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Volumn 24, Issue 4, 2015, Pages 491-505

Novel investigational therapeutics for panic disorder

Author keywords

Glutamate; Novel drugs; Orexin; Panic disorder

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; ABIO 0801; ALPRAZOLAM; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTALARMIN; ANTIPANIC AGENT; APTIGANEL; ARGININE VASOPRESSINE V1B; ARGIPRESSIN; BUSPIRONE; CAPSAZEPINE; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; DIZOCILPINE; EGLUMETAD; EMAPUNIL; ISOXAZOLINE DERIVATIVE; KETAMINE; LOSARTAN; MAPROTILINE; METABOTROPIC RECEPTOR AGONIST; N (ALPHA ETHYLBENZYL) 3 METHYL 2 PHENYL 4 QUINOLINECARBOXAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROPEPTIDE S; SARALASIN; SERTRALINE; SPANTIDE; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; VESTIPITANT; VOFOPITANT; ANXIOLYTIC AGENT; NEW DRUG;

EID: 84924726421     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2014.996286     Document Type: Review
Times cited : (30)

References (100)
  • 1
    • 84865989655 scopus 로고    scopus 로고
    • Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States
    • Kessler RC, Petukhova M, Sampson NA, et al. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res 2012;21(3):169-84
    • (2012) Int J Methods Psychiatr Res , vol.21 , Issue.3 , pp. 169-184
    • Kessler, R.C.1    Petukhova, M.2    Sampson, N.A.3
  • 3
    • 84866646660 scopus 로고    scopus 로고
    • Pharmacological treatment of anxiety disorders: Current treatments and future directions
    • Farach FJ, Pruitt LD, Jun JJ, et al. Pharmacological treatment of anxiety disorders: current treatments and future directions. J Anxiety Disord 2012;26(8):833-43
    • (2012) J Anxiety Disord , vol.26 , Issue.8 , pp. 833-843
    • Farach, F.J.1    Pruitt, L.D.2    Jun, J.J.3
  • 5
    • 84875624607 scopus 로고    scopus 로고
    • Understanding anxiety disorders: The psychology and the psychopathology of defence mechanisms against threats
    • Perna G. Understanding anxiety disorders: the psychology and the psychopathology of defence mechanisms against threats. Riv Psichiatr 2013;48(1):73-5
    • (2013) Riv Psichiatr , vol.48 , Issue.1 , pp. 73-75
    • Perna, G.1
  • 6
    • 84911433504 scopus 로고    scopus 로고
    • Etiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory-induced panic attacks
    • Johnson PL, Federici LM, Shekhar A. Etiology, triggers and neurochemical circuits associated with unexpected, expected, and laboratory-induced panic attacks. Neurosci Biobehav Rev 2014;46P3:429-54
    • (2014) Neurosci Biobehav Rev , vol.46 P3 , pp. 429-454
    • Johnson, P.L.1    Federici, L.M.2    Shekhar, A.3
  • 7
    • 77954418509 scopus 로고    scopus 로고
    • Panic disorder respiratory subtype: Psychopathology, laboratory challenge tests, and response to treatment
    • Freire RC, Perna G, Nardi AE. Panic disorder respiratory subtype: psychopathology, laboratory challenge tests, and response to treatment. Harv Rev Psychiatry 2010;18(4):220-9
    • (2010) Harv Rev Psychiatry , vol.18 , Issue.4 , pp. 220-229
    • Freire, R.C.1    Perna, G.2    Nardi, A.E.3
  • 8
    • 80054929066 scopus 로고    scopus 로고
    • Panic disorder and its subtypes: A comprehensive analysis of panic symptom heterogeneity using epidemiological and treatment seeking samples
    • Roberson-Nay R, Kendler KS. Panic disorder and its subtypes: a comprehensive analysis of panic symptom heterogeneity using epidemiological and treatment seeking samples. Psychol Med 2011;41(11):2411-21
    • (2011) Psychol Med , vol.41 , Issue.11 , pp. 2411-2421
    • Roberson-Nay, R.1    Kendler, K.S.2
  • 9
    • 0027528446 scopus 로고
    • False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis
    • Klein DF. False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis. Arch Gen Psychiatry 1993;50(4):306-17
    • (1993) Arch Gen Psychiatry , vol.50 , Issue.4 , pp. 306-317
    • Klein, D.F.1
  • 10
    • 84911407786 scopus 로고    scopus 로고
    • Lifelong opioidergic vulnerability through early life separation: A recent extension of the false suffocation alarm theory of panic disorder
    • Preter M, Klein DF. Lifelong opioidergic vulnerability through early life separation: a recent extension of the false suffocation alarm theory of panic disorder. Neurosci Biobehav Rev 2014;46P3:345-51
    • (2014) Neurosci Biobehav Rev , vol.46 P3 , pp. 345-351
    • Preter, M.1    Klein, D.F.2
  • 11
    • 1642544559 scopus 로고    scopus 로고
    • Panic disorder: From respiration to the homeostatic brain
    • Perna G, Caldirola D, Bellodi L. Panic disorder: from respiration to the homeostatic brain. Acta Neuropsychiatr 2004;16(2):57-67
    • (2004) Acta Neuropsychiatr , vol.16 , Issue.2 , pp. 57-67
    • Perna, G.1    Caldirola, D.2    Bellodi, L.3
  • 13
    • 50849092518 scopus 로고    scopus 로고
    • Neurobiology of panic disorder: From animal models to brain neuroimaging
