Tanshinone IIA attenuates renal fibrosis and inflammation via altering expression of TGF-β/Smad and NF-κB signaling pathway in 5/6 nephrectomized rats

International Immunopharmacology

Volumn 26, Issue 1, 2015, Pages 4-12

  Wang, Dong Tao ^a   Huang, Ren Hua ^a   Cheng, Xin ^a   Zhang, Zhi Hua ^b   Yang, Ya Jun ^c   Lin, Xin ^d  

^a GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^c GUANGDONG MEDICAL UNIVERSITY   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Chronic kidney disease; Renal fibrosis; Tanshinone IIA

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; CREATININE; CXCL1 CHEMOKINE; FIBRONECTIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B ALPHA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TANSHINONE IIA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; ABIETANE DERIVATIVE; HERBACEOUS AGENT; TANSHINONE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY PARENCHYMA; MACROPHAGE; MALE; NEPHRECTOMY; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN URINE LEVEL; PROTEINURIA; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT DURATION; UPREGULATION; UREA NITROGEN BLOOD LEVEL; URINALYSIS; URINARY EXCRETION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHINESE MEDICINE; DISEASE MODEL; DRUG EFFECTS; FIBROSIS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; KIDNEY; KIDNEY FUNCTION TEST; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RENAL INSUFFICIENCY, CHRONIC; SPRAGUE DAWLEY RAT;

ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DITERPENES, ABIETANE; DRUGS, CHINESE HERBAL; FIBROSIS; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY FUNCTION TESTS; MALE; MEDICINE, CHINESE TRADITIONAL; NEPHRECTOMY; NF-KAPPA B; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84924650343     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2015.02.027     Document Type: Article

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