTATION; CELL LINE; EPITHELIUM CELL; GENETIC RECOMBINATION; GENETICS; INFLUENZA A VIRUS (H5N1); METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; REVERSE GENETICS; VIROLOGY;

AVES; AVIAN INFLUENZA VIRUS; ORTHOMYXOVIRIDAE;

ADAPTATION, BIOLOGICAL; CELL LINE; EPITHELIAL CELLS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; MUTANT PROTEINS; MUTATION, MISSENSE; RECOMBINATION, GENETIC; REVERSE GENETICS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84924778316     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03328-14     Document Type: Article

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