    • Graeff FG, Del-Ben CM. Neurobiology of panic disorder: from animal models to brain neuroimaging. Neurosci Biobehav Rev 2008;32(7):1326-35
    • (2008) Neurosci Biobehav Rev , vol.32 , Issue.7 , pp. 1326-1335
    • Graeff, F.G.1    Del-Ben, C.M.2
  • 14
    • 84911456962 scopus 로고    scopus 로고
    • Executive and modulatory neural circuits of defensive reactions: Implications for panic disorder
    • Canteras NS, Graeff FG. Executive and modulatory neural circuits of defensive reactions: implications for panic disorder. Neurosci Biobehav Rev 2014;46P3:352-64
    • (2014) Neurosci Biobehav Rev , vol.46 P3 , pp. 352-364
    • Canteras, N.S.1    Graeff, F.G.2
  • 15
    • 84924668437 scopus 로고    scopus 로고
    • Panic and the brainstem: Clues from neuroimaging studies
    • Perna G, Guerriero G, Brambilla P, et al. Panic and the brainstem: clues from neuroimaging studies. CNS Neurol Disord Drug Targets 2014;13(6):1049-56
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , Issue.6 , pp. 1049-1056
    • Perna, G.1    Guerriero, G.2    Brambilla, P.3
  • 16
    • 84899800328 scopus 로고    scopus 로고
    • Brainstem response to hypercapnia: A symptom provocation study into the pathophysiology of panic disorder
    • Goossens L, Leibold N, Peeters R, et al. Brainstem response to hypercapnia: a symptom provocation study into the pathophysiology of panic disorder. J Psychopharmacol 2014;28(5):449-56
    • (2014) J Psychopharmacol , vol.28 , Issue.5 , pp. 449-456
    • Goossens, L.1    Leibold, N.2    Peeters, R.3
  • 17
    • 84911364315 scopus 로고    scopus 로고
    • The Deakin/Graeff hypothesis: Focus on serotonergic inhibition of panic
    • Paul ED, Johnson PL, Shekhar A, et al. The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic. Neurosci Biobehav Rev 2014;46P3:379-96
    • (2014) Neurosci Biobehav Rev , vol.46 P3 , pp. 379-396
    • Paul, E.D.1    Johnson, P.L.2    Shekhar, A.3
  • 18
    • 0034066256 scopus 로고    scopus 로고
    • Neuroanatomical hypothesis of panic disorder, revised
    • Gorman JM, Kent JM, Sullivan GM, et al. Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 2000;157(4):493-505
    • (2000) Am J Psychiatry , vol.157 , Issue.4 , pp. 493-505
    • Gorman, J.M.1    Kent, J.M.2    Sullivan, G.M.3
  • 19
    • 84875893842 scopus 로고    scopus 로고
    • Fear and panic in humans with bilateral amygdala damage
    • Feinstein JS, Buzza C, Hurlemann R, et al. Fear and panic in humans with bilateral amygdala damage. Nat Neurosci 2013;16(3):270-2
    • (2013) Nat Neurosci , vol.16 , Issue.3 , pp. 270-272
    • Feinstein, J.S.1    Buzza, C.2    Hurlemann, R.3
  • 21
    • 84888051360 scopus 로고    scopus 로고
    • Discovery of novel anxiolytic agents-the trials and tribulations of pre-clinical models of anxiety
    • Andrews NA, Papakosta M, Barnes NM. Discovery of novel anxiolytic agents-the trials and tribulations of pre-clinical models of anxiety. Neurobiol Dis 2014;61:72-8
    • (2014) Neurobiol Dis , vol.61 , pp. 72-78
    • Andrews, N.A.1    Papakosta, M.2    Barnes, N.M.3
  • 22
    • 84870661451 scopus 로고    scopus 로고
    • An animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamus
    • Johnson PL, Shekhar A. An animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamus. Physiol Behav 2012;107(5):686-98
    • (2012) Physiol Behav , vol.107 , Issue.5 , pp. 686-698
    • Johnson, P.L.1    Shekhar, A.2
  • 23
    • 73849143579 scopus 로고    scopus 로고
    • A key role for orexin in panic anxiety
    • Johnson PL, Truitt W, Fitz SD, et al. A key role for orexin in panic anxiety. Nat Med 2010;16(1):111-15
    • (2010) Nat Med , vol.16 , Issue.1 , pp. 111-115
    • Johnson, P.L.1    Truitt, W.2    Fitz, S.D.3
  • 24
    • 0034100686 scopus 로고    scopus 로고
    • LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats
    • Shekhar A, Keim SR. LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats. Neuropharmacology 2000;39(7):1139-46
    • (2000) Neuropharmacology , vol.39 , Issue.7 , pp. 1139-1146
    • Shekhar, A.1    Keim, S.R.2
  • 25
    • 0027211759 scopus 로고
    • Sensory circumventricular organs and brain homeostatic pathways
    • Johnson AK, Gross PM. Sensory circumventricular organs and brain homeostatic pathways. FASEB J 1993;7(8):678-86
    • (1993) FASEB J , vol.7 , Issue.8 , pp. 678-686
    • Johnson, A.K.1    Gross, P.M.2
  • 26
    • 47249110234 scopus 로고    scopus 로고
    • Neural pathways underlying lactateinduced panic
    • Johnson PL, Truitt WA, Fitz SD, et al. Neural pathways underlying lactateinduced panic. Neuropsychopharmacology 2008;33(9):2093-107
    • (2008) Neuropsychopharmacology , vol.33 , Issue.9 , pp. 2093-2107
    • Johnson, P.L.1    Truitt, W.A.2    Fitz, S.D.3
  • 27
    • 50249183558 scopus 로고    scopus 로고
    • Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic
    • Johnson P, Lowry C, Truitt W, et al. Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic. J Psychopharmacol 2008;22(6):642-52
