Supplementation of ketoacids contributes to the up-regulation of the Wnt7a/Akt/p70S6K pathway and the down-regulation of apoptotic and ubiquitin-proteasome systems in the muscle of 5/6 nephrectomised rats

British Journal of Nutrition

Volumn 111, Issue 9, 2014, Pages 1536-1548

  Wang, Dong Tao ^a,b   Lu, Lu ^a,b   Shi, Ying ^a,b   Geng, Zhen Bo ^a,b   Yin, Yi ^a,b   Wang, Ming ^a   Wei, Lian Bo ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Chronic kidney disease; Ketoacids; Muscle atrophy

Indexed keywords

ACTIN; ATROGIN 1; CASPASE 3; CREATININE; MUSCLE RING FINGER 1 PROTEIN; NITROGEN; OXOACID; PROTEASOME; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; S6 KINASE; SERUM ALBUMIN; UBIQUITIN; UREA; WNT7A PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIET SUPPLEMENTATION; DOWN REGULATION; MALE; MUSCLE MASS; NEPHRECTOMY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN RESTRICTION; PROTEIN SYNTHESIS; PROTEINURIA; RAT; SIGNAL TRANSDUCTION; TIBIALIS ANTERIOR MUSCLE; UPREGULATION; UREA NITROGEN BLOOD LEVEL;

RATTUS;

ANIMALS; APOPTOSIS; DIET, PROTEIN-RESTRICTED; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; KETO ACIDS; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; NEPHRECTOMY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; UBIQUITINATION; UP-REGULATION; WNT PROTEINS;

EID: 84898006460     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114513004091     Document Type: Article

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