    • (2008) J Psychopharmacol , vol.22 , Issue.6 , pp. 642-652
    • Johnson, P.1    Lowry, C.2    Truitt, W.3
  • 28
    • 84911441478 scopus 로고    scopus 로고
    • Serotonin in anxiety and panic: Contributions of the elevated T-maze
    • Zangrossi H Jr, Graeff FG. Serotonin in anxiety and panic: contributions of the elevated T-maze. Neurosci Biobehav Rev 2014;46P3:397-406
    • (2014) Neurosci Biobehav Rev , vol.46 P3 , pp. 397-406
    • Zangrossi, H.1    Graeff, F.G.2
  • 30
    • 84855532130 scopus 로고    scopus 로고
    • Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: Focus on pharmacology and preclinical translational models
    • Harvey BH, Shahid M. Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models. Pharmacol Biochem Behav 2012;100(4):775-800
    • (2012) Pharmacol Biochem Behav , vol.100 , Issue.4 , pp. 775-800
    • Harvey, B.H.1    Shahid, M.2
  • 31
    • 84874784089 scopus 로고    scopus 로고
    • Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder
    • Long Z, Medlock C, Dzemidzic M, et al. Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder. Prog Neuropsychopharmacol Biol Psychiatry 2013;44:131-5
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.44 , pp. 131-135
    • Long, Z.1    Medlock, C.2    Dzemidzic, M.3
  • 32
    • 33746498349 scopus 로고    scopus 로고
    • Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism
    • Hettema JM, An SS, Neale MC, et al. Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. Mol Psychiatry 2006;11(8):752-62
    • (2006) Mol Psychiatry , vol.11 , Issue.8 , pp. 752-762
    • Hettema, J.M.1    An, S.S.2    Neale, M.C.3
  • 33
    • 84872837494 scopus 로고    scopus 로고
    • Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats
    • Johnson PL, Fitz SD, Engleman EA, et al. Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats. J Psychopharmacol 2013;27(2):152-61
    • (2013) J Psychopharmacol , vol.27 , Issue.2 , pp. 152-161
    • Johnson, P.L.1    Fitz, S.D.2    Engleman, E.A.3
  • 34
    • 33745949221 scopus 로고    scopus 로고
    • Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors
    • Johnson PL, Shekhar A. Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors. J Neurosci 2006;26(26):7093-104
    • (2006) J Neurosci , vol.26 , Issue.26 , pp. 7093-7104
    • Johnson, P.L.1    Shekhar, A.2
  • 35
    • 84892403784 scopus 로고    scopus 로고
    • GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists
    • Moskal JR, Burch R, Burgdorf JS, et al. GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists. Expert Opin Investig Drugs 2014;23(2):243-54
    • (2014) Expert Opin Investig Drugs , vol.23 , Issue.2 , pp. 243-254
    • Moskal, J.R.1    Burch, R.2    Burgdorf, J.S.3
  • 36
    • 0141644133 scopus 로고    scopus 로고
    • LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress
    • Schoepp DD, Wright RA, Levine LR, et al. LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress. Stress 2003;6(3):189-97
    • (2003) Stress , vol.6 , Issue.3 , pp. 189-197
    • Schoepp, D.D.1    Wright, R.A.2    Levine, L.R.3
  • 37
    • 26944475559 scopus 로고    scopus 로고
    • Metabotropic glutamate II receptor agonists in panic disorder: A double blind clinical trial with LY354740
    • Bergink V, Westenberg HG. Metabotropic glutamate II receptor agonists in panic disorder: a double blind clinical trial with LY354740. Int Clin Psychopharmacol 2005;20(6):291-3
    • (2005) Int Clin Psychopharmacol , vol.20 , Issue.6 , pp. 291-293
    • Bergink, V.1    Westenberg, H.G.2
  • 38
    • 31144440181 scopus 로고    scopus 로고
    • Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: In vivo pharmacology of LY544344
    • Rorick-Kehn LM, Perkins EJ, Knitowski KM, et al. Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344. J Pharmacol Exp Ther 2006;316(2):905-13
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.2 , pp. 905-913
    • Rorick-Kehn, L.M.1    Perkins, E.J.2    Knitowski, K.M.3
  • 39
    • 17744390351 scopus 로고    scopus 로고
    • Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: Preliminary results
    • Kellner M, Muhtz C, Stark K, et al. Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results. Psychopharmacology (Berl) 2005;179(1):310-15
    • (2005) Psychopharmacology (Berl) , vol.179 , Issue.1 , pp. 310-315
    • Kellner, M.1    Muhtz, C.2    Stark, K.3
  • 40
    • 84863883078 scopus 로고    scopus 로고
    • Respiration and autonomic regulation and orexin
    • Nattie E, Li A. Respiration and autonomic regulation and orexin. Prog Brain Res 2012;198:25-46
    • (2012) Prog Brain Res , vol.198 , pp. 25-46
    • Nattie, E.1    Li, A.2
  • 41
    • 84862330739 scopus 로고    scopus 로고
    • Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia
    • Johnson PL, Samuels BC, Fitz SD, et al. Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia. Neuropsychopharmacology 2012;37(8):1911-22
    • (2012) Neuropsychopharmacology , vol.37 , Issue.8 , pp. 1911-1922
    • Johnson, P.L.1    Samuels, B.C.2    Fitz, S.D.3
  • 42
    • 84870689509 scopus 로고    scopus 로고
    • Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network
    • Johnson PL, Samuels BC, Fitz SD, et al. Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Physiol Behav 2012;107(5):733-42
    • (2012) Physiol Behav , vol.107 , Issue.5 , pp. 733-742
    • Johnson, P.L.1    Samuels, B.C.2    Fitz, S.D.3
  • 43
    • 0038600674 scopus 로고    scopus 로고
    • Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects
    • Salomon RM, Ripley B, Kennedy JS, et al. Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects. Biol Psychiatry 2003;54(2):96-104
    • (2003) Biol Psychiatry , vol.54 , Issue.2 , pp. 96-104
    • Salomon, R.M.1    Ripley, B.2    Kennedy, J.S.3
  • 44
    • 84863883736 scopus 로고    scopus 로고
    • Orexin, stress, and anxiety/panic states
    • Johnson PL, Molosh A, Fitz SD, et al. Orexin, stress, and anxiety/panic states. Prog Brain Res 2012;198:133-61
    • (2012) Prog Brain Res , vol.198 , pp. 133-161
    • Johnson, P.L.1    Molosh, A.2    Fitz, S.D.3
  • 45
    • 84903585751 scopus 로고    scopus 로고
    • Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze
    • Silva MS, Pereira BA, Cespedes IC, et al. Dorsomedial hypothalamus CRF type 1 receptors selectively modulate inhibitory avoidance responses in the elevated T-maze. Behav Brain Res 2014;271:249-57
    • (2014) Behav Brain Res , vol.271 , pp. 249-257
    • Silva, M.S.1    Pereira, B.A.2    Cespedes, I.C.3
  • 46
    • 80054040834 scopus 로고    scopus 로고
    • Preliminary evidence of anxiolytic effects of the CRF(1) receptor antagonist R317573 in the 7.5% CO(2) proof-of-concept experimental model of human anxiety
    • Bailey JE, Papadopoulos A, Diaper A, et al. Preliminary evidence of anxiolytic effects of the CRF(1) receptor antagonist R317573 in the 7.5% CO(2) proof-of-concept experimental model of human anxiety. J Psychopharmacol 2011;25(9):1199-206
    • (2011) J Psychopharmacol , vol.25 , Issue.9 , pp. 1199-1206
    • Bailey, J.E.1    Papadopoulos, A.2    Diaper, A.3
  • 47
    • 55349106933 scopus 로고    scopus 로고
    • Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
    • Keck ME, Kern N, Erhardt A, et al. Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder. Am J Med Genet B Neuropsychiatr Genet 2008;147B(7):1196-204
    • (2008) Am J Med Genet B Neuropsychiatr Genet , vol.147 , Issue.7 B , pp. 1196-1204
    • Keck, M.E.1    Kern, N.2    Erhardt, A.3
  • 48
    • 84860617713 scopus 로고    scopus 로고
    • Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population
    • Ishitobi Y, Nakayama S, Yamaguchi K, et al. Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population. Am J Med Genet B Neuropsychiatr Genet 2012;159B(4):429-36
    • (2012) Am J Med Genet B Neuropsychiatr Genet , vol.159 , Issue.4 B , pp. 429-436
    • Ishitobi, Y.1    Nakayama, S.2    Yamaguchi, K.3
  • 49
    • 84922430809 scopus 로고    scopus 로고
    • Effects of dorsal periaqueductal gray CRF1-and CRF2-receptor stimulation in animal models of panic
    • de Oliveira Sergio T, Spiacci A Jr, Zangrossi H Jr. Effects of dorsal periaqueductal gray CRF1-and CRF2-receptor stimulation in animal models of panic. Psychoneuroendocrinology 2014;49:321-30
    • (2014) Psychoneuroendocrinology , vol.49 , pp. 321-330
    • De Oliveira Sergio, T.1    Spiacci, A.2    Zangrossi, H.J.R.3
  • 50
    • 79960344957 scopus 로고    scopus 로고
    • A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactateinduced acute panic-like responses
    • Shekhar A, Johnson PL, Fitz SD, et al. A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactateinduced acute panic-like responses. Int J Neuropsychopharmacol 2011;14(3):355-65
    • (2011) Int J Neuropsychopharmacol , vol.14 , Issue.3 , pp. 355-365
    • Shekhar, A.1    Johnson, P.L.2    Fitz, S.D.3
  • 51
    • 0032920747 scopus 로고    scopus 로고
    • Instructional set and physiological response to CO2 inhalation
    • Welkowitz LA, Papp L, Martinez J, et al. Instructional set and physiological response to CO2 inhalation. Am J Psychiatry 1999;156(5):745-8
    • (1999) Am J Psychiatry , vol.156 , Issue.5 , pp. 745-748
    • Welkowitz, L.A.1    Papp, L.2    Martinez, J.3
  • 52
    • 84870170487 scopus 로고    scopus 로고
    • On the psychotropic effects of carbon dioxide
    • Colasanti A, Esquivel G, Schruers KJ, et al. On the psychotropic effects of carbon dioxide. Curr Pharm Des 2012;18(35):5627-37
    • (2012) Curr Pharm des , vol.18 , Issue.35 , pp. 5627-5637
    • Colasanti, A.1    Esquivel, G.2    Schruers, K.J.3
  • 53
    • 33748478373 scopus 로고    scopus 로고
    • Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus
    • Shekhar A, Johnson PL, Sajdyk TJ, et al. Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus. J Neurosci 2006;26(36):9205-15
    • (2006) J Neurosci , vol.26 , Issue.36 , pp. 9205-9215
    • Shekhar, A.1    Johnson, P.L.2    Sajdyk, T.J.3
  • 54
    • 84875210225 scopus 로고    scopus 로고
    • Baseline respiratory parameters in panic disorder: A meta-analysis
    • Grassi M, Caldirola D, Vanni G, et al. Baseline respiratory parameters in panic disorder: a meta-analysis. J Affect Disord 2013;146(2):158-73
    • (2013) J Affect Disord , vol.146 , Issue.2 , pp. 158-173
    • Grassi, M.1    Caldirola, D.2    Vanni, G.3
  • 55
    • 84911991650 scopus 로고    scopus 로고
    • Are respiratory abnormalities specific for panic disorder? A meta-analysis
    • Grassi M, Caldirola D, Di Chiaro NV, et al. Are respiratory abnormalities specific for panic disorder? A meta-analysis. Neuropsychobiology 2014;70(1):52-60
    • (2014) Neuropsychobiology , vol.70 , Issue.1 , pp. 52-60
    • Grassi, M.1    Caldirola, D.2    Di Chiaro, N.V.3
  • 56
    • 0142059028 scopus 로고    scopus 로고
    • Intracerebroventricular administration of the angiotensin II receptor antagonist saralasin reduces respiratory rate and tidal volume variability in freely moving Wistar rats
    • Olsson M, Annerbrink K, Hedner J, et al. Intracerebroventricular administration of the angiotensin II receptor antagonist saralasin reduces respiratory rate and tidal volume variability in freely moving Wistar rats. Psychoneuroendocrinology 2004;29(1):107-12
    • (2004) Psychoneuroendocrinology , vol.29 , Issue.1 , pp. 107-112
    • Olsson, M.1    Annerbrink, K.2    Hedner, J.3
  • 57
    • 84918543337 scopus 로고    scopus 로고
    • The relationship between ACE polymorphism and panic disorder
    • Gulec-Yilmaz S, Gulec H, Dalan AB, et al. The relationship between ACE polymorphism and panic disorder. In Vivo 2014;28(5):885-9
    • (2014) In Vivo , vol.28 , Issue.5 , pp. 885-889
    • Gulec-Yilmaz, S.1    Gulec, H.2    Dalan, A.B.3
  • 58
    • 76649134885 scopus 로고    scopus 로고
    • Insertion/deletion polymorphism in the gene for angiotensin converting enzyme (ACE) in panic disorder: A genderspecific effect?
    • Bandelow B, Saleh K, Pauls J, et al. Insertion/deletion polymorphism in the gene for angiotensin converting enzyme (ACE) in panic disorder: a genderspecific effect? World J Biol Psychiatry 2010;11(1):66-70
    • (2010) World J Biol Psychiatry , vol.11 , Issue.1 , pp. 66-70
    • Bandelow, B.1    Saleh, K.2    Pauls, J.3
  • 59
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce
    • Di Marzo V. Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov 2008;7(5):438-55
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.5 , pp. 438-455
    • Di Marzo, V.1
  • 60
    • 84857133914 scopus 로고    scopus 로고
    • Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin
    • Moreira FA, Aguiar DC, Terzian AL, et al. Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin? Neuroscience 2012;204:186-92
    • (2012) Neuroscience , vol.204 , pp. 186-92
    • Moreira, F.A.1    Aguiar, D.C.2    Terzian, A.L.3
  • 61
    • 20444379218 scopus 로고    scopus 로고
    • Endocannabinoid system and stress and anxiety responses
    • Viveros MP, Marco EM, File SE. Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav 2005;81(2):331-42
    • (2005) Pharmacol Biochem Behav , vol.81 , Issue.2 , pp. 331-342
    • Viveros, M.P.1    Marco, E.M.2    File, S.E.3
  • 62
    • 44449151954 scopus 로고    scopus 로고
    • Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex
    • Rubino T, Realini N, Castiglioni C, et al. Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex. Cereb Cortex 2008;18(6):1292-301
    • (2008) Cereb Cortex , vol.18 , Issue.6 , pp. 1292-1301
    • Rubino, T.1    Realini, N.2    Castiglioni, C.3
  • 63
    • 84856436786 scopus 로고    scopus 로고
    • Neuroanatomical substrates involved in cannabinoid modulation of defensive responses
    • Moreira FA, Aguiar DC, Resstel LB, et al. Neuroanatomical substrates involved in cannabinoid modulation of defensive responses. J Psychopharmacol 2012;26(1):40-55
    • (2012) J Psychopharmacol , vol.26 , Issue.1 , pp. 40-55
    • Moreira, F.A.1    Aguiar, D.C.2    Resstel, L.B.3
  • 64
    • 77953917373 scopus 로고    scopus 로고
    • Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors
    • Soares Vde P, Campos AC, Bortoli VC, et al. Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors. Behav Brain Res 2010;213(2):225-9
    • (2010) Behav Brain Res , vol.213 , Issue.2 , pp. 225-229
    • Soares Vde, P.1    Campos, A.C.2    Bortoli, V.C.3
  • 65
    • 84877156654 scopus 로고    scopus 로고
    • Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats
    • Campos AC, de Paula Soares V, Carvalho MC, et al. Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats. Psychopharmacology (Berl) 2013;226(1):13-24
    • (2013) Psychopharmacology (Berl) , vol.226 , Issue.1 , pp. 13-24
    • Campos, A.C.1    De Paula Soares, V.2    Carvalho, M.C.3
  • 66
    • 84856060775 scopus 로고    scopus 로고
    • Opposing roles for cannabinoid receptor type-1 (CB(1)) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats
    • Casarotto PC, Terzian AL, Aguiar DC, et al. Opposing roles for cannabinoid receptor type-1 (CB(1)) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats. Neuropsychopharmacology 2012;37(2):478-86
    • (2012) Neuropsychopharmacology , vol.37 , Issue.2 , pp. 478-486
    • Casarotto, P.C.1    Terzian, A.L.2    Aguiar, D.C.3
  • 67
    • 84875014535 scopus 로고    scopus 로고
    • Role of TRPV1 receptors on panic-like behaviors mediated by the dorsolateral periaqueductal gray in rats
    • Almeida-Santos AF, Moreira FA, Guimaraes FS, et al. Role of TRPV1 receptors on panic-like behaviors mediated by the dorsolateral periaqueductal gray in rats. Pharmacol Biochem Behav 2013;105:166-72
    • (2013) Pharmacol Biochem Behav , vol.105 , pp. 166-172
    • Almeida-Santos, A.F.1    Moreira, F.A.2    Guimaraes, F.S.3
  • 68
    • 84879475262 scopus 로고    scopus 로고
    • Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze
    • Gobira PH, Aguiar DC, Moreira FA. Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze. Pharmacol Biochem Behav 2013;110:33-9
    • (2013) Pharmacol Biochem Behav , vol.110 , pp. 33-39
    • Gobira, P.H.1    Aguiar, D.C.2    Moreira, F.A.3
  • 69
    • 33745261630 scopus 로고    scopus 로고
    • Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: Further evidence for an anxiolytic role for endogenous cannabinoid signaling
    • Patel S, Hillard CJ. Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. J Pharmacol Exp Ther 2006;318(1):304-11
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.1 , pp. 304-311
    • Patel, S.1    Hillard, C.J.2
  • 70
    • 58149461157 scopus 로고    scopus 로고
    • Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels
    • Micale V, Cristino L, Tamburella A, et al. Anxiolytic effects in mice of a dual blocker of fatty acid amide hydrolase and transient receptor potential vanilloid type-1 channels. Neuropsychopharmacology 2009;34(3):593-606
    • (2009) Neuropsychopharmacology , vol.34 , Issue.3 , pp. 593-606
    • Micale, V.1    Cristino, L.2    Tamburella, A.3
  • 71
    • 84862296984 scopus 로고    scopus 로고
    • N-arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze
    • John CS, Currie PJ. N-arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze. Behav Brain Res 2012;233(2):382-8
    • (2012) Behav Brain Res , vol.233 , Issue.2 , pp. 382-388
    • John, C.S.1    Currie, P.J.2
  • 72
    • 84055191672 scopus 로고    scopus 로고
    • Translocator protein (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile
    • Nothdurfter C, Rammes G, Baghai TC, et al. Translocator protein (18 kDa) as a target for novel anxiolytics with a favourable side-effect profile. J Neuroendocrinol 2012;24(1):82-92
    • (2012) J Neuroendocrinol , vol.24 , Issue.1 , pp. 82-92
    • Nothdurfter, C.1    Rammes, G.2    Baghai, T.C.3
  • 73
    • 67651117272 scopus 로고    scopus 로고
    • Translocator protein (18 kD) as target for anxiolytics without benzodiazepinelike side effects
    • Rupprecht R, Rammes G, Eser D, et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepinelike side effects. Science 2009;325(5939):490-3
    • (2009) Science , vol.325 , Issue.5939 , pp. 490-493
    • Rupprecht, R.1    Rammes, G.2    Eser, D.3
  • 74
    • 27144559964 scopus 로고    scopus 로고
    • Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms
    • Pini S, Martini C, Abelli M, et al. Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms. Psychopharmacology (Berl) 2005;181(2):407-11
    • (2005) Psychopharmacology (Berl) , vol.181 , Issue.2 , pp. 407-411
    • Pini, S.1    Martini, C.2    Abelli, M.3
  • 75
    • 0037870116 scopus 로고    scopus 로고
    • Neurosteroid secretion in panic disorder
    • Brambilla F, Biggio G, Pisu MG, et al. Neurosteroid secretion in panic disorder. Psychiatry Res 2003;118(2):107-16
    • (2003) Psychiatry Res , vol.118 , Issue.2 , pp. 107-116
    • Brambilla, F.1    Biggio, G.2    Pisu, M.G.3
  • 76
    • 0036357699 scopus 로고    scopus 로고
    • GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment
    • Strohle A, Romeo E, di Michele F, et al. GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment. Am J Psychiatry 2002;159(1):145-7
    • (2002) Am J Psychiatry , vol.159 , Issue.1 , pp. 145-147
    • Strohle, A.1    Romeo, E.2    Di Michele, F.3
  • 77
    • 0028948726 scopus 로고
    • Menstrual cycle-related sensitivity to 35% CO2 in panic patients
    • Perna G, Brambilla F, Arancio C, et al. Menstrual cycle-related sensitivity to 35% CO2 in panic patients. Biol Psychiatry 1995;37(8):528-32
    • (1995) Biol Psychiatry , vol.37 , Issue.8 , pp. 528-532
    • Perna, G.1    Brambilla, F.2    Arancio, C.3
  • 78
    • 0037317122 scopus 로고    scopus 로고
    • Induced panic attacks shift gammaaminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: Preliminary results
    • Strohle A, Romeo E, di Michele F, et al. Induced panic attacks shift gammaaminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results. Arch Gen Psychiatry 2003;60(2):161-8
    • (2003) Arch Gen Psychiatry , vol.60 , Issue.2 , pp. 161-168
    • Strohle, A.1    Romeo, E.2    Di Michele, F.3
  • 79
    • 84914665976 scopus 로고    scopus 로고
    • Gender-specific association of variants in the Akr1c1 gene with dimensional anxiety in patients with panic disorder: Additional evidence for the importance of neurosteroids in anxiety
    • Quast C, Reif A, Bruckl T, et al. Gender-specific association of variants in the Akr1c1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety? Depress Anxiety 2014;31(10):843-50
    • (2014) Depress Anxiety , vol.31 , Issue.10 , pp. 843-50
    • Quast, C.1    Reif, A.2    Bruckl, T.3
  • 80
    • 84899866997 scopus 로고    scopus 로고
    • Anxiolytic effects of vestipitant in a subgroup of healthy volunteers known to be sensitive to CO2 challenge
    • Poma SZ, Merlo-Pich E, Bettica P, et al. Anxiolytic effects of vestipitant in a subgroup of healthy volunteers known to be sensitive to CO2 challenge. J Psychopharmacol 2014;28(5):491-7
    • (2014) J Psychopharmacol , vol.28 , Issue.5 , pp. 491-497
    • Poma, S.Z.1    Merlo-Pich, E.2    Bettica, P.3
  • 81
    • 67349222818 scopus 로고    scopus 로고
    • Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: Positron emission tomographic study with [18F]SPA-RQ
    • Fujimura Y, Yasuno F, Farris A, et al. Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ. Biol Psychiatry 2009;66(1):94-7
    • (2009) Biol Psychiatry , vol.66 , Issue.1 , pp. 94-97
    • Fujimura, Y.1    Yasuno, F.2    Farris, A.3
  • 82
    • 84855544353 scopus 로고    scopus 로고
    • Effects of neurokinin-1 and 3-receptor antagonists on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray
    • Broiz AC, Bassi GS, De Souza Silva MA, et al. Effects of neurokinin-1 and 3-receptor antagonists on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray. Neuroscience 2012;201:134-45
    • (2012) Neuroscience , vol.201 , pp. 134-145
    • Broiz, A.C.1    Bassi, G.S.2    De Souza Silva, M.A.3
  • 83
    • 84903128944 scopus 로고    scopus 로고
    • Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325
    • Iijima M, Yoshimizu T, Shimazaki T, et al. Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325. Br J Pharmacol 2014;171(14):3511-25
    • (2014) Br J Pharmacol , vol.171 , Issue.14 , pp. 3511-3525
    • Iijima, M.1    Yoshimizu, T.2    Shimazaki, T.3
  • 85
    • 11844283307 scopus 로고    scopus 로고
    • Anxiety and panic: From human studies to animal research and back
    • Battaglia M, Ogliari A. Anxiety and panic: from human studies to animal research and back. Neurosci Biobehav Rev 2005;29(1):169-79
    • (2005) Neurosci Biobehav Rev , vol.29 , Issue.1 , pp. 169-179
    • Battaglia, M.1    Ogliari, A.2
  • 86
    • 27744596641 scopus 로고    scopus 로고
    • Pharmacological characterization of human and murine neuropeptide s receptor variants
    • Reinscheid RK, Xu YL, Okamura N, et al. Pharmacological characterization of human and murine neuropeptide s receptor variants. J Pharmacol Exp Ther 2005;315(3):1338-45
    • (2005) J Pharmacol Exp Ther , vol.315 , Issue.3 , pp. 1338-1345
    • Reinscheid, R.K.1    Xu, Y.L.2    Okamura, N.3
  • 87
    • 84870569948 scopus 로고    scopus 로고
    • Anxiolytic-and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze
    • Pulga A, Ruzza C, Rizzi A, et al. Anxiolytic-and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze. Eur J Neurosci 2012;36(11):3531-7
    • (2012) Eur J Neurosci , vol.36 , Issue.11 , pp. 3531-3537
    • Pulga, A.1    Ruzza, C.2    Rizzi, A.3
  • 88
    • 80052074218 scopus 로고    scopus 로고
    • Neuropeptide S receptor gene-converging evidence for a role in panic disorder
    • Domschke K, Reif A, Weber H, et al. Neuropeptide S receptor gene-converging evidence for a role in panic disorder. Mol Psychiatry 2011;16(9):938-48
    • (2011) Mol Psychiatry , vol.16 , Issue.9 , pp. 938-948
    • Domschke, K.1    Reif, A.2    Weber, H.3
  • 89
    • 42549128281 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, multiple-ascending-dose study on the effects of ABIO-08/01, a novel anxiolytic drug, on perception and cognition, utilizing event-related potential mapping and low-resolution brain electromagnetic tomography
    • Anderer P, Saletu B, Wolzt M, et al. Double-blind, placebo-controlled, multiple-ascending-dose study on the effects of ABIO-08/01, a novel anxiolytic drug, on perception and cognition, utilizing event-related potential mapping and low-resolution brain electromagnetic tomography. Hum Psychopharmacol 2008;23(3):243-54
    • (2008) Hum Psychopharmacol , vol.23 , Issue.3 , pp. 243-254
    • Anderer, P.1    Saletu, B.2    Wolzt, M.3
  • 90
    • 84924665961 scopus 로고    scopus 로고
    • A multicenter, parallelgroup, double-blind, randomized, placebocontrolled, increasing-dose study, to evaluate preliminarily the clinical effects, the safety and tolerability of ABIO 08/01, in patients suffering from panic disorder
    • [Internet]. European Medicines Agency (UK), London. EudraCT Number: 2007-001060-80, [Cited 15 October 2014]
    • PHARMA A. A multicenter, parallelgroup, double-blind, randomized, placebocontrolled, increasing-dose study, to evaluate preliminarily the clinical effects, the safety and tolerability of ABIO 08/01, in patients suffering from panic disorder. In: EudraCT [Internet]. European Medicines Agency (UK), London; 2007. EudraCT Number: 2007-001060-80 Available from: https://www. clinicaltrialsregister.eu/ctr-search/trial/2007-001060-80/IT [Cited 15 October 2014]
    • (2007) EudraCT
    • Pharma, A.1
  • 91
    • 38349090575 scopus 로고    scopus 로고
    • The state of innovation in drug development
    • Kola I. The state of innovation in drug development. Clin Pharmacol Ther 2008;83(2):227-30
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.2 , pp. 227-230
    • Kola, I.1
  • 92
    • 78650592681 scopus 로고    scopus 로고
    • Genetic moderation of CO2-induced fear by 5-HTTLPR genotype
    • Schruers K, Esquivel G, van Duinen M, et al. Genetic moderation of CO2-induced fear by 5-HTTLPR genotype. J Psychopharmacol 2011;25(1):37-42
    • (2011) J Psychopharmacol , vol.25 , Issue.1 , pp. 37-42
    • Schruers, K.1    Esquivel, G.2    Van Duinen, M.3
  • 93
    • 84883027589 scopus 로고    scopus 로고
    • Carbon dioxide inhalation as a human experimental model of panic: The relationship between emotions and cardiovascular physiology
    • Leibold NK, Viechtbauer W, Goossens L, et al. Carbon dioxide inhalation as a human experimental model of panic: the relationship between emotions and cardiovascular physiology. Biol Psychol 2013;94(2):331-40
    • (2013) Biol Psychol , vol.94 , Issue.2 , pp. 331-340
    • Leibold, N.K.1    Viechtbauer, W.2    Goossens, L.3
  • 94
    • 84857684126 scopus 로고    scopus 로고
    • Neurobiology of panic and pH chemosensation in the brain
    • Wemmie JA. Neurobiology of panic and pH chemosensation in the brain. Dialogues Clin Neurosci 2011;13(4):475-83
    • (2011) Dialogues Clin Neurosci , vol.13 , Issue.4 , pp. 475-483
    • Wemmie, J.A.1
  • 95
    • 79954467877 scopus 로고    scopus 로고
    • Unstable maternal environment, separation anxiety, and heightened CO2 sensitivity induced by gene-by-environment interplay
    • D'Amato FR, Zanettini C, Lampis V, et al. Unstable maternal environment, separation anxiety, and heightened CO2 sensitivity induced by gene-by-environment interplay. PLoS One 2011;6(4):e18637
    • (2011) PLoS One , vol.6 , Issue.4 , pp. e18637
    • D'amato, F.R.1    Zanettini, C.2    Lampis, V.3
  • 96
    • 27844539882 scopus 로고    scopus 로고
    • Antipanic efficacy of paroxetine and polymorphism within the promoter of the serotonin transporter gene
    • Perna G, Favaron E, Di Bella D, et al. Antipanic efficacy of paroxetine and polymorphism within the promoter of the serotonin transporter gene. Neuropsychopharmacology 2005;30(12):2230-5
    • (2005) Neuropsychopharmacology , vol.30 , Issue.12 , pp. 2230-2235
    • Perna, G.1    Favaron, E.2    Di Bella, D.3
  • 97
    • 82455167894 scopus 로고    scopus 로고
    • Determinants of pharmacodynamic trajectory of the therapeutic response to paroxetine in Japanese patients with panic disorder
    • Ishiguro S, Watanabe T, Ueda M, et al. Determinants of pharmacodynamic trajectory of the therapeutic response to paroxetine in Japanese patients with panic disorder. Eur J Clin Pharmacol 2011;67(12):1213-21
    • (2011) Eur J Clin Pharmacol , vol.67 , Issue.12 , pp. 1213-1221
    • Ishiguro, S.1    Watanabe, T.2    Ueda, M.3
  • 98
    • 2942534594 scopus 로고    scopus 로고
    • The association between panic disorder and the L/L genotype of catechol-O-methyltransferase
    • Woo JM, Yoon KS, Choi YH, et al. The association between panic disorder and the L/L genotype of catechol-O-methyltransferase. J Psychiatr Res 2004;38(4):365-70
    • (2004) J Psychiatr Res , vol.38 , Issue.4 , pp. 365-370
    • Woo, J.M.1    Yoon, K.S.2    Choi, Y.H.3
  • 99
    • 0035130494 scopus 로고    scopus 로고
    • Modulation by muscarinic antagonists of the response to carbon dioxide challenge in panic disorder
    • Battaglia M, Bertella S, Ogliari A, et al. Modulation by muscarinic antagonists of the response to carbon dioxide challenge in panic disorder. Arch Gen Psychiatry 2001;58(2):114-19
    • (2001) Arch Gen Psychiatry , vol.58 , Issue.2 , pp. 114-119
    • Battaglia, M.1    Bertella, S.2    Ogliari, A.3
  • 100
    • 84860636506 scopus 로고    scopus 로고
    • The R-DoC initiative: Science and practice
    • Craske MG. The R-DoC initiative: science and practice. Depress Anxiety 2012;29(4):253-6
    • (2012) Depress Anxiety , vol.29 , Issue.4 , pp. 253-256
    • Craske, M.G.1


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